Yazar "Verim, Levent" seçeneğine göre listele

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    Functional Genetic Variants in Apoptosis-associated FAS and FASL Genes and Risk of Bladder Cancer in a Turkish Population
    (Int Inst Anticancer Research, 2014) Verim, Levent; Timirci-Kahraman, Ozlem; Akbulut, Habib; Akbas, Alpaslan; Ozturk, Tulin; Turan, Saime; Yaylim, Ilhan
    Background: The present study aimed to evaluate the role of functional polymorphisms of apoptosis-associated Fatty acid synthase (FAS) and fatty acid synthase ligand (FASL) genes in bladder cancer susceptibility as first presentation in a Turkish population. Patients and Methods: Genotypes of 91 patients with bladder cancer and 101 healthy controls were evaluated for the polymorphism of FAS-1377 G/A and FASL-844 T/C genes by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: The frequency of the FAS-1377 G allele was significantly higher in patients with bladder cancer compared to controls (p<0.001). A significantly increased risk for developing bladder cancer was found for the group bearing a T allele for FASL-844 compared to the homozygous FASL-844 CC genotype (p=0.027). FAS-1377 GG genotype and FASL-844 T allele were found to be independently associated with an increased risk of bladder cancer. Additionally, gene gene interaction analysis revealed that the frequency of FAS-1377AA with FASL-844TC was significantly lower in patients with bladder cancer in comparison to those of controls (p<0.001). Extensive studies for gene gene interaction are still needed. Conclusion: Our study provides new evidence that FAS-1377 G and FASL-844 T alleles may be used as low-penetrant risk factors for bladder cancer development in a Turkish population.
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    Intravesical Migration and Calcification of Intrauterin Device: A Case Report and Review of the Literature
    (Galenos Yayincilik, 2015) Verim, Levent; Akbas, Alpaslan; Erdem, Mehmet Remzi
    Intrauterine device (IUD) is widely used for the long duration of protection, cost-effectiveness and for being a reversible contraceptive method as well as having low complication rates. Despite low complication rates, various IUD-related complications, such as spontaneous aborts, bleeding, infection, and uterine perforation may occur. Although perforation of the uterus by an IUD is not uncommon, bladder perforation is a rare complication. A regular follow-up of patients with IUDs for the complications and training of clinicians for insertion and removal are mandatory to provide better and safe family planning services. Here, we report a case of a patient with uterine perforation with a calcified IUD migration into the the bladder.
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    Primer üreter karsinomu: Olgu sunumu Olgu
    (2014) Verim, Levent; Akbaş, Alpaslan
    Üst Üriner Sistem Ürotelyal Hücre Tümörleri (ÜÜSÜHT), Alt Üriner Sistem Ürotelyal Hücre Tümörleri (AÜS-ÜHT)ne göre ender görülen urlardır. Primer Üreter Tümörleri (PÜT) ise daha da ender görülen ürotelyal urlardır. AÜÜ-ÜHTleri (özellikle mesane tümörleri) dünyada 4üncü sıklıkta görülen kanserlerdir. PÜT ise çok ender olup ÜÜS-EHTlerin yaklaşık % 1i kadardır. PÜT tanısı genellikle nonfonksiyone böbrek etyopatogenezinin araştırılmasında insidental olarak konulmaktadır. Bu yazıda, primer tümörün olağandışı yerleşim yeri, büyük bir tümör olmasına rağmen invazyon yapmamış olması ve göreceli olarak genç yaşta görülmesi nedenleriyle ender ve ilginç olan bir olgu sunulmaktadır.
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    The Approaches Taken by Family Physicians in Turkey Regarding Prostate Patients and Prostate Specific Antigen
    (Derman Medical Publ, 2016) Akbas, Alpaslan; Tekin, Murat; Verim, Levent; Gulpinar, Murat Tolga; Sancak, Eyup Burak; Ertekin, Yusuf Haydar; Uludag, Aysegul
    Aim: This survey study questioned family physicians about their approaches to lower urinary tract symptoms (LUTS) and about the clinical application of total and free prostate-specific antigens (tPSA and fPSA). Material and Method: The survey link was prepared online and sent to an email group for family physicians. The survey had 14 questions, none of which identified the respondents, concerning approaches to male patients with LUTS. Some questions were multiple choice and others allowed multiple answers to be chosen. The results were graphed and interpreted. Results: A total of 350 family physicians responded online. While 250 (72%) were family physician assistants or experts, 214 (61%) worked in family health centers. Of the 300 (85%) family physicians who had seen male patients with LUTS, only 64 (20%) stated that they performed a prostate examination. While 298 (99%) of the physicians prescribed alpha blockers, 234 (78%) physicians stated they requested a tPSA, and 134 (44%) answered that they requested an fPSA. Of the 134 physicians, 104 requested an fPSA without regard to the tPSA value. Discussion: The study identified differences in the approaches of family physicians to male patients with LUTS. DRE was not performed for the majority of patients and, as a result, unnecessary requests for fPSA were made. Increased awareness of approaches to LUTS patients can be provided for family physicians at events such as in-service training and scientific congresses.