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Öğe A Case of Posterior Mediastinal Ganglioneuroma: The Importance of Preoperative Multiplanar Radiological Imaging(Galenos Publ House, 2013) Kizildag, Betul; Alar, Timucin; Karatag, Ozan; Kosar, Sule; Akman, Tarik; Cosar, MuratGanglioneuromas are mostly seen in adolescents and young adults and they are neurogenic tumors originating from sympathetic ganglions with a benign histology. Although ganglioneuromas are benign, the treatment is surgical as they can cause pain or compression symptoms, can be locally aggressive and can lead to cord compression. We present a young adult female with a ganglioneuroma of the right posterior mediastinum who presented with lower back pain, together with the clinical features, Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) findings, differential diagnosis tips and their contribution to surgical planning.Öğe Atypical spinal tuberculosis: posterior paravertebral spread(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Komurcu, Erkam; Kizildag, Betul; Kosar, Sule; Akman, TarikSpinal tuberculosis phenomenon that is an extra pulmonary form of tuberculosis infection, the prognosis of which changes dramatically by early diagnosis and treatment, is still a significant health problem. While early diagnosis and treatment of typical spinal tuberculosis progressing typically is performed without any problems, incorrect treatment of spinal tuberculosis cases presenting atypical findings can lead to dramatic results despite the improvement in modern imaging techniques. In our study we aimed to present an atypical spinal tuberculosis case, for which a correct diagnosis based on abscess and fistula on the thigh that is unique in literature with accompanying pseudomonas co-infection presenting as an undefined atypical spread.Öğe Changes in retinal nerve fiber layer thickness after spinal surgery in the prone position: a prospective study(Elsevier Science Inc, 2015) Gencer, Baran; Cosar, Murat; Tufan, Hasan Ali; Kara, Selcuk; Arikan, Sedat; Akman, Tarik; Kiraz, Hasan AliBackground and objectives: Changes in ocular perfusion play an important role in the pathogenesis of ischemic optic neuropathy. Ocular perfusion pressure is equal to mean arterial pressure minus intraocular pressure. The aim of this study was to evaluate the changes in the intraocular pressure and the retinal nerve fiber layer thickness in patients undergoing spinal surgery in the prone position. Methods: This prospective study included 30 patients undergoing spinal surgery. Retinal nerve fiber layer thickness were measured one day before and after the surgery by using optical coherence tomography. Intraocular pressure was measured by tonopen six times at different position and time-duration: supine position (baseline); 10 min after intubation (Supine 1); 10 (Prone 1), 60 (Prone 2), 120 (Prone 3) min after prone position; and just after postoperative supine position (Supine 2). Results: Our study involved 10 male and 20 female patients with the median age of 57 years. When postoperative retinal nerve fiber layer thickness measurements were compared with preoperative values, a statistically significant thinning was observed in inferior and nasal quadrants (p=0.009 and p=0.003, respectively). We observed a statistically significant intraocular pressure decrease in Supine 1 and an increase in both Prone 2 and Prone 3 when compared to the baseline. Mean arterial pressure and ocular perfusion pressure were found to be significantly lower in Prone 1, Prone 2 and Prone 3, when compared with the baseline. Conclusions: Our study has shown increase in intraocular pressure during spinal surgery in prone position. A statistically significant retinal nerve fiber layer thickness thinning was seen in inferior and nasal quadrants one day after the spinal surgery. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.Öğe Comparison of Anterior Cervical Discectomy Fusion Techniques: Bladed and Non Bladed PEEK Cages(Turkish Neurosurgical Soc, 2016) Guven, Mustafa; Cosar, Murat; Alkan, Bahadir; Aras, Adem Bozkurt; Akman, Tarik; Safak, Ozbey; Karaarslan, OznurAIM: The aim of this study is to compare the different types of fusion materials known as PEEK cages used during anterior cervical discectomy (ACD) surgery. MATERIAL and METHODS: A total of 67 patients were operated and evaluated retrospectively under two groups (group A: 35 PEEK cage patients, group B: 32 bladed PEEK cage patients) between 2009 and 2013. Preoperative and postoperative (postoperative first day, postoperative 1st, 3rd and 12-24th mo) images were obtained. The cervical disc heights, cervical and segmental lordotic angles of the operated levels were calculated. Pain assessment was performed and fusion rates were also compared. Mann-Whitney U test was applied to compare the outcomes. RESULTS: The pain scores (especially for arm pain) were decreased significantly in both groups after surgery regardless of the type of operation technique (P<0.05). There were no significant differences between both groups at the disc height measurements of operated levels in postoperative periods (P>0.05). In addition to these; there was no significant difference between both groups of segmental and cervical lordodic angles in postoperative periods (P>0.05). There was no statistically significant difference between the fusion rates and pain scores of both groups (P>0.05). CONCLUSION: The PEEK cage and bladed PEEK cages can be used safely to obtain fusion after ACD.Öğe Condensing osteitis of the clavicle in a man: Any relationship with tooth decay?(Pakistan Medical Assoc, 2014) Altiok, Inci Baltepe; Tokmak, Mehmet; Akman, Tarik; Alkan, Bahadir; Cosar, MuratCondensing osteitis of the clavicle is a rarely seen pathology since its first description in 1974. Although mechanical stress is claimed for aetiology, but remains a dilemma for physicians. The intermittent or steady pain is variable in intensity and generally localised at the medial end of the involved clavicle, supraclavicular fossa, ipsilateral anterior thorax and shoulder. In this report, we present a 28-year-old man with the regression of the condensing osteitis of the clavicle after the extraction of a decayed tooth.Öğe Effects of Aloe Vera on Spinal Cord Ischemia-Reperfusion Injury of Rats(Taylor & Francis Inc, 2016) Yuksel, Yasemin; Guven, Mustafa; Kaymaz, Burak; Sehitoglu, Muserref Hilal; Aras, Adem Bozkurt; Akman, Tarik; Tosun, MuratAim: The purpose of this study was to evaluate the possible protective/therapeutic effects of aloe vera (AV) on ischemia-reperfusion injury (I/R) of spinal cord in rats. Materials and Methods: A total of 28 Wistar Albino rats were divided into four random groups of equal number (n = 7). Group I (control) had no medication or surgery; Group II underwent spinal cord ischemia and was given no medication; Group III was administered AV by gastric gavage for 30days as pre-treatment; Group IV was administered single dose intraperitoneal methylprednisolone (MP) after the ischemia. Nuclear respiratory factor-1 (NRF1), malondialdehyde (MDA) and superoxide dismutase (SOD) levels were evaluated. Tissue samples were examined histopathologically and neuronal nitric oxide synthase (nNOS) and nuclear factor-kappa B (NF-B) protein expressions were assessed by immunohistochemical staining. Results: NRF1 and SOD levels of ischemia group were found to be lower compared to the other groups. MDA levels significantly increased after I/R. Treatment with AV and MP resulted in reduced MDA levels and also alleviated hemorrhage, edema, inflammatory cell migration and neurons were partially protected from ischemic injury. When AV treatment was compared with MP, there was no statistical difference between them in terms of reduction of neuronal damage. I/R injury increased NF-B and nNOS expressions. AV and MP treatments decreased NF-B and nNOS expressions.Conclusions: It was observed that aloe vera attenuated neuronal damage histopathologically and biochemically as pretreatment. Further studies may provide more evidence to determine the additional role of aloe vera in spinal cord ischemia reperfusion injury.Öğe Effects of Tannic Acid on the Ischemic Brain Tissue of Rats(Springer/Plenum Publishers, 2015) Sen, Halil Murat; Ozkan, Adile; Guven, Mustafa; Akman, Tarik; Aras, Adem Bozkurt; Sehitoglu, Ibrahim; Alacam, HasanMany studies of brain ischemia have shown the role played by massive ischemia-induced production of reactive oxygen species, the main mechanism of neuronal death. However, currently, there is no treatment choice to prevent cell death triggered by reactive oxygen species. In our study, we researched the effects of tannic acid, an antioxidant, on the ischemic tissue of rats with induced middle cerebral artery occlusion. The animals were divided into three groups of eight animals. The sham group were only administered 10 % ethanol intraperitoneally, the second group had middle cerebral artery occlusion induced and were given 10 % ethanol intraperitoneally, while the third group had middle cerebral artery occlusion with 10 mg/kg dose tannic acid dissolved in 10 % ethanol administered within half an hour intraperitoneally. The rats were sacrificed 24 h later, and brain tissue was examined biochemically and histopathologically. Biochemical evaluation of brain tissue found that comparing the ischemic group with no treatment with the tannic acid-treated ischemia group; the superoxide dismutase (SOD) levels were higher, malondialdehyde (MDA) levels were lower, and nuclear respiratory factor-1 (NRF-1) was higher in the tannic acid-treated group. Histopathological examination showed that the histopathological results of the tannic acid group were better than the group not given tannic acid. Biochemical and histopathological results showed that tannic acid administration had an antioxidant effect on the negative effects of ischemia in brain tissue.Öğe Epidural Abscess Due to a Mycobacterium tuberculosis Strain with Primary Resistance to Isoniazid and Ethambutol(Ankara Microbiology Soc, 2012) Sener, Alper; Alper Akçalı; Karatag, Ozan; Kosar, Sule; Degirmenci, Yildiz; Akman, TarikTuberculosis is primarily characterized by pulmonary involvement, however, one third of the cases exhibit extrapulmonary tuberculosis. In this report, a case of epidural abscess due to Mycobacterium tuberculosis with primary resistance to isoniazid and ethambutol was presented. A 57-year-old male patient was admitted to emergency service with ten days history of weakness in legs, disability of walking and fever. Neurological examination revealed paraplegia of lower extremities, numbness distal to T2 disc level and hyperactivity of deep tendon reflexes indicating transverse myelitis. Laboratory findings were as follows; ESR: 74 mm/hour, CRP: 22 g/L, ALT: 42 IU/L, AST: 45 IU/L and white blood cell count 23.000/mm(3) (45% polymorphonuclear leukocyte, 45% lymphocyte, 10% monocyte). Spinal magnetic resonance imaging showed a fusiform abscess localized at anterior epidural space and extending along levels of C5-6 and C6-7. The longitudinal dimension of the abscess was 3 cm. The lesion was hypoin-tense on T1 and hyperintense on T2 weighted MRI images with prominent rim shaped contrast enhancement on contrast-enhanced T1-weighted images. At fourth day of hospitalization the patient underwent neurosurgical management. M.tuberculosis was isolated from the cultures of operation material by Mycobacteria Growth Incubator Tube system (MGIT, BBL; BD, USA) on the 12th day. The isolate was found susceptible to streptomycin and rifampisin, but resistant to isoniazid and ethambutol. The treatment was initiated with rifampicin 600 mg/day, pyrazinamid 2 g/day, ethambutol 1.5 g/day and levofloxacin 500 mg/day. At the end of second month levofloxacin 500 mg/day and rifampisin 600 mg/day combination was sustained and total treatment period was planned as nine months. As far as the national literature was considered, this was the first case of extrapulmonary tuberculosis with primary resistance to isoniazid and ethambutol.Öğe Epidural abscess due to a mycobacterium tuberculosis strain with primary resistance to isoniazid and etiiambutol(2012) Şener, Alper; AkçAli, Alper; Karata?, Ozan; Koşar, Şule; De?irmenci, Yildiz; Akman, TarikTuberculosis is primarily characterized by pulmonary involvement, however, one third of the cases exhibit extrapulmonary tuberculosis. In this report, a case of epidural abscess due to Mycobacterium tuberculosis with primary resistance to isoniazid and ethambutol was presented. A 57-year-old male patient was admitted to emergency service with ten days history of weakness in legs, disability of walking and fever. Neurological examination revealed paraplegia of lower extremities, numbness distal to T2 disc level and hyperactivity of deep tendon reflexes indicating transverse myelitis. Laboratory findings were as follows; ESR: 74 mm/hour, CRP: 22 g/L, ALT: 42 lU/L, AST: 45 lU/L and white blood cell count 23.000/mm' (45% polymorphonuclear leukocyte, 45% lymphocyte, 10% monocyte). Spinal magnetic resonance imaging showed a fusiform abscess localized at anterior epidural space and extending along levels of C5-6 and C6-7. The longitudinal dimension of the abscess was 3 cm. The lesion was hypoin-tense on T1 and hyperintense on T2 weighted MRI images with prominent rim shaped contrast enhancement on contrast-enhanced T1 -weighted images. At fourth day of hospitalization the patient underwent neurosurgical management. M.tuberculosis was isolated from the cultures of operation material by Mycobacteria Growth Incubator Tube system (MGIT, BBL; BD, USA) on the 12 th day. The isolate was found susceptible to streptomycin and rifampisin, but resistant to isoniazid and ethambutol. The treatment was initiated with rifampicin 600 mg/day, pyrazinamid 2 g/day, ethambutol 1.5 g/day and levofloxacin 500 mg/day. At the end of second month levofloxacin 500 mg/day and rifampisin 600 mg/day combination was sustained and total treatment period was planned as nine months. As far as the national literature was considered, this was the first case of extrapulmonary tuberculosis with primary resistance to isoniazid and ethambutol.Öğe Genistein Exerts Neuroprotective Effect on Focal Cerebral Ischemia Injury in Rats(Springer/Plenum Publishers, 2015) Aras, Adem Bozkurt; Guven, Mustafa; Akman, Tarik; Alacam, Hasan; Kalkan, Yildiray; Sılan, Coşkun; Cosar, MuratBrain ischemia and treatment are one of the important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most important causes of damage. Currently, there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in genistein, previously unstudied, on oxidative damage in cerebral ischemia. Rats were randomly divided into three groups: control group (no medication or surgical procedure), ischemia group, and artery ischemia+genistein group, sacrificed at 24 h after ischemia. The harvested brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry. Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after genistein treatment, while increased malondialdehyde levels after ischemia reduced after treatment. Apoptosis-related cysteine peptidase caspase-3 and caspase-9 values increased after ischemia, but reduced after treatment. Our study revealed that genistein treatment in cerebral ischemia reduced oxidative stress and neuronal degeneration. We believe that genistein treatment may be an alternative treatment method.Öğe In a Cerebral Palsy Patient During Finger Amputation Given the Nitrous Oxide After Occuring Pneumocephalus(Derman Medical Publ, 2014) Akman, Tarik; Guven, Mustafa; Aras, Adem Bozkurt; Akman, Canan; Cosar, MuratRanked among the causes of the cranial cavity Pneumocephalus defined as the presence of air trauma, tumors, infections, congenital anomalies cranium, iatrogenic factors, lumbar puncture, post operative cranial or spinal surgery, also can develop after epidural or spinal anesthesia such as Nitrous oxide anesthesia. In this present case because of the headaches in patients with Cerebral Palsy control cranial CT shot after we aim to provide incidentally captured rarely ethiology in pneumocephalus.Öğe Management of Type II Odontoid Fractures for Osteoporotic Bone Structure: Preliminary Report(Turkish Neurosurgical Soc, 2015) Cosar, Murat; Ozer, A. Fahir; Alkan, Bahadir; Guven, Mustafa; Akman, Tarik; Aras, Adem Bozkurt; Ceylan, DavutAIM: Anterior transodontoid screw fixation technique is generally chosen for the management of type II odontoid fractures. The nonunion of type II odontoid fractures is still a major problem especially in elderly and osteoporotic patients. Eleven osteoporotic type II odontoid fracured patients were presented in this article. MATERIAL and METHODS: We have divided 11 patients in two groups as classical and Ozer's technique.We have also compared (radiologically and clinically) the classical anterior transodontoid screw fixation (group II: 6 cases) and Ozer's transodontoid screw fixation technique (group I: 5 cases) retrospectively. RESULTS: There was no difference regaring the clinical features of the groups. However, the radiological results showed 100% fusion for Ozer's screw fixation technique and 83% fusion for the classical screw fixation technique. CONCLUSION; In conclusion, we suggest that Ozer's technique may help to increase the fusion capacity for osteoporotic type II odontoid fractures.Öğe Neuroprotective Effect of Humic Acid on Focal Cerebral Ischemia Injury: an Experimental Study in Rats(Springer/Plenum Publishers, 2015) Ozkan, Adile; Sen, Halil Murat; Sehitoglu, Ibrahim; Alacam, Hasan; Guven, Mustafa; Aras, Adem Bozkurt; Akman, TarikStroke is still a major cause of death and permanent neurological disability. As humic acids are well-known antioxidant molecules, the purpose of this study was to investigate the potential neuroprotective effects of humic acid in a focal cerebral ischemia model. Twenty-four rats were divided equally into three groups. A middle cerebral artery occlusion model was performed in this study where control (group II) and humic acid (group III) were administered intraperitoneally following an ischemic experimental procedure. Group I was evaluated as sham. Malondialdehyde (MDA), superoxide dismutase (SOD), and nuclear respiratory factor-1 (NRF-1) levels were analyzed biochemically on the right side of the ischemic cerebral hemisphere, while ischemic histopathological studies were completed on the left side to investigate the antioxidant status. Biochemical results showed that SOD and NRF-1 levels were significantly increased in the humic acid group (III) compared with the control group (II) while MDA levels were significantly decreased. On histopathological examination, cerebral edema, vacuolization, degeneration, and destruction of neural elements were decreased in the humic acid group (III) compared with the control group (II). Cerebral ischemia was attenuated by humic acid administration. These observations indicate that humic acid may have potential as a therapeutic agent in cerebral ischemia by preventing oxidative stress.Öğe Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia(Mashhad Univ Med Sciences, 2015) Guven, Mustafa; Aras, Adem Bozkurt; Akman, Tarik; Sen, Halil Murat; Ozkan, Adile; Salis, Osman; Sehitoglu, IbrahimObjective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores. Results: Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit scores of p-coumaric acid-treated rats were significantly improved after cerebral ischemia. Conclusion: Our results showed that p-coumaric acid is a neuroprotective agent on account of its strong anti-oxidant and anti-apoptotic features. Moreover, p-coumaric acid decreased the focal ischemia. Extra effort should be made to introduce p-coumaric acid as a promising therapeutic agent to be utilized for treatment of human cerebral ischemia in the future.Öğe Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats(Shenyang Editorial Dept Neural Regeneration Res, 2015) Aras, Adem Bozkurt; Guven, Mustafa; Akman, Tarik; Ozkan, Adile; Sen, Halil Murat; Duz, Ugur; Kalkan, YildirayDaidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis.Öğe Patients with Chiari Malformation Type 2 in VP Shunt Rare Complication(Derman Medical Publ, 2014) Akman, Tarik; Guven, Mustafa; Aras, Adem Bozkurt; Cikman, Oztekin; Safak, Ozbey; Karaaslan, Oznur; Akman, CananSpontaneous perforation of the bowel caused by VP shunt is a very rare complication, and if unnoticed will be fatal. Two years previously our case with Chiari malformation type 2 had revision of the distal end of the VP shunt and also myelomeningocele ends on at the end of the infant period. The case was examined laparoscopically and found to have rare spontaneous intestinal perforation at the transverse colon splenic flexure level, followed by anal prolapse of the peritoneal catheter.Öğe The ameliorative effect of ozone therapy on spinal cord ischemia in rabbits(Bayrakol Medical Publisher, 2020) Akman, Tarik; Aras, Adem Bozkurt; Simsek, Tuncer; Sehitoglu, Muserref Hilal; Yukser, Yasemin; Aslan, Esra; Akman, CananAim: Research in applications of O3 treatment for spinal cord ischemia is a rich area of study. The effects of O3 treatment on spinal cord ischemia have not been studied much to date. The aim of this study is to investigate the role of prophylactic administration of O3 on the recovery of ischemic changes in terms of oxidative stress markers in lysosomal and mitochondrial enzymatic activities in the spinal cord of male rabbits. Material and Method: Twenty-four New Zealand White (NZW) adult male rabbits (weight: 2.5-3 kg) were obtained from Saki Yenilli Experimental Animals Center (Ankara, Turkey). The rabbits were housed in plastic cages at a temperature of 21 +/- 2 degrees C, with 12 hours light/12 hours dark cyclus, fed with standard rabbit diet (Bil-Yem Ltd. Co., Ankara, Turkey) and water ad libitum for the duration of the experiment. Rabbits were randomly divided into 4 groups of 6 rabbits. The first group was accepted as control and the second group was treated with 50 mu g/mL (20 mL) ozone by rectal insufflation 5 times per day. On the 10th day, animals were sacrificed. The third sham group had infrarenal abdominal aorta cross- clamping (IAACC) performed and were sacrificed 24 hours later. The fourth group was treated with 50 mu g/mL ozone (20 mL) by rectal insufflation 5 times per day and on the 10th day, IAACC was performed. Twenty-four hours later the animals were sacrficed. Results: When data obtained from the biochemical analysis were investigated (Table 1) in the groups with induced ischemia, the expected reduction in SOD, CAT, and GPX enzyme activities was observed and an increase in MPO activity was observed. The statistical difference between ozone administered groups and the control group was significant (p < 0.05). When the ischemia+ozone group is compared with the ischemia group, the results are significant and a statistical difference is observed (p < 0.05). When GPX values in the group with ischemia-induced were investigated, the enzyme activity values were very low. A serious increase was observed in the ozone administered treatment group (p < 0.05). Discussion: Ozone (O3) is a molecule carrying three oxygen atoms forming as a result of exposure of oxygen to high energy electric currents and ultraviolet (UV) light in nature. It is found as a gas at room temperature. It is colorless, and has a characteristic smell. As ozone has a high degree of oxidation strength, it is called active oxygen in medicine. Due to its ability to increase blood circulation, it is used for treatment, not just of disorders related to circulation, but as an aid to the renewal of organic functions disrupted by many diseases.Öğe The Axon Protective Effects of Syringic Acid on Ischemia/eReperfusion Injury in a Rat Sciatic Nerve Model(Turkish Neurosurgical Soc, 2017) Tokmak, Mehmet; Sehitoglu, Muserref Hilal; Yuksel, Yasemin; Guven, Mustafa; Akman, Tarik; Aras, Adem Bozkurt; Yaka, UmutAIM: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. MATERIAL and METHODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. lschemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESULTS: lschemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONCLUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.Öğe The effect of aloe vera on ischemia-Reperfusion injury of sciatic nerve in rats(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016) Guven, Mustafa; Golge, Umut Hatay; Aslan, Esra; Sehitoglu, Muserref Hilal; Aras, Adem Bozkurt; Akman, Tarik; Cosar, MuratPurpose: Aloe vera is compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of aloe vera treatment in rats with experimental sciatic nerve ischemia/reperfusion injury. Methods: Twenty-eight male Wistar Albino rats were divided equally into 4 groups. Groups; Control group (no surgical procedure or medication), sciatic nerve ischemia/reperfusion group, sciatic nerve ischemia/reperfusion + aloe vera group and sciatic nerve ischemia/reperfusion + methylprednisolone group. Ischemia was performed by clamping the infrarenal abdominal aorta. 24 hours after ischemia, all animals were sacrificed. Sciatic nerve tissues were also examined histopathologically and biochemically. Results: Ischemic fiber degeneration significantly decreased in the pre-treated with aloe vera and treated with methylprednisolone groups, especially in the pre-treated with aloe vera group, compared to the sciatic nerve ischemia/reperfusion group (p < 0.05). A significant decrease in MDA, an increase in NRF1 level and SOD activity were observed in the groups which obtained from the AV and MP groups when compared to the sciatic nerve ischemia/reperfusion group. When all results were analysed it was seen that the aloe vera group was not statistically different compared to the MP group (p > 0.05). Conclusions: Aloe vera is effective neuroprotective against sciatic nerve ischemia/reperfusion injury via antioxidant and anti-inflammatory properties. Also aloe vera was found to be as effective as MP. (C) 2016 Elsevier Masson SAS. All rights reserved.Öğe The Effect of Coumaric Acid on Ischemia-Reperfusion Injury of Sciatic Nerve in Rats(Springer/Plenum Publishers, 2015) Guven, Mustafa; Yuksel, Yasemin; Sehitoglu, Muserref Hilal; Tokmak, Mehmet; Aras, Adem Bozkurt; Akman, Tarik; Golge, Umut HatayThe aim of the study was to determine the effect of coumaric acid on sciatic nerve ischemia/reperfusion (SNI) injury in rats. The rats were randomly divided into four groups: control group (no medication or surgical procedure), SNI group, SNI + coumaric acid (CA) group, and SNI + methylprednisolone (MP) group. Ischemia was achieved by abdominal aorta clamping, and all animals were sacrificed 24 h after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. A significant decrease in MDA, an increase in NRF1 levels, and increase in SOD activity were observed in the groups which received coumaric acid and methylprednisolone when compared to the corresponding untreated group (p < 0.05). Ischemic fiber degeneration significantly reduced in the SNI + CA and SNI + MP groups, especially in the SNI + MP group, compared to the SNI group (p < 0.05). Beta amyloid protein expressions were significantly decreased in the SNI + CA group compared to the SNI group (p < 0.05). Our study revealed that coumaric acid treatment after ischemia/reperfusion in rat sciatic nerves reduced oxidative stress and axonal degeneration. Therefore, coumaric acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
