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Öğe Assessment of left atrial functions in cardiac syndrome X(Verduci Publisher, 2015) Kuzeytemiz, M.; Tenekecioglu, E.; Yilmaz, M.; Senturk, M.; Demir, S.; Bekler, A.; Aslan, B.OBJECTIVE: Cardiac syndrome X (CSX) affects left ventricular functions due to myocardial ischaemia. In this study our aim was to determine the changes in left atrial functions in patients with CSX. PATIENTS AND METHODS: One-hundred patients (M/F; 57/43) diagnosed with CSX in whom ischaemia was detected at exercise test and myocardial perfusion scintigrapghy with normal coronary angiogram and control group of 80 subjects (M/F; 40/40) were recruited into the study. In transthoracic echocardiography and tissue doppler echocardiography, left ventricular and atrial functions were recorded. RESULTS: As compared to control group, left ventricular diastolic functions were impaired (E/A; 0.95 +/- 0.18 vs 1.11 +/- 0.29 p < 0.001), left ventricular end-diastolic pressures were increased (E/Em; 8.1 +/- 1.85 vs 6.9 +/- 1.74 p < 0.05), and left atrial maximum volume, left atrial pre-A volume, left atrial minimum volume were increased in patients with CSX. Left atrial conduit volume was significantly decreased in patients with cardiac syndrome. Left atrial passive emptying volume (LAPEV), left atrial active emptying volume (LAAEV) and left atrial total emptying volume (LATEV) were significantly increased in patients with cardiac syndrome X. Left atrial passive ejection fration (LAPEF) was found similar between the study groups. Left atrial active ejection fraction (LAAEF) was found significantly increased (37.85 +/- 11.89 vs 33.60 +/- 9.21; p = 0.009) in patients with CSX. Left atrial total ejection fraction (LATEF) was increased in the group with cardiac syndrome X but it didn't reach statistical significance (60.85 +/- 8.73 vs 58.36 +/- 8.29; p = 0.054). CONCLUSIONS: Left atrial active contractile pump function increase in response to impaired left ventricular diastolic functions in CSX. Increased left atrial pump function represents a compensatory mechanism in patients with CSX. These results point out the importance of maintaining sinus rythm in patients with CSX.Öğe Elevated Platelet-Lymphocyte Ratio Predicts Left Ventricular Systolic Dysfunction in Patients Non ST-Elevated Acute Coronary Syndrome(Excerpta Medica Inc-Elsevier Science Inc, 2014) Bekler, A.; Gazi, E.; Yilmaz, M.; Tenekecioglu, E.; Temiz, A.; Barutcu, A.; Altun, B.[Anstract Not Available]Öğe HDL-cholesterol is associated with systemic inflammation in cardiac syndrome X(Edizioni Minerva Medica, 2015) Tenekecioglu, E.; Yilmaz, M.; Demir, S.; Bekler, A.; Ozluk, O. A.; Aydin, U.; Goncu, T.Aim. Microvascular inflammation is associated with cardiac syndrome X (CSX). High-density lipoprotein cholesterol (HDL-C) reveals antiatherogenic features with stimulating endothelial NO production, inhibiting oxidative stress and vascular inflammation. We investigated relationship between HDL-C and inflammatory markers in CSX. Methods. Hundred patients with CSX and control group of 80 subjects were evaluated. Hematologic indices, lipid levels and C-reactive protein (CRP) levels were studied in patients underwent coronary angiography. Results. CRP levels were higher in CSX group than control group (4.59 +/- 3.82 mg/dL vs. 2.48 +/- 1.32 mg/dL, P<0.001). HDL-C was significantly lower in CSX group compared to control group (36.5 +/- 4.0 mg/dL vs. 47.5 +/- 12.7 mg/dL, P=0.008). White blood cell (WBC) count was higher in CSX group than in control group. Neutrophil-lymphocyte ratio (NLR) was found significantly increased in CSX group as compared to control group. On multivariate linear regression, lower HDL-C was found to be a significant predictor of higher NLR in patients with CSX independent from other clinical and biochemical variables. Conclusion. Lower HDL-C is associated with systemic inflammation in CSX. In patients with typical angina and normal epicardial coronaries,HDL-C and inflammatory markers should be investigated; one of the goals of treatment should be raising HDL-C.Öğe Relationship Between Presence of Fragmented QRS on Admission and Long Term Mortality in Patients with Non ST-Elevated Myocardial Infarction(Excerpta Medica Inc-Elsevier Science Inc, 2014) Bekler, A.; Gazi, E.; Erbag, G.; Tenekecioglu, E.; Temiz, A.; Barutcu, A.; Altun, B.[Anstract Not Available]
