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Öğe Amlodipine-induced gingival overgrowth(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2016) Ertekin, Yusuf Haydar; Ertekin, Hulya; Uludag, Aysegul; Yakar, Burkay; Tekin, Murat[Anstract Not Available]Öğe Are psychiatric outpatients assessed for smoking?(Duzce Univ, 2017) Ertekin, Hulya; Aydin, Memduha; Arslan, Mehmet; Ertekin, Yusuf Haydar; Eren, IbrahimObjectives: The presence of psychiatric disorder is not obstacle for the treatment to quit smoking; however this treatment is not preferred among primary purposes in these patients. We aimed to investigate use of tobacco, whether asked their smoking habit by a psychiatrist, the request of patients who smoke to quit smoking, whether they can get help from the psychiatric outpatient clinic of knowledge about smoking cessation and Addiction and Treatment of Smoking training of the psychiatrists effects on query of smoking status. Methods: This study was conducted at Outpatient Clinic of the Beyhekim Department of Psychiatry at Konya Education and Research Hospital between June and July 2013. Five-item questionnaire was administered to all participants after the examination in the first phase.. The outpatient clinic doctors were not informed about the questionnaire during examination because of alteration their interrogation of smoking. In September 2013, Addiction and Treatment of Smoking training were given to the psychiatrists doctors working in this study. In the second phase of this study, same questionnaire was administrated to patients of these trained doctors.. Results: 51.1% of participants were smokers. In the first phase of the study, doctors from the 18.3% (n=40) and 53.5% (n = 95) in the second phase had questioned smoking of patients. After training seminar the rate to question of doctors had significantly increased (p<0.001). % 37.9 of participants (n=69) wanted to quit smoking. % 46.9 of participants (n=186) knew that they can get help from the psychiatric outpatient clinic for smoking cessation. Conclusion: Chance to get rid of smoking addiction should be offered to patients in psychiatric outpatient clinics. Working to increase the knowledge of psychiatrics on this subject should be made.Öğe Assessment of genotoxic and cytotoxic effects in COVID-19 patients(Cukurova Univ, Fac Medicine, 2025) Aliravci, Isil Deniz; Berber, Ahmet Ali; Kenanoglu, Nihan Akinci; Ertekin, Yusuf HaydarPurpose: The objective of our study was to ascertain whether the SARS-CoV-2 virus exerts direct cytotoxic and genotoxic effects on human blood defence cells. Materials and Methods: An in vitro analysis was conducted to assess the cytotoxic and genotoxic effects of the virus using three established tests: the mitotic index (MI), micronucleus (MN), and comet assay (CA). These tests were applied to blood samples from 101 patients. The blood samples were simultaneously analyzed using the polymerase chain reaction (PCR) test. The study population included patients of all ages and genders who presented to the outpatient clinic with symptoms suggestive of a respiratory tract infection and fever. Results: The frequency of MN in the human lymphocytes of COVID-19-infected patients (1.06) was higher compared to COVID-19-negative patients (0.68). Similarly, in COVID-19-positive individuals, parameters such as tail length (3.67), tail moment (1.786), and tail intensity in the comet assay showed a significant increase compared to the negative control, indicating DNA damage. In the cytotoxicity assessment, the MI frequency of COVID-19-positive individuals (0.041) was significantly lower than that of negative controls (0.051). Gender did not influence the cyto/genotoxicity (except for tail length) in SARS-CoV-2-infected patients. Among age groups, the SARS-CoV-2 virus increased MI frequency and tail intensity only in middle-aged individuals (26-36 years). Conclusion: The SARS-CoV-2 virus has the potential to induce cytotoxic and genotoxic effects in the human lymphocytes of infected individuals.Öğe Assessment of genotoxic and cytotoxic effects in COVID-19 patients(Cukurova University, 2025) Alıravcı, Işıl Deniz; Ertekin, Yusuf Haydar; Kenanoğlu, Nihan Akıncı; Berber, Ahmet AliPurpose: The objective of our study was to ascertain whether the SARS-CoV-2 virus exerts direct cytotoxic and genotoxic effects on human blood defence cells. Materials and Methods: An in vitro analysis was conducted to assess the cytotoxic and genotoxic effects of the virus using three established tests: the mitotic index (MI), micronucleus (MN), and comet assay (CA). These tests were applied to blood samples from 101 patients. The blood samples were simultaneously analyzed using the polymerase chain reaction (PCR) test. The study population included patients of all ages and genders who presented to the outpatient clinic with symptoms suggestive of a respiratory tract infection and fever. Results: The frequency of MN in the human lymphocytes of COVID-19-infected patients (1.06) was higher compared to COVID-19-negative patients (0.68). Similarly, in COVID-19-positive individuals, parameters such as tail length (3.67), tail moment (1.786), and tail intensity in the comet assay showed a significant increase compared to the negative control, indicating DNA damage. In the cytotoxicity assessment, the MI frequency of COVID-19-positive individuals (0.041) was significantly lower than that of negative controls (0.051). Gender did not influence the cyto/genotoxicity (except for tail length) in SARS-CoV-2-infected patients. Among age groups, the SARS-CoV-2 virus increased MI frequency and tail intensity only in middle-aged individuals (26–36 years). Conclusion: The SARS-CoV-2 virus has the potential to induce cytotoxic and genotoxic effects in the human lymphocytes of infected individualsÖğe Birinci basamakta bir Peripartum Kardiyomiyopati vakası(Yusuf Haydar ERTEKİN, 2016) Yakar, Burkay; Ertekin, Yusuf Haydar; Korkut, YaseminGiriş: Peripartum Kardiyomiyopati (PKM), gebeliğin son ayında ve doğumdan sonraki ilk 5 ay içerisinde, kalp genişlemesi ve kalp kasının zayıflaması sonucu ortaya çıkan konjestif kalp yetmezliği formudur. Otuz yaş ve üzeri gebelik, multiparite, kronik hipertansiyon ve eklampsi PKM gelişiminde önemli risk faktörleridir. Nefes darlığı, çarpıntı, halsizlik, alt extremitede ödem gibi hastalığın erken belirtileri, gebeliğin son dönemlerinde normal karşılaşılabilecek sorunlar olduğundan kalp yetmezliğinden ayırt edilemeyip erken tanı gözden kaçabilmektedir. PKM tanısı anamnez, fizik muayene ve ekokardiyografi ile konur.Vaka Sunumu: Otuzdört yaşındaki kadın hasta, bir aylık bebeğinin aşısını yaptırmak için aile hekimliği polikliniğimize müracaat etti. Hastanın nefes darlığı, çarpıntı ve öksürük şikayeti mevcuttu. Özgeçmişinden iki sağlıklı doğum yaptığı, soygeçmişinde ise annesinin Primer Hipertansiyon ve Tip 2 Diyabet hastası olduğu öğrenildi. Gebeliklerinde ve öncesinde herhangi bir hastalık veya ilaç kullanım öyküsü yoktu. Fizik muayenesinde kan basıncı 120/70mmHg, nabzı ritmik ve 122/dakika, kalp seslerinde üfürümü yok, her iki akciğer bazallerde ralleri mevcut, batın muayenesi doğal saptandı. Her iki alt ekstremitede ise gode bırakan ödemi mevcuttu. Anamnez derinleştirildiğinde çarpıntısının doğumdan iki hafta önce başladığı ve postpartum birinci haftada artış gösterdiği öğrenildi. Kalp yetmezliği ve pulmoner emboli ön tanıları düşünülerek kardiyoloji uzmanına sevk edilen hasta akut dekompanse kalp yetmezliği tanısıyla yoğun bakıma yatırılarak tedavi edildi.Sonuç: PKM gebelikte sık karşılaşılan çarpıntı ve nefes darlığı şikayetlerinin nonspesifik olması sebebiyle erken tanısı güç bir hastalıktır. Hastalığın 30 yaş üzeri annelerde daha sık ortaya çıkması ve günümüzde anne olma yaşının ileri yaşlara gelmesi sebebiyle birinci basamakta PKM’yle karşılaşma olasılığı artmaktadır. Aile hekimleri düşük prevalansta görülen bu hastalığın risk faktörlerini sorgulama, semptomlarını takip etme ve uzmanına danışma yöntemleriyle üstesinden gelebilirÖğe Characteristics of health care workers with SARS-CoV-2 at a COVID-19 hospital in Turkiye: Homologous versus heterologous vaccination(Professional Medical Publications, 2024) Aliravci, Isil Deniz; Ertekin, Yusuf Haydar; Can, Gamze; Alkan, SevilObjective: Given the limited studies on types of vaccination and infection rates among health care workers (HCWs) in T & uuml;rkiye, we analyzed the demographic, clinical, and vaccination characteristics as well as the attitudes of HCWs who have been infected with COVID-19. Methods: We retrospectively analyzed demographic and clinical data on breakthrough COVID-19 infections in HCWs from hospital surveillance data collected between April 5, 2020, and November 1, 2022. The comparison was based on four subgroups that consisted of unvaccinated, one-shot-vaccinated, homologous vaccinated, and heterologous vaccinated individuals. Participants who received various combinations of Sinovac/CoronaVac and/or BioNTech/Pfizer vaccines were compared for detection of COVID-19. Results: During a 33-month period of 744 HCWs who contracted COVID-19, women (65.3%) and nurses (28.9%) were the most affected, followed by doctors (25.8%). Of the infected HCWs, only 1.3% required hospitalization, 0.3% required ICU support, and 98.4% were outpatients. By vaccination status, 143 of the HCWs (19.2%) were unvaccinated, 292 (39.2%) were homologously vaccinated, 294 (39.5%) were heterologously vaccinated, 15 (2%) received a single shot, 206 (27.7%) received two shots, and 165 (22.2%) received three shots. All HCWs contracted COVID-19 at a mean of 134- days (range:1-539) after vaccination. While the proportions of homologously and heterologously vaccinated HCWs were similar, the time elapsed from vaccination to contracting COVID-19 varied (mean 143.4 +/- 106.7 vs.126.4 +/- 82.43 +/- 82.43 days). Conclusions: Among both outpatients and inpatients with COVID-19, women HCWs outnumbered men HCWs. HCWs who received homologous vaccination contracted COVID-19 later than those who received heterologous vaccination.Öğe Children with drug poisoning: Demographic characteristics and assessment of familial factors(Anatolian Journal of Clinical Investigation, 2015) Yakar, Burkay; Ertekin, Yusuf Haydar; Ertekin, HülyaIn this study; drug intoxication, which is one of the most common childhood health problems, demographic characteristics, and to document the before and after the event was aimed to investigate the role of familial factors. The dermographic properties of the children admitted to our emergency department with drug intoxication, the properties regarding to the drug,family behaviours and attitude, the other facts that will effect the drug intake, were documented retrospectively between 01.04.2009-01.10.2009 from the questionary form. Of the 137 intoxication cases that were documented, mean age was 5.3±4.72 (5month-15age), 80 cases were girl (58.3%), 57 were boy (41.6%). When preschool children (n=101, 73.3%) (51 girls,50 boys) compared with school children(n=36, 26.8%), in school children girls were more in the foreground. The number of the admittance to the emergency department in 6 months was 59310. The ratio of the 137 intoxication cases to all intoxication cases was 0.23%. In our case series, the ratio of 85 intoxication cases to all emegency admittance generates 0.14%(62% of all intoxication cases).The most often drugs leading to intoxication were paracetamol (27%), antidepressant (8.1%), and pseudoefedrin (9.4%). The drug intake was especially for attempting suicide in the adolescent period girls. In our country, the probability of intoxication was higher when the children often left alone at home, the drugs were easy to reach and the package of drug has no protection.The families education and income were generally lower. Preventing drug intoxication in childhood period, children protection in the drugs are important as well as family education. In this subject, the community and social organizations should work well conducted. © 2015, Anatolian Journal of Clinical Investigation. All rights reserved.Öğe Clozapine and Aripiprazole-Induced Stuttering: A Case Report of Turner Syndrome with Schizophrenia(Kure Iletisim Grubu A S, 2016) Ertekin, Hulya; Ertekin, Yusuf Haydar; Sahin, Basak; Yayla, Sinan; Turkyilmaz, Ersin; Kara, MedineTurner Syndrome (TS) is the most common chromosomal anomaly in women. Its psychiatric manifestations have not been clearly defined. Occurrence of schizophrenia is higher in patients with TS than in the normal population. The literature has reported instances associating stuttering as a side effect of antipsychotic drugs, particularly clozapine-induced stuttering. We found only one case report describing aripiprazole-associated stuttering. In the present case report, we present a female patient with TS-diagnosed schizophrenia who had been treated with aripiprazole because she developed stuttering during treatment with clozapine and then developed dose-dependent stuttering with aripiprazole.Öğe Correlation between vaspin and PANSS scores in schizophrenia patients with obesity(Sage Publications Inc, 2020) Ertekin, Hülya; Uysal, Sema; Aydın, Memduha; İlhan, Bilge; Ertekin, Yusuf HaydarObjective: Metabolic abnormalities such as diabetes, dyslipidemia, abdominal obesity, metabolic syndrome, and abnormal levels of plasma adipokines have been observed in patients with schizophrenia. This study aimed to investigate the differences and correlations of plasma vaspin levels with metabolic parameters in patients with schizophrenia and to compare with healthy controls. Method: We measured plasma levels of vaspin and metabolic parameters of 100 patients with schizophrenia and 95 healthy controls. Patients with schizophrenia were evaluated with the Positive and Negative Syndrome Scale (PANSS) and The Global Assessment of Functioning. Results: Mean levels of body mass index, waist circumference, triglyceride, and low-density lipoprotein cholesterol of the patients were statistically higher than those of the healthy controls (p = 0.002, p < 0.001, p = 0.03, and p = 0.002, respectively). Plasma levels of vaspin were 0.96 +/- 0.73 ng/ml in patients with schizophrenia and 0.29 +/- 0.15 ng/ml in the healthy controls (p < 0.001). Plasma vaspin levels were statistically higher in patients with schizophrenia than healthy controls both in groups with and without metabolic syndrome and obesity (p < 0.001). Plasma vaspin levels showed a positive correlation with triglyceride in patients with schizophrenia (r = 0.26, p = 0.007). There were positive correlations between vaspin and PANSS scores in schizophrenia patients with obesity (PANSS Positive: r = 0.42, p = 0.01; PANSS Negative: r = 0.42, p = 0.01; PANSS General: r = 0.43, p = 0.01; PANSS Total: r = 0.47, p = 0.006). Conclusions: Our study showed a significant relationship and positive correlation between vaspin and PANSS scores in schizophrenia patients with obesity. Vaspin may play an important role in the metabolic processes of patients with schizophrenia.Öğe Effect of Topically Applied Azithromycin on Corneal Epithelial and Endothelial Apoptosis in a Rat Model of Corneal Alkali Burn(Lippincott Williams & Wilkins, 2016) Arikan, Sedat; Karaca, Turan; Ertekin, Yusuf Haydar; Comez, Arzu Taskiran; Ersan, Ismail; Demirtas, Selim; Elmas, SaitPurpose: To investigate the antiapoptotic effect of topically administered azithromycin (AZM) on corneal epithelial and endothelial cells in a rat model of corneal alkali burn. Methods: Twenty-four Wistar albino rats were divided into 4 equal groups as pseudovehicle (group 1), control (group 2), alkali burned (group 3), and treatment (group 4) groups. Alkali injury was induced only in the right corneas of rats belonging to groups 3 and 4 using 1N NaOH. The rats in group 3 and the rats in group 4 were respectively treated either with an artificial tear gel or with 1.5% AZM eye drops for 5 days. At the fifth day of the experiment, the apoptosis in the corneal epithelium and endothelium of all rats was assessed using a terminal dUTP nick-end labeling (TUNEL) assay. In addition, tumor necrosis factor-alpha (TNF-alpha) density in the corneal epithelium was measured in all rats. Results: The mean numbers of TUNEL+ cells in the corneal epithelium and endothelium of rats in group 3 were 117.1 +/- 23.8 and 34.6.+/- 11.3, respectively, whereas in group 4, they were 75.8 +/- 15.7 and 14.7 +/- 3.5, respectively. Also the mean TNF-alpha densities in the corneal epithelium in group 3 and group 4 were 2.65 +/- 1.3 and 1.65 +/- 1.1, respectively. There was a significant decrease in the mean number of TUNEL+ cells in the corneal epithelium and endothelium and in the mean TNF-alpha density in the corneal epithelium of rats in group 4, when compared with group 3. Conclusions: Topically applied AZM can decrease TNF-alpha-induced apoptosis in corneal alkali burn.Öğe Effect of Using Tri-Axial (3D) Sensor-Assisted Pedometer Measuring Moderate- to High-Intensity Physical Activity on Body Composition: Randomised Controlled Trial(Duzce Univ, 2018) Ertekin, Yusuf HaydarObjective: The effect of tracking the recommended dose of physical activity with pedometer on body composition was investigated. Methods: Participants were randomly assigned to control, walking (PAC) and pedometer (PAC-PED) groups, and moderate-to high-intensity physical activity was prescribed. The participants performed the recommended exercises in PAC group by taking notes on follow-up cards, in PAC-PED group by pedometer, and in control group without a follow-up. Results: A total of 50 participants, 23 in the control group, 11 in the PAC group and 16 in the PAC-PED group, were completed. The average age of all participants was 47.1 +/- 12.8 (25 - 81), the proportion of women and men was 74% and 26%, respectively. The mean body mass index of the participants was 29.7 +/- 5.5 kg / m(2) and body fat ratio was 33.8 +/- 8.5. Participants were followed up for an average of 2.0 +/- 1.2 [0.5 - 6.3] months. There was a significant decrease in body weight in all groups. Body fat percentage did not change in the control group, but significantly decreased in the PAC and PAC-PED groups. Conclusion: While individual follow-up by card in patients with moderate-to high-intensity physical activity reduces body fat ratio, individual follow-up by pedometer reduces body fat ratio even more. Body fat ratio does not change when individual follow-up is not performed.Öğe Herkes için Egzersize Hazırbulunuşluk Anketinin (EGZ-A+) Türkçe versiyona uyarlaması(Yusuf Haydar ERTEKİN, 2018) Ertekin, Yusuf HaydarGiriş: Herkes için Egzersize Hazırbulunuşluk Anketi (EGZ-A+), Amerikan Spor Hekimliği Birliğinin egzersize başlamadan önce sağlık taraması için önerdiği araçlardan biridir.Yöntem: Türkçe çeviriden sonra, aile hekimliği polikliniklerinden yeterli sayıda örnekleme uygulandı. Aynı zamanda katılımcılardan sosyodemografik özellikler toplandı. Veriler SPSS paket programı kullanılarak değerlendirildi.Bulgular: Test/tekrar test analizine göre, ölçek güvenilirliği önemli derecede yüksekti (r = 0,87, p <0,001). Katılımcıların ortalama yaş ± standart sapma ve vücut kütle indeksi sırasıyla 48,0 ± 16,1 ve 27,9 ± 5,9 iken, %58,6’sı (n = 178) erkek cinsiyettir. Hipertansiyon, şeker hastalığı ve sigara içme sıklığı sırasıyla %32,2 (n = 98), %26,0 (n = 79) ve %37,8 (n = 115) idi. Sonuç: Katılımcılar arasında mevcut tıbbi koşulların yüksek oranı, toplum tarafından kullanılmasının gerekliliğini ortaya koymaktadır. Bu çalışma PAR-Q+ ölçeğinin Türkçe uyarlamasını güvenli bir şekilde kullandığını göstermiştir. Bu aracın aile hekimleri tarafından yaygın olarak kullanılması gerektiğine inanıyoruzÖğe İlköğretim sekizinci sınıf öğrencilerinde internet bağımlılığı: Çanakkale örneklemi(2016) Ertekin, Yusuf Haydar; Ertekin, Hülya; Uludağ, Ayşegül; Tekin, MuratAmaç: İnternetin yaygın ve etkili kullanımı, özellikle çocuklar ve gençler olmak üzere tüm toplumu etkilemektedir. Bu çalışmanın amacı ergenliğin başlangıç dönemlerinde yer alan ilköğretim 8. sınıf öğrencilerinde internet bağımlılığı sıklığını araştırmak ve gelir düzeyi ile ilişkisini saptamaktı. Gereç ve Yöntem: Çalışmamız kesitsel-tanımlayıcı desende bir çalışma olup evrenini Çanakkale il merkezinde bulunan 8. sınıf öğrencileri oluşturmuştur. İnternet bağımlılığını tespit etmek amacıyla Young'ın geliştirdiği İnternet Bağımlılığı Ölçeği kullanılmıştır. Bulgular: Çalışmaya %47,0'si (s = 120) kız, %53,0'ü (s = 137) erkek olmak üzere toplam 257 öğrenci alındı. Erkek öğrencilerin ölçek puan ortalaması 29,3 ± 20,0, kız öğrencilerin ise 26,5 ± 17,0 olup aralarındaki fark istatistiksel olarak anlamlı değildi (p>0,05). İnternet bağımlı öğrenci sıklığı %0,8 (s = 2) idi ve her iki bağımlı öğrenci de yüksek gelir düzeyli ailelerin çocuklarının okuduğu okulda eğitim görmekteydi. Olası internet bağımlılığı erkek öğrencilerde kızlardan daha fazlaydı ancak istatistiksel olarak anlamlı farklılık yoktu (p>0,05). Gelir düzeyi yüksek olan ailelerin çocuklarının okuduğu okullarda; düşük olan okula göre internet bağımlı ya da olası bağımlı olan öğrenci sayısı anlamlı olarak daha yüksekti (p = 0,018). Sonuç: Çalışmamıza katılan ilköğretim düzeyindeki adolesan öğrencilerde internet bağımlılığı oldukça düşüktür. Olası internet bağımlılığında erkek cinsiyet ve yüksek gelir düzeyi etkili gibi görünmektedir.Öğe Knowledge, attitude and anxiety of medical students about the current COVID-19 outbreak in Turkey(2020) Yakar, Burkay; Kaygusuz, Türkkan; Pirinçci, Edibe; Önalan, Erhan; Ertekin, Yusuf HaydarIntroduction: The aim of this study was to assess the knowledge, attitude, and behavior of medical students about the COVID-19 and the effect of the outbreak on the students' anxiety levels. Methods: The cross-sectional study was carried out between 07-14 April, with the online questionnaire forms applied to the medical students. A questionnaire forms were sent to one of every two students in the faculty using the systematic sampling method. A total of 530 volunteers were included in the study. The data was collected through a self-administered questionnaire of the socio-demographic characteristics, opinions about the epidemic, knowledge, and attitude of medical students regarding COVID-19. Anxiety levels of the participants were measured with the StateTrait anxiety inventory. Results: A total of 530 medical students had a mean score of knowledge and attitude of 7.83±1.27 and 45.18±5.12, respectively. Participants demonstrated good knowledge and a positive attitude towards COVID-19. Clinical period students had a higher level of knowledge (p<0.001) and positive attitude (p=0.025) compared to preclinical students. While the knowledge score was higher in men (p = 0.033), the attitude score was higher in women (p <0.001). There was a negative correlation between attitude scores and state (p=0.003) and trait anxiety scores (p<0.001). Conclusion: Medical students had sufficient knowledge and attitude towards COVID-19. Anxiety caused by the outbreak may have negative effects on the positive attitudes of the participantsÖğe Majör Depresif Bozukluk Tanılı Hastalarda Yeme Tutumu ve Vücut Kompozisyonunun Depresyon Şiddetiyle İlişkisi(2019) Ertekin, Hülya; Taş, Halil İbrahim; Ertekin, Yusuf Haydar; Yıldızoğlu, Çiler AçarAmaç: Majör depresif bozukluk ve obezite, tüm dünyada sık rastlanan, yüksek ekonomik maliyetlere neden olan, sıklıkla birliktelikgösteren hastalıklardır. Obezite tipi ve vücut yağ oranı dağılımıdepresyonla ilişkili önemli faktörlerdir. Bu çalışmada, majör depresif bozukluk tanılı bireylerin depresyon şiddeti, yeme tutumu özellikleri ve vücut kompozisyonlarının değerlendirilerek sağlıklı bireylerle karşılaştırılması amaçlanmıştır.Materyal ve Metot: Bu çalışmaya Ocak-Mart 2018 tarihleri arasındaMajör Depresif Bozukluk tanısı konulan 30 hasta ile 30 sağlıklı bireydahil edildi. Tüm katılımcıların Bioimpedans analizi ile vücut kompozisyonu (vücut yağ ağırlığı ve oranları) ölçümleri yapıldı. KatılımcılarSosyodemografik veri formu, Beck Depresyon ve Anksiyete Ölçeğive Yeme Tutum Testi ölçeklerini doldurdu.Bulgular: Yaş, cinsiyet ve eğitim durumu gibi sosyodemografikveriler ile vücut kitle indeksi, yeme tutumları, vücut ve abdominalyağ oranı bakımından hasta ve kontrol grubu arasında istatistikselolarak anlamlı fark saptanmadı (sırasıyla p=0,35, p=0,51, p=0,10,p=0,43, p=0,40, p=0,56). Hastaların eğitim düzeyiyle vücut kitle indeksi, vücut ve abdominal yağ oranı arasında negatif korelasyonsaptandı (sırasıyla; r=-0,50, p<0,001; r=-0,65, p<0,001; r=-0,48,p=0,001; r=-0,54, p<0,001). Hastaların anksiyete düzeyiyle abdominal yağ yüzdesi arasında negatif korelasyon saptandı (r=-0,415;p=0,039).Sonuç: Majör depresif bozukluğu olan bireylerdeki anksiyete belirtilerinin ayrıntılı olarak değerlendirilmesi ve eşik altı anksiyete belirtilerinin tedavisi, bu hasta grubunda genel beden sağlığı açısındankoruyucu olabilir.Öğe Metabolic syndrome and vaspin in patients with bipolar disorder(Elsevier Taiwan, 2018) Ertekin, Hulya; Sahin, Basak; Caliskan, Ali Metehan; Inanli, Ikbal; Ertekin, Yusuf HaydarMetabolic disorders and abnormal levels of circulating adipokines have been reported in patients with bipolar disorder (BD). The aim of this study was to investigate the differences in the correlations of vaspin plasma levels and metabolic parameters between two groups: patients with BD and mentally healthy persons. We measured plasma levels of vaspin, metabolic parameters, and metabolic syndrome (MS) in 101 patients with BD and 90 healthy control (HC) subjects. Patients with BD were evaluated with the Young Mania Rating Scale (YMRS) to assess manic symptoms and the Hamilton Depression Scale (HDS) to assess depressive symptoms. The Global Assessment of Functioning (GAF) was used to evaluate the general functions of the patients. Body mass index (BMI), weight, waist circumference (WC), fasting glucose, and triglyceride levels of the study group were statistically higher than those of the healthy controls (p = 0.001, p < 0.001, p < 0.001, p = 0.027, and p = 0.001 respectively). Plasma levels of vaspin were 0.978 ng/ml in patients with BD and 0.292 in the HC group (p < 0.001). Our study revealed associations between metabolic parameters/metabolic syndrome and vaspin plasma concentrations in patients with BD. Vaspin can play a specific role in the pathogenesis of metabolic disorders in these subjects and can be a specific indicator substance in BD. Copyright (C) 2018, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.Öğe Neutrophil Lymphocyte Ratio in Different Types of Glaucoma(2016) Arıkan, Sedat; Ersan, İsmail; Kara, Selçuk; Tufan, Hasan Ali; Kocabıyık, Ömer; Gencer, Baran; Ertekin, Yusuf HaydarAmaç: Nötrofil-lenfosit oranı(NLO)'nın primer açık açılı glokomlu (PAAG) ve psödoeksfoliasyon glokomlu (PEG) hastalarda değerlendirmektir. Gereç ve Yöntem: Kırk PAAG 'lu hasta (Grup 1), 40 PEG'li hasta (Grup 2) ve 40 glokomu olmayan yaş ve cinsiyet uyumlu bireyden (Grup 3) oluşan toplam 120 birey bu retrospektif çalışmaya dahil edildi. NLO hesaplaması bireylerin tıbbi kayıtlarından elde edilen nötrofil sayısının lenfosit sayısına bölünmesine göre yapıldı. NLO ve retina sinir lifi tabaka (RSLT) kalınlığı arasındaki korelasyon tüm gruplarda değerlendirildi. Bulgular: Grup 1, Grup 2 ve Grup 3'deki ortalama NLO değeri sırasıyla 2.3±0.2, 2.9±0.3 ve 1.7±0 şeklindeydi. Grup 1 ve Grup 3 arasında (p=0.012) ve Grup 2 ve 3 arasında ortalama NLO değeri açısından istatistiksel olarak anlamlı fark vardı (p=0.001). Ancak Grup 1 ve Grup 2 arasında NLO açısından anlamlı fark yoktu (p=0.1). Ek olarak NLO'nun RSLT'deki incelme ile ilişkili olmadığı bulundu. Sonuç: Yüksek NLO özellikle PEG'lu hastalarda glokom gelişimindeki oksidatif stres ve inflamasyonun rolünü destekleyebilir.Öğe Premenstrual Dysphoric Disorder and Affective Temperament in Patients with Polycystic Ovary Syndrome(2018) Ertekin, Hülya; Şahin, Başak; Taş, Halil İbrahim; Beyazıt, Fatma; Aşık, Mehmet; Ertekin, Yusuf HaydarINTRODUCTION: This study aimed to evaluate the affectivetemperaments of women with Polycystic Ovary Syndrome(PCOS), to assess its comorbidity with PremenstrualDysphoric Disorder (PMDD) and compare with HealthyControls (HC).METHODS: A total of 20 women with PCOS and 20 HC wereincluded in this study. Hospital Anxiety and Depression Scale(HADS) and Temperament Evaluation of Memphis, Pisa, Parisand San Diego-Autoquestionnaire version (TEMPS-A) wereapplied to all participants. The Diagnoses of PMDD and otherpsychiatric disorders were made by staff psychiatristsinterviewing all participants using DSM-5 diagnostic criteria.RESULTS: The comorbidity of PMDS in patients with PCOSwas 30% (n=6), while it was 15% (n=3) in the HC group.PMDS proportions did not differ significantly between groups.Patients with PCOS had higher major depression (25%, n=5)and anxiety disorders (20%, n=4) compared with HCs, butonly anxiety disorders were significantly higher in PCOS thanthe HC group (p=0.03).DISCUSSION and CONCLUSION: Patients with PCOS mayhave more comorbidity risk of PMDD, which is a mooddisorder according to DSM–5, and associated with menstrualcycles. Considering and treating PMDD and other psychiatricconditions may increase the quality of life and functionality ofwomen with PCOS.Öğe Prevalence of irritable bowel syndrome in primary health care(Cukurova Univ, Fac Medicine, 2017) Ozgen, Kenan; Şahin, Erkan Melih; Uludag, Aysegul; Peker, Emel; Gunayi, Zeynep; Ertekin, Yusuf HaydarPurpose: Irritable Bowel Syndrome includes a group of functional bowel diseases without organic pathology. The prevalence changes between 0.5% to 39% according to diagnostic criteria. In this study, we aimed to investigate the prevalence and characteristics of IBS in primary health care by using Rome III criteria. Material and Methods: This population-based crosssectional study was carried out among 500 adults applying to primary healthcare facilities in eanakkale, Turkey. Data were collected with a data form designed by the researchers, including the Bristol Stool Scale to evaluate defecation characteristics and the ROMA III criteria for the diagnosis of IBS during face-to-face interviews. Results: Of 500 participants, 64 (12.8%) had a previous diagnosis of Irritable Bowel Syndrome who among these were 38 women (59.4%) and 26 men (40.6%). According to the ROMA III criteria no new case was identified. The male: female ratio in Irritable Bowel Syndrome diagnosed patients was 1.46. 34.3% of the patients were diagnosed at a primary healthcare facility, and 62.5% of the patients with Irritable Bowel Syndrome were followed by family practitioners. Conclusion: The prevalence of Irritable Bowel Syndrome found similar with North America and the southern of Europe. Irritable Bowel Syndrome affects mostly females, begins 30-45 age, and constipation-predominant subtype was the most frequent. ROMA III diagnostic criteria is not seem to be appropriate to recognize Irritable Bowel Syndrome cases with mild and moderate severity in primary healthcare.Öğe Prevalence of skin disorders in primary and secondary school age children in Canakkale, Turkey: a community-based survey(Termedia Publishing House Ltd, 2016) Uludag, Aysegul; Kilic, Sevilay Oguz; Isik, Selda; Ertekin, Yusuf Haydar; Tekin, Murat; Cevizci, Sibel; Ogretmen, ZerrinIntroduction: Skin lesions may be of dermatological importance, affect appearance, and cause problems communicating with peers and may be especially more significant in childhood. Aim: Information on the prevalence of pediatric dermatoses in Western Turkey. This study was aimed to define the existing data. Material and methods: A cross-sectional study was conducted in Canakkale, Turkey, in September-December 2013. It involved 1,957 students from five randomly selected primary and secondary schools. Each student was interviewed for age, gender, and family history, and a dermatologic examination was performed by a dermatologist. Data were coded and analyzed. Results: Of the students, 79.9% revealed at least one dermatosis. The most common disease was benign neoplasms (76%), followed by pigmentary disorders (26.8%), and xerosis (5.8%). In primary schools, the acquired melanocytic nevus, hypopigmented macule, and xerosis; in secondary school the acne was statistically significantly more common. Acne and xerosis was more common in girls, and pityriasis alba was statistically more common in boys. Students who had at least one dermatosis were positively correlated with monthly income. Conclusions: In Turkish school age children, the prevalence of dermatosis is 79.9%. It may be due to not using preventive means for adequate protection from the sun and other environmental factors. Infectious dermatosis and atopic dermatitis are rare and it may depend on the adequacy of public health work.
