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    A Case of Pulmonary Tuberculosis Detected While Being Investigated with a Preliminary Diagnosis of Covid-19 Infection
    (2021) Çelik, Taylan; Borak, Tayyar Ayberk; Ekin, İbrahim Ender
    [Abstract Not Available]
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    A snapshot of pediatric inpatients and outpatients with COVID-19: a point prevalence study from Turkey
    (Springer Science and Business Media Deutschland GmbH, 2023) Yılmaz, Dilek; Üstundağ, Gülnihan; Büyükcam, Ayşe; Sali, Enes; Çelik, Ümit; Çelik, Taylan; Aylaç, Hakan
    This multi-center point prevalence study evaluated children who were diagnosed as having coronavirus disease 2019 (COVID-19). On February 2nd, 2022, inpatients and outpatients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were included in the study from 12 cities and 24 centers in Turkey. Of 8605 patients on February 2nd, 2022, in participating centers, 706 (8.2%) had COVID-19. The median age of the 706 patients was 92.50 months, 53.4% were female, and 76.7% were inpatients. The three most common symptoms of the patients with COVID-19 were fever (56.6%), cough (41.3%), and fatigue (27.5%). The three most common underlying chronic diseases (UCDs) were asthma (3.4%), neurologic disorders (3.3%), and obesity (2.6%). The SARS-CoV-2-related pneumoniae rate was 10.7%. The COVID-19 vaccination rate was 12.5% in all patients. Among patients aged over 12 years with access to the vaccine given by the Republic of Turkey Ministry of Health, the vaccination rate was 38.7%. Patients with UCDs presented with dyspnea and pneumoniae more frequently than those without UCDs (p < 0.001 for both). The rates of fever, diarrhea, and pneumoniae were higher in patients without COVID-19 vaccinations (p = 0.001, p = 0.012, and p = 0.027). Conclusion: To lessen the effects of the disease, all eligible children should receive the COVID-19 vaccine. The illness may specifically endanger children with UCDs. What is Known: • Children with COVID-19 mainly present with fever and cough, as in adults. • COVID-19 may specifically threaten children with underlying chronic diseases. What is New: • Children with obesity have a higher vaccination rate against COVID-19 than children without obesity. • Among unvaccinated children, fever and pneumoniae might be seen at a higher ratio than among vaccinated children.
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    Analyzing Medical Students’ Educational Needs for Web-Based Escape Room Design
    (Tıp Eğitimini Geliştirme Derneği, 2024) Korkmaz, Güneş; Alakurt, Turgay; Mazman, Sacide Güzin; Tekin, Murat; Tekeş, Ender; Çelik, Taylan; Saygılı, Emre Sedar
    Background: This study aims to determine the learning needs of medical students to design web-based escape rooms tailored to their needs. Methods: In this qualitative research, the educational needs of medical students in web-based escape rooms were determined using the "basic qualitative research" design. Participants were 3rd and 4th year medical students from XXX University. 23 students from 3rd year and 31 students from 4th year participated in the focus-group interviews. A semi-structured interview form was used as the data collection tool, and the data collection process took place during December 2023-January 2024. Data were analyzed through deductive content analysis. Results: The results revealed students are aware that emergency remote teaching period has pros and cons, and they used various additional resources, learning materials, and web-based applications to support their individual learning processes during this period. In addition, they prefer clinical case-based applications in the design of escape rooms. Conclusions: This study provides important findings regarding the content and design of escape room games. In escape room design, especially in emergency remote teaching practices during the COVID-19 pandemic, the positive and negative aspects perceived by students will be considered, the content and design will be developed according to students' learning needs
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    Brucellosis in childhood: retrospective evaluation of 37 cases and review of the literature
    (2022) Çelik, Taylan; Kaan, Emre
    Introduction: The aim of this study is to evaluate the demographic, clinical and laboratory characteristics and treatment results of pediatric patients followed up with the diagnosis of brucellosis in our clinic. Methods: Patients who were followed up with the diagnosis of brucellosis in Kayseri Training and Research Hospital, Pediatric Infectious Diseases Clinic between October 2016 and December 2018 were retrospectively analyzed. Results: A total of 37 patients, 26 (70.3%) male, were included in the study. The mean age of the patients whose ages ranged from 1 to 17 years was 9.3±4.3 years. Unpasteurized milk and/or dairy products were consumed in 86.5% of the patients and 48.6% had a family history of brucellosis. Joint pain (75.7%) was the most common presenting complaint. In the laboratory evaluation, 8.1% of the patients had leukopenia, 2.7% had thrombocytopenia and 21.4% had ALT elevation. Doxycycline plus rifampicin (43.2%) was the most commonly preferred treatment regimen. Addition of aminoglycoside to initial therapy in hospitalized patients was statistically higher than in outpatients (81.2% vs. 23.8%) (p=0.001). During the follow-up, relapse developed in a total of 4 (10.8%) patients, 3 of whom were outpatients. There was no statistical relationship between the initial treatment regimen and relapse (p=0.418). Conclusion: In conclusion, brucellosis should be kept in mind in terms of differential diagnosis in patients who present with joint pain in our country and who have cytopenia and/or isolated aminotransferase elevation in their investigations. Keywords: Child, Brucellosis, Leukopenia, Relapse, Thrombocytopenia
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    Çocuklarda tularemi; altı olgunun klinik, laboratuvar ve tedavi sonuçlarının değerlendirilmesi
    (Çanakkale Onsekiz Mart Üniversitesi, 2021) Çelik, Taylan; Kaan, Emre; Özcan, Eda
    Amaç: Tularemi, Francisella tularensis’in neden olduğu zoonotik bir enfeksiyon hastalığıdır. İn-sanlarda en sık ülseroglandüler formu olmak üzere, glandüler, pnömonik, orofaringeal, oküloglandüler, intestinal ve tifoidal dahil olmak üzere çeşitli klinik formlara sahiptir. Çocuk Enfeksiyon Hasta-lıkları Polikliniğinde takip edilen altı olgu ile çocuklarda tularemiyi tartışmak istedik. Yöntem: Çocuk Enfeksiyon Hastalıkları Polikli-niği’nde tularemi tanısı ile takip edilen hastaların tıbbi verileri retrospektif olarak incelendi. Bulgular: Tularemi tanısı alan toplam 6 hastanın 2’si kız 4’ü erkekti. Yaşları 7-17 arasında değişi-yordu. Dört hasta şehir şebeke suyu, 2 hasta ise köy çeşmesinden su kullanıyordu. Şehir şebeke suyu kullanan iki hastanın kaynak suyu içme öyküsü vardı. Bir hastada orofaringeal, 5 hastada ise glandüler formda tularemi saptandı. Hastaların yakınmalarının başlangıç zamanından has-tanemize başvurusu arasında geçen medyan süre 30 gün (5-60) olarak tespit edildi. Hastalarımızın en sık başvuru yakınması boyunda şişlikti, bir has-tamız ise boğaz ağrısı yakınması ile başvurmuştu. Hastalardan beş tanesine ilk tercih olarak gentami-sin, diğer hastaya ise doksisiklin başlanmıştı. Başlangıç gentamisin tedavisine yanıt alınamayan hastalarda doksisiklin veya siprofloksasin tedavi değişikliği yapılmıştı. Tularemi etkili antibiyotik kulanım gününü 36.5 (14-52) gün olarak saptadık. Sonuç: Sonuç olarak, hastalığın ilerlemesini, teda-vi başarısızlığı ve cerrahi müdahale gereksinimi azaltmak için, erken tanı ve uygun antimikrobiyal tedavinin hızla başlanması çok önemlidir
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    COVID-19 Vaccine Hesitancy of Parents of Children with Type 1 Diabetes in Türkiye: A Mixed-Methods Study
    (AVES, 2023) Çelik, Taylan; Doğan, Durmuş
    Objective: In this study, we aimed to investigate the attitudes of parents who have children with type 1 diabetes mellitus to get their children vaccinated against COVID-19. Material and Methods: The target population of the study consisted of 124 parents of children followed in Çanakkale Onsekiz Mart University Hospital, Pediatric Endocrinology Clinic with the diagnosis of type 1 di-abetes. We used an online questionnaire to determine the attitudes of parents. Results: A total of 102 parents, 76 of whom were mothers, were included in the study. Mean age of the parents was 40.5 ± 7.27, and children were 12 ± 4.07. Mean duration elapsed since the diagnosis of type 1 diabetes was 4.5 ± 3.3 years. About half of the parents thought that type 1 diabetes mellitus was a risk factor for COVID-19. While the rate of parents who were not vaccinated for COVID-19 was 21.6%, 46.1% were hesitant to vaccinate their children. The parental-related factors causing vaccine hesitation were fathers, young parents, those who weren’t worried about their children being infected with COVID-19, did not think children with type 1 diabetes mellitus were more at risk, or were unvaccinated. Child-related factors were young age or short duration of illness. In qual-itative analysis, vaccination-hesitant parents’ main concern was vaccine side effects, and they expected clear evidence-based confidence-build-ing recommendations for vaccination. Conclusion: In conclusion, it is seen that especially young parents, whose children are small or newly diagnosed, will have problems in their motivation about vaccination. © 2023 by Pediatric Infectious Diseases and Immunization Society.
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    Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections
    (2024) Çelik, Taylan; Kasap, Tolga; Çakan, Beyza; Kılıç, Nimet Aydemir
    To fight against the pandemic, which has become the most significant public health problem of modern times, the isolation of patients and early detection of the coronavirus disease-2019 (COVID-19) disease are crucial. This study aimed to show the diagnostic predictor of hemogram parameters and the rates obtained from these parameters in differentiating COVID-19 from other respiratory tract diseases. Data of patients aged between 1 month and 18 years who were admitted to the 3 rd and 2nd level pediatric emergency with the pre-diagnosis of “COVID-19-like disease” between 12 January 2022 and July 12, 2022, which is one month after the Omicron (Nu) variant was accepted as an established variant in Türkiye, were retrospectively reviewed. A total of 724 children with pre-diagnosis of COVID-19-like disease whose complete blood count and severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) polymerase chain reaction (PCR) test from oropharynx/nasopharyngeal swab samples were included in the study. Two hundred children were positive for SARS-CoV-2 PCR (27.6%). Total leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, platelets, platelet distribution width, platelet crit counts, and neutrophil/lymphocyte ratio were lower, and hemoglobin values were higher in the COVID-19 group than in the other group. These differences were statistically significant (p<0.05). When these parameters were evaluated by receiver operating characteristic analysis, the area under the curve values of the other parameters, except the eosinophil count, were statistically significant. However, when the obtained possibility ratios were examined, significant cut-off values could not be obtained regarding diagnostic predictiveness. It was found that using complete blood count parameters in the diagnostic process is not helpful in differentiating SARS-CoV-2 from other respiratory tract diseases. It is essential to conduct studies with larger sample sizes to understand whether complete blood count parameters can predict the diagnosis of COVID-19.
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    Increase in Odontogenic Cervicofacial Infection Requiring Hospitalization in Children During COVID-19 Quarantine
    (2023) Çelik, Taylan; Karaaslan, Lara
    The aim of this study was to evaluate the effect of Coronavirus disease-2019 (COVID-19) quarantines on children hospitalized for odontogenic cervicofacial infection. The data of patients aged 1 month-18 years, who were followed up with the diagnosis of odontogenic cervicofacial infection in Çanakkale Onsekiz Mart University Hospital between January 2019 and June 2021 was examined, retrospectively. Thirteen patients with a mean age of 8.5±3.8, 7 of whom were male were included in the study. Three of the patients were diagnosed in the pre-COVID-19 period and 10 of them were diagnosed in the second year of COVID-19. Five patients had a known history of dental caries. On physical examination, it was determined that all patients had dental caries in the area corresponding to the infection site. Four patients required abscess drainage, all of whom were presenting in the second year of COVID-19, we isolated Eikenella corrodens, Streptococcus anginosus and Streptococcus intermedius microorganisms in 3 patients. The mean duration of hospitalization was 5.3±3 days. In conclusion, COVID-19 quarantine causes an increase in odontogenic cervicofacial infection requiring intravenous antibiotics and abscess drainage.
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    Influenza B enfeksiyonu sırasında gelişen akut selim çocukluk çağı miyozit olgusu
    (Çanakkale Onsekiz Mart Üniversitesi, 2022) Devril, Beste; Çelik, Taylan; Aylanc, Hakan
    Akut selim çocukluk çağı miyoziti, viral enfeksiyonlar sırasında ortaya çıkan alt ekstremite distal kas gruplarında ağrı ve yürümede ani bozulma ile karakterize bir çocukluk çağı hastalığıdır. Özellikle orta çocukluk çağındaki erkek çocuklarda gözlenmektedir. Kreatin kinaz düzeyinde artış, kas gücü ve derin tendon reflekslerinin korunması, tutulan kaslarda hassasiyet miyozit tanısı için önemli bulgulardır. Kendi kendini sınırlayan bu hastalığın gereksiz ileri tetkik ve tedavi planlarını önlemek adına benzer klinik bulgular ile seyreden hastalıklardan ayrımı önemlidir. Akut selim çocukluk çağı miyozitinin tedavisinde çoğu zaman destek tedavisi yeterlidir. Bu yazıda Influenza B’ye bağlı viral üst solunum yolu enfeksiyonu sonrası yürüyememe şikâyeti ile kliniğimizdeki takip ettiğimiz sekiz yaşındaki bir erkek hasta ele alınmaktadır
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    Pathogens in Pediatric Septic Arthritis: A Multi-Center Study in Turkiye (PEDSART Study)
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024) Iseri Nepesov, Merve; Kılıç, Ömer; Salı, Enes; Yeşil, Edanur; Akar, Asuman; Çelik, Taylan
    Objectives: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, and therapeutic approach of SA in children in Turkiye, emphasizing the role of real-time polymerase chain reaction (PCR) techniques in the diagnosis. Methods: In this multi-center, prospective study, children hospitalized due to SA between February 2018 and July 2020 in 23 hospitals in 14 cities in Turkiye were included. Clinical, demographic, laboratory, and radiological findings were assessed, and real-time PCR was performed using synovial fluid samples. Results: Seventy-five children aged between 3 and 204 months diagnosed with acute SA were enrolled. Joint pain was the main complaint at admission, and the most commonly involved joints were the knees in 58 patients (77.4%). The combination of synovial fluid culture and real-time PCR detected causative bacteria in 33 patients (44%). In 14 (18.7%) patients, the etiological agent was demonstrated using only PCR. The most commonly isolated etiologic agent was Staphylococcus aureus, which was detected in 22 (29.3%) patients, while Streptococcus pyogenes was found in 4 (5.3%) patients and Kingella kingae in 3 (4%) patients. Streptococcus pyogenes and Kingella kingae were detected using only PCR. Most patients (81.3%) received combination therapy with multiple agents, and the most commonly used combination was glycopeptides plus third-generation cephalosporin. Conclusions: Staphylococcus aureus is the main pathogen in pediatric SA, and with the use of advanced diagnostic approaches, such as real-time PCR, the chance of diagnosis increases, especially in cases due to Kingella kingae and Streptococcus pyogenes.
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    Staphylococcal Pyomyositis Within Initial Course of Juvenile Dermatomyositis Patient
    (2021) Kısaarslan, Ayşenur Paç; Nalcacıoğlu, Hülya; Çelik, Taylan; Koç, Gonca
    Infectious complications are increasingly reported in patients with connective tissue diseases. These complications are both related to using immunosuppressive drugs and organ dysfunctions caused by diseases. Pyomyositis is a pyogenic infection of skeletal muscle associated with immunocompromised conditions, especially human immunodeficiency virus (HIV) infection, diabetes mellitus, malignancy, immunosuppressive drugs, and rheumatic diseases. We presented a patient with juvenile dermatomyositis complicated by staphylococcal pyomyositis initial disease course. The patient did not respond to drainage and appropriate antibiotic therapy. Abscess formation successfully regressed with IVIG. Muscle inflammation and corticosteroids are possible predisposing factors for pyomyositis.