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    A Chemically Induced Experimental Colitis Model with a Simple Combination of Acetic Acid and Trinitrobenzene Sulphonic Acid
    (Turkish Society of Gastroenterology, 2023) Cinpolat, Havva Yasemin; Buğdaycı, Güler; Şengül, Neriman; Astarcı, Hesna Müzeyyen
    Background: It was aimed to induce a new experimental colitis model by using acetic acid and trinitrobenzene sulphonic acid together and to investigate the severity of inflammation biochemically and histopathologically in comparison with other models. Methods: Fifty-six Wistar albino male rats were randomly divided into 4 groups as control, acetic acid, trinitrobenzene sulphonic acid, and combined groups, and the animals were sacrificed following the induction of colitis on the third day and on the seventh day. The serum amyloid A and myeloperoxidase were tested in plasma samples, and the tumor necrosis factor-alpha, interleukin 33, and ST2 were assayed in colon tissue samples with enzyme-linked immunosorbent assay in addition to histopathological examination. Results: There were statistically significant differences between the combined and the control groups both on the third day and on the seventh day in all parameters. There was no difference between the acetic acid group on the seventh day and the control groups in biochemical parameters. Conclusions: The acetic acid model forms acute colitis. The combined model is found to be more successful in forming inflammation when compared to other models.
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    A visual and bibliometric analysis of Parkinson’s disease biomarker research
    (2023) Cinpolat, Havva Yasemin; Akar, Ali
    Aim: Biomarker research in Parkinson’s lacks a systematic bibliometric review, despite a growing body of bibliometric studies. This study aimed to analyze publications on biomarkers that may play an important role in the diagnosis and treatment of Parkinson’s disease. Materials and Methods: In the study, bibliometric methods were used to analyze the related research in depth. Data were obtained from the Web of Science Core Collection database. Specific keywords consisting of MeSH terms were used as search criteria. The search was conducted in English and the type of publication was selected as article. Microsoft Excel, VOS viewer and the visualization and analytical capabilities of the Biblioshiny R package were used in the analysis, providing a versatile approach to achieve the study objectives. Results: A total of 461 articles on Parkinson’s disease biomarkers published between 2002 and 2023 in 170 journals met the criteria and were analyzed. Regarding publications and citations, the year 2022 stood out. Each document had an average of 6.28 co-authors. The main contributing countries were the United States, China and Italy, with a global co-authorship rate of 30.8%. Notable institutions included the University of Washington, Ruhr University Bochum and the Paracelsus Elena Clinic. \"Journal of Neurochemistry,\" was the journal with the most publications. Through their total link strength, prominent terms such as \"Parkinson’s disease\", \"biomarker\" and \"alpha-synuclein\" showed significant occurrences and thematic relevance. Conclusion: The present study presents the inaugural bibliometric evaluation of biomarkers in Parkinson’s disease. The gradual increase of papers since 2012 indicates persistent scholarly interest and foretells continued significance over the following ten years. Future research will be aided by the study’s depiction of biomarker patterns, which provides insightful information. The term \"Alpha-synuclein\" stood out, highlighting its relevance in our research.
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    Evaluation of Serum Creatinine Levels with Reference Change Value in Patients Receiving Colistin Treatment
    (Oxford University Press, 2023) Cinpolat, Havva Yasemin; Alkan, Sevil; Altinisik, Hatice Betul; Cakir, Dilek Ulker; Oguzman, Hamdi
    Objective: In this study, we aimed to evaluate the serum creatinine (SCr) levels with the reference change value (RCV) in patients receiving colistin treatment. Methods: We retrospectively recorded the SCr levels of 47 patients receiving colistin treatment before treatment and on days 3 and 7 after treatment. RCV was calculated with the asymmetrical RCV formula (Z = 1.64, P <. 05). Percent (%) increase in the SCr results of the patients was compared with RCV and values exceeding RCV were regarded as statistically significant. Results: The RCV was calculated as 15.6% for SCr. Compared with pretreatment values, SCr value on day 3 was 32/47 and on day 7 it was 36/47; as these results exceeded RCV, they were considered statistically significant. Conclusion: Use of RCV in the interpretation of results between serial measurements will provide a more rapid and sensitive method when making decisions. © 2023 The Author(s).
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    Evaluation of Serum Creatinine Levels with Reference Change Value in Patients Receiving Colistin Treatment
    (Oxford University Press, 2023) Cinpolat, Havva Yasemin; Alkan, Sevil; Altınışık, Hatice Betül; Ülker Çakır, Dilek; Oğuzman, Hamdi
    Objective In this study, we aimed to evaluate the serum creatinine (SCr) levels with the reference change value (RCV) in patients receiving colistin treatment. Methods We retrospectively recorded the SCr levels of 47 patients receiving colistin treatment before treatment and on days 3 and 7 after treatment. RCV was calculated with the asymmetrical RCV formula (Z = 1.64, P < .05). Percent (%) increase in the SCr results of the patients was compared with RCV and values exceeding RCV were regarded as statistically significant. Results The RCV was calculated as 15.6% for SCr. Compared with pretreatment values, SCr value on day 3 was 32/47 and on day 7 it was 36/47; as these results exceeded RCV, they were considered statistically significant. Conclusion Use of RCV in the interpretation of results between serial measurements will provide a more rapid and sensitive method when making decisions.
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    Maculopapular Eruption in COVID-19 Patients: A Single-Center Comparative Study
    (Galenos Publ House, 2025) Kaya, Ozge; Alkan, Sevil; Mermutlu, Selda Isik; Cinpolat, Havva Yasemin; Kilic, Sevilay Oguz
    Aim: Maculopapular eruption (MPE) due to the coronavirus disease 2019 (COVID-19) is increasingly reported. This study aimed to evaluate COVID-19 patients presenting with MPE and compare them with COVID-19 patients without MPE. Materials and Methods: COVID-19 patients with and without MPE followed up in a single tertiary center between March 2020 and December 2020 were assessed and compared in terms of demographic characteristics, clinical and laboratory findings. Results: A total of 114 COVID-19 patients (female: male ratio=0.4: 1, mean age: 51.44 +/- 16.62 years) confirmed by total polymerase chain reaction testing were evaluated. Patients with MPE during COVID-19 (n=44) and patients without MPE during COVID-19 (n= 70) were divided into two groups and compared. Among clinical findings, the incidence of fever, myalgia, anosmi and ageusia, rhinorrhea, and/or nasal congestion was significantly higher in COVID-19 patients with MPE. In terms of laboratory findings, creatinine, alkaline phosphatase (ALP), gamma-glutamyl transferase, lactate dehydrogenase, vitamin D, erythrocyte sedimentation rate, procalcitonin, ferritin, fibrinogen median levels were significantly higher in COVID-19 patients with MPE. In complete blood count, median hemoglobin, red blood cell, monocyte, eosinophil, and basophil counts were also significantly higher in the MPE group. In the multivariate logistic regression model, ALP was independently associated with MPE in COVID-19 patients (odds ratio: 1.099, 95% confidence interval: 1.056-1.144, p<0.00). Conclusion: The MPE in COVID-19 patients may be indicative of increased inflammation and organ damage. Early diagnosis and isolation of these patients and close follow-up are crucial in reducing the risk of organ damage and severe disease. In addition, ALP is an important laboratory parameter related to MPE in COVID-19 patients.
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    THE UTILITY OF HEMATOLOGICAL INDICES AT THE INITIAL ADMISSION TO THE NEUROSURGERY CLINIC IN CERVICAL DISC HERNIATION
    (Galenos Publ House, 2024) Cinpolat, Havva Yasemin; Akar, Ali; Malcok, Umit Ali; Alkan, Sevil
    Objective: This study aimed to investigate hematological indices to predict spontaneous regression in patients with cervical disc herniation (CDH) during the initial visit to outpatient clinics. Materials and Methods: This retrospective study was carried out at a single center by reviewing laboratory parameters to assess the outcomes of CDH patients. The cohort consisted of patients with CDH who had undergone surgery, those who had undergone conservative treatment and achieved spontaneous regression, and a control group without CDH. The laboratory data consisted of the neutrophil-tolymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammatory index (SIII). Results: Differences in the NLR, MLR, and SIII were statistically significant across groups (p<0.001). Compared with the spontaneous regression and control groups, the surgical intervention group presented significantly greater NLR, MLR, and SIII values. According to the comparison of the patients with CDH in terms of the level of herniation, there were no significant differences at the C4-C5 and upper levels, whereas there was a statistically significant increase in the NLR, MLR, and SIII in the surgical intervention group compared with the spontaneous regression group at the C6-C7 level (p = 0.015, p<0.001, and p = 0.003, respectively). Conclusion: This study provides valuable insights into the use of hematological indices to predict the need for surgical intervention in CDH patients. The observed associations emphasize their practical use, providing a way for further research and their inclusion in routine diagnostic protocols for CDH management.