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Öğe A Mild Type Propofol Infusion Syndrome Presentation in Critical Care(2018) Tezcan, Aysu Hayriye; Öterkuş, Mesut; Dönmez, İlksen; Öztürk, Ömür; Yavuzekinci, ZeynepPropofol infusion syndrome (PRIS) is a rare but fatal disease. Itwas occured mostly after high dose of propofol infusions for longtimes. Metabolic acidosis, hypotension, myoglobinuria, elevatedmuscle and liver enzymes, cardiac arrhythmias, cardiac arrest arecommon manifestations of the syndrome. This case report concludeda mild type of PRIS which was presented after low dose(25–50 mcg/kg/min) infusion for long time. In this case significantmetabolic acidosis, hypotension and arrhythmias were not detectedduring drug infusion. Syndrome was manifested with only significantlyelevated AST, ALT, CK, CKMB, LDH levels. Persistenceof these findings during propofol infusion without patient’s furtherclinical impairments defined as mild type of PRIS. In addition, theimprovements in the biochemical parameters deteriorated afterthe drug was discontinued proved the validity of our diagnosis.Öğe A Reason of Delayed Weaning in Critical Care: Amiodarone Pulmonary Toxicity(2017) Öterkuş, Mesut; Tezcan, Aysu Hayriye; Dönmez, İlksen; Karayol, Sunay Sibel; Öztürk, ÖmürAmiodarone is a frequently used antiarrhythmic drug in criticalcare which was used to treat especially ventricular arrhythmias.But it must known that secondary to its chemical properties, drugtends to accumulate in tissues and it presents as cardiac, ophtalmic,pulmonary and neurological side effects. Amiodarone pulmonarytoxicity (APT) is one of the life-threatening side effects ofthe drug which may present as respiratory failure. And thorax computedtomography scans demonstrate the pathology with pneumonitis,groung glass opacities and fibrosis. Dispnea and coughare common clinical presentations. But an intubated and mechanicallyventilated patient’s respiratory failure secondary to APT mayreflect as only delayed weaning as in our case. Most importantly,rapid diagnosis and early treatment are the most important factorsthat reduce the mortality of patients.