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    The Association Between Serum Uric Acid and 25-Hydroxyvitamin D in Peritoneal Dialysis Patients
    (Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2018) Bakirdogen, Serkan; Eren, Necmi; Bek, Sibel Gokcay; Yavuz, Sara; Tuncay, Mehmet
    OBJECTIVE: In peritoneal dialysis (PD) patients, a low level of serum 25-hydroxyvitamin D is associated with an increased risk of cardiovascular events. Hyperuricemia is also associated with an increased mortality rate in chronic kidney disease patients. The aim of our study was to determine whether there was a relationship between serum uric acid and 25-hydroxyvitamin D in PD patients. MATERIAL and METHODS: A total of 48 PD patients were included in the study. Uric acid and 25-hydroxyvitamin D were determined simultaneously in each patient's serum. Mean serum uric acid and 25-hydroxyvitamin D levels of the patients were compared with each other. The cases where the P-value was below 0.05 were considered statistically significant. RESULTS: There was a statistically significant positive correlation between mean serum uric acid and 25-hydroxyvitamin D levels in PD patients (p=0.003; r=0.427). CONCLUSION: Serum uric acid and 25-hydroxyvitamin D levels in peritoneal dialysis patients may be indicative of dietary incompatibility. Prospective studies involving more patients are needed in PD patients to prove a relationship between these two serum markers.
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    The Effect of Erythropoiesis-Stimulating Agents on Platelet Aggregation in Peritoneal Dialysis Patients
    (Istanbul Training & Research Hospital, 2019) Bakirdogen, Serkan; Eren, Necmi; Bek, Sibel Gokcay; Yavuz, Sara
    Introduction: Erythropoietin (Epo) is a hormone that is synthesized in the kidneys and that stimulates the erythropoiesis in the bone marrow. Epo has effects apart from the erythropoiesis. In chronic renal failure (CRF) patients, hemorrhagic diathesis is observed, and Epo production is decreased. Erythropoiesis-stimulating agents (ESAs) are widely used in the treatment of renal anemia in these patients. Our study aimed to investigate the effect of ESA5 use on platelet aggregation in peritoneal dialysis (PD) patients due to CRF. Methods: Forty-three PD patients were included in the study. Seventeen patients had been using ESAs for anemia for at least three months (ESAs user group). Twenty-six patients were not using ESAs since they did not have indications (non-ESAs user group). Platelet aggregation measurement from the whole blood was carried out in each patient by a multiplate device. The calculated values [area under the curve (AUC), aggregation, and velocity] were recorded. The results were evaluated statistically, and p<0.05 was accepted as statistically significant. Results: In the non-ESAs user group, the mean hemoglobin level was found higher when compared to the other group, and this difference was statistically significant (p<0.001). The percentage of transferrin saturation was found higher in the ESAs user group (p=0.021). It was observed that AUC, aggregation, and velocity values were lower in the ESA5 user group, and the result was not statistically significant (p values were 0.202, 0.329, 0.290, respectively). Conclusion: ESAs use in PD patients did not have any effect on platelet aggregation. Further prospective studies involving platelet aggregation tests before and after ESA treatment in dialysis patients are needed.
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    The Effects of Peripheral Platelet and Leukocyte Counts on Platelet Agregation in Peritoneal Dialysis Patients
    (2018) Bakırdöğen, Serkan; Bek, Sibel Gökçay; Eren, Necmi; Uzay, Ant; Bilgili, Ümit; Çekmen, Mustafa Baki; Yavuz, Sara
    INTRODUCTION: Studies in healthy individuals andpatients with coronary artery disease have demonstratedthat circulating platelet and leukocyte counts affect plateletaggregation. The aim of our study was to investigatewhether there is such a relationship betweenleukocyte/platelet counts and platelet aggregation in endstagerenal disease patients on peritoneal dialysis (PD).METHODS: Forty-three PD patients were included in thestudy. Multiple electrode aggregometry method capable ofmeasuring platelet aggregation in whole blood was used.RESULTS: A statistically significant positive correlationbetween platelet aggregation and leukocyte and platelet countsin complete blood count (CBC) was seen. This positivecorrelation was stronger for platelets than leukocytes.DISCUSSION and CONCLUSION: Platelet and leukocytecounts in CBC in PD patients might be important on plateletaggregation. This might be another risk factor contributing toalready increased thrombosis risk in these patients.