Yazar "Tanoğlu, Alpaslan" seçeneğine göre listele

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    Clinicopathological profile of peritoneal tuberculosis and a new scoring model for predicting mortality: an international ID-IRI study
    (Springer, 2023) Tanoğlu, Alpaslan; Erdem, Hakan; Friedland, Jon S.; Ankaralı, Handan; Garcia-Goez, Jose Fernando; Albayrak, Ayşe; Alkan Çeviker, Sevil
    Existing literature about peritoneal tuberculosis (TBP) is relatively insufficient. The majority of reports are from a single center and do not assess predictive factors for mortality. In this international study, we investigated the clinicopathological characteristics of a large series of patients with TBP and determined the key features associated with mortality. TBP patients detected between 2010 and 2022 in 38 medical centers in 13 countries were included in this retrospective cohort. Participating physicians filled out an online questionnaire to report study data. In this study, 208 patients with TBP were included. Mean age of TBP cases was 41.4 +/- 17.5 years. One hundred six patients (50.9%) were females. Nineteen patients (9.1%) had HIV infection, 45 (21.6%) had diabetes mellitus, 30 (14.4%) had chronic renal failure, 12 (5.7%) had cirrhosis, 7 (3.3%) had malignancy, and 21 (10.1%) had a history of immunosuppressive medication use. A total of 34 (16.3%) patients died and death was attributable to TBP in all cases. A pioneer mortality predicting model was established and HIV positivity, cirrhosis, abdominal pain, weakness, nausea and vomiting, ascites, isolation of Mycobacterium tuberculosis in peritoneal biopsy samples, TB relapse, advanced age, high serum creatinine and ALT levels, and decreased duration of isoniazid use were significantly related with mortality (p < 0.05). This is the first international study on TBP and is the largest case series to date. We suggest that using the mortality predicting model will allow early identification of high-risk patients likely to die of TBP.
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    Eosinophilic Esophagitis as a Rare Cause of Dysphagia: Two Case Presentation with Literature Review
    (2018) Beyazıt, Yavuz; Tanoğlu, Alpaslan
    Eosinophilic esophagitis (EO) is a chronic, immune mediateddisease of esophagus characterized with esophagealdysfunction, retrosternal heartburn, and eosinophilpredominantinflammation. Most patients with EO clinicallypresents with dysphagia, reflux-like symptoms and swallowingdifficulties. Although food allergens are mostly accused in thepathophysiology of EO, there is still unknown additionalfactors that are belived to be exist in the pathophysiology.Herein, we would like to present two patients who admitted toour clinic with the complaint of dysphagia and was diagnosedas EO. Oral fluticazone treatment was started with dietaryrestriction to both patients. A favorable outcome was achievedduring follow-up.
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    Retrospective analysis of patients underwent colonoscopic polypectomy: A two-center study
    (2020) Kamış, Fatih; Tanoğlu, Alpaslan; Çetin, Ece Ünal; Beyazıt, Yavuz; Yazgan, Yusuf
    Colonoscopy is a widely used modality for detecting colonic pathologies nearly all over the world. In this retrospective analysis, we aimed to determine the prevalence ofcolonic polyps and their histopathological results based on colonoscopies performed in the gastroenterology unit in Çanakkale Onsekiz Mart University Health Practiceand Research Hospital and Istanbul Sultan Abdulhamidhan Training and Research Hospital. Patients underwent colonoscopic examination due to lower gastrointestinalsystem complaints between 01/01/2014 and 01/12/2019 were evaluated. Patient age, gender, indications, colonoscopic findings, polyp number, size and histopathologicresults of the lesions were recorded. A total of 1040 polyps were detected from 839 polypectomy operations performed according to the colonoscopic evaluation of 9044patients between January 2014 and January 2019. Bleeding after polypectomy was observed in 8 (0.95%) patients and all of the bleedings were controlled with sclerotherapyand/or heater probe coagulation. According to the polyp detection sites, rectosigmoid region (49.7%) was followed by transverse colon (17.3%), descending colon(17.5%), ascending colon (10.5%) and caecum (5%). Adenomatous polyps were the most encountered histopathologic type followed by hyperplastic polyps (19.6%).Thirteen (1.25%) polyps were reported as adenocarcinoma. Polypectomy is an effective procedure of colonoscopy when performed by expert hands. In this retrospectiveanalysis, our results was found to be consistent with those of the literature in terms of polyp number, size and histopathologic characteristics.
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    The pathobiological harmony between the local pulmonary/ bone marrow RAS and its management via tissue-RAS modulating agents in COVID-19
    (MediHealth Academy Yayıncılık, 2022) Çetin, Ece Ünal; Beyazıt, Yavuz; Beyazıt, Fatma; Tanoğlu, Alpaslan; Haznedaroğlu, İbrahim Celaleddin
    Coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented threat to public health and healthcare systems. It presents unusual pathophysiological effects mainly characterized by immune-inflammatory response and prothrombotic state causing acute respiratory distress syndrome and multiple organ failure. SARS-CoV-2 enters target cells after binding to the angiotensin-converting enzyme 2 (ACE2) receptor and therefore has a direct effect on the renin-angiotensin system (RAS). Apart from affecting numerous organs including lungs, heart, gastrointestinal system, spleen, brain and kidneys, the spike protein of SARS-CoV-2 could attack hematopoietic stem cells and hematopoietic progenitor cells in bone marrow (BM) microenvironment together with the precursor and mature blood cells. Within this hematopoietic viral spread context, it is crucial to search the clinicopathological correlations of COVID-19 in order to develop specific potential therapeutics against pleiotropic SARS-CoV-2 actions. Therefore, pharmacological disruption of the pathological cross-talk of local BM RAS and pulmonary RAS via administration of the tissue-RAS modulating agents such as soluble ACE2, angiotensin (1-7), TXA127 and MAS receptor agonists may prevent the clinical progression of the COVID-19 syndrome via reducing the hematopoietic virus propagation and systemic multi-organ spread.
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    Üst Gastrointestinal Sistem Kanaması Şeklinde Prezente olan Dev Gastrointestinal Stromal Tümör
    (2019) Tanoğlu, Alpaslan; Beyazıt, Yavuz; Düzenli, Tolga
    Gastrointestinal stromal tümörler (GIST) gastrointestinalsistemin en sık görülen mezenkimal kaynaklıtümörleridir ve genellikle mide ve ince barsaktan kökenalırlar. Her ne kadar küçük çapları nedeniyle klinikolarak sessiz iseler de, çapları 1-2 milimetreden birkaçsantimetreye kadar ulaşabilir. GIST’lerin standarttedavisi cerrahidir, ancak hastanın risk durumuna görebir tirozin kinaz inhibitörü olan imatinib de adjuvanttedavide kullanılabilir. Biz bu vaka raporunda üstgastrointestinal sistem kanaması ile prezente olan devmide GIST’li bir hastaya sunmayı amaçladık. Hastaya,endoskopik stabilizasyon sonrası başarılı bir cerrahitedavi uygulandı.