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    A case of IVIG-resistant Kawasaki disease with gallbladder hydrops
    (OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2015) Yildirim, Şule; Binneto?lu, Fatih Köksal; Tekin, Mustafa; Battal, Fatih; Aylanç, Hakan; Aylanç, Nilüfer; Kaymaz, Nazan
    Kawasaki Disease is an acute systemic vasculitis of childhood affecting small and medium-sized arteries particularly coronary arteries. Intravenous immunoglobulin therapy decreases the major cardiovascular complication of the disease. Atypical clinical conditions may accompany to the disease and these cases seem to be more prone to intravenous immunoglobulin resistance which is an important problem in the management of the cases. Herein, we presented a case of 4-year-old boy admitted to our emergency department with fever of 5 days duration and diagnosed as Kawasaki disease based on the clinical, laboratory and imaging findings. He was resistant to intravenous immunoglobulin treatment and in the follow up resulting abdominal tenderness was explained by gallbladder hydrops. Copyright © 2015 by Türkiye Klinikleri.
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    A case with short stature, growth hormone deficiency and 46, XX, XQ27-qter deletion
    (Medical Sciences University of Teheran, 2017) Yıldırım, Şule; Topaloğlu, Naci; Tekin, Mustafa; Sılan, Fatma
    We report a case of 11-year-old girl with growth retardation and 46, XX, Xq27-qter deletion. The endocrinologic evaluation revealed growth hormone deficiency. In karyotype analysis 46, XX, Xq27-qter deletion was determined. The deletion of terminal region of chromosome 27 is most commonly being detected during the evaluation of infertility, premature ovarian insufficiency or in screening for fragile X carrier status. To our knowledge, this is the first reported case with 46, XX, Xq27-qter deletion and growth hormone deficiency. Furthermore, this case might facilitate future search for candidate genes involved in growth hormone deficiency. © 2017 Tehran University of Medical Sciences. All rights reserved.
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    A comparative study on the effects of presenting on the acquisition of English vocabulary by Turkish new words in semantically related sets learners of English at a primary school
    (Çanakkale Onsekiz Mart Üniversitesi, 2004) Tekin, Mustafa; Erten, İsmail Hakkı
    İÜ ÖZET Bu çalışma yabancı dil öğretiminde yeni sözcüklerin farklı teknikler kullanılarak, yani anlam bakımından birbiriyle bağlantılı veya bağmtısız (karışık) gruplar biçiminde sunulması ile öğrencilerin bu sözcükleri Öğrenmedeki başarısı arasındaki ilişkiyi araştırmıştır. Dahası, çalışma anlamsal kelime ağlarının (semantic clusters) kelime öğretimindeki etkisi konusunda daha fazla bilgi sahibi olmayı hedeflemiştir. Ayrıca yeni öğrenilen bir kelimenin uzunluğunun, bu kelimenin hafızada tutulmasına etkisi de incelenmiştir. Son olarak, bu çalışma, anlamsal bağıntı içinde ve bağmtısız (karışık) gruplar halinde sunulan sözcüklerin hatırlanma sürelerine bazı çıkarımlar elde etmek amacıyla odaklanmıştır. Araştırma, Çanakkale'de bir devlet ilköğretim okulunun dördüncü sınıf öğrencileri ile yürütülmüştür. Veriler nitel ve nicel araştırma yöntemleri kullanılarak elde edilmiş olup, her bir uygulamanın öncesinde ve sonrasında verilen testler nicel bir yapıya sahiptir ve araştırma sonunda verilen anket ise nitel bir tekniktir. Araştırmada ayrıca bir zaman tutma süreci de uygulanmıştır. Bu şekilde toplanan veriler, daha sonra SPSS (Statistical Package for the Social Sciences) gibi bilgisayar programlan yardımıyla değerlendirilip yorunılanmıştır. Çalışma sonuçlan ortaya çıkarmıştır ki, genel inanışın aksine, yeni sözcükleri anlam bakımından bağıntılı gruplar halinde sunmak gerçekten iyi bir kelime öğretim yöntemi değildir; çünkü, öğrenciler yeni sözcükleri karışık gruplar şeklinde öğrendiklerinde, anlamsal bağıntılı gruplar halinde öğrendikierinden daha başarılı olmaktadırlar. Dahası, testler sırasında uygulanan zaman tutma süreci yoluyla toplanan veriler şu gerçeği göstermiştir ki, öğrenciler için anlam grupları şeklinde sunulan kelimelerin testlerini tamamlamak, anlam bakımından bağıntılı olmayan kelimelerin testlerine kıyasla daha uzun zaman almaktadır. Buna rağmen, geciktirilmiş testlerin sonuçları açığa çıkarmıştır ki, anlamsal gruplar halinde sunulan kelimeler bir kere hafizaya kodlandığında daha kalıcı olmakta ve daha zor unutulmaktadır. Son olarak, çalışmada kullanılan sözcüklerin analizi sonucunda, öğrencilerin büyük kısmının uygulama sonrasında verilen ankette kısa kelimeleriiv daha kolay hatırladıklaraü söylemelerine rağmen, bir kelimenin uzunluğu ile o kelimenin hatırlanması arasında bariz bir ilişki olmadığı sonucuna varmıştır. Sonuç olarak, bu çalışma yabancı dilde kelime öğretiminde farklı tekniklerin kullanılmasına ışık tutmuş; diğer bir ifadeyle, yeni kelimelerin anlam bağıntılı veya bağıntısız sunulması ile onların öğrenilmesi arasındaki ilişkiyi aydınlatmıştır. Bulgular göstermiştir ki, her tekniğin kendine has avantajları ve dezavantajları vardır: yeni kelimeler anlam bağıntılı gruplar halinde sunulduğunda, kısa vadede daha yavaş öğrenilmekte fakat daha kalıcı olmakta; diğer taraftan anlam bakımından bağıntısız kelime grupları şeklinde öğretildiğinde ise kısa vadede daha hızlı ve iyi öğrenilmekte ancak uzun vadede daha kolay unutulmaktadır. Ayrıca, öğrenciler uzun kelimelere kıyasla, kısa kelimelerin öğrenilmesini daha kolay bulmaktadırlar. Bu bulgular ışığında çalışma, Öğretmen ve öğrencilerin amaç ve hedeflerine en uygun yöntemi seçmelerine yardımcı olmak için bu avantaj ve dezavantajların farkma varmalarını sağlamayı hedeflemektedir.
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    A Rare Case of Cystinosis Presenting with Alkalosis
    (Taylor & Francis Ltd, 2013) Topaloglu, Naci; Tekin, Mustafa; Yildirim, Sule; Gencer, Baran
    A 14-month-old girl was admitted to our clinic due to failure to thrive. Her weight and height were below the third percentile for age. Laboratory examination showed signs of alkalosis, hypokalemia, and hypochloremia. However, her urinalysis was consistent with renal tubular acidosis. Radiologic examination showed signs of active rickets. Based on clinical and laboratory findings, we focused on the probable diagnosis of cystinosis. Slit-lamp examination of the cornea confirmed our diagnosis. We should note that the presence of alkalosis does not exclude the possibility of diagnosis of cystinosis and we should be aware that if any slight doubt of cystinosis exists, patients should be carefully and completely evaluated for diagnosis.
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    A Study on Preferred Learning Styles of Turkish EFL Teacher Trainees
    (Edith Cowan Univ, 2015) Inal, Sevim; Buyukyavuz, Oya; Tekin, Mustafa
    Since people have different ways of perception, levels of motivation, and attitudes towards teaching and learning they consistently differ from each other in their preferences of learning and acquiring knowledge. Therefore, the more instructors understand the differences, the better chance they have of understanding and meeting the diverse learning needs of their students. The present study has been conducted to investigate the Turkish ELT students' learning style preferences in relation to gender and age to see if there is any relationship between achievement and learning style preferences. To perform the aim of the study Wintergerst and DeCapua's (1999) learning style indicator (LSI) was administered on 249 English trainees. To find the male and female students' learning style preference differences separately, t-test was utilized. The result indicated that Turkish students are mostly group-oriented learners and learn best through interacting with other students while learning. Gender also varies according to the three orientation areas under investigation. In the current study, no relation between achievement and learning style has been identified.
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    Akut Gastroenteritli Çocuklarda Rotavirüs Sıklığı
    (Çanakkale Onsekiz Mart Üniversitesi, 2014) Tekin, Mustafa; Topaloğlu, Naci; Yıldırım, Şule; Binnetoğlu, Köksal; Kaymaz, Nazan; Aylanç, Hakan; Battal, Fatih; Vural, Ahmet; Başer, Esra
    Viral gastroenteritlerin ve özellikle rotavirüse bağlı ishallerin epidemiyolojik ve klinik özelliklerinin takip edilmesi ve buna göre korunma ve tedavi stratejilerinin geliştirilmesi önemlidir. Bu nedenle biz de kliniğimize akut ishal nedeniyle başvuran olgularda rota virüs ishallerini araştırdık. 2011-2013 tarihleri arasında ÇOMÜ Tıp Fakültesi Hastanesi çocuk polikliniği ve acil servisine akut ishal nedeniyle baş vuran ve dışkı örnekleri incelenen 263 olgunun hastane kayıt verileri geriye dönük olarak tarandı. Dışkı örnekleri, kalitatif monoklonal antikorlarla kaplanmış kromatografik immunoassay yöntemi ile çalışan ticari bir test kiti (Rota-Adeno Virus Combo Test Device, Ecotest, Çin) ile incelenmişti. Toplam 263 akut ishalli olgu dosyası incelendi. Rota antijen pozitifliği bütün olguların 62’sinde (%23,6) saptandı. 2 yaş altı çocuklarda sıklık %34,5 olarak saptandı. Rota pozitifliğinin mevsimlere göre sıklığı sırasıyla ilkbaharda %27,8, yazın %14,6, sonbaharda %26,3 ve kışın %21,4 idi. Sonuç olarak akut ishalli olgu yönetimi yaşa ve mevsime göre yapılmalıdır. Bu tür ishalli olgularda gerekirse hızlı tanı testleri kullanılarak gereksiz antibiyotik kullanımından kaçınılmalıdır.
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    Alternative treatment applications in children with respiratory tract infections in the West of Turkey
    (Galenos Yayincilik,, 2013) Topalo?lu, Naci; Yildirim, Şule; Tekin, Mustafa; Uluda?, Ayşegül; Özgen, Kenan
    Introduction: It is known that the trend toward alternative treatments is increasing each day regardless of the differences between communities. We aimed to detect alternative treatments in our region and to determine the thoughts of families about these treatments. Materials and Methods: A total of 214 patients presenting to General Pediatrics Outpatient Clinics of Çanakkale Onsekiz Mart University Teaching and Research Hospital between October 2012 and February 2012 with fever, coughs, sore throat, wheezing and diagnosed as upper or lower respiratory tract infection and their parents are included in the study. Results: A total of 93.7% of parents were using non-drug applications with varying frequencies. Alternative practices are being used prior to drug treatment (62.7%), with drugs (28.7%), when there is no response to drugs (6.7%) or never (1.9%). Most common used applications to reduce cough was to give pure honey (30.6%) and the most common application to lower the fever was to use warm shower (48.1%). Most common source of information for these applications was relatives and family members. It was shown that the most requested resources to get information were doctors, nurses and other health care professionals with 84.5%. There was statistically signifi cant correlation between educational status and frequency of usage of non-drug applications. However, requested source of information did not change according to the educational status. Conclusions: As a result we thought that doctors and nurses dealing with child health and disease should obtain information about alternative treatments and help the parents about logical managements. © The Journal of Current Pediatrics, published by Galenos Publishing.
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    Association between teething and independent walking in healthy children
    (Turkish J Pediatrics, 2015) Kaymaz, Nazan; Yildirim, Sule; Cevizci, Sibel; Cimen, Mehmet; Topaloglu, Naci; Binnetoglu, Fatih Koksal; Tekin, Mustafa
    Developing teeth provide a reliable indication of maturation and biological age. The objective of this study was to establish whether there is any association between the time of emergence of the first primary tooth and the time when independent walking occurs. A cross-sectional study was conducted with a sample of 206 healthy children (95 girls and 111 boys) aged 12 to 60 (mean: 29.79 +/- 0.66) months who were able to walk independently. The study was conducted using a questionnaire that was filled out by the parents. The first primary tooth emerged at 6.86 +/- 0.14 (min: 3-max: 13) months; the mean independent walking time was 12.58 +/- 2.15 (min: 8.50-max: 24.00) months. There was no correlation between the first teething and independent walking times (r=0.045, p=0.523). Factors such as breastfeeding status, intake of vitamins, walker usage and body mass index were found not to affect the time of either emergence of the first deciduous tooth or independent walking. To the best of our knowledge, this is the first paper in literature to have researched the relationship between the time of emergence of the first deciduous tooth and that of independent walking. It should be explained to parents that there is no relationship between the two in order to resolve anxiety when their child acquires a tooth but does not walk, or vice versa.
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    Benign Acute Childhood Myositis due to Toxoplasmosis
    (All India Inst Medical Sciences, 2016) Yildirim, Sule; Battal, Fatih; Aylanc, Hakan; Tekin, Mustafa; Kaymaz, Nazan; Binnetoglu, Fatih Koksal; Topaloglu, Naci
    [Anstract Not Available]
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    Bronşta diş: Anamnez ve akciğer grafisinin önemi
    (2015) Battal, Fatih; Aylanç, Hakan; Bahadır, Gökhan Berktuğ; Tekin, Mustafa; Yıldırım, Şule
    Çocuklarda kronik öksürüğün nadir nedenlerinden birisi de bronşta yabancı cisim bulunmasıdır. Dokuz yaşında kız hasta, altı aydır süren öksürük şikayeti ile başvurdu. Anamnezde hastanın dişini yuttuğunu daha önce başvurduğu merkezlerde ifade etmesine rağmen astım ve pnömoni tanısı aldığı ve ilaçlarla şikayetlerinin geçmediği ve herhangi bir tetkik yapılmadığı öğrenildi. Fizik muayenesinde dinlemekle sağda ekspiryum uzunluğu olup sağ hemitoraksta dinlemekle solunum sesi azalmıştı. Kan tetkiklerine hafif lökositoz dışında özellik yoktu. Akciğer grafisinde sağ bronşial alanda opak görünümü mevcuttu. Hasta bu bulgularla solunum yolunda yabancı cisim tanısı aldı. Çocuk cerrahisine konsülte edildi ve bronkoskopi yapıldı. Sağ bronştan bir adet molar diş çıkartıldı. Öksürük şikayeti müdahale sonrasında gerileyen hastanın takiplerinde şikayeti tekrarlamadı. Olgu kronik öksürük şikayeti ile başvuran okul çağı çocuğunda anamnezin, fizik muayenenin ve akciğer grafisinin ne kadar önemli olduğunu vurgulamak amacıyla sunulmuştur.
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    Correlation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsion
    (Kare Publ, 2016) Yildirim, Ahmet; Yildirim, Sule; Topaloglu, Naci; Tekin, Mustafa; Kucuk, Adem; Erdem, Havva; Erbas, Mesut
    Objectives: Ischemia modified albumin (IMA) levels significantly increased and may be used as a diagnostic marker in ovarian torsion. The aim of this study is to investigate whether there was any correlation between IMA levels and histopathologic changes in experimental ovarian torsion. Material and methods: Fourteen Sprague-Dawley rats, each weighing 220-250 g were divided randomly into 2 groups; in Group 1, the control group (n = 7), only laparotomy was performed and in Group 2, the experimental group (n = 7), ovarian torsion was performed. Ischemia was performed for 3 h; following the ischemia period, the torsion was relieved by detwisting the adnexa and then the ovarian I/R protocol was applied for 3 h. Blood samples were taken from all of the rats to measure the IMA levels and the ovaries were surgically removed for histologic examination. A blinded pathologist examined and scored the samples. Results: The median (minimum-maximum) IMA values were 921.00 (870.00-966.00) ABSUs in the ovarian torsion group and 853.00 (782.00-869.00) ABSUs in the control group. The difference was statistically significant. In the correlation analysis, a significant and strong correlationwas found between IMA levels and histopathologic changes (Spearman's rho = vertical bar 0.987, p < 0.001). Conclusion: Positive correlation was found between the IMA levels and the histopathologic severity of the disease. This finding is important for both diagnosis of the disease and patient follow-up. As a new marker in ovarian torsion, IMA may also indicate the severity of the ovarian histopathology. Copyright (C) 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner.
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    Do we really ponder about necessity of intravenous hydration in acute bronchiolitis?
    (Corporacion Editora Medica Valle, 2016) Yildirim, Sule; Kaymaz, Nazan; Topaloglu, Naci; Binnetoglu, Fatih Koksal; Tekin, Mustafa; Aylanc, Hakan; Battal, Fatih
    Objective: The goal was to establish the role of intravenous hydration therapy on mild bronchiolitis. Methods: This was a retrospective case control study. Infants between 1 month and 2 years of age admitted to our general pediatrics ward between June 2012 and June 2013 with a diagnosis of uncomplicated acute bronchiolitis were enrolled to the study. Hospital medical files were reviewed to get information about children personal history, symptoms of the disease, disease severity scores and their management. Patients were classified into 4 groups according to the management; nebulized short-acting beta 2-agonist (salbutamol) +hydration; nebulized short-acting beta 2-agonist (salbutamol); hydration and neither bronchodilator nor hydration. We examined length of stay in the hospital as an outcome measure. Results: A total of 94 infants were studied. There was no significant difference between groups in terms of length of stay in hospital. Conclusions: IV hydration is not effective on length of stay in hospital in mild acute bronchiolitis patients.
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    Does intrauterine tobacco exposure increase the pain perception of newborns?
    (Dove Medical Press Ltd, 2016) Tekin, Mustafa; Yildirim, Sule; Aylanc, Hakan; Kaymaz, Nazan; Battal, Fatih; Topaloglu, Naci; Baser, Esra
    Background: This study aimed to assess whether there was a difference in the pain-perception levels of newborns born to mothers who smoked during pregnancy and newborns born to mothers who were not exposed to active or passive smoking during pregnancy. Materials and methods: A total of 60 newborns born by normal spontaneous vaginal birth between June 2013 and June 2014 were included in the study: 30 born to mothers who smoked during pregnancy, and 30 born to mothers not exposed to smoking. Mothers or newborns who had taken analgesics or sedative medications in the previous 24 hours, newborns not born at term, and sick newborns were not included in the study. During the routine hepatitis B-vaccination injection given at postnatal 48 hours, the newborns' behavior was monitored and recorded by video camera. The data obtained from the recordings were evaluated according to the Neonatal Pain, Agitation, and Sedation Scale and analyzed with SPSS 20. Results: The median pain score of the group exposed to tobacco smoke in utero was 8.5, while the median pain score of the unexposed group was 6 (P<0.001). Conclusion: Exposure to tobacco smoke in utero may increase the pain-perception levels of newborns.
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    Early detection of myocardial deformation by 2D speckle tracking echocardiography in normotensive obese children and adolescents
    (Turkish Soc Cardiology, 2015) Binnetoglu, Fatih Koksal; Yildirim, Sule; Topaloglu, Naci; Tekin, Mustafa; Kaymaz, Nazan; Aylanc, Hakan; Karakurt, Hasan
    Objective: To evaluate the left venticular myocardial deformation parameters in normotensive obese children and adolescents by using 2-D speckle tracking echocardiography. Methods: This observational cross-sectional study included 69 children and adolescents (aged between 10-18), 38 were normotensive obese and 31 were normal weighted. All children underwent detailed two-dimentional, Doppler and two-dimentional speckle tracking echocardiography. Student t-test, Mann-Whitney U test, chi-square test and Pearson's correlation were used in statistical analysis. Multiple linear regression analysis was used the determine independent variables on global longitudinal strain (GLS). Results: While in normal limits, diastolic blood pressure was significantly higher in obese group. Left ventricular end-diastolic diameter (LVDd) and end-systolic diameter (LVDs), interventricular septal thickness (IVSd), left ventricular posterior wall thickness (LPWD) and left ventricular mass index (LVM)/height2.7 were significantly higher in obese group compared to healthy peers (p=0.004, p=0.011, p<0.001, p=0.001, p<0.001) respectively. Obese subjects had reduced global longitudinal strain (GLS) values (p=0.001). Multiple linear regression analysis using the stepwise method were performed to assess the independent variables (age, body mass index, insulin resistance, systolic blood pressure, diastolic blood pressure, left ventricular diameters and LVM index (g/m2.7) affecting the dependent variable GLS. GLS was found significantly correlated with body mass index (BMI) (beta:0.440, p:0.001; 95% CI:0.104-0.311). Conclusion: Left ventricular strain parameters obtained by two dimentional speckle tracking echocardiography were diminished in obese children compared to normal subjects indicating that obesity in childhood is linked to decreased myocardial deformation even in the absence of comorbidities in early stages.
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    Effect of delivery mode on postpartum neonatal body temperatures
    (Taylor & Francis Ltd, 2016) Topaloglu, Naci; Binnetoglu, Fatih Koksal; Yildirim, Sule; Tekin, Mustafa; Kaymaz, Nazan; Aylanc, Hakan; Battal, Fatih
    Objective: It is known that general and local anesthesia practices disrupt the delicate balance of thermoregulation center which is already sensitive to very tiny differences of temperatures in a normal subject. We aimed to evaluate and compare the rectal temperatures of newborns born with normal vaginal delivery and cesarean section.Methods: We performed a prospective study of 106 term newborn - 40 born with normal vaginal delivery (group 1) and 66 born with cesarean section [51 spinal anesthesia (group 2), 15 general anesthesia (group 3)]. Only term babies were included in the study. Babies of eclamptic, pre-eclamptic and diabetic mothers and babies with chronic systemic diseases were excluded. Pregnants who underwent elective cesarean section were included in the study. Adolescent pregnants, pregnants with increased risks and pregnants with complicated operations were excluded. Mothers' temperatures were measured before and after the interventions. Rectal temperatures of the babies were measured immediately after birth.Results: Environmental temperature was maintained at 22-24 degrees C. Pre-operative mother temperatures were 36.310.30 degrees C in group 1, 36.36 +/- 0.26 degrees C in group 2 and 36.39 +/- 0.19 degrees C in group 3 (p=0.414). Post-operative mother temperatures were 36.39 +/- 0.27 degrees C in group 1, 36.29 +/- 0.31 degrees C in group 2 and 36.25 +/- 0.28 degrees C in group 3 (p=0.215). Rectal temperatures of the babies born with normal vaginal delivery were significantly higher than the others. It was lowest in the general anesthesia group (37.5 +/- 0.6 degrees C, 37.2 +/- 0.2 degrees C and 36.8 +/- 0.4 degrees C in group 1, 2 and 3, respectively). The temperature differences between groups were statistically significant p<0.001).Conclusions: In conclusion, it is worthy to note that temperatures of the newborns can differ according to the delivery mode. Physicians and health professionals that take care of the newborns should be aware of this difference.
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    Effect of infant feeding on epicardial fat thickness in normal weighted children
    (Anatolian Journal of Clinical Investigation, 2015) Yildirim, Şule; Binnetoğlu, Fatih Köksal; Aylanç, Hakan; Battal, Fatih; Tekin, Mustafa; Kaymaz, Nazan; Topaloğlu, Naci
    EFT is an independent predictor of coronary artery disease and closely associated with increased risk of metabolic syndrome and cardiovascular complications. This study aimed to evaluate the effect of breastfeeding on EFT thickness in normal-weighted children to predict the increased risk of coronary artery disease. This study included 84 normal weighted children (aged between 5-10 years), who admitted to pediatric cardiology department from October 2013 to March 2014. The patients were divided into 3 groups according to the feeding regimen in the first 6 months of year. Group 1 consisted of children who were exclusively breastfed in the first 6 months (n: 45). Group 2 consisted of children who were fed with both breast milk and formula (n: 37) and the Group 3 included children who only fed with formula (n: 2). Transthoracic echocardiography was performed and epicardial fat tissue measured. EFT was statistically lower in Group 1 compared to Group 2. EFT was highest in Group 3. The children who breastfed for longer time had low EFT thickness and this correlation was statistically significant (r= -0,457, p<0,001). In conclusion echocardiographically measured EFT thickness is low in breastfed children compared to formula-fed children. © 2015, Anatolian Journal of Clinical Investigation. All rights reserved.
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    Effects on vocabulary acquisition of presenting new words in semantic sets versus semantically unrelated sets
    (Elsevier Sci Ltd, 2008) Erten, Ismail Hakki; Tekin, Mustafa
    This paper reports on a study which investigated the effect on vocabulary recall of introducing new words via two different methods. A one-group quasi-experimental research design with alternating time series measures was employed. A group of 60 fourth graders were taught 80 carefully selected words either in semantically related sets or semantically unrelated sets. Also under investigation was the effect of these methods on test completion. The statistical analysis revealed that learning words in semantically unrelated sets yields better results than learning vocabulary in semantically related sets. The difference persisted in the long term. Further, test completion time was much longer for the semantically related vocabulary items, indicating a slower recall of vocabulary. The study indicated that, contrary to frequent practice in many course books, presenting new vocabulary that belongs to the same semantic set together may cause interference due to cross-association and may even hinder vocabulary learning. Such practice needs to be questioned and alternative methods that involve presenting vocabulary in unrelated sets need to be developed to facilitate vocabulary teaching and learning. (C) 2008 Elsevier Ltd. All rights reserved.
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    Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
    (Springer, 2015) Topaloglu, Naci; Kucuk, Adem; Yildirim, Sule; Tekin, Mustafa; Erdem, Havva; Deniz, Mustafa
    Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 mu g GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P < 0.001), whereas GLP-2 pretreatment significantly decreased their levels (P < 0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.
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    Health Related Quality of Life and the Quality of Sleep in School Aged Children with Functional Constipation
    (Taylor & Francis Inc, 2017) Yildirim, Sule; Kaymaz, Nazan; Tekin, Mustafa; Topaloglu, Naci; Binnetoglu, Fatih Koksal; Altinbas, Kursat; Asik, Zuhal
    The aim of the present study was to investigate the sleep quality and health related quality of life in children with functional constipation. Fifty patients (7-13 years) attended to our general pediatric outpatient clinic and diagnosed with functional constipation and 50 healthy controls were enrolled in this case-control study. Health-related quality of life was assessed by using Kid-KINDL inventory and sleep quality was assessed by using PSQI. Children with functional constipation had lower scores of quality of life compared to healthy controls. Although the total score was not statistically significant the physical well-being scores of constipated children was significantly lower than control group. The Pittsburgh Sleep Quality Index score for children with functional constipation was significantly higher than controls (2.5 +/- 2.4 and 0.5 +/- 0.6, respectively; p < 0.05). School-aged children with functional constipation had lower quality of life and quality of sleep compared to their healthy peers. Physical well-being was especially impaired in constipated children affecting daily activities negatively. Assessment of quality of sleep as well as quality of life should be a part of management of functional constipation in childhood.
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    Infants' non-nutritive sucking habits and childhood obesity
    (OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2016) Kaymaz, Nazan; Yildirim, Şule; Cevizci, Sibel; Erdem, Fehime; Topalo?lu, Naci; Tekin, Mustafa; Binneto?lu, Fatih Köksal
    Objective:Habits formed in early childhood can affect future life. The aim of this study is to investigate whether prolonged non-nutritive sucking habits (pacifiers and finger sucking) during infancy increases the probability of childhood exogenous obesity causing a habit of high frequency of feeding. Material and Methods: A case-control study was conducted including children with exogenous obesity diagnosis and healthy controls. The study was performed with questionnaires completed by parents. Body mass index above the 95th percentile were evaluated as obese. Cases with endocrine, metabolic, or genetic causes of obesity, children with chronic illness other than obesity and children with obese family members were excluded. Results: 108 children (46 boys, 62 girls) with a mean age of 9.97 years and who met the criteria were assigned to the case group and 116 healthy children (55 boys, 61 girls) with a mean age of 10.02 years were assigned to the control group. In both case and control groups there was no statistically significant difference in mean body mass index levels on both duration of pacifier usage (Independent samples t test, p=0.496 and p=0.368, respectively) and finger sucking habit (Independent samples t test, p=0.319 and p=0.377, respectively). However, the number of the children finger sucking in the case group (n=50) was higher than in the control group (n=33) (46.3% vs. 28.4%, p=0.006). Conclusion: There was no association between pacifier usage in infancy with exogenous obesity in childhood but children who suck fingers are more likely to be obese in later life. © Copyright 2016 by Türkiye Klinikleri.