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    Genotoxicity of pyrethrin misuse as chamomile substitute
    (Bayrakol Medical Publisher, 2024) Cicekliyurt, Merve M.; Akkus, Gulsum; Tufan, Begum Dermenci; Ipek, Hande; Yalcin, Sibel Oymak
    Aim: Chrysanthemum cinerariaefolium is a white-yellow, daisy-like plant known for more than one hundred fifty years of insecticide property. Although active ingredients of Chrysanthemum cinerariaefolium, pyrethrin is less toxic than organophosphate insecticides, adverse effects on immune system have been demonstrated in numerous animal studies. In our study, the genotoxic potential of accidental consumption (by mixing or unintentional causes) of Chrysanthemum cinerariaefolium instead of chamomile (Matricaria recutita) is investigated. Material and Methods: Lymphocyte isolation was performed from five male, five female donors from peripheral blood samples. Cytotoxic and genotoxic effects of pyrethrin were investigated in human peripheral lymphocyte cultures with chromosome abnormalities (CA). Micronucleus (MN), mitotic index (MI), and nucleus division index (NDI) were calculated. Cultures were treated with mixed doses of pyrethrin and chamomile in different ratios. Results: All doses compared with negative control MN, binucleate, tetranucleate, and MI were significantly increased. In the MN assay, micronucleus formation has been increased due to the gradual increase of pyrethrin/chamomile concentration. In chromosome anomaly test, results differed compared with negative and positive control, and in 24 and 48-hour applications of 1/1 mixed pyrethrin and chamomile samples were founded genotoxically. Discussion: As a result, we have observed pyrethrin has dose-related toxicity increase within the combination. We conclude that the effect of long-term accidental consumption trigger MN, binucleate, tetranucleate formation together with chromosome and chromatin type aberrations.
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    Öğe
    Relationship between oxytocin receptor gene polymorphism and hypertension in Turkish population
    (Elsevier Espana Slu, 2022) Cicekliyurt, Merve M.; Dermenci, Begum
    Introduction and objectives: Known to play a key role in uterine contraction and milk ejec-tion, the neuropeptide, oxytocin, has cardiovascular effects. To date, the known cardiovascular effects of oxytocin are blood pressure lowering (caused by natriuresis and atrial natriuretic peptide release), negative inotropic and chronotropic effect caused by parasympathetic neu-romodulation, anti-stress effect and vasodilation mediated by activation of the nitric oxide pathway. The clinical significance of the rs2268498 polymorphism in oxytocin receptors in these effects is controversial. Based on the known genetic inheritance of hypertension, our research aimed to determine whether the presence of the rs2268498 oxytocin receptor (OXTR) allele C affects hypertension in our region. Methods: This article is a case-control study conducted in the Turkish population. About 140 normotensive and 140 isolated hypertensive volunteers included in the research and genotyped with real-time PCR hybridization method via melt curve analysis.Results: Oxytocin receptor rs2268498 polymorphism was assessed in terms of the risk of hyper-tension and hypertensive individuals were compared to the control group. OXTR rs2268498 polymorphism was not found to be a significant risk factor for dominant, recessive and addi-tive modeled hypertension (ORdominant: 0.966, 95% CI: 0.57-1.61, p: 0.9; ORrecessive: 1, 95% CI: 0.58-1.71, p: 1.0 and ORoverall: 0.98, chi2=0.01).Conclusion: We concluded that rs2268498 single nucleotide polymorphism is not a risk factor for hypertension in our region.(c) 2022 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espan tilde a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).