Yazar "Zateri, Coskun" seçeneğine göre listele
Listeleniyor 1 - 20 / 22
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A rare cause of low back pain: primary Ewing sarcoma of the lumbar spine(Elsevier Science Inc, 2016) Resorlu, Hatice; Aras, Adem B.; Zateri, Coskun; Goksel, Ferdi[Anstract Not Available]Öğe An Evaluation of Provoked Vulvodynia, Pelvic Floor Muscles and Sexual Functions in Female Patients with Fibromyalgia Syndrome(Galenos Yayincilik, 2017) Resorlu, Hatice; Beyazit, Fatma; Doner, Davut; Oymak, Sibel; Zateri, CoskunObjective: The aim of our study is to investigate the genital origin of pain, particularly provoked vulvodynia (PVD) in female patients with Fibromyalgia syndrome (FMS), to reveal the relationship between PVD and pelvic floor muscle functions and to evaluate patients' sexual functions. Materials and Methods: Twenty four female patients who were diagnosed with FMS and who had not yet been treated, sexually active and 24 control cases were included to study. Severity of dyspareunia and dysmenorrhea was evaluated with a visual analogue scale, PVD was assessed using the cotton swab exam of vulva and sexual functions were evaluated with using the Female Sexual Function Index (FSFI). Additionally, pelvic floor muscles were graded using Brink scoring. Results: The severity means of menstrual term pain and dyspareunia severity were significantly higher in the patients than the control group (p=0.003, p=0.006). Significant differences were observed between the patient and control group in terms of vulvar pain in cotton swab exam and total Brink scores (both p<0.001). FSFI score was lower in the patient group than in the control group (p=0.001). A powerful correlation in the negative direction was determined between the result of cotton swab exam and Brink score (p<0.001, r=-0.575). Conclusion: The result of our study showed that dysmenorrhea, dyspareunia and PVD were significantly high in the FMS patients than in the control group. Pelvic floor muscle functions were affected in the FMS patients, and PVD was closely associated with the pelvic floor muscle functions.Öğe An Evaluation of Sexual Functions and Marital Adjustment in Female Patients with Fibromyalgia Syndrome(Galenos Yayincilik, 2019) Doner, Davut; Resorlu, Hatice; Zateri, Coskun; Sahin, Basak; Ertekin, Hulya; Oymak, SibelObjective: The purpose of this study was to investigate sexual functions and marital adjustment which are neglected issue in married female patients diagnosed with Fibromyalgia syndrome (FMS) and to reveal the factors affecting these. Materials and Methods: Sexually active, 47 married females who diagnosed with FMS and 50 healthy volunteers in a similar age group were included in the study. Beck anxiety inventory, beck depression inventory, female sexual function index (FSFI) and dyadic adjustment scale (DAS) evaluations were also performed for both groups. In the patient group, the severity of pain was evaluated by the visual analogue scale and functional impairment due to the disease was assessed by the fibromyalgia impact questionnaire (FIQ). Results: No significant difference was determined between the two groups in terms of socio-demographic features. FSFI and DAS total scores were significantly lower in the patient group compared to the controls (p<0.001, p=0.028, respectively). Low DAS scores were determined in patients with low FSFI scores (p=0.003, r=+0.043). Neither FSFI nor DAS scores have exhibited correlation with duration of disease and FIQ scores. Depression was correlated with both FSFI and DAS (p<0.001, r=-0.569; p<0.001, r=-0.546, respectively). Conclusion: In this study, sexual functions and marital adjustment were adversely affected in patients with FMS. This effect was found closely related to depression. However, there was no relationship determined between duration of the disease, the severity of pain and the functional impact.Öğe Bilateral Upper Extremity Edema in the Psoriatic Arthritis Case(Aves, 2015) Gokmen, Ferhat; Akbal, Ayla; Savas, Yilmaz; Zateri, Coskun; Karaca, Adem; Tan, Yusuf ZiyaPsoriatic arthritis (PsA) is a seronegative spondyloarthropathy characterized by peripheral arthritis, enthesis, spondylitis, and psoriasis. Lymphedema arises from the slowing of lymphatic flow because of inflammatory or noninflammatory diseases such as tumors, infections, bursitis, rheumatoid arthritis, and polymyalgia rheumatica. It is commonly encountered in one or more regions of distal extremities. Lymphedema is a rare complication of PsA, and it is commonly seen asymmetrically and in lower extremities. We aimed to report a case, who followed-up with diagnosis with PsA and with complaints of upper extremity swelling and bilateral upper extremity lymphedema diagnosed as a result of the review.Öğe Comparison of the Short-Term Efficacy of Physical Therapy in Subacromial Impingement Syndrome Patients with Stage I and II Magnetic Resonance Imaging Findings(Turkish League Against Rheumatism, 2011) Hakguder, Aral; Tastekin, Nurettin; Birtane, Murat; Uzunca, Kaan; Zateri, Coskun; Sut, NecdetObjectives: In this study, we compared the efficacy of a combined physical therapy program between stage I and II subacromial impingement syndrome patients. Patients and methods: Forty-three patients with subacromial impingement syndrome assessed as stage I and II according to the magnetic resonance imaging (MRI) findings were included in the study. Constant's and University of California Los Angeles Shoulder Scales were used to evaluate pain and function. Pain levels at rest, during motion and while asleep were also scored by visual analog scale before treatment, after treatment and at one month after treatment. Improvements within and between the groups were assessed. A physical therapy program consisting of ultrasound, superficial heat therapy and transcutaneous electrical nerve stimulation modalities combined with an appropriate exercise program was applied to both groups during half monthly sessions. Results: The between-groups comparisons performed after treatment and during follow-up revealed no significant difference in terms of the outcome measures assessed. Conclusion: Stage II patients responded to the physical therapy program as well as patients with stage I MRI findings.Öğe Cubital tunnel syndrome secondary to gouty tophi: A case report(Pakistan Medical Assoc, 2017) Resorlu, Hatice; Zateri, Coskun; Akbal, Ayla; Gokmen, Ferhat; Adam, Gurhan; Bilim, Serhad; Bozkurt, EmreGout is a chronic rheumatic disease resulting from accumulation of monosodium urate crystals in tissues. The most important risk factor for the disease is hyperuricaemia. Precipitation of uric acid in the joint in the form of monosodium urate crystals is the main factor responsible for triggering attacks of arthritis. Tophi occur as a result of urate crystals that precipitate into joints and surrounding tissues. Tophi can erode the bone where they are located and cause compression in soft tissue due to a mass effect. The following case report describes a case of cubital tunnel syndrome developed in association with tophaceous compression and resolved with surgical decompression in a patient with chronic gouty arthritis.Öğe Dramatic Response to Methyl Prednisolone of Sacroiliitis due to Isotretinoin Theraphy: A Case Report(Galenos Yayincilik, 2020) Resorlu, Hatice; Kilic, Sevilay; Zateri, CoskunAcne vulgaris is a disorder that affects the pilosebaceous follicles on the skin. Isotretinoin is used in the treatment of severe acne and it may have side effects such as arthritis, myalgia, hyperostosis, sacroiliitis in the musculoskeletal system. Rarely seen sacroiliitis is usually recovered by discontinuation of isotretinoin. In this article, it was presented that a 19-year-old patient with bilateral and widespread sacroiliitis as a result of isotretionin use. Despite the use of non-steroidal anti-inflammatory drugs, sacroiliitis, which did not regress, responded dramatically to methyl prednisolone treatment.Öğe Effects of Pain and Disability on Quality of Life in Patients with Carpal Tunnel Syndrome(Duzce Univ, 2013) Ozturk, Ayhan; Degirmenci, Yildiz; Kececi, Hulusi; Zateri, Coskun; Altan, Mehmet; Ankarali, HandanObjective: To evaluate the association between severity of carpal tunnel syndrome (CTS), pain, disability and to assess their effects on quality of life. Methods: CTS patients whose diagnosis were confirmed with nerve conduction studies were classified as mild, moderate, and severe. Pain evaluation was performed by Pain Quality Assessment Scale (PQAS) in all patients. Short form-36 (SF-36) was used to assess quality of life and Brief Disability Scale was used in the evaluation of disability. Results: 93.1% of the patients were women, and 6.9% were men. Mean age was 44.20 +/- 8.76 years (range=29-62). Mean duration of symptoms was 6.67 +/- 3.00 months (range=3-12 months). Most common symptom was paresthesia. Electrophysiological evaluations revealed moderate CTS in 43.8%, mild CTS in 44.8%, severe CTS in 6.9% of the patients. There was no significant association between CTS severity and time course subgroup of PQAS (p=0.222). But there was a statistically significant difference in the general pain subgroup and total scores of PQAS between moderate and severe CTS patients (p<0.05). There was a statistically significant difference in the mean scores of Brief Disability Questionnaire between patients with mild and severe CTS (4,46 +/- 3,61 and 11,50 +/- 4,94, p<0.05, respectively). A statistically significant negative correlation was found between the level of disability and physical function, pain, vitality, social function and mental health domains of SF-36. Conclusion: Quality of life is variably affected in patients with CTS due to the severity of CTS. On this aspect, it is important to diagnose and treat CTS on time to improve the quality of life of patients with CTS in early period, which is the best known and common compression neuropathy of upper extremity in community.Öğe FREQUENCY OF RESTLESS LEGS SYNDROME IN RHEUMATOID ARTHRITIS(Oxford Univ Press, 2011) Zateri, Coskun; Kilinc, Serdar; Birtane, Murat; Tastekin, Nurettin[Anstract Not Available]Öğe Number of Metabolic Syndrome Risk Factors is Related to Carotid Intima-Media Thickness in Rheumatoid Arthritis Patients(Turkish League Against Rheumatism, 2015) Gokmen, Ferhat; Temiz, Ahmet; Akbal, Ayla; Sen, Hacer; Zateri, Coskun; Gokmen, Esra; Bozkurt, EmreObjectives: This study aims to investigate the relationship between carotid intima-media thickness (CIMT) and clinical and metabolic variables in rheumatoid arthritis (RA) patients. Patients and methods: The study included 76 RA patients (18 males, 58 females; mean age 50.1+/-9.8 years; range 21 to 69 years) and 42 control subjects (11 males, 31 females; mean age 49.2+/-9.7; range 28 to 66 years). Erythrocyte sedimentation rate, C-reactive protein, and disease activity score were used to assess disease activation. Rheumatoid factor, anti-cyclic citrullinated peptide antibodies, and metabolic syndrome components (fasting blood glucose, high density lipoprotein-cholesterol, triglyceride, blood pressure, and waist circumference) were measured. Results: Mean disease duration was 6.9+/-6.5 years. Patients with RA had higher CIMT than the controls (0.8+/-0.1 and 0.6+/-0.2, respectively; p< 0.001). Statistically significant positive correlations were observed between CIMT and age, erythrocyte sedimentation rate, C-reactive protein, and systolic and diastolic blood pressure. The CIMT in RA patients having metabolic syndrome risk components ranging from one to four were 0.76+/-0.16, 0.82+/-0.14, 0.86+/-0.13, and 0.92+/-0.13, respectively. CIMT was positively correlated with the number of metabolic syndrome risk components. Conclusion: Our study has shown elevated CIMT in RA. Presence of metabolic syndrome components in RA patients increases tendency to atherosclerosis and constitutes a severe risk for cardiovascular disease.Öğe Prevalence of adolescent idiopathic scoliosis in Turkey: an epidemiological study(Elsevier Science Inc, 2020) Yilmaz, Hurriyet; Zateri, Coskun; Ozkan, Aslihan Kusvuran; Kayalar, Gulseren; Berk, HalukBACKGROUND CONTEXT: Studies have shown that adolescent idiopathic scoliosis (AIS) prevalence varies between 0.35% and 5.2% and it is generally accepted as an average of 2%-3% in children under age 16. There are a few narrow-scope studies based on school screening performed on the epidemiology of AIS in Turkey. Prevalence rates reported by these studies are lower than reported in neighboring countries. Of note, they were conducted in single cities, generally based on small sample size, and are different from each other in terms of methodology and age groups. The present study was conducted based on a large population in 85 schools of 40 provinces in Turkey. PURPOSE: The aim of this study was to determine the prevalence of AIS in Turkey. Secondary outcomes were to determine age, gender, curve distribution, using standard tests, and radiological verification. STUDY DESIGN: A cross-sectional epidemiological study. PATIENT SAMPLE: The sample size was calculated to estimate the prevalence of AIS in children aged 10-15 years in Turkey. OUTCOME MEASURES: Adams' forward bending test, angle of trunk rotation measurement, and posture analysis were used to screen. Students who had an angle of trunk rotation greater than or equal to five (>= 5 degrees) with scoliometer measurement or who had a positive forward bending test were referred to the mobile X-ray unit located in the school-yard on screening day. Their diagnosis was confirmed using Cobb angles of greater than or equal to 10 (>= 10 degrees). METHODS: Medical personnel, mobile radiological tools, and logistical support needed during fieldwork were provided by the Directorate General for Health Research, Ministry of Health Republic of Turkey. Spine and posture were examined in upright standing position. Examiners looked for shoulder asymmetries, scapular prominence, unequal waist, and lower limb length discrepancy. Potential scoliosis diagnosis was verified with onsite radiographic examination. Cases with a Cobb angle of >= 10 degrees detected in any region were accepted as scoliosis. The direction and location of scoliosis were determined according to the Scoliosis Research Society terminology criteria. RESULTS: A total of 16,045 students were reached whose informed consent forms were signed by their parents. The prevalence of AIS was found to be 2.3% (female, 3.1%; male, 1.5%). Radiological confirmation rate was 98.8%; 256 (69.3%) of 369 adolescents with scoliosis had a single curvature and 108 (29.3%) had a double curvature. The most common single curve type was a lumbar curve. In all, 90.5% of cases with AIS had a mild (range of 10 degrees-19 degrees) Cobb angle. CONCLUSIONS: The prevalence of AIS was 2.3% in Turkey. This prevalence rate was considerably higher than the values in previous regional studies conducted in Turkey; however, it was close to generally accepted averages in the literature. One of the strongest aspects of the study was that radiologic confirmation of each suspected case was made during the screening. (C) 2020 Elsevier Inc. All rights reserved.Öğe Prevalence of obstructive sleep apnea in female patients with fibromyalgia(Saudi Med J, 2020) Mutlu, Pinar; Zateri, Coskun; Zohra, Ali; Ozerdogan, Ozgur; Mirici, Arzu N.Objectives: To determine the prevalence of obstructive sleep apnea in female patients with fibromyalgia (FM) presenting to physical therapy outpatient clinics. Methods: The 36-item short form health survey (SF-36) questionnaire, Berlin test, and epworth sleepiness scale were administered, along with a polysomnography to 38 female patients. This cross-sectional study comprised diagnosed with FM according to the diagnostic criteria of the American College of Rheumatology, between March 2017 and August 2019, at the Faculty of Medicine Hospital, Canakkale Onsekiz Mart University, Canakkale, Turkey. Results: Of the participants, 65.9% were found to have obstructive sleep apnea (OSA). Patients with OSA were older and had a higher disease activity score for FM. A strong positive correlation was identified between the apnea-hypopnea index (AHI) and the FA disease activity score. A negative correlation was found between AHI and the subscales of SF-36. Conclusion: A clinical assessment of female patients with FM requires a multidisciplinary approach, and patients with excessive daytime sleepiness in particular are recommended to undergo polysomnography. The authors believe that the early detection and treatment of accompanying OSA will contribute not only to the quality of life, but also to the survival of patients with FM.Öğe Probable osteosarcoma risk after prolonged teriparatide treatment: comment on the article by Saag et al(Wiley-Liss, 2010) Tastekin, Nurettin; Zateri, Coskun[Anstract Not Available]Öğe Psoriatic Arthritis in Psoriasis Patients: Evaluation of Clinical and Radiological Features(Galenos Yayincilik, 2016) Resorlu, Hatice; Ogretmen, Zerrin; Kilic, Sevilay; Akbal, Ayla; Zateri, Coskun; Cevizci, SibelObjective: The purpose of this study was to perform radiological and clinical determination of the presence of psoriatic arthritis (PsA) in patients with psoriasis and to evaluate associations with clinical findings. Materials and Methods: The medical files of 72 patients with psoriasis presenting to our clinic between years 2009-2014 with a prediagnosis of PsA were reviewed retrospectively. Hand, foot and sacroiliac joint radiograms were evaluated by a radiologist who was blinded to the patient's clinical status and who is experienced on musculoskeletal radiology. Patients with psoriasis were divided into two groups according to the presence of arthritis which was determined based on radiographic findings or on Classification Criteria for Psoriatic Arthritis (CASPAR) criteria. All patients' demographic characteristics, length of disease, nail involvement, smoking-alcohol consumption were recorded. Results: The mean age of all patients was 47.24 +/- 14.61 years, and the mean duration of disease was 14.13 +/- 11.92 years. Smoking and alcohol consumptions were determined in 54.2% (n=39) and 23.6% (n=17) of the cases, respectively. Nail involvement was determined in 56.9% (n=41) of the cases. PsA was determined based on radiological findings in 58.3% (n=42) of the patients. The mean age and age at onset of disease were higher in PsA (+) patients than in radiologically non-PsA subjects. Based on clinical findings, PsA based on CASPAR criteria was determined in only 18.1% (n=13) of all patients. Conclusion: A higher level of PsA was determined using radiological evaluation in this study. The main cause of this condition is the existence of asymptomatic-subclinical patients. A detailed medical history should therefore be taken from patients, and good clinical evaluation is very important. Radiological and clinical evaluation should be performed together in the diagnosis.Öğe Risk of Falls in Patients With Ankylosing Spondylitis(Lippincott Williams & Wilkins, 2015) Dursun, Nigar; Sarikaya, Selda; Ozdolap, Senay; Dursun, Erbil; Zateri, Coskun; Altan, Lale; Birtane, MuratBackground: Risk of vertebral fractures is increased in patients with ankylosing spondylitis (AS). The underlying mechanisms for the elevated fracture risk might be associated with bone and fall-related risks. The aims of this study were to evaluate the risk of falls and to determine the factors that increase the risk of falls in AS patients. Methods: Eighty-nine women, 217 men, a total of 306 AS patients with a mean age of 40.1 +/- 11.5 years from 9 different centers in Turkey were included in the study. Patients were questioned regarding history of falls within the last 1 year. Their demographics, disease characteristics including Bath AS Disease Activity Index, Bath AS Metrology Index (BASMI), Bath AS Functional Index (BASFI), and risk factors for falls were recorded. The Short Physical Performance Battery (SPPB) test was used for evaluation of static and dynamic balance. Erythrocyte sedimentation rate, C-reactive protein, and 25-hydroxyvitamin D levels were measured. Results: Forty of 306 patients reported at least 1 fall in the recent 1 year. The patients with history of falls had higher mean age and longer disease duration than did nonfallers (P = 0.001). In addition, these patients' BASMI and BASFI values were higher than those of nonfallers (P = 0.002; P = 0.000, respectively). We found that the patients with history of falls had lower SPPB scores (P = 0.000). We also found that the number of falls increased with longer disease duration and older age (R = 0.117 [P = 0.041] and R = 0.160 [P = 0.005]). Our results show that decreased SPPB scores were associated with increased number of falls (R = 0.183, P = 0.006). Statistically significant correlations were found between number of falls and AS-related lost job (R = 0.140, P = 0.014), fear of falling (R = 0.316, P = 0.000), hip involvement (R = 0.112, P = 0.05), BASMI (R = 0.234, P = 0.000), and BASFI (R = 0.244, P = 0.000). Conclusions: Assessment of pain, stiffness, fatigue, and lower-extremity involvement as well as asking for a history of falls will highlight those at high risk for further falls. In addition to the general exercise program adopted for all patients, we suggest that a balance rehabilitation program should be valuable for the patients with risk factors for fall. Exercise may improve fear of falling and BASFI and BASMI scores. However, further study is needed to investigate these hypotheses. We believe that clinicians should train and support the patients via reducing fear of falls and maintaining good posture and functional capacity.Öğe Sarcoidosis Revealed with Skin Manifestations and Acute Arthritis(Galenos Yayincilik, 2019) Resorlu, Hatice; Kilic, Sevilay; Zateri, CoskunA 37-year-old female patient admitted to our clinic with swelling in both knees and ankles and eruptions in her body. The patient was examined for the etiology of arthritis. In the biopsy taken from the plaque lesions on the skin, granulomatous sarcoidal lesions were detected. The case was diagnosed as sarcoidosis along with clinical, laboratory, and radiological findings. Sarcoidosis started with skin involvement is rarely seen in the literature. Biopsy from specific skin lesions allows diagnosis without the need for an invasive transbronchial biopsy. Therefore, we aimed to present a case of sarcoidosis diagnosed with skin manifestations.Öğe Single-nucleotide polymorphism in Turkish patients with adolescent idiopathic scoliosis: Curve progression is not related with MATN-1, LCT C/T-13910, and VDR BsmI(Wiley, 2012) Yilmaz, Hurriyet; Zateri, Coskun; Uludağ, Ahmet; Bakar, Coskun; Kosar, Sule; Özdemir, ÖztürkThe role of genetics in the etiopathogenesis of adolescent idiopathic scoliosis (AIS) is unclear. In this study, we investigated the relationship between AIS and polymorphisms in MATN-1, LCT C/T-13910, and VDR BsmI genes. 53 Turkish adolescents with diagnosed AIS and 54 healthy adult individuals were included in the study. MATN-1, LCT C/T-13910, and VDR BsmI gene mutations were analyzed with real-time PCR. We did not detect a statistically significant difference between AIS and control groups in respect to those three different gene polymorphisms (p?Öğe The critical role of computed tomography in the differential diagnosis of acute calcific tendinitis of longus colli muscle: A case report(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2023) Karatag, Gulden; Nusran, Gurdal; Zateri, Coskun; Karatag, OzanAcute longus colli calcific tendinitis (ALCT) is a non-infectious inflammatory process. The typical clinical triad is acute neck pain, neck stiffness, and odynophagia. These findings can be confused with many common pathologies. As ALCT treatment is conservative and relatively easy, making the correct diagnosis is important. Radiology is of critical importance in the diagnosis of ACLT. The detection of prevertebral calcification by computed tomography is pathognomonic. Herein, we present a case with a sudden onset of neck and occipital pain accompanied by odynophagia following acute trauma and diagnosed with ALCT by radiological examination.Öğe The relation between chondromalacia patella and meniscal tear and the sulcus angle/trochlear depth ratio as a powerful predictor(Ios Press, 2017) Resorlu, Hatice; Zateri, Coskun; Nusran, Gurdal; Goksel, Ferdi; Aylanc, NiluferPURPOSE: To investigate the relation between chondromalacia patella and the sulcus angle/trochlear depth ratio as a marker of trochlear morphology. In addition, we also planned to show the relationship between meniscus damage, subcutaneous adipose tissue thickness as a marker of obesity, patellar tilt angle and chondromalacia patella. METHODS: Patients with trauma, rheumatologic disease, a history of knee surgery and patellar variations such as patella alba and patella baja were excluded. Magnetic resonance images of the knees of 200 patients were evaluated. Trochlear morphology from standardized levels, patellar tilt angle, lateral/medial facet ratio, subcutaneous adipose tissue thickness from 3 locations and meniscus injury were assessed by two specialist radiologists. RESULTS: Retropatellar cartilage was normal in 108 patients (54%) at radiological evaluation, while chondromalacia patella was determined in 92 (46%) cases. Trochlear sulcus angle and prepatellar subcutaneous adipose tissue thickness were significantly high in patients with chondromalacia patella, while trochlear depth and lateral patellar tilt angle were low. The trochlear sulcus angle/trochlear depth ratio was also high in chondromalacia patella and was identified as an independent risk factor at regression analysis. Additionally, medial meniscal tear was observed in 35 patients (38%) in the chondromalacia patella group and in 27 patients (25%) in the normal group, the difference being statistically significant (P - 0.033). CONCLUSIONS: An increased trochlear sulcus angle/trochlear depth ratio is a significant predictor of chondromalacia patella. Medial meniscus injury is more prevalent in patients with chondromalacia patella in association with impairment in knee biomechanics and the degenerative process.Öğe The relationship between C-reactive protein rs3091244 polymorphism and ankylosing spondylitis(Wiley-Blackwell, 2016) Akbal, Ayla; Resorlu, Hatice; Gokmen, Ferhat; Savas, Yilmaz; Zateri, Coskun; Sargin, Betul; Bozkurt, EmreAimsPrevious studies have shown that C-reactive protein (CRP) gene polymorphism can be related to inflammatory changes. The present study aimed to examine the association between CRP gene polymorphism and clinical and laboratory findings in ankylosing spondylitis (AS) patients. Materials and methodsA total of 80 patients, 40 with AS and 40 controls, were included in the study. Diagnosis of AS was made according to Assessment in AS International Working Group criteria. Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index and Bath Ankylosing Spondylitis Radiology Index scores were evaluated. CRP gene C, A and T alleles were evaluated and were determined using the analysis of melting curves after real time polymerase chain reaction. The odds ratios were calculated for all alleles and haploids of the CRP gene. We investigated the relationship between the CRP polymorphism and clinical and laboratory findings. ResultsA, C, T allele frequencies in the control group were 15%, 57.5% and 27.5%. The allele frequencies in the AS group were 38%, 68.8% and 26.2%. While C and T allele frequencies were shown to be similar in the two groups, A allele frequency was higher in the AS group compared to the control group. The CC wild allele was 42.5% in the control group and 47.5% in the AS group (P = 1.0). Odds ratios for the C allele were 1.6, for the CC haploid 1.2 and for the CT haploid 3.7. Chest expansion and finger-to-ground distance was better in the CRP gene polymorphism group compared to the no polymorphism group. ConclusionThe presence of the CRP gene CC wild haploid and C allele in patients may indicate an increased risk for AS.
