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    Effects of acute twelve minute run test on oxidative stress and antioxidant enzyme activities
    (Academic Journals, 2011) Saritas, Nazmi; Uyanik, Fatma; Hamurcu, Zuhal; Coksevim, Bekir
    The aim of this study was to investigate the effects of 12 min run test on oxidative stress, some antioxidant enzyme activities, and muscle and DNA damage. Twenty two healthy and well trained male athletes were recruited to this study. The 12 min run test, cooper test, was applied to the participating athletes. The blood samples were taken before, immediately after and 24 h after the run test, and sera and plasma were separated and then stored at -80 degrees C until the analysis. Serum MDA and NO levels as the indicators of oxidative damage; serum SOD and CAT, plasma GPx activities as the indicators of antioxidant defense system; serum 8-OHdG as the indicator of DNA damage, CK and LHD enzyme activities as the indicators of muscle damage, and glucose level were measured. Serum SOD, NO, CAT, and 8-OHdG levels showed no significant changes before, immediately after and 24 h after the run rest. There was a significant decrease in serum MDA level immediately after exercise, which is returned to baseline level after 24 h-rest period (p<0.05). Serum LHD (p<0.001) and CK activities (p<0.05) and glucose level (p<0.001) increased immediately after exercise but these increments returned to pre-exercise level after 24 h-rest period. Acute twelve minute endurance exercise increased CK, LDH and glucose decreased oxidative stress and whereas has no effect on antioxidant capacity and DNA damage in trained young men.
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    Impact of Omega-3 and Omega-9 fatty acids enriched total parenteral nutrition on blood chemistry and inflammatory markers in septic patients
    (Professional Medical Publications, 2014) Gultekin, Gamze; Sahin, Habibe; Inanc, Neriman; Uyanik, Fatma; Ok, Engin
    Objective: Lipid emulsions containing omega-3 are known to have positive effects on patient's prognosis due to anti-inflammatory properties. The aim of this study was to investigate the effects of omega-3 enriched total parenteral nutrition (TPN) emulsion containing omega-9 on biochemical parameters, inflammatory mediators in septic patients. Methods: Thirty-two participants who were not fed orally for over five days and needing TPN support were included in this prospective, randomized and double-blind clinical study. Patients were randomly divided into control (n=16), treatment (n=16) groups. The treatment group received TPN containing 80% olive oit+20% soy oil additionally 10 g fish oil enriched TPN. Control group received only olive oil containing standard lipid emulsion (1.3 +/- 0.1 g/kg/day).. Blood samples were collected for biochemical analysis on the 1st and 6th days of study. Results: The serum albumin levels significantly increased (p < 0.05) in both groups whereas total protein and prealbumin levels did not show any significant changes. In treatment group, significant decreases were determined in LTB4 and CRP levels (p < 0.05) while decreases in IL-6, TNF-alpha and leukocyte levels were not significant. No statistically significant changes were found in LTB4, CRP, IL-6, TNF-alpha and leukocyte levels of controls. Conclusion: Results of the study have shown that omega-3 enriched TPN solution containing omega-9 contributes to decrease in the levels of inflammatory mediators and to improvement in the biochemical parameters in septic patients.
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    The Rapid Analyses of Cardiac Troponins in Dogs with Dilated Cardiomyopathy, Distemper or Parvoviral Infection
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2014) Gunes, Vehbi; Uyanik, Fatma; Eren, Meryem; Kibar, Murat; Aslan, Oznur; Onmaz, Ali C.
    In this study, concentrations of cardiac troponins (cTnI and cTnT) and using a cassette kit which is a qualitative assay were used to investigate the diagnosis of myocardial damages due to different diseases in dogs. Study groups were composed of dogs with distemper infection (DI) (Group I, n=8), parvoviral infection (PVI) (Group II, n=18) and dilated cardiomyopathy (DCM) (Group III, n=18). Healthy dogs were included for each group as control. Levels of troponins (cTnI, cTnT) were determined by commercially available ELISA kits and cassette kits were used for qualitative assays. The mean concentrations of cTnI in Groups I, II and III were 2.26 +/- 0.41 ng/ml, 2.41 +/- 0.98 ng/ml and 5.076 +/- 1.32 ng/ml, respectively. Positive cTnI and cTnT expressions were determined in groups as 5/8 (62.5%) and 4/8 (50%) in group I; 5/18 (27.7%) and 5/18 (27.7%) in group II and 13/18 (72.2%) and 6/18 (33.3%) in group III, respectively. In healthy control dogs, cTnI and cTnT were determined to be negative. The cTnI concentrations were more reliable cardiac marker in dogs with cardiomyopathy. Moreover, cTnI and cTnT casette kits used in this study may be valuable diagnostic tools to diagnose the myocardial damage in dogs with DI, PVI and DCM for the small animal practioners.