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Öğe A Chemically Induced Experimental Colitis Model with a Simple Combination of Acetic Acid and Trinitrobenzene Sulphonic Acid(Turkish Society of Gastroenterology, 2023) Cinpolat, Havva Yasemin; Buğdaycı, Güler; Şengül, Neriman; Astarcı, Hesna MüzeyyenBackground: It was aimed to induce a new experimental colitis model by using acetic acid and trinitrobenzene sulphonic acid together and to investigate the severity of inflammation biochemically and histopathologically in comparison with other models. Methods: Fifty-six Wistar albino male rats were randomly divided into 4 groups as control, acetic acid, trinitrobenzene sulphonic acid, and combined groups, and the animals were sacrificed following the induction of colitis on the third day and on the seventh day. The serum amyloid A and myeloperoxidase were tested in plasma samples, and the tumor necrosis factor-alpha, interleukin 33, and ST2 were assayed in colon tissue samples with enzyme-linked immunosorbent assay in addition to histopathological examination. Results: There were statistically significant differences between the combined and the control groups both on the third day and on the seventh day in all parameters. There was no difference between the acetic acid group on the seventh day and the control groups in biochemical parameters. Conclusions: The acetic acid model forms acute colitis. The combined model is found to be more successful in forming inflammation when compared to other models.Öğe A visual and bibliometric analysis of Parkinson’s disease biomarker research(2023) Cinpolat, Havva Yasemin; Akar, AliAim: Biomarker research in Parkinson’s lacks a systematic bibliometric review, despite a growing body of bibliometric studies. This study aimed to analyze publications on biomarkers that may play an important role in the diagnosis and treatment of Parkinson’s disease. Materials and Methods: In the study, bibliometric methods were used to analyze the related research in depth. Data were obtained from the Web of Science Core Collection database. Specific keywords consisting of MeSH terms were used as search criteria. The search was conducted in English and the type of publication was selected as article. Microsoft Excel, VOS viewer and the visualization and analytical capabilities of the Biblioshiny R package were used in the analysis, providing a versatile approach to achieve the study objectives. Results: A total of 461 articles on Parkinson’s disease biomarkers published between 2002 and 2023 in 170 journals met the criteria and were analyzed. Regarding publications and citations, the year 2022 stood out. Each document had an average of 6.28 co-authors. The main contributing countries were the United States, China and Italy, with a global co-authorship rate of 30.8%. Notable institutions included the University of Washington, Ruhr University Bochum and the Paracelsus Elena Clinic. \"Journal of Neurochemistry,\" was the journal with the most publications. Through their total link strength, prominent terms such as \"Parkinson’s disease\", \"biomarker\" and \"alpha-synuclein\" showed significant occurrences and thematic relevance. Conclusion: The present study presents the inaugural bibliometric evaluation of biomarkers in Parkinson’s disease. The gradual increase of papers since 2012 indicates persistent scholarly interest and foretells continued significance over the following ten years. Future research will be aided by the study’s depiction of biomarker patterns, which provides insightful information. The term \"Alpha-synuclein\" stood out, highlighting its relevance in our research.Öğe Effect of luer-lock access device on hemolysis during blood collection via intravenous catheters in the emergency department(Walter De Gruyter Gmbh, 2025) Cinpolat, Havva Yasemin; Akman, Canan; Sahin, EdaObjectives: Emergency departments are the units where hemolysis is most frequently observed, and blood collection from intravenous catheters increases the hemolysis rate. This study aimed to compare the effects of two different blood collection methods from an intravenous catheter (an adapter and a syringe) on serum indices, complete blood count, and routine clinical chemistry tests in an emergency department. Methods: The study encompassed 104 patients from the yellow and green zones of the Emergency Department at Canakkale Onsekiz Mart University Hospital. Blood samples were obtained from an intravenous catheter with a standard syringe and an adapter into serum separator tubes and dipotassium ethylenediaminetetraacetic acid (K(2)EDTA) tubes. Serum index, aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), potassium, high-sensitivity (hs) Troponin T, and complete blood count were evaluated. Passing-Bablok regression analysis was performed, and the mean percentage difference was calculated and compared to target values via a Bland-Altman plot. Results: A statistically higher hemolysis rate was observed when blood was collected with a syringe, compared to collecting blood with an adapter (p<0.001). When the results were categorized according to the parameter-specific hemolysis index, AST, CK, potassium, LDH, and hs Troponin T results were more affected by hemolysis when blood was collected with a syringe (p<0.001). The mean percentage difference for AST and LDH exceeded the minimum target values based on biological variation. Conclusions: Using a catheter-compatible adapter in emergency departments may reduce the rate of hemolysis and provide reliable results for tests frequently affected by hemolysis.Öğe Evaluation of serial creatinine measurements with reference change value in gentamicin-treated patients: a new tool in nephrology practice?(Oxford Univ Press, 2025) Yavuz, Demet; Cinpolat, Havva Yasemin; Kal, Oznur; Erdem, Mukadder; Alkan, Sevil; Demirag, Mehmet Derya; Aydemir, NihalIntroduction In this study, we aimed to evaluate serum creatinine levels with reference change value in patients receiving treatment with gentamicin. Methods Serum creatinine levels of patients who received gentamicin were recorded retrospectively before treatment and on the 7th and 14th days after treatment. Analytical coefficient of variation (s/x) x 100 (CV) and reference change value were calculated (z = 1.64,; P < .05). The percentage increase in serum creatinine level at day 7 and day 14 compared with before treatment was considered statistically significant if it exceeded the reference change value. Nephrotoxicity was assessed by comparing changes in serum creatinine levels using reference change value and Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Results A total of 55 patients with a mean (SD) age of 53 (17) years were included in the study. The reference change value for serum creatinine was calculated as11.9%. The rate of increase in serum creatinine levels showed a statistically significant increase in 45.5% and 63.6% of patients on days 7 and 14, respectively, compared with before treatment, while the increase was statistically significant in 8.2% and 25.5% of patients, respectively, when evaluated by KDIGO criteria. Discussion We believe that it would be in the patient's best interest for clinicians to include reference change value in clinical nephrology practice alongside known acute kidney failure criteria.Öğe Evaluation of Serum Creatinine Levels with Reference Change Value in Patients Receiving Colistin Treatment(Oxford University Press, 2023) Cinpolat, Havva Yasemin; Alkan, Sevil; Altınışık, Hatice Betül; Ülker Çakır, Dilek; Oğuzman, HamdiObjective In this study, we aimed to evaluate the serum creatinine (SCr) levels with the reference change value (RCV) in patients receiving colistin treatment. Methods We retrospectively recorded the SCr levels of 47 patients receiving colistin treatment before treatment and on days 3 and 7 after treatment. RCV was calculated with the asymmetrical RCV formula (Z = 1.64, P < .05). Percent (%) increase in the SCr results of the patients was compared with RCV and values exceeding RCV were regarded as statistically significant. Results The RCV was calculated as 15.6% for SCr. Compared with pretreatment values, SCr value on day 3 was 32/47 and on day 7 it was 36/47; as these results exceeded RCV, they were considered statistically significant. Conclusion Use of RCV in the interpretation of results between serial measurements will provide a more rapid and sensitive method when making decisions.Öğe Maculopapular Eruption in COVID-19 Patients: A Single-Center Comparative Study(Galenos Publ House, 2025) Kaya, Özge; Alkan, Sevil; Mermutlu, Selda Işık; Cinpolat, Havva Yasemin; Kılıç, Sevilay OğuzAim: Maculopapular eruption (MPE) due to the coronavirus disease 2019 (COVID-19) is increasingly reported. This study aimed to evaluate COVID-19 patients presenting with MPE and compare them with COVID-19 patients without MPE. Materials and Methods: COVID-19 patients with and without MPE followed up in a single tertiary center between March 2020 and December 2020 were assessed and compared in terms of demographic characteristics, clinical and laboratory findings. Results: A total of 114 COVID-19 patients (female: male ratio=0.4: 1, mean age: 51.44 +/- 16.62 years) confirmed by total polymerase chain reaction testing were evaluated. Patients with MPE during COVID-19 (n=44) and patients without MPE during COVID-19 (n= 70) were divided into two groups and compared. Among clinical findings, the incidence of fever, myalgia, anosmi and ageusia, rhinorrhea, and/or nasal congestion was significantly higher in COVID-19 patients with MPE. In terms of laboratory findings, creatinine, alkaline phosphatase (ALP), gamma-glutamyl transferase, lactate dehydrogenase, vitamin D, erythrocyte sedimentation rate, procalcitonin, ferritin, fibrinogen median levels were significantly higher in COVID-19 patients with MPE. In complete blood count, median hemoglobin, red blood cell, monocyte, eosinophil, and basophil counts were also significantly higher in the MPE group. In the multivariate logistic regression model, ALP was independently associated with MPE in COVID-19 patients (odds ratio: 1.099, 95% confidence interval: 1.056-1.144, p<0.00). Conclusion: The MPE in COVID-19 patients may be indicative of increased inflammation and organ damage. Early diagnosis and isolation of these patients and close follow-up are crucial in reducing the risk of organ damage and severe disease. In addition, ALP is an important laboratory parameter related to MPE in COVID-19 patients.Öğe THE UTILITY OF HEMATOLOGICAL INDICES AT THE INITIAL ADMISSION TO THE NEUROSURGERY CLINIC IN CERVICAL DISC HERNIATION(Galenos Publ House, 2024) Cinpolat, Havva Yasemin; Akar, Ali; Malçok, Ümit Ali; Alkan, SevilObjective: This study aimed to investigate hematological indices to predict spontaneous regression in patients with cervical disc herniation (CDH) during the initial visit to outpatient clinics. Materials and Methods: This retrospective study was carried out at a single center by reviewing laboratory parameters to assess the outcomes of CDH patients. The cohort consisted of patients with CDH who had undergone surgery, those who had undergone conservative treatment and achieved spontaneous regression, and a control group without CDH. The laboratory data consisted of the neutrophil-tolymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammatory index (SIII). Results: Differences in the NLR, MLR, and SIII were statistically significant across groups (p<0.001). Compared with the spontaneous regression and control groups, the surgical intervention group presented significantly greater NLR, MLR, and SIII values. According to the comparison of the patients with CDH in terms of the level of herniation, there were no significant differences at the C4-C5 and upper levels, whereas there was a statistically significant increase in the NLR, MLR, and SIII in the surgical intervention group compared with the spontaneous regression group at the C6-C7 level (p = 0.015, p<0.001, and p = 0.003, respectively). Conclusion: This study provides valuable insights into the use of hematological indices to predict the need for surgical intervention in CDH patients. The observed associations emphasize their practical use, providing a way for further research and their inclusion in routine diagnostic protocols for CDH management.Öğe Use of SGLT2 Inhibitors in Patients with Chronic Kidney Disease and Urinary Tract Infection: Is There a Need for Concern?(Mdpi, 2025) Yavuz, Demet; Cinpolat, Havva Yasemin; Demir, Ayse Kevser; Kadi, Nezaket; Kal, Oznur; Sahin, Iremcan; Alkan, SevilObjective: This study aimed to investigate urinary tract infections (UTIs) and associated risk factors in patients with type 2 diabetes mellitus and chronic kidney disease (CKD), with or without treatment with sodium-glucose cotransporter-2 inhibitors (SGLT2i). Methods: We retrospectively analyzed diabetic CKD patients with available urine culture results. Patients were divided into two groups: those receiving SGLT2i therapy and those not receiving it. The groups were compared retrospectively with respect to the development of urinary tract infection at 12-month follow-up, using clinical and laboratory results. Results: A total of 151 patients with T2DM were included, with a median age of 70 years (range: 61-76), and 84 (56%) were female. Among them, 91 (60%) patients were treated with SGLT2i. BMI, plasma glucose levels, and the urine protein/creatinine ratio were significantly lower in the SGLT2i group (p = 0.002, p = 0.049, and p < 0.001, respectively), while serum urea and creatinine levels were significantly higher (p = 0.048 and p = 0.028, respectively). A total of 59 patients (39.1%) had positive urine cultures, 32 of whom (35.2%) were using SGLT2i. There was no statistically significant difference in UTI incidence between SGLT2i users and non-users (p = 0.298). Among patients with positive cultures, Escherichia coli was the most common pathogen, identified in 52.5% (n = 31) of cases. Patients with positive urine cultures were older (p = 0.005), and 39 (66%) were female (p = 0.038). According to logistic regression analysis, advanced age and female sex were identified as independent risk factors for UTI (p = 0.037; Odds Ratio = 2.172, 95% CI: 1.048-4.502 and p = 0.033; Odds Ratio = 2.169, 95% CI: 1.065-4.415, respectively). Conclusions: In diabetic patients with CKD, the use of SGLT2i reduces proteinuria without increasing the risk of urinary tract infections. Advanced age and female sex are independent risk factors for UTI.
