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  • [ X ]
    Öğe
    G protein ?3 subunit gene polymorphism in Turkish hypertensives
    (Turkish Soc Cardiology, 2008) Alioglu, Emin; Ercan, Ertugrul; Tengiz, Istemihan; Yildiz, Ahmet; Tuerk, Ugur Oensel; Saygi, Serkan; Cam, F. Sirri
    Objective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein (33 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein beta 3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein 133 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein 133 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (chi(2)=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein (33 subunit C825T gene polymorphism is associated with systolic and diastolic blood pressure. Furthermore, the study indicates that the G protein 133 subunit may be a susceptible gene to essential hypertension. (Anadolu Kardiyol Derg 2008; 8: 337-5)
  • [ X ]
    Öğe
    The role of environmental ideologies in environmental education
    (Routledge Journals, Taylor & Francis Ltd, 2025) Dincel, Deniz; Yildiz, Ahmet
    This study explores the impact of environmental ideologies on the environmental education programs of non-governmental organizations active in Turkey. The study group comprises six different non-governmental organizations, which are divided into two main groups according to their environmental ideologies: reformists and radicals. Data were generated from document analyses, in-depth interviews and direct, participatory observations. The research results demonstrated that the majority of the environmental education programs in Turkey are run by reformist environmental non-governmental organizations that consider the environmental issue from an anthropocentric and apolitical perspective and generally concentrate on behavior modification and awareness-raising by using standard education materials. In contrast, non-governmental organizations within the radical group adopt an ecocentric approach, and consider environmental problems to be the outcome of the growth-focused mainstream economic system. As a reflection of this view in their educational activities, they problematize capitalist globalization and demand structural and policy changes.