• New nimesulide derivatives with amide/sulfonamide moieties: Selective COX-2 inhibition and antitumor effects 

  Güngör, Tuğba; Özleyen, Adem; Yılmaz, Yakup Berkay; Siyah, Pınar; Ay, Mehmet; Boyuneğmez Tümer, Tuğba (Elsevier Masson s.r.l., 2021)

  Seventeen new amide/sulfonamide containing nimesulide derivatives were synthesized and characterized by several spectroscopic techniques and primarily investigated for their inhibitory potential on COX enzymes and other ...

• Dataset on the differentiation of THP-1 monocytes to LPS inducible adherent macrophages and their capacity for NO/iNOS signaling 

  Özleyen, Adem; Yılmaz, Yakup Berkay; Boyuneğmez Tümer, Tuğba (Elsevier Inc., 2021)

  When THP-1 cells are differentiated into adherent macro-phage-like cells, they respond to inflammatory stimuli by changing their phenotypes to an activation state and altering the expression of inflammation-related genes. ...

• The high frequency of chromosomal copy number variations and candidate genes in epilepsy patients 

  Albuz, Burcu; Özdemir, Öztürk; Sılan, Fatma (Elsevier B.V., 2021)

  OBJECTIVE: Epilepsy is a chronic brain disease and is estimated to affect more than 50 million people worldwide.Epilepsy is a polygenic and multifactorial disease.Genetic causes play a major role in 40–60 % of all ...

• Genotoxic and cytotoxic effects of polyethylene microplastics on human peripheral blood lymphocytes 

  Çobanoğlu, Hayal; Belivermiş, Murat; Sıkdokur, Ercan; Kılıç, Önder; Çayır, Akın (Elsevier Ltd, 2021)

  Currently, we need emerging initial data regarding how plastic exposures affect cellular and molecular components and how such interactions will be crucial for human health. We aimed to determine the genotoxic and cytotoxic ...

• Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide 

  Acar, Ümit; İnanan, Burak Evren; Navruz, Fahriye Zemheri; Yılmaz, Sevdan (Elsevier Inc., 2021)

  In this study, effects of different concentrations (0, 5, 10, 20, 30, and 40 mg/L) of glyphosate-based herbicide (GBH) on Nile tilapia (Oreochromis niloticus) were investigated after a 14-day of exposure. After determination ...

• Novel inhibitors of eukaryotic elongation factor 2 kinase: In silico, synthesis and in vitro studies 

  Cömert Önder, Ferah; Durdagi, Serdar; Kahraman, Nermin; Uslu, Tuğce Nur; Kandemir, Hakan; Ay, Mehmet (Academic Press Inc., 2021)

  Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual alpha kinase whose expression is highly upregulated in various cancers and contributes to tumor growth, metastasis, and progression. More importantly, eEF2K ...

• A nano-composite based regenerative neuro biosensor sensitive to Parkinsonism-associated protein DJ-1/Park7 in cerebrospinal fluid and saliva 

  Sonuç Karaboğa, Münteha Nur; Sezgintürk, Mustafa Kemal (Elsevier B.V., 2021)

  In this study, we developed an electrochemical-based single-use neurobiosensor based on multiwalled carbon nanotube (MWCNT)-gold nanoparticle (AuNP) nanocomposite doped, 11-amino-1-undecanethiol (11-AUT)-modified polyethylene ...

• Ultrasensitive detection of interleukin 1α using 3-phosphonopropionic acid modified FTO surface as an effective platform for disposable biosensor fabrication 

  Aydın, Elif Burcu; Sezgintürk, Mustafa Kemal (Elsevier B.V., 2021)

  In this study, we utilized a carboxyalkylphosphonic acid covered fluorine doped tin oxide (FTO) as an electrode material for fabrication of Interleukin 1α (IL-1α) immunosensor. For this aim, anti-IL-1α antibodies were ...

• The effect of foot reflexology on procedural pain before heel lancing in neonates 

  Yılmaz, D.; Yılmaz Kurt, F. (Elsevier Masson s.r.l., 2021)

  Objective: This study was designed to investigate the effect of foot reflexology on alleviating term neonates’ invasive pain caused by heel lance. Methods: In this quasi-experimental study, 60 healthy neonates were recruited ...

• Prediction of mortality in COVID-19 through combing CT severity score with NEWS, qSOFA, or peripheral perfusion index 

  Akdur, Gökhan; Daş, Murat; Bardakçı, Okan; Akman, Canan; Sıddıkoğlu, Duygu; Akdur, Okhan; Akçalı, Alper; Erbaş, Mesut; Reşorlu, Mustafa; Beyazıt, Yavuz (W.B. Saunders, 2021)

  Introduction: The assessment of disease severity and the prediction of clinical outcomes at early disease stages can contribute to decreased mortality in patients with Coronavirus disease 2019 (COVID-19). This study was ...

• Determination of agricultural land suitability with a multiple-criteria decision-making method in Northwestern Turkey 

  Everest, Timuçin; Sungur, Ali; Özcan, Hasan (Springer Science and Business Media Deutschland GmbH, 2021)

  This study was carried out in the district of Lapseki in Çanakkale, Turkey. The suitability of land in Lapseki for agriculture was evaluated by using an analytic hierarchy process. In the study, the basic parameters were ...

• Postoperative pain after different irrigation activation techniques: a randomized, clinical trial 

  Gündoğar, Mustafa; Sezgin, Güzide Pelin; Kaplan, Sema Sönmez; Özyürek, Hande; Uslu, Gülşah (Springer Japan, 2021)

  The aim of this study was to assess the effectiveness of irrigation activation techniques on postoperative pain (PP) in mandibular premolar teeth with irreversible pulpitis after single-visit endodontic treatment. A total ...

• Improving effectiveness of different deep learning-based models for detecting COVID-19 from computed tomography (CT) images 

  Acar, Erdi; Şahin, Engin; Yılmaz, İhsan (Springer Science and Business Media Deutschland GmbH, 2021)

  COVID-19 has caused a pandemic crisis that threatens the world in many areas, especially in public health. For the diagnosis of COVID-19, computed tomography has a prognostic role in the early diagnosis of COVID-19 as it ...

• The effect of meteorological variables on spontaneous pneumothorax in two regions with different altitudes 

  Daş, Murat; Alar, Timuçin; Delice, Orhan; Gedik, İsmail Ertuğrul; Bardakçı, Okan; Akman, Canan; Ulaş, Ali Bilal; Akdur, Okhan (Springer Science and Business Media Deutschland GmbH, 2021)

  Spontaneous pneumothorax (SP) is defined as the presence of free air inside the pleural space. Many studies have reported that meteorological variables may trigger SP, but the mechanism is unknown. The aim of this study ...

• The comparison of FOLFOX regimens with different doses of 5-FU for the adjuvant treatment of colorectal cancer: a multicenter study 

  Akdeniz, Nadiye; Kaplan, Muhammet Ali; Kaya, Serap; Koral, Lokman (Springer Science and Business Media Deutschland GmbH, 2021)

  Purpose: We aim to compare the efficiency and toxicity of three different 5-fluorouracil (5-FU) administration types in 5-FU, leucovorin, and oxaliplatin (FOLFOX) combination treatment for adjuvant therapy in colorectal ...

• Assessment of functional and aesthetic outcomes in septorhinoplasty 

  Şimşek, Tuğce; Erdoğan, Mehmet Mustafa; Özçetinkaya Erdoğan, Serap; Kazaz, Hasan; Tezcan, Erkan; Seyhan, Sinan (Springer Science and Business Media Deutschland GmbH, 2021)

  Purpose: The aim of this study is to review the aesthetic and functional outcomes of septorhinoplasty using questionnaires that have never been collectively used, as well as surgeons’ evaluation. Materials and methods: Our ...

• Effect of Cd dopant on structural, optical and CO2 gas sensing properties of ZnO thin film sensors fabricated by chemical bath deposition method 

  Altun, Büşra; Karaduman Er, Irmak; Çağırtekin, Ali Orkun; Ajjaq, Ahmad; Sarf, Fatma; Acar, Selim (Springer Science and Business Media Deutschland GmbH, 2021)

  Cadmium-doped zinc oxide (Cd-doped ZnO) films were produced by economic facile chemical bath deposition method. The Cd doping content was adjusted as 1%, 3%, 5% and 7%. The structural, morphological and optical properties ...

• Heavy Metal and Mineral Composition of Soil, Atmospheric Deposition, and Mosses with Regard to Integrated Pollution Assessment Approach 

  Menteşe, Sibel; Tonguç Yayıntaş, Özlem; Baş, Batuhan; İrkin, Latife Ceyda; Yılmaz, Selehattin (Springer, 2021)

  The fact that there are no real borders between the biosphere, atmosphere, lithosphere, and hydrosphere means that environmental pollution monitoring studies should not only include one of the environmental spheres. Thus, ...

• Hydrogeochemical Assessment of Groundwater for Drinking and Agricultural Use: A Case Study of Rural Areas of Alwar, Rajasthan 

  Aggarwal, Ankur; Soni, Jigyasa; Sharma, Khyati; Sapra, Mohnish; Karaca, Öznur (Springer, 2021)

  Groundwater contributes substantially to the development of arid and semi-arid regions around the globe. The present study integrates groundwater quality and its suitability for drinking and irrigation around Alwar city ...

• The effects of systemic ozone application and hyperbaric oxygen therapy on knee osteoarthritis: an experimental study in rats 

  Yılmaz, Onur; Bilge, Ali; Erken, H. Yener; Kuru, Tolgahan (Springer Science and Business Media Deutschland GmbH, 2021)

  Objective: To evaluate the effects of systemic medical ozone (O3) application and hyperbaric oxygen (HBO) therapy on surgically induced knee osteoarthritis (OA) in a rat model. Materials and methods: We performed anterior ...

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