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    FT-Raman, FT-IR, NMR structural characterization and antimicrobial activities of 1,6-bis(benzimidazol-2-yl)-3,4-dithiahexane ligand and its Hg(II) halide complexes
    (Springer/Plenum Publishers, 2008) Aghatabay, Naz Mohammed; Tulu, Metin; Mahmiani, Yaghub; Somer, Mehmet; Dulger, Basaran
    1,6-Bis(benzimidaz-2-yi)-3,4-dithiahexane ligand (L) and its mercury halide complexes were prepared and characterised. The elemental analysis, molecular conductivity, FT-Raman, FT-IR (mid, far), H-1, C-13 NMR and geometry optimization in MOPAC using MNDOd parameter on CACHE, prove the existence of neutral, mononuclear and the distorted tetrahedral [Hg(L)X-2] complexes. In all the three complexes, the ligand acts as a chelating bidentate, through two of the bridging sulphur atoms and together with the monodentate coordination of the two anionic halide ligands to the metal centre forming a possible 4-coordinate compounds. The antimicrobial activities of free ligand, its hydrochlorinated salt, mercury halides and the complexes are evaluated using disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against 10 bacteria. The obtained results from disk diffusion method are assessed in side-by-side comparison with those of Penicillin-g, Ampicillin, Cefotaxime, Vancomycin, onaxacin and Tetracyclin well-known antibacterial agents. The results from dilution procedure are compared with Gentamycin as antibacterial and Nystatin as antifungal. The antifungal activities are reported on five yeast cultures namely Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii and Hanseniaspora guillierinondii, and the results are referenced with Nystatin, Ketaconazole and Clotrimazole, commercial antifungal agents. In most cases, the compounds show broad-spectrum (Gram(+) & Gram(-) bacteria) activities that are comparatively, slightly less active or equipotent to the antibiotic and antifungal agents in the comparison tests.
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    Microwave assisted synthesis of Jeffamine cored PAMAM dendrimers
    (Pergamon-Elsevier Science Ltd, 2014) Erturk, Ali S.; Tulu, Metin; Bozdogan, Abdurrezzak E.; Parali, Tezcan
    This study reports the use of a new microwave assisted amidation method for the synthesis of Jeffamine cored poly (amidoamine) (PAMAM) dendrimers up to fourth generations. Reaction proceeding is monitored by attenuated total reflectance (ATR) without final purification. It was found that current method decreases the aminolysis time, and minimizes the excessive use of reagents and solvents. Synthesized dendrimers were purified by liquid-phase polymer-based retention (LPR) technique and characterized by H-1-NMR, C-13-NMR, EA, GPC and UV-VIS spectroscopy. (C) 2014 Elsevier Ltd. All rights reserved.
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    Synthesis, characterization and antimicrobial activity of water soluble dendritic macromolecules
    (Elsevier France-Editions Scientifiques Medicales Elsevier, 2009) Tulu, Metin; Aghatabay, Naz M.; Senel, Mehmet; Dizman, Cemil; Parali, Tezcan; Dulger, Basaran
    Several families of water soluble dendrimers were synthesized based on poly (propyleneoxide) amines (Jeffamines (R)) (PI). PI-core and branched units were constructed from both methylacrylate and ethylenediamine (P-2-P-9, and generations 0-3 with - NH2, - COOH functionalities). They were characterized by elemental analysis (HA), gel permeation chromatography (GPC) , FT-IR, H-1, and C-13 NMR. The antimicrobial activities of only water soluble compounds (P-1, P-3, P-4, P-6, P-7 and P-9) were evaluated using disk diffusion method in water as well as the minimal inhibitory concentration (MIC) dilution method against 9 bacteria. The obtained results from disk diffusion method are assessed in side-by-side comparison with those of Penicillin-g, Ampicillin, Cefotaxime, Vancomycin, Oflaxacin, and Tetracyclin, well-known antibacterial agents. The results from dilution procedure are compared with Gentamycin as antibacterial and Nystatin as antifungal. The antifungal activities are reported on five yeast cultures namely, Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, and Hanseniaspora guilliermondii, and the results are referenced with Nystatin, Ketaconazole, and Clotrimazole, commercial antifungal agents. In most cases, the compounds show broad-spectrum (Gram-positive and Gram-negative bacteria) activities that are comparatively higher or equipotent to the antibiotic and antifungall agents in the comparison tests. (C) 2008 Elsevier Masson SAS. All rights reserved.