RNA modifications as emerging therapeutic targets

Abstract

The field of epitranscriptome, posttranscriptional modifications to RNAs, isstill growing up and has presented substantial evidences for the role of RNAmodifications in diseases. In terms of new drug development, RNA modifica-tions have a great promise for therapy. For example, more than 170 type ofmodifications exist in various types of RNAs. Regulatory genes and their rolesin critical biological process have been identified and they are associated withseveral diseases. Current data, for example, identification of inhibitorstargeting RNA modifications regulatory genes, strongly support the idea thatRNA modifications have potential as emerging therapeutic targets. Therefore,in this review, RNA modifications and regulatory genes were comprehensivelydocumented in terms of drug development by summarizing the findings fromprevious studies. It was discussed how RNA modifications or regulatory genescan be targeted by altering molecular mechanisms.This article is categorized under:RNA in Disease and Development > RNA in DiseaseRNA Interactions with Proteins and Other Molecules > Protein-RNA Inter-actions: Functional ImplicationsRNA Processing > RNA Editing and Modification