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Öğe Comparison of effects of classic LMA, cobraPLA and V-gel rabbit on QTc interval(Comenius Univ, 2015) Toman, H.; Erbas, M.; Kiraz, H. A.; Sahin, H.; Ovali, M. A.; Uzun, M.AIM: We aimed to compare the effects of three different supraglottic airway devices, the classic LMA, PLA, and V-gel, on hemodynamics and QTc in rabbits under general anesthesia. METHOD: The rabbits were divided into four groups: Group C (n = 5) control group with no airway device used, Group L (n = 5, classic LMA), Group P (n = 5, CobraPLA) and Group V (n = 5, V-gel-rabbit). Basal values of heart rate (HR), mean arterial pressure (MAP) and ECG for QTc interval were measured and the measurements were evaluated at 1, 5, 15, and 30 minutes after inserting the airway device RESULTS: The values of HR, MAP and QTc in Group V at minutes 1 and 5 were significantly different to those in Group L and Group P (p < 0.05). DISCUSSION: The classic-LMA and cobraPLA cover a wide part of the perilaryngeal area with cuffs inflated to about 60 cmH(2)O of pressure resulting in mucosal compression. As V-gel rabbit does not have a cuff, it covers a smaller part of the laryngopharyngeal area, and thus does not cause mucosal compression, and the hemodynamic response is weaker. CONCLUSION: When comparing hemodynamic responses to other supraglottic airway devices, the response to V-gel rabbit is minimal and we consider that similar studies using the I-gel on humans are required (Fig. 5, Ref. 31).Öğe Effect of early tail-docking on luteinizing hormone pulse frequency in fat-tailed Tuj ewe-lambs(Shiraz Univ, 2013) Kaya, M.; Cenesiz, M.; Onder, F.; Uzun, M.; Yildiz, S.The aim of the study was to investigate the effect of tail-docking on the LH pulse frequency in female Tuj lambs. Twelve female lambs were assigned into two equal groups. A rubber ring was applied to the base of the tail for shedding off. Blood samples were collected for 8 h in the 4th and 8th months of age to determine pulsatile secretion of LH. Starting from the age of 6 months, blood samples were taken thrice weekly for progesterone analyses. There was no LH pulse in the first LH analysis but the pulses were observed in both groups in the second LH analysis. However, number of pulses was not different between groups. The plasma progesterone level was less than 1 ng/ml throughout the breeding season. In conclusion, there was no effect of the tail-docking on pulsatility of LH in fat-tailed female lambs.Öğe Effects of reduced glutathione on nitric oxide level, total antioxidant and oxidant capacity and adenosine deaminase activity(Verduci Publisher, 2010) Atakisi, O.; Erdogan, H. M.; Atakisi, E.; Citil, M.; Kanici, A.; Merhan, O.; Uzun, M.The aim of this study was to determine the effect of exogenous GSH, an important antioxidant containing thiol group, on total antioxidant capacity (TAC) and total oxidant capacity (TOC), adenosine deaminase (ADA), a significant indicator of cellular immunity, and nitric oxide (NO) concentrations in rabbits. Sixteen healthy New Zealand rabbits were divided into 2 groups as control and GSH-treated group. Animals in control group received single intraperitoneal (ip) administration of 0.9% saline. Rabbits in GSH-treated group received reduced L-glutathione (10 mg/kg) (ip). Blood samples were taken from the marginal ear vein 0, 3, 6 and 12 hours after injection. Plasma TAC and NO levels were not statistically different between control and GSH group at 0 and 12 hours. Plasma TAC level was found to be significantly higher (p<0.05) while NO level was found to be significantly lower (p<0.05) in GSH treated group when compared to control group at 3 and 6 hours. Plasma TOC and ADA activity were not statistically different between control and GSH group during experiment. In conclusion, exogenous GSH resulted in an alteration of TAC and NO but not TOC and ADA, so exogenous GSH may be a valuable enhancer of the antioxidant system.Öğe Effects of therapeutic dose of ivermectin on plasma nitric oxide and total antioxidant capacity in rabbits(Verduci Publisher, 2009) Atakisi, E.; Atakisi, O.; Topcu, B.; Uzun, M.Background: Ivermectin, an acaricide and anthielmintic drug of the family of avermectins may produce free radicals thus resulting cytotoxic effect on the parasite. Nitric oxide (NO) acts as free radicals and as host defense mechanisms. The antioxidant capacity (TAC) can be described by the analysis of single components in the defense systems against free radicals. It was aimed to study the effects of therapeutic doses of ivermectin on the plasma adenosine deaminase (ADA) and gamma glutamyl transpeptidase activities (GGT), total antioxidant capacity (TAC), nitric oxide (NO) and total protein, albumin, globulin levels in rabbits. Material and Methods: Twenty healthy New Zealand rabbits were allocated to 2 equal groups. Group I received 0.5 mg/kg and Group II received 1 mg/kg of ivermectin via subcutaneous injection. Blood samples were collected before the experiment, at 24 and 120 hours following the treatments. Results: Ivermectin at therapeutic doses increased plasma NO level at 24 h while decreased TAC at 120 h and did not alter other parameters. Conclusion: These findings may suggest that ivermectin is a safe antiparasitic drug for mammals but to less extent, it may have an effect on the oxidant/antioxidant balance.Öğe Investigation of endocrine and immunological response in fat tissue to hyperbaric oxygen administration in rats(C M B Assoc, 2016) Sen, H.; Erbag, G.; Ovali, M. A.; Oztopuz, R. O.; Uzun, M.Though HBO treatment is becoming more common, the mechanism of action is not fully known. The positive effects of HBO administration on the inflammatory response is thought to he a possible basic mechanism. As a result, we aimed to research whether endocrine and immunological response of tat tissue changes in rats given HBO treatment model. This research was carried out on Wistar albino rats, they were treated with hyperbaric Oxygen therapy. Their fatty tissue were taken from the abdomen, gene expression of the cytokines and adipokines mTere analyzed with Real time PCR method. When the gene expression of hormones and cytokines by fat tissue was examined, the leptin, visfatin, TNF-alpha, IL-1 beta and IL-10 levels in the HBO treatment group were statistically significantly increased compared to the control group (1)=0.0313, p=0.0156, p=0.0156, p=0.0156, p=0.0313). In conclusion, in our study we identified that HBO administration affected the endochrinological functions of fat tissue.Öğe Investigation of histopathological effects after intra-arterial sugammadex injection in an experimental animal model(Comenius Univ, 2016) Kiraz, H. A.; Toman, H.; Erbas, M.; Karabulut, Yuyucu Y.; Simsek, T.; Hanci, V; Uzun, M.PURPOSE: Intra-arterial injection of medications are related to mortality and morbidity. It was aimed to investigate the histopathological effects caused by two different intra-arterial doses of sugammadex, a new selective relaxant binding agent used to reverse the effects of steroidal systemic muscle relaxants used in surgeries carried out under general anesthesia. METHODS: A total of 15 rabbits were randomly divided into 3 groups. The control group was given 1 mL saline bolus into the central artery of the ear. The other two groups (Group Sgdx2 and group Sgdx16) were given 2 and 16 mg/kg sugammadex, respectively, intra-arterially. RESULTS: In control group, histopathological evaluation was in normal limits. The cross-sections belonging to Group Sgdx2 did not have any significant pathological change compared with control group (p > 0.05). Edema and single-cell necrosis were significantly higher in Group Sgdx16 when compared to control group (p < 0.05). In comparison to Group Sgdx2, single-cell necrosis was significantly higher in Group Sgdx16 (p < 0.05). CONCLUSION: Being broadly used in anesthesia, sugammadex should be administered with care because when given by intra-arterial route it may cause tissue damage and tissue loss and the patients' arteries should be carefully checked (Tab. 2, Fig. 3, Ref. 21). Text in PDF www.elis.sk.Öğe Investigation of oral selegiline and rasagiline administration on QT interval in conscious rabbits(Verduci Publisher, 2009) Uzun, M.; Alp, R.; Uzlu, E.; Alp, S.; Citil, M.; Topcu, B.; Erdogan, H. M.Rasagiline (RSG) and selegiline (SEL) are potent selective monoamine oxidase-B inhibitors and used in the treatment of Parkinson's disease. Selegiline is metabolized in vivo to I-methamphetamine and I-amphetamine which effect cardiovascular system. Therefore, the aim of this study was to evaluate and to compare the effects of long-term use of these drugs on QT interval in conscious rabbits. The study involved 17 New Zealand rabbits of both sexes, aged between 7 and 14 months. Control group (CG, n=6) was orally given isotonic saline solution at dose of 0.5 cc/per rabbit. The SEL group (SG, n=6) received 5 mg/per rabbit SEL orally twice daily (09:00 am and 09:00 pm) for 14 days. The RSG group (RG, n=5) was orally given of RSG at 1 mg/per rabbit daily for 14 days. Electrocardiographic records were taken before the experiment (baseline) and at 1st, 7th, and 14th days of experiment by direct writing electrocardiograph for two groups. Heart rate (HR), QT and QTc values were determined from ECG records. HR did not significantly differ in both treatment groups through the experimental period when compared to baseline values. The significant prolongation of QT and QTc values were observed at 7th, and 14th day (p < 0.01) in SG and 1st day of experiment in RG (p < 0.05) as compared to baseline values. In conclusion, the results obtained suggest a statistically significant effect of SEL on QTc prolongation when compared to RAS. QTc prolongations should be taken into account in Parkinson's disease where autonomic system is involved.Öğe Protective role of melatonin against caspase depended apoptosis in thoracic aorta tissue of pinealectomised rat(Wiley, 2017) Doganlar, Z. B.; Doganlar, O.; Uzun, M.; Ovali, M. A.; Ongoren, G.[Anstract Not Available]Öğe The effects of melatonin administration on KCNQ and KCNH2 gene expressions and QTc interval in pinealectomised rats(C M B Assoc, 2017) Ovali, M. A.; Uzun, M.Melatonin is a hormone secreted from the pineal gland and has different cardiovascular effects. KCNQ genes expressed in aorta related with vascu-lar tone and KCNH2 gene characterised in left ventricle associated with QT duration. The aim of this study was to investigate the effects of melatonin on the regulation of the blood pressure and the relationships between the expressions of aorta KCNQ1-5, left ventricle KCNH2 genes and the QTc interval. For that purpose, 42 male adult Sprague-Dawley rats were devided into six groups; SHAM, SHAM+L-NAME, PLT, PLT+L-NAME, PLT+MEL and PLT+L-NAME+MEL. Pinealectomy operation was applied in PLT groups. L-NAME was added in drinking water (40 mg/kg/day) and melatonin was given subcutanously (5 mg/kg/day). The blood pressure, heart rate (HR) and QTc interval values were recorded on 0, 1st, 7th, 14th and 21st days of experiment. Left ventricle and thoracic aorta samples were obtained to investigate the changes of gene expression levels of KCNQ1-5 and KCNH2, respectively. The increased blood pressure and HR were observed in SHAM+L-NAME, PLT, and PLT+L-NAME groups compared to MEL and SHAM groups (p<0.05). On the other hand, the long QTc interval was recorded in PLT and all L-NAME groups compared to others (p<0.05). The decreases in KCNH2 gene expression levels were observed in groups have QTc prolongation. In conclusion, PLT operation could cause an increasing in blood pressure, HR and QTc duration, melatonin was able to prevent these increasings and could change KCNQ and KCNH2 gene expresion profiles. Further molecular studies are required to evaluate these effects.
