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    Characteristics of hospitalised COVID-19 patients and parameters associated with severe pneumonia
    (John Wiley & Sons Ltd, 2021) Turan, Onur; Mirici, Arzu; Duru Akçalı, Serap; Turan, Pakize Ayşe; Batum, Özgür; Şengül, Aysun
    Background: After the first case of coronavirus disease 2019 (COVID-19) was reported in China in December 2019, it caused a global pandemic, including Turkey. Objectives: The aim of this study was to analyse the characteristics of hospitalised COVID-19 patients and assess the parameters related to severe pneumonia. Methods: Included in the study were hospitalised COVID-19 patients with positive naso-oropharyngeal swabs. Patients’ demographics, admission symptoms, laboratory and radiological findings were recorded retrospectively. Results: Of 1013 patients, 583 were males (57.6%) and 430 were females (42.4%), with a mean age of 53.7 ± 17.9. More than half of the patients had at least one comorbidities, the most common of which were hypertension and diabetes mellitus. Cough (59.8%), fatigue (49.5%) and fever (41.2%) were the most common presenting symptoms. Of the hospitalised COVID-19 patients, 84.9% had pneumonia and 83.5% had typical radiological COVID-19 appearances (94.5%: ground-glass areas). The most common laboratory findings were high C-reactive protein (CRP) (73.6%) and lactate dehydrogenase (LDH) (46.2%) levels, as well as lymphopenia (30.1%). Severe pneumonia was present in 28.1% of COVID-19 patients. Multivariate logistic regression analysis indicated that advanced age, hypotension, anaemia and elevated CRP and LDH serum levels were independent risk factors for the severity of COVID-19 pneumonia (P =.011,.006,.017,.003 and.001, respectively). Conclusion: This study, as one of the first multicentre studies about characteristics of COVID-19 in Turkey, may guide about disease-related parameters and severity of pneumonia. Age, blood pressure, complete blood count and routine biochemical tests (including CRP and LDH) would appear to be important parameters for the evaluation of the severity of COVID-19 pneumonia.
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    Characteristics of hospitalized COVID-19 patients and parameters associated with severe pneumonia
    (The European Respiratory Society, 2021) Turan, Muzaffer Onur; Mirici, Arzu; Akçalı, Serap Duru; Turan, Pakize Ayşe; Batum, Özgür; Şengül, Aysun; Ünsal, Zuhal Ekici
    Objectives: The aim of this study is to analyse characteristics of hospitalized COVID-19 patients in Turkey. Methods: Hospitalized COVID-19 patients with positive naso-oropharyngeal swab examples from 10 different centers were included. Demographics, admission symptoms, laboratory and radiological findings were recorded retrospectively. Results: Of 1013 patients included in the study, there were 583 male (57.6%) and 430 female (42.4%), with the mean age of 53.7±17.9. More than half (%51.7) of the patients had at least one comorbid disease; the most common ones were hypertension and diabetes mellitus. Cough (59.8%), fatigue (49.5%) and fever (41.2%) were the most common presenting symptoms. There was pneumonia in 84.9% of hospitalized COVID-19 patients; 83.5% had typical radiological COVID-19 appearance (94.5%: ground glass areas). The most common laboratory findings were high CRP (73.6%) and lactat dehydrogenase (LDH) (46.2%) levels and lymphopenia (30.1%). Severe pneumonia was present in 28.1% of COVID-19 patients. Multivariate logistic regression analysis indicated that high age, hypotension, anemia, elevated serum levels of CRP and LDH were independent risk factors for severity of COVID-19 pneumonia (p=0.011, 0.006, 0.017, 0.003 and 0.001, respectively). Conclusion: Our study, which is one of the first multicenter studies about COVID-19 characteristics in Turkey, is thought to be a guide for COVID-19 patients in terms of clinical features . Age, blood pressure measurement, complete blood count and routine biochemical tests (including CRP and LDH) seem to be important parameters for evaluating the severity of pneumonia in COVID-19 patients.
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    The value of preoperative pulmonary assessment in predicting postoperative pulmonary complications
    (Wolters Kluwer Medknow Publications, 2019) Diken, Özlem Ercen; Fazlıoğlu, Nevin; Sarıoğlu, Nurhan; Ogan, Nalan; Yılmaz, Nafiye; Tanrıverdi, Hakan; Şengül, Aysun
    OBJECTIVE: We aimed to determine the preoperative parameters that may predict postoperative pulmonary complications (POPCs) and the value of some current practical indexes in predicting POPCs. MATERIALS and METHODS: Our study is a retrospective cohort study carried out in 9 different centers. Patients admitted to the chest diseases outpatient clinic for preoperative evaluation were followed up during the 6-month study period. Patients with or without postoperative complications were evaluated retrospectively, and the effect of some parameters and indexes recorded during the preoperative evaluation of chest diseases on POPC development was investigated statistically. RESULTS: A total of 307 patients were included in the study. POPCs were observed in 100 patients (32.6%). About 13% of these complications were respiratory tract infections, 59% were respiratory failure, 45% were pleural effusion, and 42% were atelectasis, which were the most common pulmonary complications. The probability of experiencing POPCs by patients with chronic obstructive pulmonary disease (COPD) is 2.5 (1.18-5.67) times more than those without COPD. We determined that patients with the history of upper respiratory tract infection during the preoperative period are 5.3 times more likely to have POPCs; similarly, the number was 4.7 for patients undergoing cardiac operation and 3.3 for patients with interstitial infiltration. CONCLUSION: The risk of pulmonary complications was higher for those with the history of upper respiratory tract infection during the preoperative period, those undergoing cardiac surgery, those with the shortness of breath, those with the history of COPD, and those with the reticular/interstitial infiltrations in the chest X-ray. These parameters should be examined carefully in the preoperative period and should be careful in terms of pulmonary complications that may develop during the postoperative period.