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    The 5-Year Incidence of Type 2 Diabetes Mellitus in Women Older Than 15 Years in Ankara, Turkey: A Population-Based Study
    (Bmj Publishing Group, 2010) Maral, Isil; Tutuncu, Neslihan Bascil; Bakar, Coskun; Durukan, Elif; Budakoglu, I. Irem; Ozkan, Secil; Aycan, Sefer
    Background: Type 2 diabetes mellitus (DM) is a significant cause of morbidity and premature mortality especially in adults. In Turkey, there are few studies on DM incidence. This study aimed to determine the incidence of type 2 DM in women 15 years or older in Turkey. Methods: This prospective cohort study was performed from December 2002 to May 2003. Preliminary population-based screening was performed in 1997 and 1998 on women 15 years or older living in 4 villages in the Go lbazN, Ankara province. Five hundred sixty-three women who were considered nondiabetic in the first study comprised the population for the present study. Data collection was accomplished by using a questionnaire and randomly measuring the blood glucose levels of the women. The chi(2) and Fisher exact tests were used to analyze the risk factors for DM. Results: The 5-year incidences of type 2 DM, impaired glucose tolerance, and impaired fasting glucose were 2.3%, 0.4%, and 0.7%, respectively. The 5-year incidence of type 2 DM increased with age (P < 0.05). The DM incidence was 6.2% in those with mixed-type hypertension and 4.0% in those with a body mass index of 30 kg/m(2) or higher. At 5-year follow-up, age (>= 35 years), hypertension, and body mass index (>= 30 kg/m(2)) were the risk factors for incidence of abnormal glucose metabolism (P < 0.05). Conclusions: The incidence of abnormal glucose metabolism in this study is in accord with that in the literature. Our results will contribute to our understanding of the incidence of DM in women in Turkey.
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    The Antibody Response to Endoplasmic Reticulum Stress in Hashimoto's Thyroiditis
    (Galenos Yayincilik, 2013) Asik, Mehmet; Sahin, Mustafa; Anaforoglu, Inan; Arikan, Serap; Haydardedeoglu, Filiz Eksi; Ertugrul, Taner Derun; Tutuncu, Neslihan Bascil
    Purpose: We aimed to investigate the presence of antibodies (Anti-BIP) against binding immunoglobulin protein (BIP), an endoplasmic reticulum (ER) chaperone with immune modulator and anti-apoptotic effects in Hashimoto's thyroiditis (HT) patients. Material and Method: We included sixty-two autoimmune thyroiditis patients, 20 with euthyroid autoimmune thyroiditis, 27 with subclinical hypothyroidism and 15 with hypothyroid, and a control group of 37 healthy subjects. Results: No statistically significant difference was determined in anti-BIP levels among the HT subgroups or in comparison with the control group (p= 0.889). Discussion: Although BIP activation has been shown in vitro in thyroid cells, no difference was determined in our study in anti-BIP levels between the HT patient subgroups and the control group. This suggests that antibodies developing against BIP through apoptosis and/or T cell response are either not related to HT or at levels that cannot be determined by measuring serum.