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    Öğe
    A novel biosensing system based on ITO-single use electrode for highly sensitive analysis of VEGF
    (Taylor & Francis Ltd, 2020) Akgun, Mert; Kemal Sezginturk, Mustafa
    Nowadays, breast cancer is one of the riskiest and common cancer types. The early diagnosis of breast cancer is very important just as in other cancer types. Recent investigations demonstrate the biomarkers can be useful for the disease phase. These biomarkers are the very important materials to determine the good or bad diagnostic of the patient. Vascular endothelial growth factor is considered the most powerful mitogen for endothelial cells and also is an important regulator of vascular permeability and angiogenesis. In the frame of this study, it is purposed to design an electrochemical immunosensor system based on indium-tin oxide covered polyethylene terephthalate electrode. Electrochemical impedance spectroscopy, which is a quick and sensitive method, was used for vascular endothelial growth factor determination. Electrochemical impedance spectroscopy and cyclic voltammetry techniques were used in all optimisation processes of the produced biosensor. Scanning electron microscopy images, energy-dispersive X-ray spectra and mapping, atomic force microscopy and infrared spectra were examined to support the optimisation studies and to reveal surface morphology and chemical components. In the electrochemical characterisation studies, repeatability, reproducibility, storage, regeneration, single frequency impedance, square wave voltammetry and Kramer's-Kronig transform studies were performed. The measurements were taken in human serum.
  • [ X ]
    Öğe
    Geraniol and cinnamaldehyde as natural antibacterial additives for poly(lactic acid) and their plasticizing effects
    (Walter De Gruyter Gmbh, 2020) Akgun, Mert; Basaran, Ihsan; Suner, Salih C.; Oral, Ayhan
    The main goal of this study is to prepare antibacterial poly(lactic acid) (PLA) containing cinnamaldehyde and geraniol and to evaluate the antibacterial activity and assess the changes of physical properties of the PLA films. Cinnamaldehyde- and geraniol-incorporated (10%, 20%, 30%, and 50% v/w) PLA films were prepared via solution-casting. While preparing these films, plasticizers were not added to the matrix. Antibacterial activities of these films against Escherichia coli and Staphylococcus aureus were investigated by the disk diffusion method. Thermal degradation characteristics were analyzed via thermogravimetric analysis (TGA), glass transition, crystallization, and melting temperatures, and enthalpies of the films were determined from differential scanning calorimetry (DSC) scans. Tensile strength and elongationat-break values of neat PLA and antibacterial-compound-containing films were evaluated and compared after the mechanical tests. Moreover, the changes in the polymer morphology were observed by SEM analysis, and opacity of the films was determined by UV-vis spectroscopy. Our results showed that both compounds provided antibacterial effect to the PLA, with cinnamaldehyde being more effective than geraniol. Moreover, plasticization effects of the compounds were confirmed by DSC analysis.