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    Are blood pressure values compatible with medication adherence in hypertensive patients
    (Wolters Kluwer Medknow Publications, 2016) Uludag, A.; Sahin, E. M.; Agaoglu, H.; Gungor, S.; Ertekin, Y. H.; Tekin, M.
    Background and Aim: In the management of hypertension (HT), maintaining the medication adherence with treatment is as important as starting treatment. Studies have shown that the majority of patients taking medication do not reach their target values. This study aimed to investigate the relationship between the patient medication adherence and blood pressure (BP) values and reflection to general well-being. Material and Methods: The study included 259 primary HT patients. The patients with BP measurements completed the Medication Adherence Self-Efficacy Scale-Short Form 13 and the World Health Organization-5 (WHO-5) well-being index. A Holter device was attached, and 24 h BP monitoring was completed. Results: The mean points for medication adherence scale was 29.2 10.3 (1u40) and mean WHO-5 points was 13.7 4.6 (4u25) for patients. Clinical mean systolic BP was 140.0 12.6 and diastolic 84.8 9.0 mm Hg, while 24 h mean BP was systolic 119.5 10.6 and diastolic 73.3 8.1 mm Hg. While there was negative correlation between medication adherence scale scores and clinical systolic BP (r = 0.171; P = 0.006), there was no correlation with other BP readings. There was no correlation with the WHO-5 score and clinical readings, though there was a positive correlation between ambulatory mean systolic and diastolic BP (r = 0.141; P = 0.023 and r = 0.123; P = 0.049, respectively). There was positive correlation between the patient's medication adherence scores and the WHO-5 scores (r = 0.141; P = 0.023). Conclusion: When clinicians assess medication adherence of patients, they should benefit from objective BP measurements and scales. Subjective and objective findings are important while making clinical decision.
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    Investigation of the effects of oleuropein rich diet on rat enteric bacterial flora
    (Comenius Univ, 2016) Kiraz, A.; Simsek, T.; Tekin, S. Z.; Elmas, S.; Tekin, M.; Sahin, H.; Altinisik, H. B.
    OBJECTIVES AND BACKGROUND: Oleuropein is a phenolic compound of olive leaves. Enteric bacterial flora is very important for human health and diet is a directly affecting factor of enteric bacterial flora composition. In this study, it was hypothesized that oleuropein could reduce total aerobic bacterial count in rat caecal flora. METHODS: Twenty adult, male, Wistar albino rats were randomly divided into two groups. Group C (n=10) was fed with standard rat chow and water for 30 days. Group 0 (n=10) received olive leaf extract 20 mg/kg/day by intragastric gavage in addition to standard rat chow and water for 30 days. One gram of caecal content was collected from each rat and then consecutive 10-fold serial dilutions were prepared with a final concentration of 10(-8). Then 0.1 ml of each dilution were spread onto the surfaces of Plate Count Agar and Violet Red Bile Glucose Agar to enumerate the aerobic enteric bacteria. RESULTS: Total aerobic bacterial counts of Group 0 were significantly lower than of Group C in all agar plates inoculated with ceacal samples for every dilution (p<0.05). CONCLUSION: Adding oleuropein to enteral feeding solutions of critically ill patients may be adventageous in the presence of clinical conditions predisposing to bacterial translocation by reducing enteric bacterial counts (Tab. 1, Ref. 32). Text in PDF www.elis.sk.
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    PREVALENCE AND MUTATIONS OF ?-THALASSEMIA TRAIT AND ABNORMAL HEMOGLOBINS IN PREMARITAL SCREENING IN CANAKKALE PROVINCE, TURKEY
    (Macedonian Acad Sciences Arts, 2016) Uludag, A.; Uysal, A.; Uludag, A.; Ertekin, Y. H.; Tekin, M.; Kutuk, B.; Sılan, Fatma
    The prevalence of beta-thalassemia (beta-thal) carriers in Turkey varies according to region but in general it is 2.0%. Canakkale is a city in the Aegean region of Turkey but no study about beta-thal frequency in Canakkale has been published to date. In this study, we aimed to investigate the frequency of beta-thal mutations in this province. A total of 4452 couples (8904 individuals) applied for premarital thalassemia scans at the Canakkale State Health Directorate Laboratory between January 2008 and June 2012 and scanning was done with high performance liquid chromatography (HPLC). Of 125 beta-thal carriers seen at the Medical Genetics Clinic, Canakkale Onsekiz Mart University, Canakkale, Turkey, for genetic counseling, 46 participated in the study. The remaining 79 patients could not be reached. The prevalence for beta-thal carriers in Canakkale was identified as 1.4% (125/8904). One couple were both beta-thal carriers. beta-Globin gene analysis of 46 carriers found the total frequency of the three most common mutations was 45.6%. These mutations were found to be HBB: c. 93-21G>A [IVS-I-110 (G>A)], 26.08% (12/46); HBB: c. 17_ 18delCT [codon 5 (-CT)], 10.85% (5/46); HBB: c. 20delA [codon 6 (-A)] 8.69% (4/46). This is the first report on the frequency and mutation profiles of beta-thal for Canakkale. The incidence of beta-thal carriers in Canakkale is below the average for Turkey. The most frequently observed mutation profile and rate of beta-thal in our region is different from the other regions of Turkey.
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    Protective effect of glucagon-like peptide-2 in experimental corrosive esophagitis
    (Oxford Univ Press Inc, 2015) Tekin, M.; Topaloglu, N.; Kucuk, A.; Deniz, M.; Yildirim, S.; Erdem, H.
    Corrosive esophageal injuries are one of the life-threatening morbidities leading to esophageal stricture and perforation affecting all age groups but especially children due to accidental ingestions in this age group. Glucagon-like peptide-2 (GLP-2) is an intestinal polypeptide with potent anti-inflammatory effects. Its effects are studied in various studies but not in corrosive esophagitis. We aimed to investigate whether it has protective effect in experimental corrosive esophagitis, in the absence of existing studies into possible links. Twenty-four Wistar-albino rats, weighing 220-240 g, were randomized into three groups (n=8 in each). First group is control, second one is sham operated, and the third one is treatment group. Median laparotomy was made in all groups. In sham and treatment groups, esophagus was loosened and suspended from 1cm proximal to the esophageal junction. The esophagus segment between suspenders was exposed to 0.1mL 5% NaOH for 10 seconds. In the treatment group, rats were given GLP-2 for 7 days intraperitoneally. After 7 days, all rats were sacrified and esophagi were totally removed. In the histopathologic examination, esophageal tissues were compared in terms of inflammation, muscularis mucosa injury, and collagen deposition of tunica muscularis. Histopathologic changes in the esophageal tissues of groups were compared. Histopathologic injury in the GLP-2 treated group was significantly less than sham group (P<0.05). There was statistically significant healing in the GLP-2 treatment group. It is concluded that GLP-2 has a preventive effect on inflammation and collagen accumulation in an experimental corrosive esophagitis. In the light of the information that initial lesions in the early phase are predictors of complications, GLP-2 is a promising agent that has an anti-inflammatory effect in caustic injuries.
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    THE MEFV GENE PATHOGENIC VARIANTS AND PHENOTYPE-GENOTYPE CORRELATION IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER IN THE CANAKKALE POPULATION
    (Macedonian Acad Sciences Arts, 2016) Battal, F.; Sılan, Fatma; Topaloglu, N.; Aylanc, H.; Yildirim, S.; Binnetoglu, Koksal F.; Tekin, M.
    The aim of the current study was to determine the frequency of the Mediterranean fever (MEFV) gene pathogenic variants in 60 children diagnosed with familial Mediterranean fever (FMF) and to compare the phenotype-genotype correlation. Genomic DNA was isolated by the spin-column method from peripheral blood samples (collected in vacutainers containing EDTA) and buccal smears. The MEFV gene profiles for the current FMF cohort were genotyped by pyrosequencing and direct Sanger sequencing techniques for the target pathogenic variants. The most prominent clinical symptoms were abdominal pain (53.4%), fever (23.4%) and arthritis (23.3%). Eighteen different pathogenic variants were identified and the most frequent were p. Met694Val (20.0%), p. Glu148Gln (13.3%), p. Met680 Ile (11.7%) and p. Arg202Gln (11.7%). Abdominal pain, fever and arthritis were the most common presenting clinical characteristics. Results showed that not only clinical characteristics, but also genotyping of the MEFV gene is needed to establish the correct diagnosis of FMF in children and other family members.