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    Evaluation of Epilepsy Prevalence and Clinical Correlations in Individuals aged 18 and over in Çanakkale City Center
    (2023) Tan, Tülay; Yücel, Selma; Oymak, Sibel; Karaman, Handan Işın Özışık
    Objective: Epilepsy; is a common neurological disease characterized by sudden and recurrent seizures, especially affecting the young population. The burden of epilepsy is not limited to seizures. The disease also significantly affects personal, familial and social quality of life by causing psychological problems. In this study, it was aimed to determine the prevalence of epilepsy and to determine the effect of epilepsy on quality of life and sleep hygiene in people aged 18 years and older living in Çanakkale city center. Method: In our study, 397 participants aged 18 years and older residing in Çanakkale city center were interviewed. Sociodemographic characteristics, personal and family history, and epilepsy disease history were questioned. World Health Organization Quality of Life Scale (WHOQOL-BREF) and Sleep Hygiene Index (SHI) scales were applied to patients with epilepsy diagnosis. Results: 2.0% (n=8) of the participants had a diagnosis of epilepsy. 75% (n=6) of patients with epilepsy were female. There was a family history of epilepsy in 62.5% (n=5) of individuals with epilepsy, a family history of febrile seizures in 25% (n=2), and a family history of consanguinity between parents in 12.5% (n=1). There was no significant difference between the groups with and without epilepsy in terms of the mean SHI scores (p=0.400). There was no difference in the WHOQOL-BREF quality of life scale in terms of bodily domain, mental domain, social domain and environmental domain sub-scores (p>0.05). Conclusion: In our study, the prevalence of epilepsy was found to be 2%. Most of the patients were female. There was an increased rate of consanguineous marriage in the families of the patient group. Again, a devastating majority of the patient group had a family history of epilepsy or a history of febrile convulsions. Sleep hygiene and quality of life scales did not differ between the patient group and the control group. This may be due to the very small number of our patient group. There is a need for larger-scale studies on this subject in our region.
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    Öğe
    MULTİPLE SKLEROZ HASTALARINDA APOE GEN EKSPRESYONUNUN BELİRLENMESİ
    (2021) Çakına, Suat; Yücel, Selma; Polat, Cemre Çağan
    AMAÇ: Apolipoprotein E (ApoE), lipoprotein parçacıklarının reseptör aracılı endositozunda ligand olarak işlev gören bir glikoproteindir. ApoE'nin Alzheimer ve multipl skleroz gibi nörojeneratif hastalıklar ile ilişkisini gösterençalışmalar vardır. Bu çalışmanın amacı ApoE gen ekspresyonu ile MS arasında bir ilişki olup olmadığını araştırmaktır.GEREÇ VE YÖNTEM: ApoE gen ekspresyonunun multiple skleroz hastlığı üzerinde etkisini saptamak amacıyla yaptığımız çalışmamıza 35 hasta ve 20 sağlıklı birey dahil edilmiştir. ApoE mRNA ekspresyonunun seviyesi, Revers-Transkriptaz Polimeraz Zincir Reaksiyonu (qRT-PCR) ile belirlendi. İstatiksel analiz için SPSS paket programı kullanılarak,t testi, ki-kare testi, Kruskal-Wallis testi ve Mann-Whitney U testi yapıldı ve p <0,05 istatistiksel olarak anlamlı kabul edildi.BULGULAR: Sonuç olarak, ApoE gen ekspresyonunun çoklu skleroz hastalarında ve sağlıklı kişilerin gerçek zamanlı PCR teknikleri kullanılarak karşılaştırılması, gruplar arasında istatistiksel olarak anlamlılık göstermedi (p=0.95).SONUÇ: Çalışmamız ApoE gen ekspresyonunun MS hastalığı ile ilişkili olabileceğini desteklememektedir. ApoE'nin Multipl Skleroz hastalığında rolünü belirlemek için ileri çalışmalara ihtiyaç vardır.
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    Öğe
    OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH MIGRAINE WITHOUT
    (2020) Cakina, Suat; Yücel, Selma; Polat, Cemre Cagan; Oztürk, Şamil
    Aim: Migraine is a multifaceted neurological disease whose molecular mechanisms are not yet clearly defined. Oxidative stress is also believed to play a role in the pathogenesis of migraine. The purpose of this study was to evaluate serum paraoxonase (PON) and arylesterase (ARE) activities, thiols levels, ischemia-modified albumin (IMA), the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in patients with migraine without aura. Materials and Methods: 30 patients (5 males and 25 females) and 30 matched healthy controls (8 males and 22 females) were enrolled. Serum PON and ARE activities, thiols levels, IMA, TAS, TOS and OSI were determined by using the spectrophotometric method in the study groups. Statistical analysis was conducted using Mann–Whitney U test and independent samples t-test, and p<0.05 was considered as statistically significant. Results: PON and ARE levels were significantly lower in the migraine without aura group compared with the control group p<0.05. Conclusion: Our results suggested that the PON and ARE levels might be associated with migraine without aura. In migraine patients, it is recommended that oxidative stress markers be investigated with a larger population and these parameters are taken into consideration.