Yazar "Tunali, Mustafa" seçeneğine göre listele

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    Applying nano-HA in addition to scaling and root planing increases clinical attachment gain
    (Korean Acad Periodontology, 2022) Uysal, Ozge; Ustaoglu, Gulbahar; Behcet, Mustafa; Albayrak, Onder; Tunali, Mustafa
    Purpose: This study evaluated the efficacy of treating periodontitis using subgingival nano-hydroxyapatite powder with an air abrasion device (NHAPA) combined with scaling and root planing (SRP). Methods: A total of 28 patients with stage III periodontitis (grade B) were included in this study, although 1 was lost during follow-up and 3 used antibiotics. The patients were divided into a test group and a control group. All patients first received whole-mouth SRP using hand instruments, and a split-mouth approach was used for the second treatment. In the test group, the teeth were treated with NHAPA for 15 seconds at 70% power per pocket. Subgingival plaque samples were obtained from the 2 deepest pockets at the test and control sites before treatment (baseline) and 3 months after treatment. The full-mouth plaque index (PI), gingival index (GI), papillary bleeding index (PRI), bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and at 1- and 3-month post-treatment. Real-time polymerase chain reaction was used to determine the colonisation of Treponema denticola (Td), Porphyromonas,gingivalis(Pg), and Aggrega Odder actinomycelemcomitans in the subgingival plaque. Results: From baseline to the first month, the test group showed significantly larger changes in BOP and CAL (43.705%+/- 27.495% and 1.160 +/- 0.747 mm, respectively) than the control group (36.311%+/- 27.599% and 0.947 +/- 0.635 mm, respectively). Periodontal parameters had improved in both groups at 3 months. The reductions of PI, GI, BOP, PD, and CAL in the test group at 3 months were greater and statistically significant. The total bacterial count and Td and Pg species had decreased significantly by the third month in both groups (P<0.05). Conclusions: Applying NHAPA in addition to SRP improves clinical periodontal parameters more than SRP alone. Subgingival NHAPA may encourage clot adhesion to tooth surfaces by increasing surface wettability.
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    Authors’ response
    (Faculdade De Odontologia De Bauru, 2022) Saglam, Ebru; Ozsagir, Zeliha Betul; Unver, Tugba; Alinca, Suzan Bayer; Toprak, Ali; Tunali, Mustafa
    [No abstract available]
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    Fibrin clot adherence on cleaned and decontaminated titanium abutment surfaces: An in vitro study
    (Wiley, 2024) Ulusoy, Habibe Ozturk; Ercan, Esra; Ozatik, Orhan; Tunali, Mustafa
    Statement of ProblemOsseointegration is now primarily established, but soft tissue integration is still susceptible to failure and problematic on implant surfaces. So, implant dentistry is increasingly focusing on improving peri-implant soft tissue integration.PurposeThe present study aimed to evaluate the blood fibrin clot formation and adhesion on the abutment after cleaning and decontamination and determine the suitable abutment surface associated with fibrin clot attachment.Materials and MethodsForty-two abutments (14 per group) were used in the present study: a brand-new (BN), contaminated with biofilm (CO) and decontaminated with an enzymatic cleaner and autoclave sterilization (DEC). For a fibrin clot, 9 mL of whole human blood and abutments was centrifuged at 2700 rpm for 12 min. Clots were divided into two parts for histomorphometry and scanning electron microscopy (SEM) analysis. Twelve abutments disconnected from the clot and two not treated with blood were observed under SEM.ResultsResidual debris and biofilm were observed on the abutment surface in the CO group but not in other groups. Healthy and organized fibrin clots formed on all abutments. The fibrin extension areas are distributed uniformly in BN and DEC groups but irregularly in CO. The surface percentage of the fibrin clot extensions was 41.76% +/- 6.73, 26.99% +/- 6.40, and 37.83% +/- 9.72 for the BN, CON, and DEC groups, respectively. The blood clot-attached areas in the CO group were statistically lower than the other groups. No difference was observed between the BN and DEC groups.ConclusionsThis study confirmed that surface contamination could influence blood clot attachment on the abutment surfaces. Cleaning and sterilization can have a favorable effect on soft tissue healing on abutment surfaces.
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    Innovative i-PRF semisurgical method for gingival augmentation and root coverage in thin periodontal phenotypes: a preliminary study
    (Quintessence Publishing Co Inc, 2023) Alan, Ralf; Ercan, Esra; Firatli, Yigit; Firatli, Erhan; Tunali, Mustafa
    Objectives: The aim of the study was to evaluate the effect of in-jectable platelet-rich fibrin (i-PRF) on gingival thickness and gingi-val recession in individuals with thin periodontal phenotypes.Method and materials: In this prospective study, i-PRF was ap-plied via a semisurgical method to augment 53 tooth regions with thin periodontal phenotypes. In order to ensure that sufficient blood clot formed on the side of the gingiva facing the bone and that i-PRF reached the area, a minimal incision was made with the help of a scalpel in the apical region of the relevant region, and the periosteum was elevated with a microsurgical instrument. To en-sure sustained exposure to angiogenetic growth factors and en-hance the histoconductive properties, i-PRF injection was applied to the relevant areas in four sessions at 10-day intervals.Results: An increase in gingival thickness was achieved in 92.5% of the areas treated with i-PRF, and the desired gingival thickness (0.8 mm) was achieved in 44.9% of these areas. In addition, signif-icant reductions in the amount of recession were observed in 83.3%ofthe 12 gingival recession areas (P= .005). Moreover, com-plete coverage was achieved in 60% of these regions.Conclusion: With the new i-PRF sem isu rgica I method, it was shown that gingi-val thickness can be increased in tooth regions with thin gingiva, and that areas of gingival recession can be covered. Further com-prehensive studies are needed to fully understand the role of i-PRF in enhancing angiogenesis and the histoconductive properties of this fu lly autogenous blood concentrate. (Quintessence Int2023;54: 734-743; doi:10.3290/j.gi.b4328831)
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    Management of Deep Gingival Recessions by Modified Coronally Advanced Tunnel Technique with Titanium Platelet Rich Fibrin Membrane or Connective Tissue Graft: 36 Months Follow-up Clinical Study
    (Marmara Univ, Inst Health Sciences, 2020) Koyuncuoglu, Cenker Zeki; Ercan, Esra; Uzun, Bilge Cansu; Tunali, Mustafa; Firatli, Erhan
    Objective: The goal of the study is to evaluate the results of Titanium-Platelet Rich Fibrin (T-PRF) membrane and Connective Tissue Graft (CTG) with modified coronally advanced tunnel technique (MCATT) in treatment of deep gingival recession defects. Methods: Twenty-one systemically healthy patients displaying 62 Miller Class I/II gingival recession defects >= 3.0 mm in depth, treated either with MCATT with CTG or with T-PRF membrane were included in this retrospective study. The periodontal parameters were assessed at baseline, and at 6 and 36 months after surgery. The percentages of the mean root coverage (MRC) and complete root coverage (CRC) were calculated. Results: The probing depth values were decreased at 36 months according to baseline values for both groups (p<0.05). Keratinized tissue (KT) was increased at 6 months according to baseline for both groups (from 1.69 +/- 0.74 mm to 3.61 +/- 0.67 mm for T-PRF; and 3.40 +/- 1.60 mm to 4.52 +/- 2.33 for CTG). The 36th month measurement of KT showed an increase in the T-PRF group compared to the 6th month measurement, while the CTG group showed a significant decrease (3.86 +/- 0.76 mm and 2.76 +/- 1.45 mm, respectively). The CRC ratios were 80% and 56% at 6 and 36 months, respectively for the CTG group. However, this ratio remained the same (64.86%) for the T-PRF group. There was statistically significant difference between CRC ratios of both groups at 36 months (p<0.05). Conclusion: T-PRF membrane with MCATT procedure is as predictable as CTG with MCATT for management of deep gingival recessions. However, future prospective studies about this topic with a split-mouth design are needed.
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    Nano-Hydroxyapatite Airborne-Particle Abrasion System as an Alternative Surface Treatment Method on Intraorally Contaminated Titanium Discs
    (Quintessence Publishing Co Inc, 2020) Gumus, Kerem Caglar; Ustaoglu, Gulbahar; Kara, Levent; Ercan, Esra; Albayrak, Onder; Tunali, Mustafa
    The aim of this study was to test the nano-hydroxyapatite powder decontamination method on intraorally contaminated titanium discs and to compare this method with current decontamination methods in the treatment of peri-implantitis. Contaminated discs were assigned to six treatment groups (n = 10 each): titanium hand curette; ultrasonic scaler with a plastic tip (appropriate for titanium); ultrasonic scaler with a plastic tip (appropriate for titanium) + H2O2; short-term airflow system (nano-hydroxyapatite airborne-particle abrasion for 30 seconds); long-term airflow system (nano-hydroxyapatite airborne-partide abrasion for 120 seconds); Er:YAG laser (120 mJ/pulse at 10 Hz). There were also two control groups (n = 10 each): contaminated disc (negative control) and sterile disc (positive control). Scanning electron microscopy, energy-dispersive x-ray spectroscopy, and dynamic contact angle analysis were used to determine the most effective surface-treatment method. The highest percentage of carbon (C) atoms was observed in the negative control group, and the lowest percentage of C atoms was found in the long-term airflow group, followed by the short-term airflow, laser, ultrasonic + H2O2, ultrasonic, and mechanical groups. When the groups were examined for wettability, the lowest contact angle degree was observed in the long-term airflow, short-term airflow, and laser groups. Nano-hydroxyapatite and laser treatments for detoxifying and improving infected titanium surfaces may show the most suitable results for reosseointegration.
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    Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality
    (Springer, 2024) Tunali, Mustafa; Ercan, Esra; Pat, Suat; Sarica, Emrah; Bagla, Aysel Guven; Ayturk, Nilufer; Siddikoglu, Duygu
    The quality of platelet-rich fibrin (PRF) is contingent on the surface characteristics interfacing with blood. Titanium's superior platelet activation, surpassing silica, has made Titanium-platelet-rich fibrin (T-PRF) a favored autogenous bone graft material due to its extended degradation time. Pioneering a novel approach, this study aims to achieve an enhanced fibrin structure using glass tubes coated with nano-titanium, marking the surface's debut in our PRF production endeavors. Employing a rapid thermionic vacuum arc (TVA) process under high vacuum, we conducted comprehensive analyses of the tubes. Comprehensive analyses, including X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS), were conducted on the nano-titanium-coated glass tubes. Three PRF types were formulated: silica-activated leukocyte- and platelet-rich fibrin (L-PRF, control group), machined-surface titanium tubes (T-PRF), and nano-titanium-coated tubes (nanoT-PRF). Analyses unveiled denser fibrin areas in nanoT-PRF than T-PRF, with the least dense areas in L-PRF. Cell distribution paralled between nanoT-PRF and T-PRF groups, while L-PRF cells were embedded in the fibrin border. NanoT-PRF exhibited the densest autogenous fibrin structure, suggesting prolonged in vivo resorption. Additionally, we explore the potential practicality of single-use production for nanoT-PRF tubes, introducing a promising clinical advancement. This study marks a significant stride in innovative biomaterial design, contributing to the progress of regenerative medicine.