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    Correlation between Bethatrophin and 25(OH)D Concentrations in a Group of Subjects With Normal and Impaired Glucose Metabolism
    (Georg Thieme Verlag Kg, 2017) Turkon, H.; Yalcin, H.; Toprak, B.; Demirpence, M.; Yasar, H. Y.; Colak, A.
    Aim Inducing beta cell replication is a potential therapeutic approach for the treatment of diabetes mellitus. Recently betatrophin was suggested as a novel stimulator of beta cell proliferation in mice but its role in humans remains to be established. We aimed to investigate betatrophin concentration and its association with metabolic parameters in a group of individuals with normal glucose tolerance, pre-diabetes and diabetes mellitus who had not been previously treated. Methods A total of 72 subjects were recruited for this cross sectional study: 23 subjects with normal glucose tolerance (NGT), 22 subjects with prediabetes, and 27 subjects with diabetes mellitus (DM). Circulating betatrophin concentration, 75 g oral glucose tolerance test, fasting insulin, glycosylated hemoglobin, 25hydroxy vitamin D and HOMA IR were measured. Results The difference in betatrophin values did not reach statistical significance between the 3 groups [NGT: 206 (176-297) pg/mL, Prediabetes: 232 (181-254) pg/mL, DM: 245 (205-526) pg/mL, p = 0.078]. Betatrophin was negatively significantly correlated with BMI and positively significantly correlated with 25(OH) vitD (p = 0.043 and p = 0.001 respectively). Multivariate linear regression showed that 25(OH) vitD (beta = 0.440 p = 0.001) and fasting glucose (beta = 0.003 p = 0.038) were variables associated with betatrophin concentration (R2 = 0.251). Conclusions In a group of subjects ranging from those with normal glucose tolerance to newly diagnosed diabetes, we found that 25(OH) D and fasting glucose were factors associated with serum betatrophin concentration.