Yazar "Uludağ, Ahmet" seçeneğine göre listele
Listeleniyor 1 - 20 / 67
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe 9qh+'liği Molar Gebelik İçin Bir Risk Faktörü mü?(2016) Güngör, Ayşe Nur Çakır; Sılan, Fatma; Kılınç, Nihal; Gencer, Meryem; Uludağ, Ahmet; Coşar, Emine; Koç, EvrimPolimorfizm olarak kabul edilen 9qh+'liğinin daha önce bazı sorunlara neden olduğunu gösteren çalışmalar olmakla birlikte molar gebelikte daha önce tanımlanmamıştır. Vakalarımız literatürdeki ilk iki 9qh+'liği ile birlikte tanımlanan molar gebelik vakası olması yönüyle önemlidirÖğe A new record for the flora of Turkey: Eichhornia crassipes (Mart.) Solms (Pontederiaceae)(2014) Üremiş, I.; Uludağ, Ahmet; Arslan, Z.F.; Abacı, O.Eichhornia crassipes (Mart.) Solms (Pontederiaceae) is reported for the first time for the flora of Turkey. This invasive alien plant was observed in the Asi River (also called the Orontes River), which runs from Lebanon, through Syria to Turkey. The observation was made in the river near the border with Syria. This site is the in the district of Altinözü in the province of Hatay in the East Mediterranean region. Turkey is divided into grids for floral purposes by the book 'Flora of Turkey' and the plants described were collected in grid sector C6. The authors concluded that E. crassipes (water hyacinth) can establish and spread in Turkey. © 2014 OEPP/EPPO.Öğe Alien flora of Turkey: checklist, taxonomic composition and ecological attributes(Pensoft Publishers, 2017) Uludağ, Ahmet; Aksoy, Necmi; Yazlik, Ayse; Arslan, Zubeyde Filiz; Yazmis, Efecan; Uremis, Ilhan; Cossu, Tiziana AntonellaThe paper provides an updated checklist of the alien flora of Turkey with information on its structure. The alien flora of Turkey comprises 340 taxa, among which there are 321 angiosperms, 17 gymnosperms and two ferns. Of the total number of taxa, 228 (68%) are naturalized and 112 (32%) are casual. There are 275 neophytes (172 naturalized and 103 casual) and 61 archaeophytes (52 naturalized and 9 casual); four species could not be classified with respect to the residence time. In addition, 47 frequently planted taxa with a potential to escape are also listed. The richest families are Asteraceae (38 taxa), Poaceae (30), Fabaceae (23) and Solanaceae (22). As for the naturalized alien plants, the highest species richness is found in Asteraceae (31 taxa), Poaceae (22), Amaranthaceae (18) and Solanaceae (15). The majority of alien taxa are perennial (63.8% of the total number of taxa with this life history assigned, including those with multiple life histories), annuals contribute 33.8% and 2.4% are biennial aliens. Among perennials the most common life forms are phanerophytes, of which 20.3% are trees and 12.6% shrubs; woody vines, stem succulents, and aquatic plants are comparatively less represented. Most of the 340 alien taxa introduced to Turkey have their native ranges in Americas (44.7%) and Asia (27.6%). Of other regions, 9.1% originated in Africa, 4.4% in Eurasia, 3.8% in Australia and Oceania and 3.5% in the Mediterranean. The majority of taxa (71.9%) were introduced intentionally, whereas the remaining (28.1%) were introduced accidentally. Among the taxa introduced intentionally, the vast majority are ornamental plants (55.2%), 10.0% taxa were introduced for forestry and 6.7% as crops. Casual alien plants are most commonly found in urban and ruderal habitats (40.1%) where naturalized taxa are also often recorded (27.3%). Plants that occur as agricultural weeds are typically naturalized rather than casual (16.0% vs 7.1%, respectively). However, (semi) natural habitats in Turkey are often invaded by alien taxa, especially by those that are able to naturalize.Öğe An infertile case of 47,XYY syndrome without autistic spectrum: Cost effective well-define of extra Y chromosome by GTG, C bandings, QF-PCR and FISH analyses(2016) Özdemir, Öztürk; Paksoy, Barış; Gürgen, Atilla; Oruç, Mine; Yıldız, Onur; Uysal, Diğdem; Uludağ, AhmetOtistik spektrum bozukluklarının, otozomal ve seks kromozom bozukluklukları ile birlikteliği birçok kez rapor edilmekle birlikte sınırlı sayıda literatür bilgisi Y kromozomunu işaret etmektedir. Biz bu sunumda sitogenetik ve moleküler genetik tekniklerinin birlikte kullanımı ile otistik bulguları olmayan bir super-erkek olgunun doğru ve etkin tanı almasının önemini raporlamayı amaçladık. Bu olguda, lenfosit hücre kültürü ile elde edilen metafaz örnekleri GTG, C bantlama, QF-PCR ve FISH yöntemleri ile otomatik karyotiplemeleri yapıldı. Dil ve sosyal işlev bozuklukları gibi otistik spektrum bulguları olmayan olgumuzun sitogenetik ve moleküler genetik analizler sonrasında ekstra Y kromozomu taşıdığı ve 47,XYY(super-erkek) karyotipinde olduğu anlaşılmıştır. Olgunun, yapılan ayrıntılı karyotip analizinde başka bir sayısal ve/veya yapısal kromozom anomalisine rastlanmamıştır. Olgunun sahip olduğu ekstra Y kromozomu, GTG, C bantlama, FISH ve QF-PCR teknikleri birlikte kullanılarak hastanın etkin ve doğru tanı alması sağlanmıştır. Olguda saptanan her iki Y kromozomun benzer boyut ve C bant paterninde olması, ekstra Y kromozomun yine babadan gelen normal Y kromozomun zigot sonrası endoredublikasyonundan kaynaklanabileceği tartışılmıştır.Öğe Analysis of methylation patterns of some tumor suppressor genes in non-small cell lung cancer using the multiplex ligation-dependent probe amplification [MLPA] method(Çanakkale Onsekiz Mart Üniversitesi, 2013-05) Uludağ, Ahmet; Artan, Sevilhan; Tepeli, Emre; Büyükpınarbaşılı, Nur; Müslümanoğlu, M. Hamza; Özdemir, Muhsin; Öznur, Murat; Aslan, Hüseyin; Çilingir, Oğuz[No Abstract Available]Öğe Annual Change of Marine Litter in a Rocky Area on the Coast of the Çanakkale Strait(Çanakkale Onsekiz Mart Üniversitesi, 2022) Yenici, Elif; Aslan, Herdem; Tekeli, Zeynep; Uludağ, AhmetÇanakkale Boğazı işlek bir su yolu olmasının yanında bölge insanı ve turuistlerin ziyaret ettiği önemli bir rekreasyon alanıdır. Bu çalışma, 2021 ve 2022 yıllarında Çanakkale Boğazı’nın Çanakkale şehir merkezindeki denizden doldurularak kazanılmış kayalık bir kesiminde, çöp birikiminin boyutu, çöplerin tipleri, malzeme olarak çöpün türü ve kullanım amaçlarını belirlemek için yürütülmüştür. 2021 yılında 3528 adet, 2022 yılında ise 1777 adet çöp toplanmıştır. Çöp yoğunluğu, Türkiye kıyılarında gerçekleştirilen önceki çalışmaların çoğundan çok daha yüksek bulunmuştur. En yaygın deniz çöpünü 2021'de %80,24 ve 2022'de %59,65 ile plastikler oluşturmuştur. En fazla karışık ambalaj malzemelerinin toplanması, gıda ve içecek sektöründe plastik malzemelerin çok yaygın kullanıldığını göstermiştir. Uygun çöp imha yöntemleri, biyolojik olarak parçalanabilen ambalaj malzemelerinin kullanımı, sahil temizliği ve atık yönetimi konusunda halkın bilinçlendirilmesi, özellikle kıyı bölgelerinde başarılı çöp yönetimi için kritik öneme sahiptir.Öğe Assessment of nonchemical weed management of windmill palm (Trachycarpus fortunei) nursery(Cambridge Univ Press, 2025) İnci, Deniz; Uludağ, Ahmet; Al-Khatib, KassimThe windmill palm is a distinctive outdoor ornamental palm adapted to cooler climates. Weeds pose significant challenges in palm nurseries, particularly during seedling and establishment stages. This research was conducted in a nursery with 5,500 windmill palm seedlings, starting in April 2014, when the palm trees were 3 yr old. Experiments were terminated in October 2018 when weed control was no longer necessary due to the advanced growth of the palm trees. The objectives of this study were to determine the weed composition and diversity, elucidate the effects of mechanical weed management (MWM) on growth rate of palm, and develop a sustainable program to maximize palm tree growth through effective weed management and soil tillage. Few herbicides are registered for nursery use in Türkiye; thus, weed control was performed mechanically using garden hoeing machines between rows and hand hoeing for intrarow strips. The most common and dense weeds were purple nutsedge, annual mercury, and common purslane in summer and autumn, and burning nettle in winter and spring. In 2014, weed densities were 100, 127, and 145 weeds m-2 for MWM, hand-weeding (HW), and nontreated (NT) plots, respectively. Transplanted palm seedlings required at least two, ideally three growing seasons of intensive weed control until the palm tree crowns block sunlight and suppress weed growth. The research indicated that palm trees in the MWM treatment had approximately 84 leaves and a height of 210 cm by October 2018, compared with 54 leaves and a height of 136 cm for HW, and 40 leaves and 100 cm height for NT. These results highlight the critical role of MWM in promoting optimal growth of Chinese windmill palms. Effective and sustainable weed management, combining MWM and HW, is essential for producing high-quality palm trees. The research provides valuable insights for nursery managers and contributes to best practices for cultivating windmill palm trees in similar climatic regions.Öğe Association between ABCB1 (MDR1) Gene 3435 C>T Polymorphism and Colchicine Unresponsiveness of FMF Patients(Taylor & Francis Ltd, 2011) Ozen, Filiz; Sılan, Coşkun; Uludağ, Ahmet; Candan, Ferhan; Sılan, Fatma; Ozdemir, Semra; Atik, SinemThe multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and drugs. The TT genotype of 3435 codon in exon 26 of MDR1 gene causes overexpression of gene activity and effluxes many chemically diverse compounds across the plasma membrane. We studied the association between C3435T polymorphisms (single nucleotide polymorphism) of MDR1 gene and colchicine-resistant familial Mediterranean fever (FMF) patients. Total genomic DNA samples from 52 FMF patients of colchicine unresponsiveness were used for FMF (MEFV) and MDR1 genes profile analyses. Target genes were genotyped by multiplex PCR-based reverse-hybridization Strip Assay method. The preliminary current results showed increased T allele frequency (0.596) in colchicine unresponsiveness of FMF patients. The distributions of the CC, CT, and TT genotypes in colchicine nonresponder FMF patients were 17%, 46%, and 37%, respectively. Our results indicate that C3435T polymorphism in exon 26 of MDR1 gene is associated with colchicine resistance in nonresponder FMF patients during the common therapy protocol.Öğe Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension(K Faisal Spec Hosp Res Centre, 2014) Ogretmen, Zerrin; Hiz, Meliha Merve; Sılan, Fatma; Uludağ, Ahmet; Özdemir, ÖztürkBACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of endothelial nitric oxide synthase (eNOS Glu298Asp) gene polymorphism in hypertensive and/or non-hypertensive psoriatic patients (2) to investigate the possible relationship between the eNOS Glu298Asp polymorphism and the risk of hypertension among psoriatic patients in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in Canakkale, Turkey PATIENTS AND METHODS: Gene profiles of 75 psoriatic patients (21 hypertensive and 54 normotensive patients) and 55 healthy (normotensive and non-psoriatic) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for patients and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0, Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS Glu298Asp single-nucleotide polymorphism (SNP) was determined in psoriatic patients when compared with normotensive non-psoriatic healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in hypertensive psoriatic patients when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive psoriatic patients (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS Glu298Asp polymorphism and hypertension among psoriatic patients in the Turkish population. The T allele frequency of eNOS Glu298Asp SNP was different in hypertensive psoriatic patients, and the difference was statistically significant when compared with the normotensive psoriatic patients and healthy controls. These results need to be confirmed by large-scale studies.Öğe Attitude of Term II and III Students in Canakkale Onsekiz Mart University School of Medicine Towards Problem Based Learning(Yusuf Haydar ERTEKİN, 2016) Uludağ, Ayşegül; Uludağ, Ahmet; Saçar, Mustafa; Ertekin, Yusuf; Tekin, MuratIntroduction: Problem based learning (PBL) presents complicated real life problems and provides students to use analysing and synthesis abilities while reaching a solution. Students decide on solution pathways and produce concept maps on their own. Problem based learning represents experience-based learning which requires active participation for characterization and solution of the problem. In this study we aimed to evaluate the attitude of medical students to PBL sessions.Methods: In this descriptive designed study, attitude scale towards PBL applied to the Canakkale Onsekiz Mart University School of Medicine term II and III students just after PBL sessions. Results: One hundred twenty five students agreed to participate the study. Reliability co-efficient (co-efficient alfa) of PBL attitude scale (test with 38 clauses) was 0.777. Group work sub-group mean score of term III students was significantly higher than term II students (p=0.050). Lesson subject sub-group mean score was significantly higher in term II students (p=0.036). There were no significant difference between other sup-groups (p>0.05). Conclusion: Students were found to be positive attitude to PBL sessions. Term III students adopted more than term II students. Experiencing more PBL sessions can be important for adopting group work. It would be a mistake to talk about positive attitude towards PBL because of the limited number of PBL sessions in this school of medicineÖğe Avrupa Birliği İstilâcı Yabancı Türler Yasası(Türkiye Herboloji Derneği, 2015) Uludağ, Ahmetİstilâcı yabancı türler (İYT) biyolojik çeşitliliği tehdit eden beş ana unsurdan biri olarak kabul edilmektedir. Son yıllarda konuya farkındalığın artması, İYTler üzerindeki araştırma ve uygulamaların artmasına sebep olmuştur. Birçok ülkede de tedbirlerin alınması amacıyla kanunî düzenlemeler yapılmıştır. Avrupa Birliği (AB) de bir kanunî düzenleme yapmış ve 2015 yılı Ocak ayında yürürlüğe girmiştir. Başlangıçta, 2008 yılında nasıl bir mevzuatla sonuçlanacağı belirtilmeden bir AB komisyonu tebliği ile başlayan çalışmalar kanunun kabulüyle (regulation) sonuçlanmıştır: “İstilâcı yabancı türlerin girişi ve yayılışını önleme ve idare etme yasası”, orijinal ismiyle “Regulation (EU) No 1143/2014 of the European Parliament and of the Council of 22 October 2014 on the prevention and management of the introduction and spread of invasive alien species”. Üye ülkelerin tamamının uyması ve uygulaması mecburî bir mevzuat şekli olan “regulation” konunun sınırlarını çok ayrıntılı olarak açıklamıştır. Çünkü İYT konusu bitki sağlığı, hayvan sağlığı, deniz gibi konulardaki mevzuatla bazen iç içe geçebilmektedir. Kanun aksiyoner bir stratejiyi hedef almaktadır. Kanun ABnin esas alacağı İYTlerini uzmanlarla birlikte belirlemeyi, üye ülkelerin bir denetleme ve gözlem sistemi oluşturmasını mecbur etmektedir. Ayrıca üye ülkelerin kendileri için ayrıca İYT listeleri belirleyebileceğini ve ülkelerin özel durumlarının da olabileceğini ihtiva etmektedir. Türkiye’nin AB ile ticaret hacmi göz önüne alındığında, bir şekilde bizi de etkileyeceği göz ardı edilmemelidir. Bunun da ötesinde Türkiye’nin biyolojik çeşitliliği ve konumu böyle bir kanuna ihtiyacımızı da açıkça göstermektedir [EN] İstilâcı yabancı türler (İYT) biyolojik çeşitliliği tehdit eden beş ana unsurdan biri olarak kabul edilmektedir. Son yıllarda konuya farkındalığın artması, İYTler üzerindeki araştırma ve uygulamaların artmasına sebep olmuştur. Birçok ülkede de tedbirlerin alınması amacıyla kanunî düzenlemeler yapılmıştır. Avrupa Birliği (AB) de bir kanunî düzenleme yapmış ve 2015 yılı Ocak ayında yürürlüğe girmiştir. Başlangıçta, 2008 yılında nasıl bir mevzuatla sonuçlanacağı belirtilmeden bir AB komisyonu tebliği ile başlayan çalışmalar kanunun kabulüyle (regulation) sonuçlanmıştır: “İstilâcı yabancı türlerin girişi ve yayılışını önleme ve idare etme yasası”, orijinal ismiyle “Regulation (EU) No 1143/2014 of the European Parliament and of the Council of 22 October 2014 on the prevention and management of the introduction and spread of invasive alien species”. Üye ülkelerin tamamının uyması ve uygulaması mecburî bir mevzuat şekli olan “regulation” konunun sınırlarını çok ayrıntılı olarak açıklamıştır. Çünkü İYT konusu bitki sağlığı, hayvan sağlığı, deniz gibi konulardaki mevzuatla bazen iç içe geçebilmektedir. Kanun aksiyoner bir stratejiyi hedef almaktadır. Kanun ABnin esas alacağı İYTlerini uzmanlarla birlikte belirlemeyi, üye ülkelerin bir denetleme ve gözlem sistemi oluşturmasını mecbur etmektedir. Ayrıca üye ülkelerin kendileri için ayrıca İYT listeleri belirleyebileceğini ve ülkelerin özel durumlarının da olabileceğini ihtiva etmektedir. Türkiye’nin AB ile ticaret hacmi göz önüne alındığında, bir şekilde bizi de etkileyeceği göz ardı edilmemelidir. Bunun da ötesinde Türkiye’nin biyolojik çeşitliliği ve konumu böyle bir kanuna ihtiyacımızı da açıkça göstermektedirÖğe Biological weed control(Elsevier, 2018) Uludağ, Ahmet; Uremis, Ilhan; Arslan, MehmetThe biological approach, as an integral part of integrated and sustainable weed control approaches, has an increasing importance and consideration due to increasing environmental and anthropogenic problems. Successful weed control through use of biological agents has a background of more than a couple of centuries. In this chapter, we started with a more classical way of biological approach to introduce arthropods, mainly insects, followed by examples of redistribution of local arthropods. In the bioherbicide section, we have focused on formulated natural products and formulations. Biological weed control faces problems such as inadequacy of finance, some side effects, and conflicting views. However, biological methods are expected to provide more promising weed control practices in the future. © 2018 Elsevier Inc. All rights reserved.Öğe C-reactive protein gene and Toll-like receptor 4 gene polymorphisms can relate to the development of psoriatic arthritis(Springer London Ltd, 2015) Akbal, Ayla; Oguz, Sevilay; Gokmen, Ferhat; Bilim, Serhat; Resorlu, Hatice; Sılan, Fatma; Uludağ, AhmetWe aimed to determine in psoriatic arthritis (PsA) patients the Toll-like receptor (TLR) 4 and C-reactive gene (CRP) polymorphisms and allele frequency and to investigate the relationship between clinical parameters and gene polymorphisms. We enrolled in this study 31 PsA and 41 healthy control subjects. PsA diagnosis was according to CASPAR criteria. Bath ankylosing spondylitis diseases activity index, Maastricht ankylosing spondylitis enthesitis score, and Bath ankylosing spondylitis functional index were measured. C, A, and T alleles of CRP and A and G alleles of TLR 4 were determined using the analysis of melting curves after real-time PCR. CRP A, C, and T allele frequency in controls was 26.8, 73.2, and 36.6 %, respectively. In the PsA patient group, A, C, and T allele frequency was 9.7, 87.1, and 12.9 %, respectively. Between control and PsA groups, there was a significant difference in A, C, and T allele frequency (P = 0.008, 0.038, and 0.001, respectively). The frequency of CRP gene polymorphisms (CA, AA, CT, TA, and TT alleles) in the control group was 56.1 % and in the PsA group was 22.6 %. There was a significant difference between the two groups (P = 0.004). The absence of a CRP gene polymorphism was a risk factor for PsA (odds ratio 4.3, 95 % CI; 1.5-12.4, P = 0.005). TLR gene haploid frequency was investigated, and all control subjects had the wild-type AA allele. PsA patient GA allele frequency was 6.5 %. There was no significant difference between the two groups (P = 0.182). GA mutant allele frequency was related to PsA (odds ratio 7.03, 95 % CI; 0.32-151.9, P = 0.214). We have shown that CRP gene polymorphisms are higher in control subjects than PsA patients, and TLR 4 gene polymorphisms were found to be related to PsA.Öğe Changes in the weed flora of cotton fields in the Eastern Mediterranean region of Turkiye(2023) Serim, Ahmet Tansel; Özkıl, Mine; Üremiş, İlhan; Uludağ, AhmetCotton is the most dominant field crop, especially in higher soil saline parts of the Eastern Mediterranean region of Türkiye. This study aims to determine the current statues of weed flora of cotton fields in the East Mediterranean region, to compare it with weed flora in 1991-1992 and to understand whether a weed flora shift has occurred in these fields. Eighty-two cotton fields were surveyed during the growing season (July and August) in 2018, and thirty-seven weed species distributed in 17 families were found in the survey fields, where 18, 23, 17, and 33 of them were recorded in the Kahramanmaraş, Hatay, Mersin, and Adana provinces, respectively. Canonical correspondence analysis revealed that the phytosociological composition of the cotton fields was significantly related to the P content of the soil, average temperature, and cumulative rainfall. The current weed survey also indicated that these fields were under the threat of some invasive alien plant species that had not been found in previous surveys, such as Ipomoea triloba L., Amaranthus palmeri L., and Cucumis melo var. agrestis Naudin. Although cotton fields in the region were reduced by two-thirds in 2018 compared to 1991-1992, weed richness increased. Weed flora shifts were influenced by crop, crop rotation, herbicide use, irrigation, and landscape factors of cotton fields in the East Mediterranean Region of Türkiye.Öğe Classifying Weed Development Stages Using Deep Learning Methods: Classifying Weed Development Stages with DenseNET, Xception, SqueezeNET, GoogleNET, EfficientNET CNN Models Using ROI Images(Science and Information Organization, 2025) Çiçek, Yasin; Gülbandılar, Eyyüp; Çıray, Kadir; Uludağ, AhmetThe control of harmful weeds holds a significant place in the cultivation of agricultural products. A crucial criterion in this control process is identifying the development stages of the weeds. The technique to be used is determined based on the weed's growth stage. This study addresses the application of deep learning methods in classifying growth stages using images of various weed species to predict their development periods. Four different weed species, obtained from seeds collected in Turkey-Afyonkarahisar-Sinanpaşa Plain, were used in the study. The images were captured with a Nikon D7000 camera equipped with three different lenses, and the ROI extraction was performed using Lifex software. Using these ROI images, deep learning models such as DenseNet, EfficientNet, GoogleNet, Xception, and SqueezeNet were evaluated. Performance metrics including accuracy, F1 score, precision, and recall were employed. In the 4-class dataset with ROI annotations, DenseNet and Xception achieved an accuracy of 86.57%, while EfficientNet demonstrated the highest performance with an accuracy of 89.55%. Following the initial tests, it was concluded that classes 3 and 4 exhibited extreme similarity caused most of the prediction errors. Merging the said classes significantly increased the accuracy and F1 scores across all models. In image classification tests, SqueezeNet and GoogleNet demonstrated the shortest processing times. However, while EfficientNet lagged slightly behind these models in terms of speed, it exhibited superior accuracy. In conclusion, although the use of ROI improved classification performance, class merging strategies resulted in a more significant performance enhancement.Öğe Combined Effect of Factor V Leiden, MTHFR, and Angiotensin-Converting Enzyme (Insertion/Deletion) Gene Mutations in Hypertensive Adult Individuals: A Population-Based Study from Sivas and Canakkale, Turkey(Mary Ann Liebert, Inc, 2011) Demirel, Yeltekin; Dogan, Sezai; Uludağ, Ahmet; Sılan, Coşkun; Atik, Sinem; Sılan, Fatma; Özdemir, ÖztürkBackground: Hypertension is one of the leading causes of mortality and morbidity in the world, which is influenced by environmental and genetic factors. The methylenetetrahydrofolate reductase (MTHFR) and angiotensin-converting enzymes (ACE) are possible candidate genes that may influence both body fatness and blood pressure (BP). The purpose of this study was to examine the carriage of gene combinations of the ACE (insertion/deletion [I/D]), MTHFR 677T and 1298C, and lipid profiles in patients with essential hypertension (EH) in Turkey. Methods: A total of 150 adult individuals (50 hypertensive, 50 first-degree relatives, and 50 healthy controls) from Sivas/Turkey with the same age and gender were assessed for body composition, lipid profiles, resting BP, and gene profiles. Additionally, 149 individuals (99 hypertensive, 50 controls) from Canakkale/Turkey had been investigated for ACE I/D polymorphism. Peripheral blood samples were genotyped using strip assay reverse-hybridization multiplex polymerase chain reaction tests for target genes. Results: Heterozygous mutation in FV Leiden was found to be higher in the hypertensive and first-degree relatives when compared with the control group (p < 0.05). Homozygous DD alleles of the ACE gene were also higher than the ACE I/D and control groups (p < 0.05). The high rates of cholesterol and low-density lipoprotein and low rates of high-density lipoprotein were found in patients with EH when compared with the control. Conclusion: Results show that ACE with DD alleles and mutated alleles of FV Leiden and MTHFR genes were significantly different between genotypes and have a combined effect on EH in Turkish population. Further studies are needed to investigate the genetics of obesity, EH, and BP phenotypes in the current adult population.Öğe Combined point mutations in codon 12 and 13 of KRAS oncogene in prostate carcinomas(Springer, 2012) Sılan, Fatma; Gultekin, Yener; Atik, Sinem; Kilinc, Davran; Alan, Cabir; Yildiz, Fazilet; Uludağ, AhmetProstate cancer is a common malignancy that develops by structural mutation(s) and/or other genetic alterations in specific genes.The G to T transversions in codon 12 and C to T transitions in codon 13 of KRAS proto-oncogene are predominant point mutations that occur in about 20% of different cancers in human. In the current study it was aimed to investigate the prevalence and predictive significance of KRAS mutations in patients with prostate carcinomas. In a total of 30 fresh tumoural tissue specimens were investigated in patients with prostate carcinoma. All tumoural specimens were histo-pathologically diagnosed and genotyped for codon 12, 13 KRAS point mutations by reverse hybridisation and direct sequencing methods. KRAS mutations were found in 12 (40%) samples with 29 samples deriving from adenocarcinomas and 1 sample was small cell prostate carcinoma. In 1 (3.44%) sample codon 12 was found to be mutated and in 2 (6.8%) samples codon 13 and in 9 (31%) samples combined codon 12 and 13 were found to be mutated particularly in higher grade of tumoural tissues. Our study, based on representative collection of human prostate tumours, indicates that combined mutations in codons 12 and 13 KRAS are relatively infrequent and most commonly occur in prostate carcinomas.Öğe Comparing the emergence of Echinochloa crus-galli populations in different locations. Part II: similarities and threshold parameters(Wiley, 2022) Royo-Esnal, Aritz; Onofri, Andrea; Taab, Alireza; Loddo, Donato; Necajeva, Jevgenija; Uludağ, Ahmet; Synowiec, AgnieszkaThe variability in the emergence process of different populations was confirmed for two Echinochloa crus-galli populations, one from Italy (IT) and the second from Norway (NO). Seeds were sown in 12 localities over Europe and the Middle East, and the emergence patterns of IT and NO were compared with those of several local populations at each location. Seeds of each population were sown in pots buried to the ground level. The base temperature (T-b) for emergence was estimated by (1) analysing logistic models applied to the field emergence of IT and NO, and (2) a germination assay set in winter 2020 at constant temperatures (8, 11, 14, 17, 20, 26, 29 degrees C) with newly collected seeds in 2019 from the same fields where IT and NO had previously been harvested in 2015. The logistic models developed for IT and NO in each location showed that the emergence pattern of IT was similar to that of the local populations in Poland, Italy, Spain, Turkey South and Iran, while NO fitted better to those in Sweden and Latvia. No germination was obtained for IT in a germination chamber, but the estimated T-b with the logistic model was 11.2 degrees C. For NO, the estimated T-b was 8.8 degrees C in the germination chamber and 8.1 degrees C in the field. Results suggest that adaptation to local environmental conditions has led to inter-population differences in T-b and parameter estimates of thermal-time models to predict the emergence of E. crus-galli should only be used for populations with similar climatic and habitat conditions.Öğe Concurrent demyelinizing central nervous system involvement in a case of Familial Mediterranean Fever with the M694V mutation(Yuzuncu Yil Universitesi Tip Fakultesi, 2014) Ozkan, Adile; Kosar, Sule; Uludağ, Ahmet; Haznedaroglu, Mete; Karaman, Handan Isın OzısıkFamilial Mediterranean Fever (FMF) is a hereditary disease seen mainly around the Mediterranean. The most common mutations are M694V, M680I, V726A and E148. Neurological findings and magnetic resonance imaging (MRI) abnormalities resembling multiple sclerosis have been reported in a few cases. We present a case where an M694V mutation was found together with familial Mediterranean fever and multiple sclerosis-type demyelinizing disease as this combination is rarely seen. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe Cotton cultivation(John Wiley & Sons Ltd, 2016) Economou, Garifalia; Uludağ, Ahmet; Kraehmer, Hansjoerg[Anstract Not Available]
