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Öğe Alterations in Iris Structure and Pupil Size Related to Alpha-1 Adrenergic Receptor Antagonists Use: Implications for Floppy Iris Syndrome(Mary Ann Liebert, Inc, 2013) Tufan, Hasan Ali; Gencer, Baran; Kara, Selcuk; Comez, Arzu Taskiran; Kurt, Hasan Anil; Alan, CabirPurpose: To evaluate structural alterations of iris and pupil diameters (PDs) in patients using systemic alpha-1-adrenergic receptor antagonists (alpha-1ARAs), which are associated with intraoperative floppy iris syndrome (IFIS). Methods: Eighty-eight eyes of 49 male were evaluated prospectively. Patients were assigned to 2 different groups. Study group included 23 patients taking any systemic alpha-1ARAs treatment, and control group included 26 patients not taking any systemic alpha-1ARAs treatment. All patients underwent anterior segment optical coherence tomography to evaluate iris thickness at the dilator muscle region (DMR) and at the sphincter muscle region (SMR). The PD was measured using a computerized infrared pupillometer under scotopic and photopic illumination. Results: The study group included 46 eyes of 23 patients and the control group included 42 eyes of 26 patients. Most treated patients were on tamsulosin (16/23). Mean age was similar in the study and control groups (61.9 +/- 7.1 vs. 60.3 +/- 8, 2 years, nonsignificant). DMR (506.5 +/- 89.4 vs. 503.6 +/- 83.5 mu m), SMR (507.8 +/- 78.1 vs. 522.1 +/- 96.4 mu m) and the DMR/SMR ratio (1.0 +/- 0.15 vs. 0.99 +/- 0.23 mm) was similar in the study and control groups and these differences were nonsignificant. Scotopic PDs were also similar in both groups (3.99 +/- 1.11 vs. 3.74 +/- 1.35, nonsignificant). A significantly reduced photopic PD (2.89 +/- 0.55 vs. 3.62 +/- 0.64, P < 0.001) and an increased scotopic/photopic PD (1.42 +/- 0.44 vs. 1.02 +/- 0.30, P < 0.001) were found in the study group. Conclusions: Evaluating PD alterations might be more useful than evaluating iris structural alterations in predicting IFIS. There is still a need for a reliable method that will determine the possibility of IFIS.Öğe Association between serum inhibin-B levels and coronary artery disease in aging males(Termedia Publishing House Ltd, 2013) Kocoglu, Hasan; Alan, Cabir; Cakir, Dilek Ulker; Malkoc, Ercan; Cosansu, Kahraman; Kinlmaz, Bahadir; Ertung, YunusIntroduction: Atherosclerosis is a systemic disorder. It is a frequent leading cause of coronary artery disease (CAD). Similarly, atherosclerotic vascular alterations could lead to testicular arterial blood flow reduction and impairment of testicular function with age. Inhibin-B has been validated as a valuable serum marker of testicular functions and its correlation with testicular volume was shown in some studies done before. The purpose of this study is to investigate the association between serum inhibin-B levels and CAD in elderly men. Material and methods: Between March 2009 and March 2010, fifty-two 50-80-year-old consecutive patients with Gensini score over 20 and ejection fraction (EF) > 50% were included in the study as the CAD group. Fifty healthy men without any cardiac disease history were recruited as the control group. All patients in the CAD group who had indications for coronary artery angiography underwent selective coronary artery angiography. Results: Inhibin-B, total testosterone and testicular volume levels were found to be significantly lower in the CAD group in comparison with the control group (p = 0.004, p < 0.0001, and p = 0.001 respectively). Conclusions: In this study, although no correlation was found in CAD patients between Gensini score and inhibin-B or testicular volume, inhibin-B levels and testicular volume were significantly lower in patients with CAD than in healthy men. In order to fully assess the relationship between serum inhibin-B levels and CAD, multi-centered prospective and longitudinal studies must be done in elderly male patients.Öğe Association between the androgen levels and erectile function, cognitive functions and hypogonadism symptoms in aging males(Taylor & Francis Ltd, 2011) Kocoglu, Hasan; Alan, Cabir; Soydan, Hasan; Ates, Ferhat; Adayener, Cuneyt; Eren, Ali Erhan; Ersay, Ahmet ResitPurpose: Aging in men is characterized by a moderate decrease in plasma testosterone (T) levels. However, the association between partial androgen deficiency of the aging male and clinical symptoms and the ideal screening test are controversial. In this study, we investigated the association between the androgen levels and erectile function, cognitive functions and hypogonadism symptoms in aging males. Materials and methods: We investigated the association between total (TT), calculated free (FT) and bioavailable (BT) testosterone, and various clinical and laboratory parameters in 103 healthy males, 50-80 years old. Biochemical assessment was done after overnight fasting. Questionnaires were used to test for hypogonadism symptoms, erectile and cognitive functions. Results: TT levels were not correlated with aging in this study. However, FT and BT were found to decrease with age due to rising sex hormone binding globulin. TT levels were strongly correlated with FT and BT levels (respectively p = 0.0001, p = 0.0001). TT, FT and BT were only correlated with cognitive functions (p = 0.012, p = 0.004, p = 0.02 respectively). There was no correlation between TT, FT and BT levels and erectile function and hypogonadism symptoms. Conclusion: T values in our study sample did not correlate with clinical signs and symptoms of hypogonadism. Thus, according to our data, symptoms in the aging male should not be indiscriminately assigned to a decrease in TT, FT or BT levels.Öğe Asymmetric dimethyl arginine levels in testicular tissue and blood of rats with induced experimental varicocele(Elsevier Espana Slu, 2014) Alan, Cabir; Ertung, Yunus; Cakir, Dilek Ulker; Topaloglu, Naci; Ersay, Ahmet Resit; Basturk, GokhanIntroduction: Varicocele is one of the reasons for testicular dysfunction and is frequently known to accompany infertility. The basic pathology of varicocele is the development of endothelial dysfunction. The most important factors in development of endothelial dysfunction are impaired endothelial-linked vasodilatation, increase in free oxygen radicals, reduced synthesis and release of nitric oxide (NO), abnormal vasoconstriction and increased levels of dimethyl arginine. Our aim was to identify and illustrate the relationship between asymmetric dimethyl arginine (ADMA) and NO levels in testicular tissue and plasma of rats with induced experimental varicocele. Materials and methods: Twenty-one adolescent (average 6 weeks) male rats were included in the study and randomly divided into 3 groups. Group 1 (control, n=6) did not undergo any procedure. Group 2 (sham, n=6) had the left renal vein circled proximally but ligation was not performed. Group 3 (varicocele-induced, n=9) had partial ligation of the proximal left renal vein to induce left varicocele. Superoxide dismutase (SOD) enzyme activity and levels of end-products of NO, nitrite and nitrate salts were investigated in testis tissue. Nitrite/nitrate and ADMA levels were investigated in plasma. Histopathological examination was completed with routine hematoxylin-eosine and TUNEL dyes. Results: Tissue SOD and plasma ADMA values were clearly increased in the varicocele group compared to the other groups; tissue and plasma nitrite/nitrate levels were clearly reduced in the varicocele group and this was observed to be statistically significant between the groups. Conclusion: We believe our study has opened an important window on the relationship between infertility observed in varicocele patients and ADMA. We believe that broad-series prospective studies to support this are required. (C) 2014 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Biofeedback in the Treatment of Nocturnal Enuresis: May Be an Alternative Method of Treatment?(Derman Medical Publ, 2015) Topaloglu, Naci; Alan, Cabir; Ersay, Ahmet Resit; Eren, Ali Erhan; Basturk, Gokhan; Alan, HandanAim: Biofeedback is re-education of correct voiding to children with visual, tactile and sensorial stimuli. Biofeedback in the treatment of dysfunctional voiding and urinary incontinence can be used. However, in the treatment of nocturnal enuresis is not included in the routine treatment options. We aimed to investigate the feasibility and effectiveness of biofeedback in the treatment of nocturnal enuresis. Material and Method: 50 children aged 5 years or older, who suffered a case of not wetting more than six-month period and admitted complaints of nocturnal urinary incontinence were included in the study. The mean age of patients was 9,4 +/- 2,52 (6-15). 27 patients (54%) were female and 23 patients (46%) were males. Biofeedback treatment performed to patients as 4 sessions. Each sessions were 30 minutes long every week. All patients were informed and advised to do the same exercise for 30 minutes every day at home. Results: Following the biofeedback treatment, incidence of wetting was found to have decreased significantly. 13% (3) of male patients and 11,1% (3) of female patients have not benefits from treatment. 87% (20) of male and 88,9% (24) of female patients have benefits from the treatment, frequency of urinary incontinence was reduced. Following the treatment, clinical improvement was 88%, while the rate of completely dryness was 54%. Statistical difference was found significantly at the incidence of wetting between before and after the treatment (p<0,05). Discussion: The positive results achieved in a short time indicates that the biofeedback method including the active participation of the child and the family in an environment of play, without medication, is candidate for the alternative treatment to nocturnal enuresis treatment.Öğe Combined point mutations in codon 12 and 13 of KRAS oncogene in prostate carcinomas(Springer, 2012) Sılan, Fatma; Gultekin, Yener; Atik, Sinem; Kilinc, Davran; Alan, Cabir; Yildiz, Fazilet; Uludağ, AhmetProstate cancer is a common malignancy that develops by structural mutation(s) and/or other genetic alterations in specific genes.The G to T transversions in codon 12 and C to T transitions in codon 13 of KRAS proto-oncogene are predominant point mutations that occur in about 20% of different cancers in human. In the current study it was aimed to investigate the prevalence and predictive significance of KRAS mutations in patients with prostate carcinomas. In a total of 30 fresh tumoural tissue specimens were investigated in patients with prostate carcinoma. All tumoural specimens were histo-pathologically diagnosed and genotyped for codon 12, 13 KRAS point mutations by reverse hybridisation and direct sequencing methods. KRAS mutations were found in 12 (40%) samples with 29 samples deriving from adenocarcinomas and 1 sample was small cell prostate carcinoma. In 1 (3.44%) sample codon 12 was found to be mutated and in 2 (6.8%) samples codon 13 and in 9 (31%) samples combined codon 12 and 13 were found to be mutated particularly in higher grade of tumoural tissues. Our study, based on representative collection of human prostate tumours, indicates that combined mutations in codons 12 and 13 KRAS are relatively infrequent and most commonly occur in prostate carcinomas.Öğe Comparison of Effects of Alpha Receptor Blockers on Endothelial Functions and Coagulation Parameters in Patients with Benign Prostatic Hyperplasia(Elsevier Science Inc, 2011) Alan, Cabir; Kirilmaz, Bahadir; Kocoglu, Hasan; Ersay, Ahmet Resit; Ertung, Yunus; Eren, Ali ErhanOBJECTIVE To investigate the effects of alpha receptor blockers used in the treatment of benign prostatic hyperplasia (BPH) on endothelial functions, coagulation parameters, and arterial blood pressure. MATERIALS AND METHODS One-hundred fifteen patients admitted to the treatment protocol because of symptomatic BPH were included in this prospective study. Patients were given the following treatments: doxazosin 4 mg/d (n = 25), terazosin 5 mg/d (n = 26), alfuzosin 10 mg/d (n = 26), tamsulosin 0.4 mg/d (n = 21), and observation (n = 17). All cases were evaluated before treatment and in the 12th week of treatment, according to biochemical parameters, endothelial functions, and arterial blood pressure. Biochemical parameters were bleeding time, coagulation time, prothrombin time, activated partial thromboplastin time, total prostate-specific antigen (PSA), and free PSA. Endothelial functions were evaluated with ultrasonography of the brachial artery. RESULTS When coagulation tests were evaluated, there were significant increases in bleeding and coagulation times in the groups using doxazosin and terazosin. Doxazosin and terazosin lowered arterial blood pressure significantly compared with other treatments. With regard to effects on endothelial function, there were significant differences in flow-mediated dilation rates of the brachial artery at 60 and 90 seconds before and during treatment in the alfuzosin and terazosin groups. CONCLUSIONS Alpha receptor blockers can decrease the risk of cardiovascular complications by both reducing platelet aggregation and protecting endothelial functions in patients with prostatic hyperplasia. The only drug with a favorable effect in all 4 areas of interest, including BPH symptoms, blood pressure, platelet aggregation, and endothelial functions, was terazosin. UROLOGY 77: 1439-1443, 2011. (C) 2011 Elsevier Inc.Öğe CT and MRI findings of renal infestation by a huge active hydatid cyst(2013) Kizildag, Betul; Dagistan, Emine; Gurel, Safiye; Alan, CabirHydatid cysts derived from a type of tapeworm called Echinococcus granulosis larvaes which can situate in various organs or tissues in human body. It encounters as an endemic zoonosis in many regions all over the world including eastern part of Turkey. Renal involvement of hydatid cysts is uncommon even in endemic areas. The imaging properties vary according to the phase of the disease. Although it is a benign condition, the diagnosis of a renal hydatid cyst is critical in managing treatment and complications, such as nephrectomy, medical treatment before surgery and the risk of anaphylaxis or dissemination during intervention. Herein authors reported a case of an isolated involvement of the right kidney by a huge active hydatid cyst in a young man who was treated surgically, emphasising its ultrasound, CT, contrast-enhanced MR and diffusion-weighted imaging findings.Öğe Diagnostic Value of Plasma Pentraxin3- Level For Diagnosis of Erectile Dysfunction(2018) Eren, Ali Erhan; Ersay, Ahmet Reit; Demirci, Emrah; Alan, Cabir; Basturk, GökhanPURPOSE: Erectile dysfunction (ED) is a sexual dysfunction described as the inability to develop or maintain an erection of the penis adequate for sexual intercourse, and its prevalence increases with age. Seen as a common sexual disorder worldwide, organic causes are the underlying reason for 80 percent of ED cases, with the most characteristic pathology responsible for organic ED being atherosclerosis. This study investigates the diagnostic value of plasma PTX-3 levels in arterial ED. MATERIALS AND METHODS: This study included a total of 45 patients who were admitted to the urology and cardiologyoutpatient clinics of the Medical Faculty of Canakkale Onsekiz Mart University (COMU) and consented to participate in this study. Patients were categorized into three equal groups in number: (1) patients with ED diagnosed with coronary artery disease (CAD) (15 patients in total); (2) patients with ED not having coronary artery disease or any other equivalent diseases (diabetes mellitus, hypertension and hyperlipidemia) (15 patients in total);and (3) ordinary patients with no ED (15 patients in total). An interview was conducted at the andrology polyclinic with each patient in order to ascertain detailed information on their medical and sexual history and on demographic characteristics. All patients were also administered the International Index of Erectile Function (IIEF) questionnaire. RESULT: The findings from this study investigating the diagnostic value of plasma PTX-3 levels in ED were statistically significant for two comparisons: the differences between the peripheral blood and cavernous blood values of the patient groups (group 1 and 2) and the control group (group 3), and the differences between the peripheral blood and cavernous blood values of group 2 (patients with ED who do not have CAD) and the control group (group 3). CONCLUSION: As PTX-3 is more specific than the formerly recognized biochemical markers in endothelial dysfunction, it can be used in the diagnosis of vascular originated ED.Öğe Diagnostic Value of Plasma Pentraxin3-Level For Diagnosis of Erectile Dysfunction(Urol & Nephrol Res Ctr-Unrc, 2018) Eren, Ali Erhan; Ersay, Ahmet Resit; Demirci, Emrah; Alan, Cabir; Basturk, GokhanPurpose: Erectile dysfunction (ED) is a sexual dysfunction described as the inability to develop or maintain an erection of the penis adequate for sexual intercourse, and its prevalence increases with age. Seen as a common sexual disorder worldwide, organic causes are the underlying reason for 80 percent of ED cases, with the most characteristic pathology responsible for organic ED being atherosclerosis. This study investigates the diagnostic value of plasma PTX-3 levels in arterial ED. Materials and Methods: This study included a total of 45 patients who were admitted to the urology and cardiology outpatient clinics of the Medical Faculty of Canakkale Onsekiz Mart University (COMU) and consented to participate in this study. Patients were categorized into three equal groups in number: (1) patients with ED diagnosed with coronary artery disease (CAD) (15 patients in total); (2) patients with ED not having coronary artery disease or any other equivalent diseases (diabetes mellitus, hypertension and hyperlipidemia) (15 patients in total); and (3) ordinary patients with no ED (15 patients in total). An interview was conducted at the andrology polyclinic with each patient in order to ascertain detailed information on their medical and sexual history and on demographic characteristics. All patients were also administered the International Index of Erectile Function (IIEF) questionnaire. Result: The findings from this study investigating the diagnostic value of plasma PTX-3 levels in ED were statistically significant for two comparisons: the differences between the peripheral blood and cavernous blood values of the patient groups (group 1 and 2) and the control group (group 3), and the differences between the peripheral blood and cavernous blood values of group 2 (patients with ED who do not have CAD) and the control group (group 3). Conclusion: As PTX-3 is more specific than the formerly recognized biochemical markers in endothelial dysfunction, it can be used in the diagnosis of vascular originated ED.Öğe Disorders of sex development(Elsevier Doyma Sl, 2013) Alan, Cabir; Altundas, Ramazan; Topaloglu, Naci; Haciveliogiu, Servet Ozden; Kocoglu, Hasan; Ersay, Ahmet ResitBackground: Disorders of sex development (DSD), which has the possibility of the risk of life-threatening endocrinologic emergencies of the newborn, require a careful multidisciplinary approach. Objectives: The aim of our study is to consolidate the proposed classification, evaluation and management of DSD. Materials and methods: The literatures related with DSD were reviewed to find the best approach for this disease. Results: The detailed history, systemic physical examination of the patient, particular laboratory and imagine evaluations are needed for the urgent treatment of life-threatening abnormalities and the gender assignment. Conclusion: The gender should be assigned depending on the definitive diagnosis, fertility potential, genital appearance, surgical options, and the parents' opinion. (C) 2013 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Esparta, S.L. All rights reserved.Öğe Effect of stress urinary incontinence on female sexual functions(2012) Hacivelio?lu, Servet; Alan, Cabir; Koço?lu, Hasan; Alan, Handan; Ersay, Ahmet ReşitObjective: To evaluate the effects of urinary incontinence on female sexual functions. Material and Methods: The study included a total of sexually active 78 female patients with the complaint of urinary incontinence and were diagnosed as stress urinary incontinence. For assessment of sexual functions, the short form of Pelvic Organ Prolapsed / Urinary Incontinence Sexual Questionnaire (PISQ-12) was filled out by interview with each patient. The questionnaire was made up of 12 questions and answers were graded on a 5-point Likert Scale from "never" to "always". Results: The mean age of 78 the participants was 55.87±10.64 years (range 24-65). The rates of post-menopausal and premenopausal state were 70% (n=54) and 30% (n=24) respectively. The mean duration of incontinence was 6,20±5,10 (1-26) year. We found that the mean of total scores on PISQ--12 questionnaire was 13,70±11,14. These low results indicated that sexual functions deteriorated in patients who had urinary incontinence. The PISQ --12 score of the postmenopausal patients (11,91±3,73) was less than that of premenopausal patients (14,59±2,27) (p<0.05). In addition, as the patient's age and the number of parity increased, it seemed that the amount of deterioration in sexual dysfunction also increased. Conclusion: Female sexual function is negatively affected by urinary incontinence. Copyright © 2012 by Türkiye Klinikleri.Öğe Efficacy of duloxetine in the early management of urinary continence after radical prostatectomy(S. Karger AG, 2014) Alan, Cabir; Eren, Ali E.; Ersay, Ahmet R.; Kocoglu, Hasan; Basturk, Gokhan; Demirci, EmrahAim: To evaluate the efficacy of early duloxetine therapy in stress urinary incontinence occurring after radical prostatectomy (RP). Material and Method: Patients that had RP were randomly divided into 2 groups following the removal of the urinary catheter. Group A patients (n = 28) had pelvic floor exercise and duloxetine therapy. Group B patients (n = 30) had only pelvic floor exercise. The incontinence status of the patients and number of pads were recorded and 1-hour pad test and Turkish validation of International Consultation on Incontinence Questionnaire-Short Form test were applied to the patients at the follow-up. Results: When the dry state of the patients was evaluated, 5, 17, 3, and 2 of 28 Group A patients stated that they were completely dry in the 3rd, 6th, 9th and 12th month respectively and pad use was stopped. There was no continence in 30 Group B in the first 3 months. Twelve, 6, and 8 patients stated that they were completely dry in the 6th, 9th and 12th month, respectively. But 3 of 4 patients in whom dryness could not be provided were using a mean of 7.6 pads in the first day and a mean of 1.3 pads after 1 year. When pad use of the patients was evaluated, the mean monthly number of pad use was determined to be 6.2 (4-8) in the initial evaluation, 2.7 (0-5) in the in 3rd month, 2 (0-3) in the 6th month and 1.6 (0-2) pad/d in the 9th month in the group taking medicine. The mean monthly number of pads used was determined to be 5.8 (4-8) in the initial evaluation, 4.3 (3-8) in the 3rd month, 3 (0-6) in the 6th month and 1.6 (0-6) pad/d in the 9th month in the group not taking medicine. Conclusion: According to the results, early duloxetine therapy in stress urinary incontinence that occurred after RP provided early continence. © 2014 S. Karger AG, Basel.Öğe Efficacy of early duloxetine therapy in urinary incontinence occurred after radical prostatectomy(Wiley-Blackwell, 2013) Eren, Ali Erhan; Alan, Cabir; Bastruk, Gokhan[Anstract Not Available]Öğe Endothelial Dysfunction and Ischemia-Modified Albumin Levels in Males with Diabetic and Nondiabetic Erectile Dysfunction(Hindawi Ltd, 2022) Kurt, Hasan Anil; Demirci, Emrah; Alan, CabirIn this study, we aimed to determine endothelial dysfunction and ischemia-modified albumin (IMA) levels in patients diagnosed with erectile dysfunction (ED) and to examine the relationship between these and diabetes disease. 86 male patients (46 patients with diabetes, age: 51.5 +/- 9.2 and 40 patients with nondiabetes (control group), age: 54.78 +/- 12.2) were included in the study. IMA, a new indicator of tissue ischemia and oxidative stress, was checked. Superoxide dismutase (SOD) activity, another oxidative stress indicator, was examined. Endothelin-1 (ET-1), one of the parameters of endothelial dysfunction, was measured. Additionally, endothelial function was evaluated with flow-mediated vasodilatation (FMD). Student's t-test was used for statistical evaluation. p values less than 0.05 were considered statistically significant. SOD activity was significantly lower in the diabetic group than in the control group, and ET-1 was significantly higher (p < 0.001). IMA was found to be significantly higher in the diabetic group than the control group (p < 0.001). FMD was significantly lower in diabetic group compared to the control group (p < 0.002). According to our findings, the co-occurrence of erectile dysfunction and diabetes demonstrates a complex condition that includes endothelial dysfunction, oxidative stress, and tissue ischemia. When the correlation of indicators, which are markers, was examined, the severity of the co-occurrence of diabetes and erectile dysfunction was again demonstrated.Öğe Enurezisli erişkin hastalarda biofeedback tedavisinin etkinliği(2016) Sancak, Eyüp Burak; Akbaş, Alpaslan; Alan, Cabir; Ersay, Ahmet ReşitAmaç: Çalışmanın amacı; primer monosemptomatik enurezisli (MsE) erişkinlerde, biofeedback tedavisinin etkinliğini araştırmaktır. Gereç ve Yöntemler: Prospektif dizaynlı bu çalışmada, primer MsE'li erişkin hastalar çalışmaya dahil edildi. Nörojen mesaneli, gündüz işeme problemi olan, anatomik anomalisi olan ve enurezisle ilişkili başka hastalığı olan hastalar çalışmaya alınmadı. Kriterlere uyan 13 hastanın demografik verileri kaydedildi. Biofeedback öncesinde ve tedavinin bitiminden sonra 3. ayda, hastaların enurezis sıklıkları, üroflovmetri değerleri, rezidüel idrar miktarları (PVR) ve total mesane hacmi (TMH) (işeme hacmi + PVR) değerlendirildi. Biofeedback tedavinin başarısı, ayda bir kez veya daha az gece ıslatması olarak tanımlandı. Bulgular: Altı erkek ve yedi kadını içeren toplam 13 hastanın yaş ortalaması 29.2 ± 8.2 idi. Biofeedback tedavisi öncesinde aylık enurezis sıklığı 23.4 ± 5.9 iken, tedavi sonrasında 5.2 ± 8.9 olarak hesaplandı (p=0.002). Biofeedback tedavisi öncesi ve sonrasında; PVR, maksimum idrar akım hızı (Qm) ve ortalama akım hızı (Qa) açısından fark saptanmadı. Biofeedback tedavisi sonrası, TMH'nin 277.8 ml'den 329.9 ml'ye yükseldiği belirlendi (p=0.001). Sonuç: Primer MsE olan erişkin hastalarda biofeedback tedavisi, güvenli basit ve kolay uygulanabilen bir tedavi seçeneğidir. Mesane kapasitesini artırdığı saptanan bu tedavi, bu özel hasta grubu için önerilebilir.Öğe Human os penis(Polish Urological Assoc, 2010) Ersay, Ahmet Resit; Alan, Cabir; Kocoglu, HasanThis report presents a case of a 45-year-old male suffering from a rod-like mass at the base of his penis. He has been aware of its existence since puberty. Physical examination revealed a bone-hard, mobile, stick-like structure behind the corpus spongiosum in the median plane. A calcified periurethral rod-like 5 cm mass at the ventral aspect of intercorporeal septum of the penis was noted on computed tomography (CT) scan. The patient, who had no symptoms associated with erectile dysfunction, refused further diagnostic tests and intervention.Öğe Is cognitive processing affected in adults with hypospadias?: P300 study(De Gruyter Poland Sp Z O O, 2015) Tekeli, Hakan; Kocoglu, Hasan; Alan, Cabir; Tavsanli, Mustafa Emir; Yasar, Halit; Malkoc, Ercan; Kendirli, Mustafa TanselBackground: Hypospadias is a common urogenital system disorder. The frenulum, which is the most sensitive area of the glans penis, is not present in patients with hypospadias. This may lead to a failure in sexual and ejaculatory function, and cause emotional problems affecting cognitive processes. Aim: We aimed to study auditory Event Related Potentials (ERP) in patients with hypospadias to understand the status of cognitive function. Materials and Methods: Seventeen patients with hypospadias who presented to the Urology Outpatient Clinic of anakkale Military Hospital, and 11 healthy individuals of similar age were chosen. The auditory oddball paradigm with ERP from the Cz and Fz head regions were studied. The latency and amplitude of the P300 wave were measured. Results: Both, the study and control groups consisted of young males. Although the study group had a longer P300 latency and lower P300 amplitude when compared to control group, the results were not statistically significant (p: 0.059 and 0.346 respectively). Conclusion: Although the results are not statistically significant, our findings indicate that there may be cognitive changes in patients with hypospadias. Further studies of larger sample size and older patient cohorts are needed.Öğe Kadınlarda idrar kaçırma tedavisinde uygulanan vaginal cerrahi girişimin cinsel fonksiyon üzerine olan etkisi(2009) Alan, Cabir; Ersay, Ahmet Reşit; Alan, Handan; Zor, Murat; Kilciler, MeteAmaç: Vajenin ön kısmının zengin sinir ağı nedeniyle kadın seksüel fonksiyonunda önemli bir yere sahip olduğu yapılan çalışmalarla gösterilmiştir. Kadınlarda idrar kaçırma prevalansı oldukça yüksek bir sağlık sorunudur. İdrar kaçırmanın birden fazla tipi vardır ve her biri içinde ayrı tedavi seçenekleri sunulmaktadır. Bu çalışmada idrar inkontinansının tedavisi için yapılan transvajinal girişimlerin seksüel fonksiyonları etkileyip etkilemediği araştırıldı. Gereç ve yöntem: Ekim 2005-Ağustos 2008 yılları arasında stres üriner inkontinans (SUI) nedeniyle transobturator vaginal tape (TOT) operasyonu uygulanan 54 kadın hastanın seksüel yönden aktif ve partneri olan 48’ine (%88) kliniğimizce oluşturulan 10 soruluk bir sorgulama formu doldurtuldu. Sorgulama formundaki 3 soru kontinans durumu ile, 7 soru ise cinsel fonksiyon durumu ile ilgiliydi. Kuruluk ile cinsel doyum arasındaki ilişki ki-kare ve fisher exact test kullanılarak karşılaştırıldı. Bulgular: TOT uygulanan hastaların ortalama yaşı 51.9 (38-68) ve ortalama takip süresi 14.7 ay (7.5-26.9) olarak saptandı. Cinsel fonksiyon değerlendirmesinde hastaların 5’i (%10), cinsel ilişki sırasında ağrı tarifledi ve bu olguların preoperatif dönemde de disparoni yakınması mevcuttu. Operasyon öncesi ve sonrası ilişki sırasındaki cinsel doyum farkı sorgulandığında hastaların 11’i (%23) olumsuz yönde etkilendiğini belirtti. Bu olguların menapozal durumu incelendiğinde tamamının menapozal dönemde olduğu ve 5’inde preoperatif dönemde de cinsel fonksiyon bozukluğu belirtileri olduğu belirlendi. Kuruluk (idrar kaçırmanın ortadan kalkması) ile cinsel doyuruculuk arasındaki ilişki incelendiğinde; kuru olan 47 hastanın 34’ü (%73) değişiklik olmadığını belirtti. Sonuç: Vaginal yoldan uygulanan bir girişim olan TOT operasyonu minimal invaziv bir cerrahi girişimdir ve ciddi seksüel disfonksiyona neden olmamaktadır. Postoperatif dönemde ortaya çıkan cinsel işlev bozukluğu ile ilgili şikayetler, postmenapozal hormonal durumun değişmesine bağlı olabilir.Öğe Nitric oxide and asymmetric dimethyl arginine (ADMA) levels in an experimental hydronephrotic kidney caused by unilateral partial ureteral obstruction(Brazilian Soc Urol, 2016) Alan, Cabir; Kurt, Hasan Anil; Topaloglu, Naci; Ersay, Ahmet Resit; Cakir, Dilek Ulker; Basturk, GokhanAim: Our aim is to measure asymmetric dimethyl arginine and nitric oxide levels in rats with induced unilateral acute ureteral obstruction to research the effects on the kidney. Material and Methods: The study included 21 adolescent (average age 6 weeks) Sprague-Dawley male rats weighing between 240-290g divided at random into 3 groups. Group-1: Control group (n= 6): underwent no procedures. Group-2: Sham group ( n= 6): underwent the same procedures as the experimental group without ureter and psoas muscle dissection. Group-3: Group with induced partial unilateral ureteral obstruction (n= 9). All rats were sacrificed after 12 weeks. Superoxide dismutase enzyme activity and nitrite and nitrate salt levels were measured in renal tissue. Plasma nitrite-nitrate and ADMA levels were examined. Results: In the experimental group histopathological changes observed included renal pelvis dilatation, flattened papillae, sclerotic glomerulus and fibrosis. In the experimental group tissue SOD and blood ADMA levels were higher than the control and sham groups (p< 0.05) while tissue NO and plasma NO values were lower than in the sham and control groups (p< 0.05). Conclusion: Oxidative stress and disruption of NO synthesis play an important role in renal function and histopathological changes after obstructive renal disease. To prevent renal complications developing after obstructive nephropathy we believe that a new strategy may be research on reducing ADMA.
