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    Evaluation of the risk of atherosclerosis in patients with adrenal incidentaloma using the ultrasound biomarkers EFT and CIMT
    (Acta Medica Mediterranea, 2015) Şen, Hacer; Uysal, Fatma; Binnetoğlu, Emine; Aşik, Mehmet; Erbağ, Gökhan; Güneş, Fahri; Eroğlu, Mustafa
    Introduction: Adrenal incidentalomas (AIs) are masses frequently observed on radiological examination that have attracted attention due to their coincidence with metabolic disorders. Recently, the relationship between atherosclerosis and adrenal incidentalomas has been noted. Epicardial fat tissue (EFT) and carotid artery intima-media thickness (CIMT) measurements show the development of atherosclerosis (AS). The aim of this study is to evaluate the risk of cardiovascular disease in AI patients using EFT and CIMT readings. Materials and methods: Our study included 63 AI patients and 48 healthy controls. All patients were evaluated for blood pressure, Body Mass Index(BMI), EFT, CIMT, and lipid parameters. AI patients were also investigated for hormonal secretion. The relationship between risk of atherosclerosis and EFT, CIMT was analyzed. Results: Control subjects (mean EFT, 3.92 ± 1.14 mm) had lower EFT than patients with subclinical Cushing's syndrome (SCS) and non-functional adenoma (NFA) (mean EFT, 6.22 ± 1.97 mm and 5.44 ± 1.61 mm, respectively) (both P < 0.001). There was no difference in EFT between SCS and NFA patients. CIMT was significantly lower in control subjects (mean CIMT, 0.65 ± 0.11 mm) than in NFA patients (mean CIMT, 0.75 ± 0.18 mm) (P < 0.01). The EFT of SCS patients was not significantly different from the EFT of either NFA patients or controls. Conclusion: EFT thickness measurements may be helpful as an early atherosclerosis marker in AI patients.
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    Öğe
    Plasma levels of Nesfatin-1 in patients with polycystic ovary sydrome
    (Acta Medica Mediterranea, 2014) Binneto?lu, Emine; Erba?, Gökhan; Gencer, Meryem; Turkön, Hakan; Aşik, Mehmet; Güneş, Fahri; Şen, Hacer
    Introduction: Polycycstic ovary syndrome (PCOS) is an important disorder in women of reproductive age which is characterised with menstrual dysfunction, anovulation and hyperandrogenism. 5-10% of the female population affected by this syndrome. Nesfatin-1 is a new anorexigenic hormone which is expressed from several regions of hypothalamus and peripheral tissues. Nesfatin-1 is related with obesity, insulin resistance and appetite. We aimed to evaluated the nesfatin-1 levels in patients with PCOS. Material and methods: Sixty-five patients (37 patients with PCOS and 28 healthy control subjects) were enrolled in the study. We included newly diagnosed patients with PCOS in our study. Diagnosis of PCOS was based on the 2003 ESHRE/ASRM diagnostic criteria. Results: The patients with PCOS and controls were similar in terms of mean age body mass index (BMI), waist/hip (W/H) ratio and homeostasis model assessment-insulin resistance (HOMA-IR) index. Plasma Nesfatin-1 levels were similar between groups. There was no correlation between plasma Nesfatin-1 levels and other parameters. Conclusion: In conclusion nesfatin-1 may be play important role in glucose metabolism and insulin resistance. In this study due to the absence of insulin resistance in PCOS patients, levels of Nesfatin -1 were similar with control group. Nesfatin levels were associated with glucose metabolism, but further studies are needed in this regard.