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    Assessment of thyroid disease in patients who underwent surgical treatment of primary hyperparathyroidism
    (Duzce University Medical School, 2014) Özkul, Faruk; Toman, Hüseyin; Erbağ, Gökhan; Erbaş, Mesut; Anaforoğlu, İnan; Şen, Hacer; Binnetoğlu, Emine
    Purpose: In this study we aimed to evaluate thyroid pathologies in patients with primary hyperparathyroidism who underwent surgery for parathyroidectomy. Methods: Patients who underwent parathyroidectomy for primary hyperparathyroidism between the years of 2006-2012 were included in this retrospective study. Before and after surgery, hormonal and biochemical examinations of the patients and results of preoperative imaging studies were recorded. Results: Of the patients included in the study, 86 were female and 12 were male. Preoperative mean serum calcium level was 12.25 ± 1.48 mg/dL (normal range 8.5-10.1 mg/dL), mean parathyroid hormone (PTH) level was 425.09 ± 440.47 pg/mL (normal range 11-65 pg/mL). The thyroid ultrasound records of 93 patients were available. Of these patients, 26 (28%) had normal ultrasound, 18 (19.4%) had solitary nodule, 43 (46.2%) had multinodular goiter and 4 (4.3%) had thyroiditis (without nodule) and 2 (% 2.2) had solitary nodule with thyroiditis. Adenoma was detected by ultrasonography in 45.2 % of patients, and by scintigraphy in 72.7 of patients. Parathyroidectomy and thyroidectomy were performed at the same time in 54 of 98 patients (65.1%). Of these patients Seven (7.1%) had papillary thyroid cancer, 30 (30.6%) had benign multinodular goiter, 8 patients (8.2%) had benign solitary nodule, 2 patients (2%) had lymphocytic thyroiditis, and 7 (7.1%) had normal thyroid tissue. Conclusion: Thyroid diseases are frequently encountered with primary hyperparathyroidism. Therefore, before performing parathyroidectomy with minimally invasive procedure, patients must be evaluated for thyroid disorders. © 2012 Düzce Medical Journal.
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    Co-occurrence of papillary and follicular thyroid carcinoma in a patient with Hodgkin’s disease
    (2013) Aşık, Mehmet; Özkul, Faruk; Toman, Hüseyin; Durmuş, Ahmet; Anaforoğlu, İnan; Güneş, Fahri; Akbal, Erdem
    [Abstract Not Available]
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    Öğe
    Landscape of congenital adrenal hyperplasia cases in adult endocrinology clinics of Türkiye-a nation-wide multicentre study
    (Springer, 2024) Ertorer, Melek Eda; Anaforoğlu, İnan; Yılmaz, Nusret; Akkuş, Gamze; Turgut, Seda; Ünlühizarcı, Kürşad; Soyluk Selçukbiricik, Özlem; Saygılı, Emre Sedar; Karakılıç, Ersen
    Background and aims Congenital adrenal hyperplasia (CAH) is a group of disorders that affect the production of steroids in the adrenal gland and are inherited in an autosomal recessive pattern. The clinical and biochemical manifestations of the disorder are diverse, ranging from varying degrees of anomalies of the external genitalia to life-threatening adrenal insufficiency. This multicenter study aimed to determine the demographics, biochemical, clinical, and genetic characteristics besides the current status of adult patients with CAH nationwide. Methods The medical records of 223 patients with all forms of CAH were evaluated in the study, which included 19 adult endocrinology clinics. A form inquiring about demographical, etiological, and genetic (where available) data of all forms of CAH patients was filled out and returned by the centers. Results Among 223 cases 181 (81.16%) patients had 21-hydroxylase deficiency (21OHD), 27 (12.10%) had 11-beta-hydroxylase deficiency (110HD), 13 (5.82%) had 17-hydroxylase deficiency (17OHD) and 2 (0.89%) had 3-beta-hydroxysteroid-dehydrogenase deficiency. 21OHD was the most prevalent CAH form in our national series. There were 102 (56.4%) classical and 79 (43.6%) non-classical 210HD cases in our cohort. The age of the patients was 24.9 ± 6.1 (minimum-maximum: 17–44) for classical CAH patients and 30.2 ± 11.2 (minimum-maximum: 17–67). More patients in the nonclassical CAH group were married and had children. Reconstructive genital surgery was performed in 54 (78.3%) of classical CAH females and 42 (77.8%) of them had no children. Thirty-two (50.8%) NCAH cases had homogenous and 31 (49.2%) had heterogeneous CYP21A2 gene mutations. V281L pathological variation was the most prevalent mutation, it was detected in 35 (55.6%) of 21OHD NCAH patients. Conclusion Our findings are compatible with the current literature except for the higher frequency of 110HD and 17OHD, which may be attributed to unidentified genetic causes. A new classification for CAH cases rather than classical and non-classical may be helpful as the disease exhibits a large clinical and biochemical continuum. Affected cases should be informed of the possible complications they may face. The study concludes that a better understanding of the clinical characteristics of patients with CAH can improve the management of the disorder in daily practice.