Yazar "Yazici, Ibrahim" seçeneğine göre listele

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    Investigation of the effects of chronic hypertrophic adenotonsillitis on olfaction and quality of life
    (Deomed Publ, Istanbul, 2013) Guclu, Oguz; Yazici, Ibrahim; Toroslu, Tolgahan; Derekoy, Fevzi Sefa
    Objective: To investigate the effects of the chronic hypertrophic adenotonsillitis on olfaction and quality of life. Methods: Pediatric patients, aged 7-8 years, were prospectively included in three groups; Group I-Adenotonsillar diseases (n=15), Group II-Control (n=15) and Group III-Postoperative group (n=15). Patients were evaluated with the Sniffin' Sticks 12 item smell identification test and obstructive sleep disorder-6 (OSD-6) quality of life survey. Results: Total smell identification (SI) scores were 6.93 +/- 1.75 in the adenotonsillar disease, 8.73 +/- 1.10 in the control and 7.67 +/- 1.59 in the postoperative groups, respectively. Total SI score in the adenotonsillar disease group was significantly lower than the control group (p<0.05). The postoperative group SI scores were higher, but not at the level of the control group. Total OSD-6 scores were 18.80 +/- 4.75 for the adenotonsillar disease, 5.20 +/- 2.40 for the control and 5.07 +/- 2.02 for the postoperative groups, respectively. The adenotonsillar disease group score was significantly higher than the scores of the other two groups (p<0.05). Conclusion: Adenotonsillar diseases affect both quality of life and smell function. Six months after surgery quality of life reaches normal standards. Smell function is observed to have partially recovered by the sixth month. This situation may be due to obstructive symptoms resolving in the early postoperative period, while symptoms related to mucosal or inflammatory pathologies recover more slowly.
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    Öğe
    Micronucleus, nucleoplasmic bridge and nuclear bud frequencies in patients with laryngeal carcinoma
    (Pacini Editore, 2020) Yazici, Ibrahim; Caglar, Ozge; Guclu, Oguz; Cobanoglu, Hayal; Coskun, Mahmut; Coskun, Munevver; Kilic, Aytac
    The aim of the study is to determine and compare micronucleus (MN), nucleoplasmic bridge (NPB) and nuclear bud (NBUD) frequencies in patients with laryngeal carcinoma and healthy controls. The study was conducted in the School of Medicine of Onsekiz Mart University. A total of 102 volunteers, 51 of whom had laryngeal carcinoma and 51 of whom were healthy control subjects, participated in this study. The Cytokinesis-Block Micronucleus Assay (CBMN) was applied to peripheral blood lymphocytes taken from patients and controls. We evaluated MN, NPBs and NBUDs frequencies in patients with laryngeal carcinoma and compared the results with those in the control group. The frequencies of MN, NPBs and NBUDs of patients with laryngeal carcinoma were found significantly higher than those in the control group (P = 0.01, P = 0.004, P = 0.01, respectively). MN, NPB and NBUD frequencies were also compared in the patients with and without pesticide exposure, and the means of all frequencies was higher in patients with pesticide exposure (P = 0.001, P = 0.02 respectively). The MN, NPBs and NBUDs frequencies of the patients with laryngeal cancer were significantly higher than those of the control group, and pesticide exposure might be a risk factor that increases genomic instability and risk of laryngeal cancer.