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    A Pharmacological Perspective on Plant?derived Bioactive Molecules for Epilepsy
    (Springer, 2021) Sharifi-Rad, Javad; Quispe, Cristina; Herrera-Bravo, Jesus; Martorell, Miquel; Sharopov, Farukh; Boyuneğmez Tümer, Tuğba; Kurt, Begüm; Lankatillake, Chintha; Docea, Anca Oana; Moreira, Ana Catarina; Dias, Daniel A.; Mahomoodally, Mohamad Fawzi; Lobine, Devina; Cruz-Martins, Natalia; Kumar, Manoj; Calina, Daniela
    Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifcally proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that favonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant efect, pharmacological models, seizure-inducing factors and response, efective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.
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    Öğe
    Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics
    (Mdpi, 2020) Sharifi-Rad, Mehdi; Lankatillake, Chintha; Dias, Daniel A.; Docea, Anca Oana; Mahomoodally, Mohamad Fawzi; Lobine, Devina; Chazot, Paul L.
    Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.