Yazar "Tokmak, Mehmet" seçeneğine göre listele

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    Chronic Spinal Epidural Hematoma in an Adult
    (Modestum Ltd, 2015) Tokmak, Mehmet; Aras, Adem Bozkurt; Altiok, Inci Baltepe; Guven, Mustafa; Cosar, Murat
    Spinal epidural hematoma (SEH) causing neurological deficit is a rare clinical entity. It may have either traumatic origin or it may occur spontaneously. Majority of the reported cases of SEH had nontraumatic causes and most of them were in the acute stage. Early chronic traumatic SEH in an adult is very rare and its prompt diagnosis with magnetic resonance imaging (MRI) is crucial for the accurate management of the patient. Our case was 56 year-old man presented at our neurosurgery clinic with a complaint of progressive burning pain, weakness, paresthesia over the left leg and hypoesthesia over the pelvic region. In this report, we presented a postraumatic lumbar SEH which is a unique presentation of chronic traumatic SEH because of long time interval between the trauma and beginning of the symptoms.
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    Condensing osteitis of the clavicle in a man: Any relationship with tooth decay?
    (Pakistan Medical Assoc, 2014) Altiok, Inci Baltepe; Tokmak, Mehmet; Akman, Tarik; Alkan, Bahadir; Cosar, Murat
    Condensing osteitis of the clavicle is a rarely seen pathology since its first description in 1974. Although mechanical stress is claimed for aetiology, but remains a dilemma for physicians. The intermittent or steady pain is variable in intensity and generally localised at the medial end of the involved clavicle, supraclavicular fossa, ipsilateral anterior thorax and shoulder. In this report, we present a 28-year-old man with the regression of the condensing osteitis of the clavicle after the extraction of a decayed tooth.
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    Determining the Morphometry and Variations of the Confluens Sinuum and Related Structures Via a Silicone Painting Technique on Autopsy Patients
    (Lippincott Williams & Wilkins, 2014) Cosar, Murat; Seker, Askin; Ceylan, Davut; Tatarli, Necati; Sahin, Fevzi; Tokmak, Mehmet; Songur, Ahmet
    In this study, we aimed to investigate the morphometric and morphologic structures of the confluens sinuum (CS) and related structures with a silicone painting technique. We studied 30 cadavers. Twelve of them were washed with alcohol and filled with a silicone painting technique via the vena jugularis interna, internal carotid artery, and vertebral artery. The other 18 were autopsied postmortem. The CS and related structures were dissected under microscope. Their anatomy was investigated, and variations were noted. The diameters of the sinus sagittalis superior (SSS), CS, occipital sinus (OS), sinus rectus (SR), and bilateral transverse sinus (TS), and the angle between SSS and SR were measured. The mean diameters were 11.7 mm for SSS, 22.3 mm for CS, 5.25 mm for OS, 7.5 mm for SR, and 9.7 (right) and 9.1 mm (left) for TS. The angle between the SR and SSS was 58 degrees. There was no difference in the bilateral venous structures that drained to the SSS and TS. There was an extra drainage to the CS from the left side in 4 cases. The right TS was located superiorly in 7 cases compared with the left TS, and this process was correlated with the type of CS. A septum in the SSS was detected in 2 cases. In addition, we encountered an OS in 80% of the cases. We conclude that the septum inside the CS affects the dominancy of the TS, the angle between the SSS and SR, and the other venous variations.
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    Spontaneous Regression of Lumbar Disc Herniation After Weight Loss: Case Report
    (Turkish Neurosurgical Soc, 2015) Tokmak, Mehmet; Baltepe Altiok, Inci; Guven, Mustafa; Aras, Adem Bozkurt; Cosar, Murat
    Diagnosis, treatment, and surgery for lumbar disc herniations have existed for over a century. However, during the last three decades, there have been many new developments in imaging techniques, surgical procedures, physical medicine, and rehabilitation. In light of this, the most effective and appropriate treatment is controversial. Spontaneous regression of sequestrated, extruded, or protruded disc herniation has often been reported in the literature, although it is still a rare phenomenon. After a thorough review of the literature, we did not find any case report about this phenomenon after weight loss. In this report, though, we present a recent case about spontaneous regression of extruded disc herniation following weight loss.
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    The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model
    (2017) Tokmak, Mehmet; Sehıtoglu, Muserref Hilal; Yuksel, Yasemin; Güven, Mustafa; Akman, Tarık; Aras, Adem Bozkurt; Yaka, Umut
    AIm: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. mATERIAl and mEThODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. Ischemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESUlTS: Ischemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONClUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
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    The Axon Protective Effects of Syringic Acid on Ischemia/eReperfusion Injury in a Rat Sciatic Nerve Model
    (Turkish Neurosurgical Soc, 2017) Tokmak, Mehmet; Sehitoglu, Muserref Hilal; Yuksel, Yasemin; Guven, Mustafa; Akman, Tarik; Aras, Adem Bozkurt; Yaka, Umut
    AIM: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. MATERIAL and METHODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. lschemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESULTS: lschemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONCLUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
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    The Effect of Coumaric Acid on Ischemia-Reperfusion Injury of Sciatic Nerve in Rats
    (Springer/Plenum Publishers, 2015) Guven, Mustafa; Yuksel, Yasemin; Sehitoglu, Muserref Hilal; Tokmak, Mehmet; Aras, Adem Bozkurt; Akman, Tarik; Golge, Umut Hatay
    The aim of the study was to determine the effect of coumaric acid on sciatic nerve ischemia/reperfusion (SNI) injury in rats. The rats were randomly divided into four groups: control group (no medication or surgical procedure), SNI group, SNI + coumaric acid (CA) group, and SNI + methylprednisolone (MP) group. Ischemia was achieved by abdominal aorta clamping, and all animals were sacrificed 24 h after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. A significant decrease in MDA, an increase in NRF1 levels, and increase in SOD activity were observed in the groups which received coumaric acid and methylprednisolone when compared to the corresponding untreated group (p < 0.05). Ischemic fiber degeneration significantly reduced in the SNI + CA and SNI + MP groups, especially in the SNI + MP group, compared to the SNI group (p < 0.05). Beta amyloid protein expressions were significantly decreased in the SNI + CA group compared to the SNI group (p < 0.05). Our study revealed that coumaric acid treatment after ischemia/reperfusion in rat sciatic nerves reduced oxidative stress and axonal degeneration. Therefore, coumaric acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
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    The Neuroprotective Effect of Coumaric Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats
    (Springer/Plenum Publishers, 2015) Guven, Mustafa; Sehitoglu, Muserref Hilal; Yuksel, Yasemin; Tokmak, Mehmet; Aras, Adem Bozkurt; Akman, Tarik; Golge, Umut Hatay
    The main causes of spinal cord ischemia are a variety of vascular pathologies causing acute arterial occlusions. We investigated neuroprotective effects of coumaric acid on spinal cord ischemia injury in rats. Rats were divided randomly into four groups of eight animals as follows: control, ischemia, ischemia + coumaric acid, and ischemia + methylprednisolone. In the control group, only a laparotomy was performed. In all other groups, the spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. Levels of malondialdehyde and nuclear respiratory factor 1 were analyzed, as were the activity of superoxide dismutase. Histopathological and immunohistochemical evaluations were performed. Neurological evaluation was performed with the Tarlov scoring system. The ischemia + coumaric acid group was compared with the ischemia group, and a significant decrease in malondialdehyde and levels was observed. Nuclear respiratory factor 1 level and superoxide dismutase activity of the ischemia + coumaric acid group were significantly higher than in the ischemia group. In histopathological samples, the ischemia + coumaric acid group is compared with the ischemia group, and there was a significant increase in numbers of normal neurons. In immunohistochemical staining, hypoxia-inducible factor-1 alpha and NF-kappa B immunopositive neurons were significantly decreased in the ischemia + coumaric acid group compared with that in the ischemia group. The neurological deficit scores of the ischemia + coumaric acid group were significantly higher than the ischemia group at 24 h. Our results revealed for the first time that coumaric acid exhibits meaningful neuroprotective activity following ischemia-reperfusion injury of the spinal cord.
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    The Neuroprotective Effect of Coumaric Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats (vol 38, pg 1986, 2015)
    (Springer/Plenum Publishers, 2024) Guven, Mustafa; Sehitoglu, Muserref Hilal; Yuksel, Yasemin; Tokmak, Mehmet; Aras, Adem Bozkurt; Akman, Tarik; Golge, Umut Hatay
    [Anstract Not Available]
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    The Neuroprotective Effect of Syringic Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats
    (Springer/Plenum Publishers, 2015) Tokmak, Mehmet; Yuksel, Yasemin; Sehitoglu, Muserref Hilal; Guven, Mustafa; Akman, Tarik; Aras, Adem Bozkurt; Cosar, Murat
    Acute arterial occlusions via different vascular pathologies are the main causes of spinal cord ischemia. We investigated neuroprotective effects of syringic acid on spinal cord ischemia injury in rats. Rats were divided into four groups: (I) sham-operated control rats, (II) spinal cord ischemia group, (III) spinal cord ischemia group performed syringic acid, and (IV) spinal cord ischemia group performed methylprednisolone intraperitoneally. Spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. The spinal cord was removed after the procedure. The biochemical and histopathological changes were observed within the samples. Functional assessment was performed for neurological deficit scores. A significant decrease was seen in malondialdehyde levels in group III as compared to group II (P < 0.05). Besides these, nuclear respiratory factor-1 and superoxide dismutase activity of group III were significantly higher than group II (P < 0.05). In histopathological samples, when group III was compared with group II, there was a significant decrease in numbers of apoptotic neurons (P < 0.05). In immunohistochemical staining, BECN1 and caspase-3-immunopositive neurons were significantly decreased in group III compared with group II (P < 0.05). The neurological deficit scores of group III were significantly higher than group II at twenty-fourth hour of ischemia (P < 0.05). Our study revealed that syringic acid pretreatment in spinal cord ischemia/reperfusion reduced oxidative stress and neuronal degeneration as a neuroprotective agent. Ultrastructural studies are required for syringic acid to be developed as a promising therapeutic agent to be utilized for human spinal cord ischemia in the future.
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    The Neuroprotective Effect of Syringic Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats (vol 38, pg 1969, 2015)
    (Springer/Plenum Publishers, 2024) Tokmak, Mehmet; Yuksel, Yasemin; Sehitoglu, Muserref Hilal; Guven, Mustafa; Akman, Tarik; Aras, Adem Bozkurt; Cosar, Murat
    [Anstract Not Available]