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    HEPCIDIN AND VITAMIN D LEVELS: MUTUAL EFFECTS IN ANEMIA OF CHRONIC KIDNEY DISEASE
    (2021) Ustuner, Berna; Bek, Sibel Gökçay; Eren, Necmi; Bakirdogen, Serkan; Kalender, Betül Gönüllü
    Objective: Hepcidin is a peptide with anti-microbial properties that is largely synthesized in the liver and has important roles in iron homeostasis,with serum levels elevated in chronic inflammatory conditions, including chronic kidney disease (CKD). Our aim was to discuss on the role ofvitamin D in regulation of hepcidin and anemia of CKD.Methods: The study group included 103 patients with CKD and 59 healthy individuals. The serum concentration of hepcidin was measured usingELISA, and the association to the following factors was evaluated: age, sex, body mass index, renal functions (estimated glomerular filtration rate,eGFR), drug history, serum biochemistry, complete blood count, iron and total iron binding capacity, ferritin, vitamin D, high sensitive C-reactiveprotein, C-reactive protein, and the erythrocyte sedimentation rate.Results: The mean age of the CKD group was 58.63 ± 11.8 years (with 16, 26, 27, 19, and 15 patients; respectively in each chronic kidney diseasestage, from I through V and nine on haemodialysis, six on peritoneal dialysis). The mean hepcidin concentration was higher in the chronic kidneydisease (30.3±24.7 ng/ml) than control (17.8 ± 8.4ng/ml) group (p<0.05). There was a positive association between hepcidin and CRP, ESR and thefollowing serum factors (urea, creatinine, ferritin, phosphate, pH, parathyroid hormone and alkaline phosphatase), with a negative association witheGFR, haemoglobin, haematocrit, calcium, magnesium, 25-OH vitamin D and bicarbonate levels.Conclusion: Hepcidin levels were found negatively correlated with 25-OH vitamin D levels which was related with the inflammatory effects ofvitamin D and hepcidin.