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    Psychometric properties of the Turkish version of the premenstrual dysphoric disorder questionnaire for DSM-5 (CTDP-DSM-5)
    (Springernature, 2025) Korkmaz, Sukru Alperen; Ertekin, Hulya; Yapar, Senem; Aperribai, Leire
    Introduction Premenstrual dysphoric disorder (PMDD) is a syndrome marked by severe mood and physical symptoms during the menstrual luteal phase. This study aimed to evaluate the validity and reliability of the Turkish CTDP-DSM-5 (CTDP-TR), developed by Aperribai et al. (2016), in response to the insufficient diagnosis of PMDD in clinical settings, as per the DSM-5 or ICD-11. Methods Data were collected from women through an electronic questionnaire. A total of 336 participants were included in the analysis. The Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Premenstrual Symptoms Screening Tool (PSST) scales were administered alongside the CTDP-TR; the data were analyzed for construct validity, internal consistency, test-retest reliability, convergent validity, and criterion validity. Results The CTDP-TR is a 25-item screening tool based on DSM-5. Confirmatory factor analysis of the CTDP-TR revealed a two-factor structure with acceptable fit indices (CFI = 0.903; TLI = 0.888; RMSEA = 0.057, SRMR = 0.056, chi 2/df = 2.08, p < 0.001). The total score of the scale demonstrated excellent internal consistency (alpha = 0.89), a strong correlation with PSST (r = 0.715), and excellent discrimination in ROC analysis (AUC = 0.943). CTDP-TR scores correlated significantly with PHQ-9 (r = 0.547) and GAD-7 scores (r = 0.510), effectively distinguishing individuals with depression from those without (Cohen's d = 1.171) and individuals with anxiety from those without (Cohen's d = 1.145). The rate of positive screening for PMDD was 43.5%. Conclusions The CTDP-TR is a straightforward, valid, and reliable screening tool aligned with DSM-5 for PMDD in Turkiye, providing a basis for early identification and referral, rather than a stand-alone diagnosis. The existence of this scale is crucial for public health, as it addresses the absence of a standard, DSM-5-oriented tool for PMDD screening in Turkiye.
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    Tics Induced by Mirtazapine in an Adolescent
    (Korean College of Neuropsychopharmacology, 2025) Yapar, Senem; Bolat, Nurullah
    Mirtazapine is an antidepressant approved by the FDA whose mechanism of action involves antagonism of alpha-2, H1, 5-HT2A, 5-HT2C, and 5-HT3 receptors. Tics are sudden, rapid, purposeless, recurrent, non-rhythmic motor movements or vocalizations. There have been previous case reports of various medications causing tics. In this article, we report tic symptoms that we thought developed in association with mirtazapine treatment. Copyright© 2025, Korean College of Neuropsychopharmacology.