Yazar "Tunc, Serhat" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    An Unusual Case: The Comorbidity of Mood Disorder and 17-?-Hydroxylase Deficiency
    (Aves, 2013) Tunc, Serhat; Yigiter, Sera; Altinbas, Kursat; Kurt, Erhan; Oral, Timucin
    17-alpha-hydroxylase enzyme has a crucial role in the steroid biosynthesis and, deficiency of this enzyme is an autosomal recessive monogenic disorder which is one of the two hypertensive form of congenital adrenal hyperplasia. It is characterized with the deficiency in glucocorticoid, adrenal androgen, and sex steroid synthesis with concomitant mineralocorticoid excess due to genetic defect in steroid biosynthesis. The relationship of hormone system physiology with psychiatric signs and syndromes are complex. Any problem in the hypothalamo-pituitary axis may cause psychiatric syndromes. On the other hand, many psychiatric disorders, such as mood-anxiety symptoms, depression, mania, psychosis, and delirium can be seen secondary to the treatment of hormone deficiency. We present the case of a male patient with pseudohermaphroditism who has been followed and treated in Rasit Tahsin Mood Clinic with the diagnosis of mood disorder not otherwise specified and was diagnosed with 46,XY karyotype and 17-alpha-hydroxylase deficiency after referring to a hospital with delayed puberty. Considering the medical literature, 17-alpha-hydroxylase deficiency has been evaluated from the aspects of gender-related behavioral disorders, psychological developmental and anxiety disorders. To the best of our knowledge, in the medical literature, this is the first case of 17-alpha-hydroxylase deficiency associated with mood disorder. Here, the relationship between mood disorders and hypothalamo-pituitary axis is discussed in the light of the literature.
  • [ X ]
    Öğe
    Comparison of temperament and clinical features of bipolar disorder patients with and without suicide attempt history
    (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2014) Tunc, Serhat; Yenilmez, Yelda; Altinbas, Kursat
    Objective: Suicide attempt is quite frequently encountered in the course of bipolar disorder (BD). In recent years many studies were conducted for examining the relationship between temperamental characteristics and clinical characteristics of patients with BD. The aim of this study is to compare the specific temperament features and clinical features of BD patients with and without a history of suicide attempt (SA) to test the hypothesis that depressive, cyclothymic and irritable temperament scores are higher in bipolar patients with suicide history. Methods: We enrolled a total of 100 patients, 50 of them with a history of SA, 50 without at Bakirkoy Training and Research Hospital for Psychiatry, Neurology and Neurosurgery. All patients were diagnosed according to DSM-IV-TR criteria for 'bipolar disorder in remission' and signed a written informed consent before study entry. Sociodemographic data were collected and temperament was assessed by the means of TEMPS-A. Results: Depressive, cyclothymic and irritable temperament scores were significantly higher in BD patients with SA than in those without. Moreover cigarette and alcohol consumption, family history for psychiatric illness, presence of other psychiatric disorders, history of childhood trauma, episode duration, history of hypo/manic switch were also significantly higher in the group with than without SA. Discussion: Our study confirmed other findings reported in the literature on risk factors associated with suicide behavior. In addition, we also found that depressive, cyclothymic and irritable temperament scores are higher in patients with SA. The assessment of temperament could be added in the evaluation of patients in order to predict possible suicide behavior.