DSpace Arşivi :: by Yazar "Ukinc, Kubilay" değerine göre listeleniyor

Yazar "Ukinc, Kubilay" seçeneğine göre listele

Listeleniyor 1 - 14 / 14

A Case of Type 2 Diabetes Complicated With Primary Pyomyositis
(Lippincott Williams & Wilkins, 2009) Ukinc, Kubilay; Bayraktar, Miyase; Uzun, Oemruem
Primary pyomyositis is a deep bacterial pyogenic infection of the skeletal muscles that can cause abscess formation. Due to the indefinite nature of the symptoms and signs of pyomyositis, the diagnosis is difficult to make. A 57-year-old male patient with a 10-year history of type 2 diabetes mellitus was seen with a complaint of right calf pain, swelling, and stiffness that was present for 2 months. Temperature was 38.2 degrees C. Hommans sign was positive and peripheral pulses were palpable. Laboratory values showed a white blood cell count of 18300/mu L, an erythrocyte sedimentation rate of 85 mm/h, and a CRY of 18.3 mg/dL. MRI showed a 26 X 8-cm abscess and an 8 X 5.5-cm focus of pyomyositis inside the gastrocnemius muscle. Parenteral amikacin+sulbactam-ampicillin was begun. Culture revealed Staphylococcus aureus.
A new technique to simplify the minimally invasive parathyroidectomy: Ultrasound-assisted guided wire localization for solitary parathyroid adenomas
(Pakistan Medical Assoc, 2016) Ozkul, Faruk; Arik, Muhammed Kasim; Eroglu, Mustafa; Faydaci, Umut; Toman, Huseyin; Tas, Sukru; Ukinc, Kubilay
Objective: To investigate the benefits of ultrasound-assisted guided wire localization in MIP for selected cases. Methods: In this prospective, nonrandomised study, we included 36 patients with solitary parathyroid adenomas diagnosed preoperatively by 99m Tc sesta MIBI scintigraphy and/or neck ultrasonography. An ultrasound-guided wire was placed in the solitary parathyroid adenoma preoperatively. MIPs were performed under local anaesthesia plus sedation. After the excision, the parathyroidectomy was confirmed with postoperative ultrasonography. Results: There were 36 patients included in our study. The mean age was 54.89 +/- 11.28 years, and 30 patients were females (83.3%). Preoperative PTH and calcium (Ca) levels were 269.5 pg/mL (83.5-5,000 pg/mL) and 12.2 mg/dL (11.1-20 mg/dL), respectively. Postoperative serum PTH and Ca levels were 42.04 +/- 26.65 pg/mL and 8.95 +/- 0.74 mg/dL, respectively. The mean operation time was 21.69 +/- 6.4 minutes and the average hospitalisation time was 18 hours (range: 10-72 hours). Conclusions: Ultrasound-assisted guided wire localization may be useful in selected MIP cases. The MIP advantages include higher success rates and being easy to learn and practise.
A novel indicator of widespread endothelial damage and ischemia in diabetic patients: ischemia-modified albumin
(Springer, 2009) Ukinc, Kubilay; Eminagaoglu, Selcuk; Ersoz, Halil Onder; Erem, Cihangir; Karahan, Caner; Hacihasanoglu, Arif Bayram; Kocak, Mustafa
Ischemia-modified albumin (IMA) is a novel marker of tissue ischemia. Nowadays, IMA is accepted as a marker of oxidative stress. In this study, we aimed at establishing an association between IMA and hyperglycemia, blood pressure, lipid parameters, microvascular complications, hsCRP, and microalbuminuria in type 2 diabetes patients without overt macrovascular disease and acute ischemia. Fifty type 2 diabetes mellitus patients without a history of macrovascular disease or end-stage renal disease were enrolled into the study. Age-matched 30 healthy individuals were also included in the study as a control group. Plasma IMA (0.329 +/- A 0.046 and 0.265 +/- A 0.045 AbsU; P < 0.0001) and hsCRP levels (0.51 +/- A 0.36 and 0.32 +/- A 0.17 mg/dl; P < 0.0001) were significantly higher in the diabetic group compared to healthy controls. IMA level was significantly correlated with hsCRP (r = 0.76; P < 0.0001), HbA1c (r = 0.72; P < 0.0001), microalbuminuria (r = 0.40; P = 0.004), systolic blood pressure (r = 0.28; P = 0.049), diastolic blood pressure (r = 0.44; P = 0.005), and HOMA-IR (r = 0.42; P = 0.005) levels in the entire diabetic subjects. In the diabetic patients group, presence of microalbuminuria was associated with a higher plasma IMA level (0.355 +/- A 0.035 and 0.265 +/- A 0.0045 AbsU; P < 0.0001, patients with microalbuminuria and control subjects, respectively). In the type 2 diabetes patients with nephropathy, IMA level (0.355 +/- A 0.035 and 0.311 +/- A 0.046 AbsU; P = 0.002) was determined higher compared to the diabetes patients without nephropathy. Diabetic patients without an overt cardiovascular disease still have a higher serum IMA level compared to healthy controls. The correlation of high plasma IMA levels with high hsCRP and microalbuminuria levels in diabetic subjects indicates the presence of a chronic ischemic process. Therefore, elevated IMA levels may indicate an underlying subclinical vascular disease in type 2 diabetes mellitus patients.
Diagnostic value of prostate-specific antigen (PSA) and free prostate specific antigen (fPSA) in women with ovulatory and anovulatory polycystic ovary syndrome
(Springer, 2009) Ukinc, Kubilay; Ersoz, Halil Onder; Erem, Cihangir; Hacihasanoglu, Arif Bayram
Diagnosis of polycystic ovary syndrome (PCOS) is very difficult in women with ovulatory cycles. We assessed the diagnostic value of prostate-specific antigen (PSA) and free prostate-specific antigen (fPSA) in women with ovulatory or anovulatory PCOS. Study group consisted of 62 women with PCOS and 35 healthy female controls. PCOS group was divided into two subgroups as anovulatory (n = 42; 68%, Group A) and ovulatory group (n = 20; 32%, Group B). A cut-off level of PSA and fPSA was established for the sensitivity, specificity, positive likelihood ratio, area under curve, diagnostic accuracy, and positive and negative predictive values of diagnosis of PCOS. In group A, a PSA level of greater than 10 pg/ml yielded a sensitivity of 73.2%, a specificity of 80%, and a diagnostic accuracy of 73%, with a positive predictive value of 88.2% and a negative predictive value of 59.3%. An fPSA level of greater than 2.1 pg/ml yielded a sensitivity of 71.2%, a specificity of 80.4%, and a diagnostic accuracy of 87%, with a positive predictive value of 87.2% and a negative predictive value of 58.4%. In group B, a PSA level of greater than 10 pg/ml yielded a sensitivity of 65%, a specificity of 80%, and a diagnostic accuracy of 73%, with a positive predictive value of 76.5% and a negative predictive value of 69.6%. An fPSA level of greater than 2.1 pg/ml yielded a sensitivity of 65.4%, a specificity of 80.4%, and a diagnostic accuracy of 87%, with a positive predictive value of 75.5% and a negative predictive value of 68.4%. Circulating androgens and hirsutism are independently associated with the degrees of PSA and fPSA in PCOS women. Increased plasma levels of PSA (> 10 pg/ml) and fPSA (> 2.1 pg/ml) could be helpful as a diagnostic tool for women with ovulatory or anovulatory PCOS.
Effects of one year simvastatin and atorvastatin treatments on acute phase reactants in uncontrolled type 2 diabetic patients
(Humana Press Inc, 2009) Ukinc, Kubilay; Ersoz, Halil Onder; Erem, Cihangir; Hacihasanoglu, Arif Bayram; Karti, Suleyman Sami
Type 2 diabetes mellitus is the leading cause of macrovascular diseases and related death. Additionally, diabetes mellitus is frequently complicated by other cardiovascular risk factors, such as hypercholesterolemia, hypertension, obesity, hypercoagulability, and inflammation. We wanted to evaluate and compare the effects of treating with a one-year course of atorvastatin or simvastatin on inflammatory markers such as high sensitive C-reactive protein (hsCRP), fibrinogen, and ferritin in uncontrolled type 2 diabetic patients. Also, we planned to investigate the correlation between inflammatory markers and metabolic parameters. Fifty type 2 diabetic patients (30 women, 20 men; mean age: 49.9 +/- A 8.5 years) were enrolled into the study. Twenty healthy subjects, matched on body mass index and age, were also included in the study as a control group. Diabetic patients were divided into two groups and received simvastatin or atorvastatin (Group S and A, respectively). After 1 year of statin treatment (Group A), there were significant decreases in total cholesterol (217.3 +/- A 46.5-173.8 +/- A 37.2 mg/dl; P < 0.0001), LDL-cholesterol (146.7 +/- A 50.3-102.3 +/- A 31.1 mg/dl, P < 0.0001), hsCRP (0.88 +/- A 0.62-0.35 +/- A 0.18 mg/dl, P < 0.0001), fibrinogen (258.2 +/- A 16.9-215.5 +/- A 10.6 mg/l; P < 0.0001), and ferritin (118.2 +/- A 73.9-81.2 +/- A 72.5 ng/ml, P < 0.0001) levels compared to basal values. In the S group, there were significant decreases in total cholesterol (224.4 +/- A 61.2-175.0 +/- A 47.8 mg/dl; P < 0.0001), LDL-cholesterol (140.9 +/- A 56.7-110.9 +/- A 42.2 mg/dl, P < 0.0001), hsCRP (0.98 +/- A 1.3-0.46 +/- A 0.25 mg/dl, P < 0.0001), fibrinogen (265.7 +/- A 26.8-222.1 +/- A 20.6 mg/l; P < 0.0001), and ferritin (136.7 +/- A 101.1-85.6 +/- A 32.1 ng/ml, P < 0.0001) levels compared to basal values. At the end of the study, a dagger hsCRP, a dagger fibrinogen, and a dagger ferritin levels were correlated with a dagger LDL (r = 0.42; P = 0.005, with a dagger hsCRP), (r = 0.40; P = 0.008, with a dagger fibrinogen), (r = 0.46; P = 0.002, with a dagger ferritin) and a dagger HDL (r = -0.50; P < 0.0001, with a dagger hsCRP), (r = -0.32; p = 0.042, with a dagger fibrinogen), (r = -0.48; P < 0.0001, with a dagger ferritin) cholesterol levels. Atorvastatin and simvastatin treatments were found to be effective for the control of hypercholesterolemia and resulted in a significant decrease in acute phase reactants in uncontrolled type 2 diabetic patients.
Graves' Disease Associated with Alopecia Areata Developing after Hashimoto's Thyroiditis
(Medical Assoc Nippon Medical Sch, 2013) Asik, Mehmet; Binnetoglu, Emine; Sen, Hacer; Tekeli, Zeliha; Uysal, Fatma; Ukinc, Kubilay
Graves' disease and Hashimoto's thyroiditis are the most common autoimmune thyroid diseases. Hypothyroidism can develop in patients with Graves' disease, either spontaneously or as a result of radioactive iodine therapy or surgery. However, it is rare for patients with Hashimoto's thyroiditis to subsequently develop Graves' disease. We report a case of alopecia areata associated with Graves' disease in a 41-year-old woman who had previously been diagnosed with Hashimoto's disease. Alopecia areata is an autoimmune disease associated with other autoimmune diseases such as thyroid disorders, anemia, and other skin disorders.
Hypothyroid Graves' disease complicated with elephantiasis nostras verrucosa (ENV): a case report and review of the literature
(Springer, 2009) Ukinc, Kubilay; Bayraktar, Miyase; Gedik, Arzu
Thyroid dermopathy is not a frequent feature of hyperthyroid Graves' disease, being present in less than 5% of the patients. Graves' disease has been shown to exist in euthyroid or hypothyroid forms in untreated patients. Here, we describe a case of hypothyroid Graves' disease with elephantiasis nostras verrucosa (ENV), which is an extreme form of thyroid dermopathy (TD). A 58-year-old female patient was admitted to the emergency department with somnolence, hypothermia, and bradycardia. Her mental status gradually worsened, resulting in a deep coma. She was intubated and followed in the intensive care unit, as she needed mechanical ventilatory assistance due to respiratory failure. She also had bilateral non-pitting edema, a cobblestone-like appearance, and hyperkeratotic greenish-brown-colored lesions in the pretibial and dorsal regions of the feet that were compatible with ENV. Hypothyroid Graves' disease is a very rare condition among autoimmune thyroid disorders, and ENV is an extremely rare form of TD. Here, we present a patient with hypothyroid Graves' disease and ENV.
Letter to the Editor: Treatment of Paget's Disease in Patients With Renal Impairment
(Endocrine Soc, 2015) Asik, Mehmet; Kadioglu, Gulay Kocak; Eroglu, Mustafa; Sen, Hacer; Erbag, Gokhan; Ukinc, Kubilay
[Anstract Not Available]
Löfgren's syndrome: An acute variant of sarcoidosis diagnosed by mediastinoscopy
(College of Physicians and Surgeons Pakistan, 2015) Alar, Timuçin; Gunes, Fahri; Muratli, Asli; Gedik, Ismail Ertugrul; Tekeli, Zeliha; Ukinc, Kubilay
Löfgren's syndrome is an acute clinical form of sarcoidosis that is first described by Sven Löfgren as bilateral hilar lymphadenopathy together with Erythema Nodosum (EN) and accompanying arthritis/arthralgia. This syndrome has some differences in terms of treatment, prognosis and recurrence compared to sarcoidosis. In this report, we describe a 70 years old lady who admitted with multiple erythematous lesions and arthralgia of both lower extremities and she was diagnosed as Löfgren's syndrome via mediastinoscopy.
Lofgren's Syndrome: An Acute Variant of Sarcoidosis Diagnosed by Mediastinoscopy
(Coll Physicians & Surgeons Pakistan, 2015) Alar, Timucin; Gunes, Fahri; MuratlE, Asli; Gedik, Ismail Ertugrul; Tekeli, Zeliha; Ukinc, Kubilay
Lofgren's syndrome is an acute clinical form of sarcoidosis that is first described by Sven Lofgren as bilateral hilar lymphadenopathy together with Erythema Nodosum (EN) and accompanying arthritis/arthralgia. This syndrome has some differences in terms of treatment, prognosis and recurrence compared to sarcoidosis. In this report, we describe a 70 years old lady who admitted with multiple erythematous lesions and arthralgia of both lower extremities and she was diagnosed as Lofgren's syndrome via mediastinoscopy.
Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy
(Springer, 2009) Ukinc, Kubilay; Ersoz, Halil Onder; Karahan, Caner; Erem, Cihangir; Eminagaoglu, Selcuk; Hacihasanoglu, Arif Bayram; Yilmaz, Mustafa
Hyperhomocysteinemia is a well-defined risk factor for endothelial dysfunction and atherosclerosis. A point mutation (677 C-T) of MTHFR gene results in a significant increase at plasma homocysteine levels. In this study we aimed to evaluate the effects of MTHFR gene mutation and consequent hyperhomocysteinemia on the development of diabetic microvascular complications in comparison with the other defined risk factors. Diabetic patients without a history of macrovascular complication or overt nephropathy enrolled into the study. The presence of MTHFR 677 C-T point mutation was evaluated by Real-Time PCR technique by using a LightCycler. MTHFR heterozygous mutation was present in 24 patients over 52. Patients with diabetes were divided into two groups according to the presence of MTHFR gene mutation. Both groups were well matched regarding age and diabetes duration. Metabolic parameters, plasma homocysteine, microalbuminuria, folic acid, and vitamin B12 levels were also studied. Presence of neuropathy and retinopathy were evaluated by specific tests. Duration of diabetes, BMI, systolic and diastolic blood pressure, plasma CRP, HbA1c, and lipid levels were not different between the two groups. Plasma homocysteine (12.89 +/- A 1.74 and 8.98 +/- A 1.91 mu mol/l; P < 0.0001) and microalbuminuria levels (73.40 +/- A 98.15 and 29.53 +/- A 5.08 mg/day; P = 0.021) were significantly higher in the group with MTHFR gene mutation while creatinine clearance levels (101.1 +/- A 42.6 and 136.21 +/- A 51.50 ml/min; P = 0.008) were significantly lower. Sixteen over 22 (73%) of the patients with diabetic nephropathy had MTHFR gene mutation, while this was only 27% (8 over 30) in normoalbuminuric patients (P = 0.017). There was a significant correlation of plasma homocysteine level with microalbuminuria (r = 0.54; P = 0.031) in the patients with diabetic nephropathy who had C677T polymorphism. We did not find any specific association of MTHFR gene mutation and hyperhomocysteinemia with retinopathy or neuropathy.
SERUM ISCHEMIA MODIFIED ALBUMIN LEVELS IN SUBCLINICAL CUSHING'S SYNDROME
(Carbone Editore, 2016) Ozku, Faruk; Turkon, Hakan; Cakir, Dilek Ulker; Eroglu, Mustafa; Tutunculer, Funda Kirtay; Faydaci, Umut; Ukinc, Kubilay
Introduction: Subclinical Cushing's syndrome (SCS) is defined as biochemical overt cortisol excess in the absence of the classical signs and symptoms of Cushing's disease. The prevalence of SCS is reported as between approximately 5% and 24% in patients with adrenal incidentalomas (AI). SCS has increased cardiovascular and metabolic risk factors, and metabolic syndrome. Recently some studies demonstrated oxidative stress enhancement in Cushing's disease. Ischemia-modified albumin (IMA) is a marker of ischemia and oxidative stress and is increased in different clinical conditions such as cardiovascular diseases and metabolic syndrome. However, it has not been investigated in the patients with SCS. We aimed to evaluate serum IMA levels in the patients with SCS. Materials and methods: A total of 128 patients with AI were included in this study (17 patients with SCS and 111 patients with non-functional adenomas (NFA)). All patients were evaluated for the presence of adrenal masses using adrenal computed tomography (CT) scans. Serum IMA levels were measured by using a calorimetric method. Results: Serum IMA levels were significantly higher in SCS patients than in NFA patients (p < 0.05). Serum IMA was significantly correlated with waist circumference, low-density lipoprotein (LDL) levels and SCS. Furthermore, regression analysis revealed that serum IMA levels are independent and positively associated only with SCS. Conclusion: We concluded that elevated serum IMA levels might be accepted as a useful marker in patients with SCS. In order to reveal the pathological role of IMA levels in patients with SCS more studies are required.
Severe hyperparathyroidism in patient with right thyroid hemiagenesis
(Pakistan Medical Assoc, 2015) Eroglu, Mustafa; Ozkul, Faruk; Barutcu, Ebru Cakan; Arik, Kasim; Adam, Gurhan; Bilen, Yildiz; Ukinc, Kubilay
Thyroid hemiagenesis is an infrequent congenital disorder which is rarely associated with hyperparathyroidism. We present a case of an adult woman who presented with hyperparathyroidism and ipsilateral thyroid hemiagenesis. Parathyroid adenoma was excised by minimal invasive parathyroidectomy.
Severe osteomalacia presenting with multiple vertebral fractures: a case report and review of the literature
(Humana Press Inc, 2009) Ukinc, Kubilay
Adequate exposure to sunlight and fortification of dairy products with vitamin D have eliminated vitamin D deficiency secondary to inadequate endogenous production or nutrition in the majority of countries. Insufficient vitamin D intake secondary to using unfortified foods and social customs (such as avoiding sun exposure), however, contribute to the development of disease. Poor diet, a lack of sun exposure, and the age related decline in the dermal synthesis of 7-dehydrocholesterol are among the factors that predispose to vitamin D deficiency and consequent bone disease. Here, we present a case of severe osteomalacia presenting with multiple vertebral fractures due to poor diet and a lack of exposure to sunlight.

Yazar "Ukinc, Kubilay" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri