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Öğe Correlation between calcium and phosphorus in cord blood and birth size in term infants(Edizioni Minerva Medica, 2016) Colak, Ayfer; Yildiz, Omur; Toprak, Burak; Turkon, Hakan; Halicioglu, Oya; Coker, IsilBACKGROUND: Calcium supplementation during pregnancy was suggested to affect fetal growth. We aimed to investigate the association between calcium and phosphorus in cord blood and birth size parameters in term infants. METHODS: The study included 70 pregnant women and their neonates. Birth weight, birth length and head circumference of the neonates were measured. Cord blood samples were obtained at delivery. Maternal and cord blood calcium, phosphorus and parathyroid hormone were measured. The association between variables was evaluated with Pearson correlation coefficient. RESULTS: Cord blood calcium levels were significantly positively correlated with birth weight, birth length and head circumference (r=0.308 P=0.009, r=0.324 P=0.006, r=0.296 P=0.013 respectively). Cord phosphorus was significantly positively correlated with birth length (r=0.358 P=0.002). In subjects with higher phosphorus levels cord calcium were more strongly correlated with birth weight, birth length and head circumference than in the overall group (r=0.487 P=0.003, r=0.515 P=0.002, r=0.396 P=0.018 respectively). CONCLUSIONS: Cord blood calcium and phosphorus levels are associated with birth size parameters. There may be interactions between calcium and phosphorus to affect fetal growth.Öğe Diagnostic performances of serum liver enzymes and cytokines in non-alcoholic fatty liver disease(2014) Turkon, Hakan; Çolak, Ayfer; Toprak, Burak; Yıldız, Coşkun; Hasturk, Aybike; Yıldız, Ömür; Binnetoğlu, EmineAmaç: Alkolik olmayan yağlı karaciğer hastalığı gittikçe artan prevalansla dünya çapında insanları etkilemektedir. Bu hastalığın tanısı ve evrelendirilmesi için invaziv olmayan testlere ihtiyaç vardır. Bu çalışmada rutin karaciğer enzimleri ve sitokinlerin alkolik olmayan yağlı karaciğer hastalığında tanısal performanslarını değerlendirmeyi amaçladık.Yöntemler: 20-62 yaşları arasında 88 kişi çalışmaya dahil edildi. Serum ALT, AST, GGT, trigliserid, TNF-alfa, IL-6 ve IL-8 düzeyleri 40 yağlı karaciğer hastası ve benzer VKİ ve demografik özellikleri olan 48 sağlıklı bireyde ölçüldü. Serum biyobelirteçlerinin yağlı karaciğer hastalığındaki tanısal performansları ROC analizi ile değerlendirildi.Bulgular: ALT ve AST tüm grupta yağlı karaciğer hastalığı olan bireyleri belirlemede iyi performans gösterdi (AUC=0,817; %95 CI[0,721-0,913], AUC=0,815; %95 CI[0,718-0,911] sırasıyla) ancak obez bireylerde ALT ve AST zayıf performans gösterdi (AUC=0,659; %95 CI[0,478-0,841], AUC=0,680; %95 CI[0,498-0,861] sırasıyla). Sitokinler arasında TNF-alfa yağlı karaciğer hastalığı tanısında tüm grupta ve obez hastalarda en iyi performansı gösterdi (AUC=0,892; %95 CI[0,824-0,959], AUC=0,858; %95 CI[0,739-0,977] sırasıyla). Tüm grupta TNF-alfa için en iyi cut-off değeri %75 sensitivite ve %93 spesifisite ile 10,65pg/mL bulundu. IL6 ve IL8 zayıf performans gösterdi.Sonuç: TNF-alfa alkolik olmayan yağlı karaciğer hastalarını tespit etmede iyi bir parametre olabilirÖğe The effect of sleeve gastrectomy on serum irisin levels in patients with morbid obesity(Via Medica, 2016) Demirpence, Mustafa; Yilmaz, Hamiyet; Colak, Ayfer; Yalcin, Hulya; Toprak, Burak; Turkon, Hakan; Ugurlu, LeventIntroduction: Irisin, a recently identified myokine, is associated with increased energy expenditure and has a potential role in obesity. Therefore, we investigated circulating irisin levels in morbidly obese patients undergoing sleeve gastrectomy (SG). Materials and methods: Thirty morbidly obese patients undergoing SG and 30 healthy subjects were included. All participants were evaluated at baseline and again at three months post-SG. Body weight and height, the lipid profile, and plasma glucose, HbA1c, insulin, and irisin levels were measured at each visit. Results: The two groups had similar mean age and sex distribution. Serum irisin was significantly lower in the morbidly obese subjects compared with the controls (p - 0.003) and negatively correlated with BMI, body weight, insulin levels, and HOMA-IR (p - 0.006, p = 0.011, p = 0.046, p = 0.048, respectively). When the morbidly obese patients were re-evaluated three months post-SG, their weight and BMI had significantly decreased (both p = 0.001). Similarly, the insulin, HbA1c, HDL-cholesterol, and HOMA-IR values significantly decreased (p - 0.001, p - 0.028, p - 0.006, and p - 0.001, respectively). However, irisin levels remained unchanged (p = 0,267). Conclusion: Although the irisin levels were significantly lower in the morbidly obese subjects, they did not change after SG-induced weight loss.Öğe The Effectiveness of Temperature Versus Aprotinin in Maintaining the Preanalytical Stability of Adrenocorticotrophin(Oxford Univ Press, 2016) Turkon, Hakan; Toprak, Burak; Yalcin, Hulya; Colak, Ayfer; Ozturk, NurinnisaObjective: To investigate the effect of temperature and protease inhibitor on adrenocorticotrophin (ACTH) stability. Methods: We collected blood specimens from 10 donors into K3 EDTA (ethylenediaminetetraacetic acid) and K3 EDTA + aprotinin tubes. Plasma specimens were held at room temperature and at 2 degrees C to 8 degrees C for 0, 2, 4, 8, 24, and 72 hours. ACTH concentrations in 4 storage conditions were compared with repeated-measures analysis of variance (ANOVA) at each time point. Results: ACTH concentrations substantially decreased after a 72-hour time period. At the 72nd hour, standard EDTA tubes and EDTA + aprotinin tubes stored at 4 degrees C showed the optimal stability. EDTA + aprotinin tubes stored at room temperature performed more strongly than standard EDTA tubes stored at room temperature. Conclusion: Our results show that refrigerated storage is more effective than protease inhibitor addition to maintain ACTH stability. We recommend using aprotinin tubes, especially for specimens standing at room temperature.
