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    Evaluation of Exposure to HAV and Vaccination Status of Chronic HBV Cases-A Nationwide Multicenter Study
    (Galenos Publ House, 2025) Tosun, Selma; Batirel, Ayse; Zerdali, Esra Yerlikaya; Aydin, Merve; Tutuncu, Ediz; Parlak, Emine; Tabki, Muhammed Ozan
    Objectives: Patients diagnosed with chronic hepatitis B virus (HBV) should be tested for hepatitis A virus (HAV) and vaccinated if they are seronegative. However, this test is often neglected. This study aims to investigate the status of HAV testing in chronic HBV patients. Materials and Methods: A multicenter study is being conducted by the Viral Hepatitis Combat Association with 16 centers across the country, including patients who have been receiving treatment for chronic HBV for at least 14 years. The anti-HAV immunoglobulin G (IgG) testing and vaccination status of the patients in this study were evaluated retrospectively. The patients' data recorded in a web-based program were transferred to an Excel form, and the necessary analyses were performed. Statistical analysis was performed using SPSS for Windows, version 22.0 (IBM Corp., Armonk, NY, USA). Categorical measurements were summarized as numbers and percentages, continuous measurements as mean and standard deviation, and chi-square or Fisher's exact test statistics were used to compare categorical variables. Results: The study group included 2966 individuals, 1832 of whom were male (61.8%) and 1134 of whom were female (38.2%). Of these patients, 1819 individuals (61.3%) were tested for anti-HAV IgG, while 1147 individuals (38.7%) were not. Of the 1819 individuals tested for anti-HAV IgG, 1688 (92.8%) were seropositive, and 131 (7.2%) were seronegative. It was determined that seropositivity increased significantly with age, and seronegativity was 23% among those aged 18-26 and 21% among those aged 27-33 (p=0.00001). According to the obtained data, HAV seronegativity was detected in one-fourth of individuals younger than 26 years and one-fifth of individuals aged 27-33. At 40 and above, seronegativity decreases significantly, falling to 5% and below. Conclusion: Due to the changes observed in HAV epidemiology in our country in recent years, HAV seronegativity is high in young adults. According to our study data, anti-HAV IgG should be tested once in all chronic HBV patients, especially patients under the age of 35, and vaccination of seronegative individuals should not be neglected.