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Öğe Enantioselective synthesis of 2-aziridinyl phosphonates and studies of their biological activities(Amer Chemical Soc, 2016) Dogan, Ozdemir; Cakir, Sidika Polat; Beksultanova, Nurzhan; Altanlar, Nurten; Simsek, Duygu[Anstract Not Available]Öğe Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities(Pergamon-Elsevier Science Ltd, 2017) Dogan, Ozdemir; Cakir, Sidika Polat; Beksultanova, Nurzhan; Altanlar, Nurten; Simsek, Duygu; Karabiyik, HasanA new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity. (C) 2017 Elsevier Ltd. All rights reserved.Öğe Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities(Tubitak Scientific & Technological Research Council Turkey, 2014) Hossain, Mohammad Shakhawoat; Cakir, Sidika Polat; Karaduman, Ayse Betul; Yamac, Mustafa; Demir, Ayhan SitkiA series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl) aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.
