Yazar "Zateri, Coşkun" seçeneğine göre listele
Listeleniyor 1 - 6 / 6
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Attitudes of patients with spondylarthritis or rheumatoid arthritis regarding biological treatment during COVID-19 pandemic: A multi-center, phone-based, cross-sectional study(Turkish League Against Rheumatism (TLAR), 2021) Zateri, Coşkun; Birtane, Murat; Aktaş, İlknur; Sarıkaya, Selda; Rezvani, Aylin; Altan, Lale; Dursun, NigarObjectives: In this study, we aimed to investigate the medical treatment attitudes of patients with spondylarthritis or rheumatoid arthritis (RA) who were using biological drugs during the novel coronavirus-2019 (COVID-19) pandemic. Patients and methods: In this multi-center, cross-sectional study, a total of 277 patients (178 males, 99 females; median age: 45 years; range, 20 to 77 years) who were using biological disease-modifying anti-rheumatic drugs (bDMARDs) for rheumatic diseases and were reached by phone between June 1st, 2020 and June 30th, 2020 were included. Demographic characteristics, working status, type of the rheumatic disease, comorbidities, smoking habits, and type of the bDMARDs were recorded. Disease activity was evaluated using the Visual Analog Scale (VAS). The patients were asked whether they continued the treatment plan, as it was before or changed and, if changed, how they changed the plan and what happened after the change. Results: Of the patients, 229 had spondylarthritis and 48 had RA. A total of 36.1% of the patients were smokers, and the most common comorbidity was hypertension (17.3%). Totally, 5.8% of the patients had a history of contact with a COVID-19 positive person. Only three (1.1%) patients were diagnosed with COVID-19 infection and none of them died. Of the patients, 64.3% continued their treatment, while 35.7% adopted various changes. Most patients made the decision about the treatment plan on their own (n=160, 57.8%), while 38.3% of them consulted their physicians and 13.9% of them consulted any health staff. The only significant parameter for changing the drug course was receiving intravenous bDMARDs (by infusion at hospital) (p=0.001). These patients had also a higher disease activity as measured by VAS, compared to the patients receiving non-infusion therapy (p=0.021). As a result of these changes, severity of the symptoms increased in 91 (32.9%) patients. Disruption of regular biological treatment and prior infusion therapy more likely worsened the complaints (p<0.001 and p=0.024, respectively). Conclusion: Intravenous bDMARD therapy seems to be the main factor affecting the continuity of the treatment in the pandemic period. During the pandemic period, alternative treatment options should be considered other than infusion therapy not to interrupt the treatment of these patients.Öğe Farelerde Oluşturulan Romatoid Artrit Leptin Reseptör Antikoru (Obr-Ab) Kullanılarak Tedavi Edilebilir Mi?(2017) Edremitlioğlu, Mustafa; Turkon, Hakan; Kılınç, Nihal; Zateri, CoşkunLeptinin proinflamatuar bir sitokin gibi davrandığı ve proinflamatuar sitokinlerin saIgısını artırdığı bilinmektedir. Bu nedenle romatoid artrit tablosunu şiddetlendirmesi beklenebilir. Bu çalışmanın amacı, leptin reseptör antikoru verilerek leptin etkisinin önlenmesinin Balb-c farelerdeki artrit gelişimine ve şiddetine etkisini incelemektir. Bu amaçla aşağıdaki şekilde oluşturulan dört grup hayvan kullanılmıştır: 1- Kontrol grubu (K) 2- Artrit grubu (A) 3- Erken dönemde leptin reseptör antikoru verilen artrit grubu (LE) 4- Geç dönemde leptin reseptör antikoru verilen artrit grubu (LG) Artrit oluşturmak için kollajen tip-II antikoru ile uyarılan artrit (CAIA) modeli kullanılmıştır. Leptin reseptör antikoru (OBR IgG) hayvanların bir bölümüne artritin tetiklendiği gün olan 0. günde (LE grubu), bir bölümüne ise 5. günde (LG grubu) uygulanmıştır. Deneye alınan tüm farelerde 20 gün boyunca klinik artrit skorlaması yapılmıştır. Yirminci gün kan ve doku örnekleri alınarak deney protokolü sonlandırılmıştır. Alınan doku örnekleri artrit gelişimi ve şiddeti yönünden histopatolojik skorlama ile ayrıca değerlendirilmiştir. Alınan kan örneklerinden plazma leptin, IL-1?, IL-6, IL-17A, TNF-? düzeyleri ELISA yöntemiyle belirlemiştir. Artrit gelişimi kollajen tip-II antikoru uygulanmasından 5 gün sonra gözlenmeye başlanmış ve 9-10. günlerde en şiddetli halini almıştır. Bu günden sonra yavaşça azalmakla birlikte, 20. günün sonunda hala gözlenebilir düzeyde artrit bulguları kaydedilmiştir. Hem sıfırıncı (LE) hem de beşinci günde (LG) leptin reseptör antikoru uygulanan gruplarda klinik artrit skorunun 7. güne kadar, leptin reseptör antikoru verilmeyen yani sadece artritli gruptaki (A) hayvanlarla benzer olduğu görülmüştür. Buna karşın 8. günden itibaren LE ve LG gruplarındaki klinik artrit skoru deney sonuna kadar A grubundan daha düşük seyretmiştir. Histopatolojik skorlamada LE ve LG gruplarında pannus oluşumu ve kıkırdak hasarında anlamlı olmayan ve minimal bir azalma gözlendi. Plazma leptin ve sitokin düzeylerinde gruplar arasında her hangi bir fark gözlenmedi. Elde edilen sonuçlar, leptin reseptör antikoru uygulanmasının artrit şiddetini azaltmada etkili olabileceği konusunda ümit vermektedir. Bu konuda daha büyük deney gruplarının kullanıldığı ileri çalışmalara gerek vardır.Öğe Progressive parsonage turner syndrome and steroid treatment(Anatolian Journal of Clinical Investigation, 2014) Akbal, Ayla; Gökmen, Ferhat; Reşorlu, Hatice; Yeşil, Çağdaş; Zateri, Coşkun; Karatağ, Ozan[No abstract available]Öğe Psöriatik artritli bir olguda bilateral üst ekstremite ödemi(2015) Gökmen, Ferhat; Akbal, Ayla; Savaş, Yılmaz; Zateri, Coşkun; Karaca, Adem; Tan, Yusuf ZiyaPsöriatik artrit (PsA), seronegatif spondiloartropati grubunda yer alan,periferal artrit, entezit, spondilit ve psöriasis ile karakterize infamatuvarromatizmal bir hastalıktır. Lenfödem ekstremite distalinde daha fazlabir veya birden fazla bölgede görülebilen, tümörler, enfeksiyonlar,busitler, romatoid artrit, polimiyalji romatika gibi birçok infamatuvar venoninfamatuvar hastalığa sekonder olarak gelişebilen lenfatik akımdakiyavaşlama ile gelişen bir hastalıktır. Lenfödem PsAda nadir gelişen birkomplikasyondur. Sıklıkla asimetrik ve daha çok alt ekstremitede görülür.Bu yazıda PsA tanısı ile takip ettiğimiz ve her iki üst ekstremitede şişlikşikayeti ile başvuran ve yapılan incelemelerde bilateral üst ekstremite lenfödemi tanısı koyduğumuz olgu rapor edilmiştir.Öğe The fate of manuscripts rejected by the Turkish Journal of Physical Medicine and Rehabilitation(Turkish Society of Physical Medicine and Rehabilitation, 2024) Külcü, Duygu Geler; Tur, Birkan Sonel; Yanık, Burcu; Doğan, Şebnem Koldaş; Bardak, Ayşe Nur; Zateri, Coşkun; Evcik, DenizObjectives: The aim of this study was to evaluate the fate of the articles after they were rejected from the Turkish Journal of Physical Medicine and Rehabilitation (Turk J Phys Med Rehab). Materials and methods: Between January 2016 and December 2021, rejected manuscripts by the Turk J Phys Med Rehab were retrospectively analyzed and whether these rejected articles were published in another journal was identified. For the manuscripts published elsewhere, article type, change in the article name, and the number and order of authors were noted. The index of the new journal, the impact factor for SCI-E journals and journal quartile were recorded. Whether the journal was a national journal/international journal, a specialty or non-specialty journal, and whether the impact factors were higher, lower, or the same as Turk J Phys Med Rehab were evaluated. Results: Totally, 76% of 1,051 rejected articles were accepted for publication in another journal, after an average of 13.73 months. The name of the article, the order of the authors, and the number of the authors remained unchanged in 71.4%, 79.3%, and 80.8% of the articles, respectively. A total of 69.9% of the journals were non-specialty journals and 61.8% were general international medical journals. In addition, 32.6% of the journals were included in the SCI-E, and 70.9% of the articles in SCI-E were included in the Q4 and Q3 scope. The impact factor with 51.9% were lower or the same with the Turk J Phys Med Rehab. Conclusion: Our study results showed that a high percentage of the articles rejected by the Turk J Phys Med Rehab found a place in another journal later, and that non-specialty journals that accept general articles were more prominent in the selection of journal. The fact that an article rejected from a journal can be corrected and amended in accordance with valuable reviewer comments by improving its academic quality and seeking success in other journals may be promising for researchers who submit their articles to journals. © 2024 Turkish Society of Physical Medicine and Rehabilitation. All rights reserved.Öğe The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity(2018) Sılan, Fatma; Özdemir, Öztürk; Zateri, Coşkun; Savaş, Yılmaz; Akbal, Ayla; Reşorlu, Hatice; Sargın, BetülObjective. We aimed to evaluate the frequency of toll-like receptor 4 (TLR4) gene polymorphism and itsrelationship between disease activity in patients with ankylosing spondylitis (AS). Methods. Forty-one ASpatients (25 male/16 female) fullfilling the 1984 Modified New York Criteria and 41 healthy controls (25male/16 female) were included in this study. Disease activity of the AS patients was assesed by Bath AnkylosingSpondylitis Disease Activity Index (BASDAI). The TLR4 gene polymorphism of AS patients and healthycontrols were analyzed by Real-Time Polymerase Chain Reaction (PCR) System. Results. Three (7.3%) patientswith AS had TLR4 gene polymorphism compared with healthy controls (0/41; 0%). Two of these patients hadheterozygous mutation and one had homozygous mutation. Significant correlation was not found betweenTLR4 gene polymorphism and BASDAI score (p > 0.05). Conclusions. In our study, TLR4 gene polymorphismwas higher in patients with AS compared with control group. But, this polymorphism was not associated withdisease activity, erythrocyte sedimentation rate and C-reactive protein levels
