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    Comparison of two different laparoscopic hysterectomies: laparoscopic hysterectomy vs. total laparoscopic hysterectomy
    (Galenos Yayincilik, 2010) Gol, Mert; Kizilyar, Aysen
    Objective: The aim of this study was to compare the efficacy and safety of laparoscopic hysterectomy (LH) and Total Laparoscopic Hysterectomy (TLH). Methods: Both types of hysterectomy were performed by retroperitoneal uterine artery sealing using LigaSure (TM) by four-puncture. A total of 45 patients were operated on by LH and 22 by TLH. The mean operation time, amount of intraoperative bleeding, drop in hemoglobin concentration, weight of removed uterus, major and minor per-post operative complications, and rate of conversion to the classical abdominal approach in the two groups were compared. Results: The mean operation time in TLH (110 min.) was significantly longer than in (65 min.). This was mainly due to the shorter mean operating time in the vaginal part of LH group (13 min.) compared to laparoscopic dissection of uterosacral ligaments and vaginal suturing (42 min.) in the TLH group. Median blood loss was also significantly higher in the group (278 ml.) compared to the LH group (110 ml.). There were no significant differences in the mean drop of hemoglobin concentration, uterine weight, major and minor complications and conversion to laparotomy between the groups. Conclusion: TLH seems to he a faster and more demanding method than With its shorter operation time and less bleeding, TLH may be preferred to TLH.
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    Effect of Fetal Sex on Apoptosis-Regulating Proteins in Trophoblasts of Full-Term Human Placenta
    (Karger, 2008) Gol, Mert; Tuna, Burcin
    Objective: Pregnant women with female fetuses have higher maternal serum human chorionic gonadotropin (hCG) levels compared to those pregnant women with male fetuses. Apoptosis in the placenta has a role in hCG secretion. In the present study, we examined the effect of fetal gender on apoptosis-regulating proteins in the trophoblast cells of human term placenta. Study Design: 34 uncomplicated, singleton, term pregnancies, 17 had male and 17 had female fetuses, were recruited in the study. Apoptosis-regulating proteins of the trophoblast cells were measured by using immunohistochemistry for Bcl-2 and Bax. Staining index values were compared between the female and male pregnancies. Results: There were no sex differences in Bcl-2 and Bax proteins. There were no correlations between maternal serum and cord blood hCG levels, and staining index values of two proteins in trophoblast cells. Conclusions: The difference in maternal serum and cord blood hCG levels in correlation with fetal sex is not associated with apoptosis-regulating proteins in the trophoblast cells of human term placenta. Copyright (C) 2008 S. Karger AG, Basel
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    Influence of high-dose methotrexate therapy on the primordial follicles of the mouse ovary
    (Wiley-Blackwell Publishing, Inc, 2009) Gol, Mert; Saygili, Ugur; Koyuncuoglu, Meral; Uslu, Turhan
    Objective: High-dose methotrexate (MTX) is one of the most prescribed agents in many malignant diseases affecting girls and young women of reproductive ages. This animal study directly measures the primordial follicle loss following exposure to high-dose MTX. Study Design: Nine inbred Balb/c mice aged 7-8 weeks in the study group were administered 5 gr/m(2) MTX as a single agent intraperitoneally, whereas nine mice in the control group received saline. Seven days later the mice were killed and total numbers of the primordial follicles remaining, in both ovaries were counted. Result: In the high-dose MTX group, the mean number of primordial follicles (mean +/- standard deviation) was significantly different (202 +/- 38) versus the control group (327 +/- 81.7; P = 0.002). Conclusions: Our study shows that high-dose MTX causes damage to the primordial follicles of the ovaries of mice. This result may be important because young women taking high-close MTX may suffer diminished reproductive performance and premature cessation of menses in the years following therapy.
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    Recurrent Pregnancy Loss and Its Relation to Combined Parental Thrombophilic Gene Mutations
    (Mary Ann Liebert, Inc, 2012) Ozdemir, Ozturk; Yenicesu, Gonca Imir; Silan, Fatma; Koksal, Binnur; Atik, Sinem; Ozen, Filiz; Gol, Mert
    Background and Aim: Recurrent pregnancy loss (RPL) is a heterogeneous disorder that has been associated with antiphospholipid syndrome and other prothrombotic parameters. We aimed to investigate the prevalence of 12 thrombophilic gene mutations in RPL couples in the current results. Method: In a total of 543 Turkish women with RPL and 327 of their male partners (870 individuals with RPL), and a control group of 106 fertile couples (control) were analyzed for factor V leiden (FVL), factor V H1299R, factor II prothrombin G20210A, FXIII V34L, b-fibrinogen -455G>A, plasminogen activator inhibitor-1 (PAI-1), GPIIIa L33P (HPA-1 a/b L33P), methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, ACE I/D, Apo B R3500Q, and Apo E genes. Results: The overall, heterozygous and/or homozygous point mutations in FVL -FVR2, ApoE2, PAI-1, MTHFR C677T - A1298C, and ACE genes were associated with RPL. There was no meaningful association between RPL and other studied genes. Conclusion: The homozygosity of 4G in PAI-1 and MTHFR C677T genes in women with RPL, and heterozygosity of FVL, FVR2, ACE, and ApoE2 genes in both parents play crucial role in RPL and should be considered as a risk factor in RPL. Current results showed that RPL is related to combined parental (not only maternal) thrombophilic gene mutations.