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    A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury
    (Elsevier Science Inc, 2012) Turkmen, Suha; Mentese, Ahmet; Karaguzel, Ersagun; Karaca, Yunus; Kucuk, Adem; Uzun, Aysegul; Yulug, Esin
    Objective: To compare the effects of N-acetylcysteine (NAC) and ethyl pyruvate (EP) on experimental testicular ischemia-reperfusion (I/R) injury. Design: Randomized, controlled, experimental study. Setting: University hospital. Animal(s): Twenty-four mature male Wistar rats. Intervention(s): Rats were divided into four groups: control group, torsion-detorsion (T/D) group, EP group, and NAC group. In the pretreatment of the NAC and EP groups, 20 mg/kg NAC and 50 mg/kg EP were given intraperitoneally (IP) 30 minutes before detorsion. Main Outcome Measure(s): Serum ischemia-modified albumin (IMA), tissue and serum malondialdehyde, and myeloperoxidase activity levels and histopathological damage scores were then compared. Result(s): Ethyl pyruvate and N-acetylcysteine exhibited a protective effect against I/R injury. Of the biochemical parameters evaluated as a result of testicular I/R, only IMA levels were significantly elevated. There was a strong and significant correlation between serum IMA levels and histopathological injury scores, and the increase in serum IMA level exhibited a strong parallel with the increase in histopathological injury. In the EP group, although the histopathological injury score was similar to that of the control group, serum IMA levels were significantly elevated. Conclusion(s): Both NAC and EP, the effects of which on I/R injury are evaluated in the present study, reduce such injury in testicular torsion-detorsion. Comparing their effects on IMA levels, NAC may be regarded as a relatively more effective treatment than EP. (Fertil Steril (R) 2012; 98: 626-31. (C) 2012 by American Society for Reproductive Medicine.)
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    Evaluation of hepatic and remote organ injury in an experimental liver ischemia-reperfusion model in rats and the effects of quercetin on this damage
    (Turkish Assoc Trauma Emergency Surgery, 2025) Ari, Neziha Senem; Yulug, Esin; Ari, Bunyamin; Kaya, Cansu; Kose, Goksen Derya Reis; Zengin, Tugba; Keskin, Oguzhan
    BACKGROUND: This study aims to show the changes in the liver, lung, kidney, and heart in the liver ischemia-reper fusion model rats and the effect of quercetin on these changes histopathologically and immunohistochemically. METHODS: Eighteen Sprague Dawley rats were classified into three groups: Group 1 sham, Group 2 ischemia-reper fusion Group 3 ischemia-reper fusion + quercetin (IR+Q). For three days, distilled water was given to Group 1, and quercetin was given Group 3 via gavage. At the end of the third day, abdominal opening-closing was applied to Group 1, and 4 hours of reperfusion applied to Groups 2 and 3 after 1 hour of ischemia by clamping the hepatoduodenal ligament, and all rats were euthanized. Liver, kidney, and heart tissue samples were stained with Hematoxylin Eosin (HE), Masson Trichrome, Periodic Acid-Schiff (PAS), and TUNEL (Terminal deoxynucleotidyl transferase (TdT) deoxyuridine triphosphate nick end labeling assay) to assess apoptosis and examined histopathologically and immunohistochemically under a light microscope. RESULTS: In the liver, the damage score was significantly higher in the IR group than in the sham group, while it was significantly in the IR+Q group than in the IR group. While there was no significant difference between the groups in semi-quantitative scoring parameters, the Apoptotic Index was significantly higher in the IR group than in the sham group and significantly lower in the group than in the IR group. In the lung, no significant difference in lung damage scores between the groups was observed. While Apoptotic Index was significantly higher in the IR group than in the sham group, it was significantly lower in the IR+Q group than IR group. In the kidneys, tubular cell degeneration and intertubular vascular congestion were significantly higher in the IR group than the sham group. While the Apoptotic Index was higher in the IR group than in the sham and IR+Q groups, it was higher in the group than in the sham group. In the heart, there was no difference between the groups in terms of myocardial cell degeneration vascular damage. The apoptotic index was significantly higher in the IR group than in the sham and IR+Q groups. CONCLUSION: Our results indicate that histopathological damage occurs in the liver, lung, kidney, and heart in the experimentally created IR model, and quercetin application decreases IR-related damage and apoptosis in these organs.