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    Investigation of the protective effects of L-carnitine and L-arginine on cardiovascular changes induced by ACTH and dexamethasone in rabbits
    (Tubitak Scientific & Technological Research Council Turkey, 2013) Topcu, Birkan; Uzun, Metehan
    Aim: To determine the protective effects of L-carnitine on cardiovascular changes that may occur in rabbits treated with adrenocorticotropic hormone (ACTH) and dexamethasone (DEX). Materials and methods: Rabbits of equal weight were divided into 7 groups with 6 animals in each. Blood samples were collected from all groups on days 1, 7, and 14, and blood pressure values and ECG monitoring were recorded. Nitric oxide (NO), creatine kinase MB (CK-MB), and troponin I (TnI) levels were determined in blood samples. Heart rate, QT, and corrected QT (QTc) values were calculated from ECG records. Results: The QT and QTc times were prolonged significantly (P < 0.001) in the ACTH-treated groups compared to the control group, and L-carnitine had no protective effect. Moreover, CK-MB (P < 0.05) and TnI (P < 0.001) levels were higher in the ACTH-treated groups than they were in the control group. Conclusion: Application of ACTH results in prolongation of QT and QTc intervals and increases in GK-MB and TnI levels, which are indicators of heart muscle damage.
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    Öğe
    The Effects of Intravenous Oxytocin and Methylergonovine Administration on QT Interval in Rabbits
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2009) Uzun, Metehan; Karaca, Mehmet; Topcu, Birkan; Kurt, Yunus
    The aim of this study was to evaluate changes in heart rate (HR), QT, and QTc values in conscious female New Zeland rabbits which intravenously received oxytocin (OXT), methylergonovine (ME) and OXT plus ME at different dosages. Animals were divided in to 9 equal groups; Group 1 (n = 6, received 0.5 U OXT per animal), group 2 (n = 6, received 1 U OXT per animal), group 3 (n = 6, received 3 U OXT per animal), group 4 (n = 6, 0.1 mg ME per animal), group 5 (n = 6, received 0.2 mg ME per animal), group 6 (n = 6, received 0.3 mg ME per animal), group 7 (n = 6, received 0.5 U OXT + 0.1 mg ME per animal), group 8 (n = 6, received 1 U OXT + 0.2 mg ME per animal) and group 9 (n = 6, received 3 U OXT + 0.3 mg ME per animal). Electrocardiographical recording were taken from all animals before injection and then at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18 and 20. minutes of each drug administration. The HR, QT and QTc values were estimated from ECG recording. The HR values decreased in OXT and OXT plus ME injected groups (P < 0.001). In these groups prolongation of QT and QTc intervals were observed after drug injection during the 1-3 minutes (P < 0.001). There were not determined significant changes of all observed parameters in ME injected groups. In conclusion, it should be taken into consideration by the physicians QT prolongation and short-term and serious bradycardia due to OXT application. The results of the study also suggest that ME may be safer than OXT in terms of HR and QT intervals.