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    Öğe
    Çanakkale Onsekiz Mart üniversitesi Hematoloji Bilim Dalı'na başvuran hematolojik maligniteli hastaların retrospektif olarak değerlendirilmesi
    (Çanakkale Onsekiz Mart Üniversitesi, 2021) Tok, Burak; Acar, Celal
    Giriş ve Amaç: Çalışmamızda; hastanemize tanı, tedavi veya takip amaçlı başvuran hematolojik maligniteli hastaların sıklığının cinsiyet, yaş ve tanıya göre dağılımının saptanması, hastalara eşlik eden kronik hastalıkların, hastaların yaşam sürelerinin ve hayatta kalma durumlarının belirlenmesi amaçlandı. Materyal-Metod: Çanakkale Onsekiz Mart Üniversitesi Uygulama ve Araştırma Hastanesi Hematoloji Bölümü'ne Mart 2019- Temmuz 2020 tarihleri arasında başvuran veya tanı konulan hematolojik maligniteli hastalar retrospektif olarak incelenmiştir. Bulgular: Çalışmamızda hematolojik maligniteli toplam 411 olgunun 191 tanesi (%46) kadın, 220 tanesi (%54) erkek olarak saptanmıştır. Tanı alan 48 hasta hayatta değildir. Toplamda ölüm oranı %11,7'dir. Hematolojik maligniteli olguların %1'ini ALL, %4'ünü AML, %4'ünü HL, %21'ini NHL, %18'ini plazma hücre diskrazisi, %7'sini MDS ve %33'ünü kronik miyeloproliferatif hastalıklar oluşturmaktadır. En sık NHL alt tipi DBBHL iken en sık görülen KMPH alt tipi ise esansiyel trombositoz olarak saptandı. Hematolojik malignitelere en sık eşlik eden kronik hastalığın ise hipertansiyon olduğu görüldü. Sonuç: Mevcut bilgilerimize göre ülkemizde ve bölgemizde hematolojik maligniteler konusunda düzenli istatistiksel veriler bulunmamaktadır. Biz bu çalışmada; az sayıda hastaya rağmen Çanakkale ve yakın çevresindeki hematolojik hastalıkların sıklığını saptamayı ve bu verilerin literatür ile uyumlu olup olmadığını saptamayı hedefledik. Sonuç olarak; hematolojik malignitelerin görülme sıklığının daha doğru belirlenebilmesi için daha fazla sayıda hasta içeren epidemiyolojik çalışmalara ihtiyaç duyulmaktadır. Anahtar Kelimeler: Hematolojik malignite, retrospektif çalışma, kronik hastalık, istatistik, epidemiyoloji.
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    Öğe
    THE EFFECT OF CALISTHENIC EXERCISES ON SOME PHYSICAL PARAMETERS AND MUSCLE STRENGTH IN WOMEN WHO UNDERWENT MASTECTOMY
    (2025) Umay, Büşra; Eroğlu, Şeyma; Tok, Burak; Koç, Hürmüz
    This study was conducted to determine the effects of calisthenic exercises on certain physical parameters and muscle strength in women who have undergone mastectomy surgery. A total of 30 women, aged between 40 and 60 years, who were receiving post-mastectomy treatment at Çanakkale Onsekiz Mart University Training and Research Hospital, voluntarily participated in the study. Participants were selected using a simple random sampling method. Individuals deemed eligible for measurements by a specialist oncologist were included in the study. Institutional permission and ethical approval were obtained from the Faculty of Medicine at Çanakkale Onsekiz Mart University. The participants’ ages were determined based on official identification. Measurements included height, body weight, body fat percentage, circumference measurements, handgrip strength, leg and back strength. The results were presented as arithmetic means (x?) and standard deviations (sd). Independent samples t-test was used to determine differences between groups. The level of significance was set at p<0.05. According to the findings, differences in body mass index, body fat percentage, waist circumference, waist-to-hip ratio, back strength, and relative strength values were statistically significant between the groups (p<0.05). Although numerical differences were observed in other variables, these were not statistically significant (p>0.05). In conclusion, the more favorable values observed in certain physical characteristics and strength parameters among women who engaged in calisthenic exercises after mastectomy suggest that calisthenic resistance exercises may have a positive impact on muscular system function.
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    Öğe
    The Levels of Serum Mg, NO and IMA in Chronic Kidney Disease
    (2020) Bakırdöğen, Serkan; Demir, Sabire Ceren; Türkon, Hakan; Çakir, Dilek Ülker; Tok, Burak
    NTRODUCTION: In chronic kidney disease (CKD) patients, serum levels of ischemia-modified albumin (IMA), are found to be higher compared to the normal population. As oxidative stress increases, nitric oxide (NO) production reduces linked to endothelial dysfunction. Magnesium (Mg) increases NO production by endothelium. The aim of the study was to compare serum IMA, NO, and Mg levels in patients with CKD (stage 1-4).METHODS: The study included 29 CKD patients with stage 1-4. Additionally, a control group comprised 40 healthy volunteers. Serum IMA, NO, and Mg testing was performed in both groups. Serum Mg was analyzed with the colorimetric method, IMA was analyzed with the rapid colorimetric method, while NO was analyzed with ELISA. Statistical significance was accepted as p < 0.05.RESULTS: Serum IMA levels were significantly higher in the patient group than in the control group. (p=0.023), while there were no differences between the groups in terms of serum NO and Mg (p>0.05). In the patient group a statistically significant and positive correlation was identified betweenserum IMA and NO (p=0.023, r=0.421). There was no statistically significant correlation between serum IMA and Mg (p=0.96). There was a statistically significant and negative correlation between serum NO and Mg (p=0.02, r=-0.43).DISCUSSION AND CONCLUSION:Examination of the serum NO and Mg levels in CKD patients (stage 1-4) was not found to be beneficial to predict oxidative stress.