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Öğe A Rare Case of Cystinosis Presenting with Alkalosis(Taylor & Francis Ltd, 2013) Topaloglu, Naci; Tekin, Mustafa; Yildirim, Sule; Gencer, BaranA 14-month-old girl was admitted to our clinic due to failure to thrive. Her weight and height were below the third percentile for age. Laboratory examination showed signs of alkalosis, hypokalemia, and hypochloremia. However, her urinalysis was consistent with renal tubular acidosis. Radiologic examination showed signs of active rickets. Based on clinical and laboratory findings, we focused on the probable diagnosis of cystinosis. Slit-lamp examination of the cornea confirmed our diagnosis. We should note that the presence of alkalosis does not exclude the possibility of diagnosis of cystinosis and we should be aware that if any slight doubt of cystinosis exists, patients should be carefully and completely evaluated for diagnosis.Öğe Association between teething and independent walking in healthy children(Turkish J Pediatrics, 2015) Kaymaz, Nazan; Yildirim, Sule; Cevizci, Sibel; Cimen, Mehmet; Topaloglu, Naci; Binnetoglu, Fatih Koksal; Tekin, MustafaDeveloping teeth provide a reliable indication of maturation and biological age. The objective of this study was to establish whether there is any association between the time of emergence of the first primary tooth and the time when independent walking occurs. A cross-sectional study was conducted with a sample of 206 healthy children (95 girls and 111 boys) aged 12 to 60 (mean: 29.79 +/- 0.66) months who were able to walk independently. The study was conducted using a questionnaire that was filled out by the parents. The first primary tooth emerged at 6.86 +/- 0.14 (min: 3-max: 13) months; the mean independent walking time was 12.58 +/- 2.15 (min: 8.50-max: 24.00) months. There was no correlation between the first teething and independent walking times (r=0.045, p=0.523). Factors such as breastfeeding status, intake of vitamins, walker usage and body mass index were found not to affect the time of either emergence of the first deciduous tooth or independent walking. To the best of our knowledge, this is the first paper in literature to have researched the relationship between the time of emergence of the first deciduous tooth and that of independent walking. It should be explained to parents that there is no relationship between the two in order to resolve anxiety when their child acquires a tooth but does not walk, or vice versa.Öğe Asymmetric dimethyl arginine levels in testicular tissue and blood of rats with induced experimental varicocele(Elsevier Espana Slu, 2014) Alan, Cabir; Ertung, Yunus; Cakir, Dilek Ulker; Topaloglu, Naci; Ersay, Ahmet Resit; Basturk, GokhanIntroduction: Varicocele is one of the reasons for testicular dysfunction and is frequently known to accompany infertility. The basic pathology of varicocele is the development of endothelial dysfunction. The most important factors in development of endothelial dysfunction are impaired endothelial-linked vasodilatation, increase in free oxygen radicals, reduced synthesis and release of nitric oxide (NO), abnormal vasoconstriction and increased levels of dimethyl arginine. Our aim was to identify and illustrate the relationship between asymmetric dimethyl arginine (ADMA) and NO levels in testicular tissue and plasma of rats with induced experimental varicocele. Materials and methods: Twenty-one adolescent (average 6 weeks) male rats were included in the study and randomly divided into 3 groups. Group 1 (control, n=6) did not undergo any procedure. Group 2 (sham, n=6) had the left renal vein circled proximally but ligation was not performed. Group 3 (varicocele-induced, n=9) had partial ligation of the proximal left renal vein to induce left varicocele. Superoxide dismutase (SOD) enzyme activity and levels of end-products of NO, nitrite and nitrate salts were investigated in testis tissue. Nitrite/nitrate and ADMA levels were investigated in plasma. Histopathological examination was completed with routine hematoxylin-eosine and TUNEL dyes. Results: Tissue SOD and plasma ADMA values were clearly increased in the varicocele group compared to the other groups; tissue and plasma nitrite/nitrate levels were clearly reduced in the varicocele group and this was observed to be statistically significant between the groups. Conclusion: We believe our study has opened an important window on the relationship between infertility observed in varicocele patients and ADMA. We believe that broad-series prospective studies to support this are required. (C) 2014 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Benign Acute Childhood Myositis due to Toxoplasmosis(All India Inst Medical Sciences, 2016) Yildirim, Sule; Battal, Fatih; Aylanc, Hakan; Tekin, Mustafa; Kaymaz, Nazan; Binnetoglu, Fatih Koksal; Topaloglu, Naci[Anstract Not Available]Öğe Biofeedback in the Treatment of Nocturnal Enuresis: May Be an Alternative Method of Treatment?(Derman Medical Publ, 2015) Topaloglu, Naci; Alan, Cabir; Ersay, Ahmet Resit; Eren, Ali Erhan; Basturk, Gokhan; Alan, HandanAim: Biofeedback is re-education of correct voiding to children with visual, tactile and sensorial stimuli. Biofeedback in the treatment of dysfunctional voiding and urinary incontinence can be used. However, in the treatment of nocturnal enuresis is not included in the routine treatment options. We aimed to investigate the feasibility and effectiveness of biofeedback in the treatment of nocturnal enuresis. Material and Method: 50 children aged 5 years or older, who suffered a case of not wetting more than six-month period and admitted complaints of nocturnal urinary incontinence were included in the study. The mean age of patients was 9,4 +/- 2,52 (6-15). 27 patients (54%) were female and 23 patients (46%) were males. Biofeedback treatment performed to patients as 4 sessions. Each sessions were 30 minutes long every week. All patients were informed and advised to do the same exercise for 30 minutes every day at home. Results: Following the biofeedback treatment, incidence of wetting was found to have decreased significantly. 13% (3) of male patients and 11,1% (3) of female patients have not benefits from treatment. 87% (20) of male and 88,9% (24) of female patients have benefits from the treatment, frequency of urinary incontinence was reduced. Following the treatment, clinical improvement was 88%, while the rate of completely dryness was 54%. Statistical difference was found significantly at the incidence of wetting between before and after the treatment (p<0,05). Discussion: The positive results achieved in a short time indicates that the biofeedback method including the active participation of the child and the family in an environment of play, without medication, is candidate for the alternative treatment to nocturnal enuresis treatment.Öğe Correlation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsion(Kare Publ, 2016) Yildirim, Ahmet; Yildirim, Sule; Topaloglu, Naci; Tekin, Mustafa; Kucuk, Adem; Erdem, Havva; Erbas, MesutObjectives: Ischemia modified albumin (IMA) levels significantly increased and may be used as a diagnostic marker in ovarian torsion. The aim of this study is to investigate whether there was any correlation between IMA levels and histopathologic changes in experimental ovarian torsion. Material and methods: Fourteen Sprague-Dawley rats, each weighing 220-250 g were divided randomly into 2 groups; in Group 1, the control group (n = 7), only laparotomy was performed and in Group 2, the experimental group (n = 7), ovarian torsion was performed. Ischemia was performed for 3 h; following the ischemia period, the torsion was relieved by detwisting the adnexa and then the ovarian I/R protocol was applied for 3 h. Blood samples were taken from all of the rats to measure the IMA levels and the ovaries were surgically removed for histologic examination. A blinded pathologist examined and scored the samples. Results: The median (minimum-maximum) IMA values were 921.00 (870.00-966.00) ABSUs in the ovarian torsion group and 853.00 (782.00-869.00) ABSUs in the control group. The difference was statistically significant. In the correlation analysis, a significant and strong correlationwas found between IMA levels and histopathologic changes (Spearman's rho = vertical bar 0.987, p < 0.001). Conclusion: Positive correlation was found between the IMA levels and the histopathologic severity of the disease. This finding is important for both diagnosis of the disease and patient follow-up. As a new marker in ovarian torsion, IMA may also indicate the severity of the ovarian histopathology. Copyright (C) 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner.Öğe Disorders of sex development(Elsevier Doyma Sl, 2013) Alan, Cabir; Altundas, Ramazan; Topaloglu, Naci; Haciveliogiu, Servet Ozden; Kocoglu, Hasan; Ersay, Ahmet ResitBackground: Disorders of sex development (DSD), which has the possibility of the risk of life-threatening endocrinologic emergencies of the newborn, require a careful multidisciplinary approach. Objectives: The aim of our study is to consolidate the proposed classification, evaluation and management of DSD. Materials and methods: The literatures related with DSD were reviewed to find the best approach for this disease. Results: The detailed history, systemic physical examination of the patient, particular laboratory and imagine evaluations are needed for the urgent treatment of life-threatening abnormalities and the gender assignment. Conclusion: The gender should be assigned depending on the definitive diagnosis, fertility potential, genital appearance, surgical options, and the parents' opinion. (C) 2013 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Esparta, S.L. All rights reserved.Öğe Do we really ponder about necessity of intravenous hydration in acute bronchiolitis?(Corporacion Editora Medica Valle, 2016) Yildirim, Sule; Kaymaz, Nazan; Topaloglu, Naci; Binnetoglu, Fatih Koksal; Tekin, Mustafa; Aylanc, Hakan; Battal, FatihObjective: The goal was to establish the role of intravenous hydration therapy on mild bronchiolitis. Methods: This was a retrospective case control study. Infants between 1 month and 2 years of age admitted to our general pediatrics ward between June 2012 and June 2013 with a diagnosis of uncomplicated acute bronchiolitis were enrolled to the study. Hospital medical files were reviewed to get information about children personal history, symptoms of the disease, disease severity scores and their management. Patients were classified into 4 groups according to the management; nebulized short-acting beta 2-agonist (salbutamol) +hydration; nebulized short-acting beta 2-agonist (salbutamol); hydration and neither bronchodilator nor hydration. We examined length of stay in the hospital as an outcome measure. Results: A total of 94 infants were studied. There was no significant difference between groups in terms of length of stay in hospital. Conclusions: IV hydration is not effective on length of stay in hospital in mild acute bronchiolitis patients.Öğe Does Glp-2 have a protective effect on cerebral ischemia/reperfusion model?(Tubitak Scientific & Technological Research Council Turkey, 2015) Topaloglu, Naci; Memi, Gulsun; Kaner, Tuncay; Deniz, Mustafa; Sahin, Onder; Guven, Mustafa; Cosar, MuratBackground/aim: To investigate the neuroprotective effects of glucagon-like peptide 2 (Glp-2), which increases cerebral blood flow, on the hippocampal complex after cerebral ischemia/reperfusion (I/R) injury in rats. Materials and methods: Animals were randomized into 4 groups: sham, I/R + 0.9% NaCl, I/R + pre-Glp-2, and I/R + post-Glp-2. Cerebral ischemia was performed via the occlusion of the bilateral internal carotid artery for 40 min and continued with a reperfusion process. At the end of 6 h of reperfusion, animals were decapitated in all groups and brain tissues were removed. Malondialdehyde (MDA) and natural intracellular antioxidant glutathione (GSH) levels and myeloperoxidase (MPO) activities were measured in the left hippocampal tissue. The right hippocampal tissues of all group members were taken for histopathologic study. Results: MDA levels and MPO activities increased from Group I to Group II and decreased from Group II to Groups III and IV. On the other hand, GSH levels were not significantly different among the groups. The number of apoptotic hippocampal tissue cells increased from Group I to Group II and decreased from Group II to Groups III and IV. Conclusion: Our preliminary study revealed that Glp-2 treatment may decrease oxidative damage from I/R in cerebral tissue.Öğe Does intrauterine tobacco exposure increase the pain perception of newborns?(Dove Medical Press Ltd, 2016) Tekin, Mustafa; Yildirim, Sule; Aylanc, Hakan; Kaymaz, Nazan; Battal, Fatih; Topaloglu, Naci; Baser, EsraBackground: This study aimed to assess whether there was a difference in the pain-perception levels of newborns born to mothers who smoked during pregnancy and newborns born to mothers who were not exposed to active or passive smoking during pregnancy. Materials and methods: A total of 60 newborns born by normal spontaneous vaginal birth between June 2013 and June 2014 were included in the study: 30 born to mothers who smoked during pregnancy, and 30 born to mothers not exposed to smoking. Mothers or newborns who had taken analgesics or sedative medications in the previous 24 hours, newborns not born at term, and sick newborns were not included in the study. During the routine hepatitis B-vaccination injection given at postnatal 48 hours, the newborns' behavior was monitored and recorded by video camera. The data obtained from the recordings were evaluated according to the Neonatal Pain, Agitation, and Sedation Scale and analyzed with SPSS 20. Results: The median pain score of the group exposed to tobacco smoke in utero was 8.5, while the median pain score of the unexposed group was 6 (P<0.001). Conclusion: Exposure to tobacco smoke in utero may increase the pain-perception levels of newborns.Öğe Early detection of myocardial deformation by 2D speckle tracking echocardiography in normotensive obese children and adolescents(Turkish Soc Cardiology, 2015) Binnetoglu, Fatih Koksal; Yildirim, Sule; Topaloglu, Naci; Tekin, Mustafa; Kaymaz, Nazan; Aylanc, Hakan; Karakurt, HasanObjective: To evaluate the left venticular myocardial deformation parameters in normotensive obese children and adolescents by using 2-D speckle tracking echocardiography. Methods: This observational cross-sectional study included 69 children and adolescents (aged between 10-18), 38 were normotensive obese and 31 were normal weighted. All children underwent detailed two-dimentional, Doppler and two-dimentional speckle tracking echocardiography. Student t-test, Mann-Whitney U test, chi-square test and Pearson's correlation were used in statistical analysis. Multiple linear regression analysis was used the determine independent variables on global longitudinal strain (GLS). Results: While in normal limits, diastolic blood pressure was significantly higher in obese group. Left ventricular end-diastolic diameter (LVDd) and end-systolic diameter (LVDs), interventricular septal thickness (IVSd), left ventricular posterior wall thickness (LPWD) and left ventricular mass index (LVM)/height2.7 were significantly higher in obese group compared to healthy peers (p=0.004, p=0.011, p<0.001, p=0.001, p<0.001) respectively. Obese subjects had reduced global longitudinal strain (GLS) values (p=0.001). Multiple linear regression analysis using the stepwise method were performed to assess the independent variables (age, body mass index, insulin resistance, systolic blood pressure, diastolic blood pressure, left ventricular diameters and LVM index (g/m2.7) affecting the dependent variable GLS. GLS was found significantly correlated with body mass index (BMI) (beta:0.440, p:0.001; 95% CI:0.104-0.311). Conclusion: Left ventricular strain parameters obtained by two dimentional speckle tracking echocardiography were diminished in obese children compared to normal subjects indicating that obesity in childhood is linked to decreased myocardial deformation even in the absence of comorbidities in early stages.Öğe Effect of delivery mode on postpartum neonatal body temperatures(Taylor & Francis Ltd, 2016) Topaloglu, Naci; Binnetoglu, Fatih Koksal; Yildirim, Sule; Tekin, Mustafa; Kaymaz, Nazan; Aylanc, Hakan; Battal, FatihObjective: It is known that general and local anesthesia practices disrupt the delicate balance of thermoregulation center which is already sensitive to very tiny differences of temperatures in a normal subject. We aimed to evaluate and compare the rectal temperatures of newborns born with normal vaginal delivery and cesarean section.Methods: We performed a prospective study of 106 term newborn - 40 born with normal vaginal delivery (group 1) and 66 born with cesarean section [51 spinal anesthesia (group 2), 15 general anesthesia (group 3)]. Only term babies were included in the study. Babies of eclamptic, pre-eclamptic and diabetic mothers and babies with chronic systemic diseases were excluded. Pregnants who underwent elective cesarean section were included in the study. Adolescent pregnants, pregnants with increased risks and pregnants with complicated operations were excluded. Mothers' temperatures were measured before and after the interventions. Rectal temperatures of the babies were measured immediately after birth.Results: Environmental temperature was maintained at 22-24 degrees C. Pre-operative mother temperatures were 36.310.30 degrees C in group 1, 36.36 +/- 0.26 degrees C in group 2 and 36.39 +/- 0.19 degrees C in group 3 (p=0.414). Post-operative mother temperatures were 36.39 +/- 0.27 degrees C in group 1, 36.29 +/- 0.31 degrees C in group 2 and 36.25 +/- 0.28 degrees C in group 3 (p=0.215). Rectal temperatures of the babies born with normal vaginal delivery were significantly higher than the others. It was lowest in the general anesthesia group (37.5 +/- 0.6 degrees C, 37.2 +/- 0.2 degrees C and 36.8 +/- 0.4 degrees C in group 1, 2 and 3, respectively). The temperature differences between groups were statistically significant p<0.001).Conclusions: In conclusion, it is worthy to note that temperatures of the newborns can differ according to the delivery mode. Physicians and health professionals that take care of the newborns should be aware of this difference.Öğe Experimental Esophagitis Model Preventing Tracheal Aspiration(Wroclaw Medical Univ, 2015) Kiraz, Hasan A.; Erbas, Mesut; Kucuk, Adem; Topaloglu, Naci; Erdem, Havva; Sahin, Hasan; Toman, HuseyinBackground. Corrosive esophagitis injuries are a serious clinical problem with many agents used for diagnosis and treatment. Experimental esophagus burn models use a method described mainly in studies by Gehanno and Guedon, and modified by Liu and Richardson. Objectives. The aim of this study was to describe a new esophagitis model that prevents tracheal aspiration. Material and Methods. In this study we used 16 Wistar albino rats weighing between 220-240 g. The experimental animals were randomly divided into two groups: the model group (group M, n: 8) and control group (group C, n: 8). The necessary anesthesia was administered. Passing through a median laparotomy incision, the abdomen was entered and in group M and C the esophagus was freed and held by a suture at the gastroesophageal junction. After this procedure, about 1 cm proximal to the gastroesophageal junction, the esophagus was suspended by a suture. The esophagus segment between the two sutures was exposed to 0.1 mL 10% NaOH in group M and 0.1 mL saline in group C for 20 s. Ten days later all experimental animals were sacrificed and their esophagus removed. After dying with hematoxylin and eosine trichrome, the histopathological evaluation results for the rats in all groups were investigated with a light microscope. Results. Histopathological examination indicated submucosal collagen increase, damage to muscularis mucosa and tunica muscularis and collagen deposition. In the model group, the rats had high neutrophils and tissue damage accompanied by necrosis. In the control group, the rats had minimal or no tissue damage and fibrosis was not observed. Conclusions. Our procedure is relatively less invasive and easy to apply with corrosive esophagitis only in the required region, and at the same time treatment medications can be easily administered.Öğe Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats(Springer, 2015) Topaloglu, Naci; Kucuk, Adem; Yildirim, Sule; Tekin, Mustafa; Erdem, Havva; Deniz, MustafaGlucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 mu g GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P < 0.001), whereas GLP-2 pretreatment significantly decreased their levels (P < 0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.Öğe Health Related Quality of Life and the Quality of Sleep in School Aged Children with Functional Constipation(Taylor & Francis Inc, 2017) Yildirim, Sule; Kaymaz, Nazan; Tekin, Mustafa; Topaloglu, Naci; Binnetoglu, Fatih Koksal; Altinbas, Kursat; Asik, ZuhalThe aim of the present study was to investigate the sleep quality and health related quality of life in children with functional constipation. Fifty patients (7-13 years) attended to our general pediatric outpatient clinic and diagnosed with functional constipation and 50 healthy controls were enrolled in this case-control study. Health-related quality of life was assessed by using Kid-KINDL inventory and sleep quality was assessed by using PSQI. Children with functional constipation had lower scores of quality of life compared to healthy controls. Although the total score was not statistically significant the physical well-being scores of constipated children was significantly lower than control group. The Pittsburgh Sleep Quality Index score for children with functional constipation was significantly higher than controls (2.5 +/- 2.4 and 0.5 +/- 0.6, respectively; p < 0.05). School-aged children with functional constipation had lower quality of life and quality of sleep compared to their healthy peers. Physical well-being was especially impaired in constipated children affecting daily activities negatively. Assessment of quality of sleep as well as quality of life should be a part of management of functional constipation in childhood.Öğe Importance of Rectal Urgency in Childhood Irritable Bowel Syndrome(Korean Soc Neurogastroenterology & Motility, 2014) Topaloglu, Naci; Akbal, Erdem; Yildirim, Sule[Anstract Not Available]Öğe ISCHEMIA-MODIFIED ALBUMIN AS AN OXIDATIVE STRESS BIOMARKER IN OBESE CHILDREN(Nobel Ilac, 2015) Topaloglu, Naci; Yildirim, Sule; Tekin, Mustafa; Binnetoglu, Fatih Koksal; Cakir, Dilek Ulker; Erdem, Fehime; Cevizci, SibelObjective: Ischemia modified albumin (IMA) is a marker that is considered as an oxidative stress biomarker. In this study we investigated the IMA levels, an oxidative stress marker, in obesity that leads to free radical formation, in children. Material and Method: Fifty obese and fifty normal weighted children as a control were included in the study. Blood samples were collected for biochemical parameters and serum IMA values. Results: Serum IMA levels were significantly higher in obese group than non-obese group (p<0.001). Median and minimum-maximum IMA values of obese and control groups were 930 (min: 673-max 1332) and 864 (min: 496-max: 1068) respectively. Conclusion: IMA may be used as an important marker to show oxidative stress in childhood obesity.Öğe Knowledge, attitude and behavior of mothers related to acute respiratory infections(Edizioni Minerva Medica, 2016) Peker, Emel; Sahin, Erkan M.; Topaloglu, Naci; Uludag, Aysegul; Adaoglu, Hasret; Gungor, SelenBACKGROUND: The aim of this paper was to evaluate the level of knowledge and general attitude to acute respiratory diseases and behavior of antibiotic usage and related factors. METHODS: The study included 122 mothers of children between 2 and 16 years of age who applied the complaint of respiratory infections and experienced the respiratory infections previous year, to policlinics between January and May 2012. A survey form was used to evaluate the sociodemographic properties of the mothers, and the level of knowledge, attitude and behavior of mothers to childhood acute respiratory infections, fever and antibiotic use. RESULTS: Of the children, 58.1% applied with cough, and 40.9% applied with fever to the doctor. Before attendance 28.6% of mothers had used antibiotics and 27.8% antipyretics. The rate use of not prescribed antibiotics was 12.3%. Before medical evaluation of children, the use of a variety of traditional and alternative medical methods was at the high rate of 57.4%. The average attitude scores of mothers about the antibiotics use for acute respiratory infections fell into the category of being against antibiotic use and income level toward antibiotic use and a correlation between duration of mother's education against antibiotic use. CONCLUSIONS: We found that the level of knowledge of parents about medications used by their children was insufficient and there is a high percentage of non-prescription use of antibiotics. In low income and low education level of parents the use of antibiotics increased. Health workers must correctly inform parents about symptoms, course and medication. The effects of health education in the management of common diseases must be evaluated with studies.Öğe Mean Platelet Volume and Ischemia Modified Albumin Levels in Cord Blood of Infants of Diabetic Mothers(Elsevier Taiwan, 2014) Topaloglu, Naci; Yildirim, Sule; Tekin, Mustafa; Kaymaz, Nazan; Tutunculer, Funda; Ozdemir, Cem; Cosar, EmineBackground: Gestational diabetes mellitus (GDM) is a risk for the health of both the pregnant women and her infant. Its unfavorable effects start in utero and continue after birth. It is known that GDM increases oxidative stress and decreases antioxidant enzyme activities. In this study we aimed to investigate cord blood mean platelet volume (MPV) and ischemia-modified albumin (IMA) levels of infants of diabetic mothers (IDM). Methods: Twenty-nine pregnant women with GDM between 37 and 41 gestational weeks who gave birth by spontaneous vaginal delivery were enrolled as study participants together with 20 healthy pregnant women as a control group. Weight, length, and head circumference of babies were measured by the same standard tape immediately after birth. Five milliliters of umbilical venous blood were obtained to study MPV and IMA levels. Results: There was statistically significant difference in levels of MPV (p = 0.037) and IMA < 0.001) between groups. They increased in IDM compared with their healthy peers. Conclusion: Evaluation of MPV and IMA together is useful for representing the potential oxidative stress of IDM. Copyright (C) 2014, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Nitric oxide and asymmetric dimethyl arginine (ADMA) levels in an experimental hydronephrotic kidney caused by unilateral partial ureteral obstruction(Brazilian Soc Urol, 2016) Alan, Cabir; Kurt, Hasan Anil; Topaloglu, Naci; Ersay, Ahmet Resit; Cakir, Dilek Ulker; Basturk, GokhanAim: Our aim is to measure asymmetric dimethyl arginine and nitric oxide levels in rats with induced unilateral acute ureteral obstruction to research the effects on the kidney. Material and Methods: The study included 21 adolescent (average age 6 weeks) Sprague-Dawley male rats weighing between 240-290g divided at random into 3 groups. Group-1: Control group (n= 6): underwent no procedures. Group-2: Sham group ( n= 6): underwent the same procedures as the experimental group without ureter and psoas muscle dissection. Group-3: Group with induced partial unilateral ureteral obstruction (n= 9). All rats were sacrificed after 12 weeks. Superoxide dismutase enzyme activity and nitrite and nitrate salt levels were measured in renal tissue. Plasma nitrite-nitrate and ADMA levels were examined. Results: In the experimental group histopathological changes observed included renal pelvis dilatation, flattened papillae, sclerotic glomerulus and fibrosis. In the experimental group tissue SOD and blood ADMA levels were higher than the control and sham groups (p< 0.05) while tissue NO and plasma NO values were lower than in the sham and control groups (p< 0.05). Conclusion: Oxidative stress and disruption of NO synthesis play an important role in renal function and histopathological changes after obstructive renal disease. To prevent renal complications developing after obstructive nephropathy we believe that a new strategy may be research on reducing ADMA.
