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    Clinical and Demographic Characteristics and Two-Year Efficacy and Safety Data of 508 Multiple Sclerosis Patients with Fingolimod Treatment
    (Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2023) Terzi, Murat; Helvaci, Elif Merve; Sen, Sedat; Boz, Cavit; Cilingir, Vedat; Akcali, Aylin; Beckmann, Yesim
    Introduction: Fingolimod is the first oral immunomodulatory treatment used as secondary care therapy in the treatment of multiple sclerosis for the last 10 years. The objective of our study is to reveal the experiences of the first generic fingolimod active ingredient treatment in different centers across Turkey. Method: The first generic fingolimod efficacy and safety data of patients followed-up in 29 different clinical multiple sclerosis units in Turkey were analyzed retrospectively. Data regarding efficacy and safety of the patients were transferred to the data system both before the treatment and on the 6th, 12th and 24th month following the treatment. The data were analyzed using the IBM SPSS 20.00. P value of <0.05 was considered to be statistically significant. Results: A total of 508 multiple sclerosis patients, 331 of whom were women, were included in the study. Upon comparing the Expanded Disability Status values before and after the treatment, a significant decrease was observed, especially at month 6 and thereafter. Since bradycardia occurred in 11 of the patients (2.3%), the first dose had to be longer than 6 hours. During the observation of the first dose, no issues that could prevent the use of the drug occured. Side effects were seen in 49 (10.3%) patients during the course of fingolimod treatment. Respectively, the most frequent side effects were bradycardia, hypotension, headache, dizziness and tachycardia. Conclusion: The observed results regarding efficacy and safety were similar to clinical trial data in the literature and real life data in terms of the first equivalent with fingolimod active ingredient.
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    Öğe
    Clinical and Demographic Characteristics and Two-Year Efficacy and Safety Data of 508 Multiple Sclerosis Patients with Fingolimod Treatment (vol 60, pg 23, 2023)
    (Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2023) Terzi, Murat; Helvaci, Elif Merve; Sen, Sedat; Boz, Cavit; Cilingir, Vedat; Akcali, Aylin; Beckmann, Yesim
    [Anstract Not Available]
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    Öğe
    Corrigendum to “The role of oligoclonal band count and IgG index in treatment response and disease activity in multiple sclerosis” [Multiple Sclerosis and Related Disorders 83 (2024) 105391]
    (Elsevier Sci Ltd, 2025) Taşkıran, Esra; Terzi, Murat; Helvacı, Elif Merve; Eser, Meltem Zeycan; Avcı, Bahattin; Faruk, Turan Ömer; Yetkin, Mehmet Fatih; Çam, Mustafa
    [No abstract available]
  • [ X ]
    Öğe
    The role of oligoclonal band count and IgG index in treatment response and disease activity in multiple sclerosis
    (Elsevier Sci Ltd, 2024) Taskiran, Esra; Terzi, Murat; Helvaci, Elif Merve; Eser, Meltem Zeycan; Avci, Bahattin; Faruk, Turan Omer; Yetkin, Mehmet Fatih
    Background/aim: Multiple sclerosis (MS) is an inflammatory demyelinating central nervous system (CNS) disease. Among the paraclinical tests, brain and spinal Magnetic Resonance Imaging (MRI) is primarily involved in the diagnosis process, and cerebrospinal fluid (CSF) analysis is fundamental in diagnosing MS and the differential diagnosis. A positive relationship was demonstrated between oligoclonal band (OCB) positivity, CSF band number and immunoglobulin G(IgG) index. The study aimed to evaluate whether the number of OCB can predict disease activity and determine a correlation with the IgG index. Methods: Our study included 401 MS patients who had relapsing-remitting multiple sclerosis (RRMS), primary progressive multiple sclerosis (PPMS), secondary progressive multiple sclerosis (SPMS), clinic isolated syndrome (CIS), radiologic isolated syndrome (RIS), Neuromyelitis optica spectrum disorder (NMOSD) and Acute disseminated encephalomyelitis (ADEM) with OCB number groups of 2-4, 4-8, 8-12, and 12 and above. Results: No significant correlation was observed between IgG index, pre-and post-treatment EDSS (Expanded Disability Status Scale Scores) and disease-modifying therapies (DMT). Drug response was better in the patient group with band number between 2 and 8 and post-treatment EDSS scores were lower (1.62 +/- 0.44). Conclusion: The study results suggested that band number may be as valuable as the IgG index and a predictive biomarker for disease activity.