Yazar "Tan, Yusuf Ziya" seçeneğine göre listele

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    Alterations in the telomere length distribution of cell-free DNA in human cancer
    (Elsevier Science Bv, 2016) Urfali, Mine; Silan, Fatma; Tan, Yusuf Ziya; Celiker, Fatmanur; Guler, Zeliha; Ozdemir, Ozturk
    [Anstract Not Available]
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    Assessment of Heart Rate Recovery with GATED-Myocardial Perfusion Scintigraphy Outcome in Patients with Coronary Artery Disease: A Retrospective Study and Institutional Experience
    (Galenos Yayincilik, 2016) Tan, Yusuf Ziya; Ozdemir, Semra; Altun, Burak; Celik, Fatmanur
    Objective: This study aimed to investigate the effects of assessment with myocardial perfusion scintigraphy (MPS) and heart rate recovery (HRrec) measurements in combination to evaluate the current status of patients with a diagnosis or suspicion of coronary artery disease (CAD). Methods: A total of 350 patients were included in the study. CAD group consisted of 200 patients with stable angina pectoris and a known history of CAD, while the control group consisted of 150 patients with suspicious stress test who had no history of known CAD. In order to calculate the HRrec index, the treadmill exercise test was performed in all patients according to the Bruce protocol. The MPS results were evaluated for the presence or absence of myocardial ischemia and infarction by visual and quantitative (summed stress score and summed difference score) assessments. Results: When the MPS results and HRrec were evaluated together, there was no statistically significant difference in the non-CAD group. But, when GATED-MPS was evaluated alone in the triple-vessel patient group, 27 (36%) patients were found to be normal while evaluated with HRrec, four (5.3%) patients were found to be normal. Conclusion: HRrec measurements obtained during stress MPS is important in patient evaluation. Therefore, evaluation of MPS results and HRrec measurements together may provide a more accurate estimation of possible presence of CAD in patients.
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    Assessment of Heart Rate Recovery with GATED-Myocardial Perfusion Scintigraphy Outcome in Patients with Coronary Artery Disease: A Retrospective Study and Institutional Experience
    (2016) Tan, Yusuf Ziya; Özdemir, Semra; Altun, Burak; Çelik, Fatmanur
    Bu çalışmada koroner arter hastalığı (KAH) olan ya da şüphesiyle incelenen hastaların mevcut durumlarının daha iyi değerlendirilmesi için miyokard perfüzyon sintigrafisi (MPS) ve kalp toparlanma hızlarının birlikte değerlendirilmesinin sonuçlar üzerine olan etkisi araştırıldı. Yöntem: Çalışma retrospektif özellikte olup toplam üç yüz elli hasta dahil edildi. Anjina pektoris ve KAH öyküsü bulunan 200 kişi hasta grubunu, KAH öyküsü bulunmayan 150 hasta ise kontrol grubunu oluşturdu. Hastalara Bruce protokolüne göre efor testleri yaptırılarak kalp toparlanma hızları ölçüldü. MPS sonuçları kalp hızı toparlanma indeksleri ile birlikte değerlendirildi. Bulgular: Koroner hastalığı olmayan hasta grubunda MPS sonuçları ve kalp hızı toparlanma indeksleri birlikte değerlendirildiğinde istatiksel olarak anlamlı fark bulunmadı. Ancak, üç damar hasta grubunun değerlendirilmesinde sadece MPS sonuçları yapılan değerlendirmede hastaların 27'si (%36) normal bulunurken, kalp hızı toparlanma indeksleri ile birlikte değerlendirildiğinde hastaların dördü (%5,3) normal olarak saptandı. Sonuç: Stres MPS sırasında elde edilen kalp hızı toparlanma ölçümleri hastaların değerlendirilmesinde önemlidir. Bu nedenle, MPS sonuçlarının kalp hızı toparlanma ölçümleri ile birlikte değerlendirilmesi olası KAH varlığını daha doğru öngörebilir
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    Attenuation of partial unilateral ureteral obstruction - induced renal damage with hyperbaric oxygen therapy in a rat model
    (Brazilian Soc Urol, 2017) Sancak, Eyup Burak; Tan, Yusuf Ziya; Turkon, Hakan; Silan, Coskun
    Objective: The objective of the present study was to evaluate the effectiveness of HBO therapy on biochemical parameters, renal morphology and renal scintigraphy in rats undergoing chronic unilateral partial ureteral obstruction (UPUO). Material and methods: Thirty-five rats were divided into five equal groups: Control group; Sham group; HBO group; UPUO group and UPUO/HBO group. The effects of HBO therapy were examined using biochemical parameters and histopathological changes. After calculating the score for each histopathological change, the total histopathological score was obtained by adding all the scores. In addition, dynamic renal scintigraphy findings were evaluated. Results: Serum parameters indicating inflammation, serum tumor necrosis factoralpha, ischemia modified-albumin, IMA/albumin ratio and Pentraxin-3 levels, were observed to be high in the UPUO group and low in the UPUO/HBO treatment group. Similarly, in the treatment group, the reduction in malondialdehyde, total oxidant status and oxidative stress index levels and increase in total antioxidant capacity values were observed to be statistically significant compared to the UPUO group (p< 0.001, p= 0.007, p< 0.001, p= 0.001, respectively). The total score and apoptosis index significantly decreased after administration of HBO treatment. Dynamic 99mTc-MAG3 renal scintigraphy also showed convincing evidence regarding the protective nature of HBO against kidney injury. In the UPUO/HBO therapy group, the percentage contribution of each operated kidney increased significantly compared to the UPUO group (41.73% versus 32.72%). Conclusion: The findings of this study indicate that HBO therapy had a reno-protective effect by reducing inflammation and oxidative stress, and preserving renal function after renal tissue damage due to induction of UPUO.
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    Bilateral Upper Extremity Edema in the Psoriatic Arthritis Case
    (Aves, 2015) Gokmen, Ferhat; Akbal, Ayla; Savas, Yilmaz; Zateri, Coskun; Karaca, Adem; Tan, Yusuf Ziya
    Psoriatic arthritis (PsA) is a seronegative spondyloarthropathy characterized by peripheral arthritis, enthesis, spondylitis, and psoriasis. Lymphedema arises from the slowing of lymphatic flow because of inflammatory or noninflammatory diseases such as tumors, infections, bursitis, rheumatoid arthritis, and polymyalgia rheumatica. It is commonly encountered in one or more regions of distal extremities. Lymphedema is a rare complication of PsA, and it is commonly seen asymmetrically and in lower extremities. We aimed to report a case, who followed-up with diagnosis with PsA and with complaints of upper extremity swelling and bilateral upper extremity lymphedema diagnosed as a result of the review.
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    Comparison of fragmented QRS and myocardial perfusion-gated SPECT findings
    (Lippincott Williams & Wilkins, 2013) Ozdemir, Semra; Tan, Yusuf Ziya; Colkesen, Yuecel; Temiz, Ahmet; Turker, Fatmanur; Akgoz, Semra
    AimFragmented QRS (fQRS) complex is an ECG parameter that has recently been introduced and investigated. It is assumed that fQRS occurs because of disruptions in ventricular conduction due to ventricular infarction and ischemia. Therefore, in this article, we aimed to investigate the relationship between the detection of infarction and ischemia on myocardial perfusion-gated single-photon emission computed tomography images and appearance of fQRS on ECG.Materials and methodsWe retrospectively reviewed the records of patients with a diagnosis of coronary artery disease who were referred to our institution for myocardial perfusion scintigraphy. In total, 261 patients (122 women and 139 men, with a mean age of 6110.33 years) with and without fQRS (136 and 125, respectively) were included in the present study. The myocardial perfusion scintigraphy results were evaluated for the presence or absence of myocardial ischemia and infarction by visual and quantitative (summed stress score, summed rest, summed difference score, summed motion score, and summed thickening score) assessments. Statistical analysis was performed to determine the relationship between the presence of fQRS and myocardial ischemia and/or infarction. Student's t-test and the Mann-Whitney U-test were used for comparing the results. Pearson's (2)-test and Fisher's exact tests were also used to compare the distribution of variables between the two groups.ResultsThe prevalence of ischemia and infarction were found to be, respectively, 4.38-fold and 5.95-fold higher in patients with fQRS compared with the control group. Moreover, the prevalence of both ischemia and infarction was found to be 10.54-fold higher in patients with fQRS compared with the control group.ConclusionThere is a highly statistically significant possibility of detecting ischemia and infarction in perfusion myocardial scintigrams of patients whose ECGs have fQRS. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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    Comparison of SUVmax values obtained from F-18 FDG PET/CT and cell-free DNA levels measured from plasma in oncology patients
    (Galenos, 2019) Çelik, Fatmanur; Tan, Yusuf Ziya; Özdemir, Semra; Sılan, Fatma
    Objectives: The aim of this study was to compare the quantitative value of standardized uptake value (SUV) SUVmax obtained from F-18 FDG positron emission tomography/computed tomography (PET/CT) imaging of oncology patients with the cell-free DNA (cfDNA) amounts measured in plasma of patients and thus investigate if cfDNA is a significant marker to identify the presence of malignancy in the early period. Methods: A total of 184 patients were included in the study. The clinical, histopathologic, laboratory and treatment parameters were extracted from patient files. SUVmax and cfDNA quantities were assessed. Results: There was no statistically significant difference in plasma cfDNA values between patient and control groups. The comparison of SUVmax and cfDNA values in the study showed that there was a weak correlation between SUVmax and cfDNA. There was a significant difference between tumor size and SUVmax values. However, there was no statistically significant difference between tumor size and cfDNA. Conclusion: cfDNA measurements in the blood as a screening test have provided hope for early diagnosis and monitoring of cancer patients. Comparison of cfDNA levels obtained from plasma and quantitative parameters from PET/CT images of oncology patients in detailed advanced studies with larger patient series are required. © 2019 by Turkish Society of Nuclear Medicine Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi.
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    Comparison of SUVmax Values Obtained from F-18 FDG PET/CT and Cell-free DNA Levels Measured from Plasma in Oncology Patients
    (2019) Çelik, Fatmanur; Tan, Yusuf Ziya; Özdemir, Semra; Sılan, Fatma
    Objectives: The aim of this study was to compare the quantitative value of standardized uptake value (SUV) SUVmax obtained from F-18 FDG positron emission tomography/computed tomography (PET/CT) imaging of oncology patients with the cell-free DNA (cfDNA) amounts measured in plasma of patients and thus investigate if cfDNA is a significant marker to identify the presence of malignancy in the early period.Methods: A total of 184 patients were included in the study. The clinical, histopathologic, laboratory and treatment parameters were extracted from patient files. SUVmax and cfDNA quantities were assessed.Results: There was no statistically significant difference in plasma cfDNA values between patient and control groups. The comparison of SUVmax and cfDNA values in the study showed that there was a weak correlation between SUVmax and cfDNA. There was a significant difference between tumor size and SUVmax values. However, there was no statistically significant difference between tumor size and cfDNA.Conclusion: cfDNA measurements in the blood as a screening test have provided hope for early diagnosis and monitoring of cancer patients. Comparison of cfDNA levels obtained from plasma and quantitative parameters from PET/CT images of oncology patients in detailed advanced studies with larger patient series are required.
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    Confirmation of Brain Death with Positron Emission Tomography
    (Georg Thieme Verlag Kg, 2020) Ozdemir, Semra; Tan, Yusuf Ziya; Ozturk, Fulya Koc; Battal, Fatih
    After recent advances regarding organ transplantation, accurate and timely diagnosis of brain death has gained importance. In the diagnosis of brain death, in addition to clinical findings, various ancillary tests are very crucial. In this study, the scintigraphic imaging of the brain death of an 8-year-old girl with both Tc-99m diethylenetriaminepentaacetic and 18F-fluorodeoxyglucose (FDG) has been presented. This case study shows that 18F-FDG positron emission tomography-computed tomography imaging can be a useful technique in evaluating brain death in patients.
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    Evaluation of liver perfusion in diabetic patients using 99mTc-sestamibi
    (Springer Wien, 2015) Sen, Hacer; Tan, Yusuf Ziya; Binnetoglu, Emine; Asik, Mehmet; Gunes, Fahri; Erbag, Gokhan; Gazi, Emine
    Objective The liver is an important organ for various aspects of glucose metabolism, including glucose uptake, storage, and synthesis. It is a major organ in the metabolic process with perfusion provided by both the portal vein and hepatic artery. In diabetic patients organ perfusion is reduced and this is linked to atherosclerosis, and as a result complications occur. In this study, we aimed to evaluate liver perfusion by scintigraphic methods in diabetic patients. Design and patients We retrospectively investigated 1,100 myocardial perfusion scintigraphies taken between January 2011 and December 2012 at Canakkale Onsekiz Mart University Medical Faculty Nuclear Medicine Department. A total of 66 patients who were diagnosed with diabetes mellitus and had myocardial perfusion scintigraphies were included in the study. The control subjects included 127 patients without diabetes mellitus who were chosen at random. Patients with chronic liver disease were not included in the study. The values from liver regions of interest (liver-ROI) rates and heart regions of interest (heart-ROI) rates were compared between the patients and controls. Results Patients were grouped according to the presence of diabetes. In the diabetes mellitus group, the liver-ROI average was lower (p = 0.66) than in the controls. In the control group, the average liver-ROI/heart-ROI ratios were higher than the ratio in the diabetes mellitus group (p = 0.019). Multivariate variance analysis showed that the diabetes mellitus liver-ROI/heart-ROI ratio was independent of other risk factors (p = 0.003; F: 9.6). Powered by Editorial Manager. and ProduXion Manager. from Aries Systems Corporation. Conclusions This study shows that liver perfusion in diabetic patients is reduced compared with those without diabetes. Prospective studies with larger patient groups are required.
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    FDG PET-CT Finding in Bilateral Renal and Bone Involvement of Diffuse Large B-Cell Lymphoma
    (Galenos Yayincilik, 2014) Tan, Yusuf Ziya; Yilmaz, Sabire; Ozhan, Meftune; Halac, Metin
    Thirty-six year old male patient with pathological fracture of the left tibia underwent intramedullary and soft tissue curettage. The histopathological examination revealed diffuse large B cell lymphoma. The patient underwent F18-FDG PET-CT scanning for initial staging. FDG PET-CT scan revealed hypermetabolic lesions at the left tibia and in bilateral kidneys. After the systemic chemotherapy and local radiotherapy to the tibia, repeated FDG PET/CT scan showed improvement of the previous hypermetabolic lesions, suggesting good response to therapy. Bone and renal involvement is an uncommon variant of diffuse large B-cell lymphoma and FDG PET-CT is an useful whole body imaging modality in these cases.
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    FDG PET-CT Finding in Bilateral Renal and Bone Involvement of Diffuse Large B-Cell Lymphoma
    (2014) Tan, Yusuf Ziya; Yılmaz, Sabire; Özhan, Meftune; Halaç, Metin
    Otuz altı yaşındaki erkek hastaya sol tibiasında patolojik kırık nedeniyle yapılan intramedüller ve yumuşak doku küretaj biyopsisi sonucu diffüz büyük B-hücreli lenfoma gelmesi üzerine, başlangıç evrelemesi için F18-FDG PET-BT incelemesi uygulandı. FDG PET-BT incelenmesinde sol tibia distalinde ve bilateral böbreklerde hipermetabolik tutulum izlendi. Sistemik kemoterapi ve sol tibiaya lokal radyoterapi yapıldıktan sonra tekrar edilen FDG PET-BT incelemesinde önceki hipermetabolik tutulumların düzeldiğinin görülmesi iyi yanıt varlığını düşündürdü. Kemik ve böbreklerde nadir tutulum gösteren diffüz büyük B-hücreli lenfomalarda FDG PET-BT tüm vücut görüntüleme yararlı bir tekniktir.
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    Fragmented QRS and prediction of paroxysmal atrial fibrillation episodes
    (Professional Medical Publications, 2014) Temiz, Ahmet; Gazi, Emine; Gungor, Omer; Altun, Burak; Barutcu, Ahmet; Bekler, Adem; Tan, Yusuf Ziya
    Objective: Prior studies have demonstrated the relationship between cardiovascular diseases and fragmented QRS (fQRS). fQRS was also associated with ventricular arrhythmias. Our objective was to find out the relationship between fQRS and paroxysmal atrial fibrillation (PAF). Method: A total of 301 patients without overt structural heart disease were prospectively included in the study. Patients were divided in to 2 groups according to presence of fQRS. Multivariate logistic regression analysis was used to assess the predictive value of fQRS for predicting PAF. Results: One hundred and three patients had fQRS. Patients with fQRS were older (53 +/- 16.8 vs 45.3 +/- 17.2, p < 0.001), with larger left atrium (LA) (33.2 +/- 5.9 vs 30.1 +/- 5.9 mm, p=0.001), with thicker interventricular septum (IVS) (10.2 +/- 1.9 vs 9.5 +/- 2.3 mm, p=0.032), more diabetic (19.8 vs 10.6%, p= 0.029) and have more PAF episodes (22.3 vs 4.1%, p < 0.001) in comparison with patients without fQRS. fQRS was an independent predictor of detecting PAF episode (odds ratio, 9.69; 95% confidence interval, 2.46-38.15, p= 0.001). Hypertension and diabetes mellitus were also predictive. Conclusion: The presence of fQRS independently predicted PAF episodes in holter monitoring (HM). Further studies are needed to clarify the clinical implications of this finding.
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    Fragmented QRS is associated with frequency of premature ventricular contractions in patients without overt cardiac disease
    (Turkish Soc Cardiology, 2015) Temiz, Ahmet; Gazi, Emine; Altun, Burak; Gungor, Omer; Barutcu, Ahmet; Bekler, Adem; Tan, Yusuf Ziya
    Objective: In this study, we aimed to demonstrate whether the presence of fragmented QRS (fQRS) is associated with the frequency of premature ventricular contractions (PVCs). Methods: We retrospectively analyzed 282 cases by 24-hour Holter monitorings (HMs) between August 2012 and February 2013. Firstly, the patients were divided into 2 groups with respect to presence of fQRS and then divided into 3 groups with respect to frequency of PVCs as Group 1: seldom PVC (<120 PVCs/day), Group 2: moderate-frequency PVC (120-720 PVCs/day), and Group 3: frequent PVC (>720 PVCs/day). We investigated the predictors of frequent PVCs by using multinomial logistic regression analysis. Results: Ninety-eight patients had fQRS. There was no difference between the 2 groups with respect to body mass index, gender, hypertension, and diabetes mellitus. Patients with fQRS were older (54.9 +/- 15.6 vs. 47.0 +/- 16.3, p<0.001) and had more family history of coronary artery disease (25% vs. 13%, p=0.012). Patients with fQRS was more likely to be on aspirin therapy (28.6% vs. 10.4%, p<0.001) and have a larger left atrium diameter (33.5 +/- 5.7 vs. 30.4 +/- 5.8, p=0.001). Presence of fQRS was significantly associated with the frequency of PVCs (for frequent PVC 27.7% vs. 7.6%, p<0.001; for moderate-frequency PVC 18.4% vs. 11.4%, p=0.012); 26.2% of Group 1 (n=202) had fQRS, 46.2% of Group 2 (n=39) had fQRS, and 65.9% of Group 3 (n=41) had fQRS. In the multinomial regression analysis, only age (odds ratio: 4.24, 95% confidence interval 2.08-8.64, p=0.001) and fQRS (odds ratio: 2.11, 95% confidence interval 1.00-4.45, p=0.05) were predictors of frequent PVCs. Conclusion: This study demonstrated that the presence of fQRS is associated with frequent PVCs in patients without overt structural heart disease.
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    Fragmented QRS is associated with frequency of premature ventricular contractions in patients without overt cardiac disease
    (2015) Temiz, Ahmet; Gazi, Emine; Altun, Burak; Güngör, Ömer; Barutçu, Ahmet; Bekler, Adem; Tan, Yusuf Ziya
    Amaç: Bu çalışmada, fragmente QRS (fQRS) varlığının prematüre ventriküler atım (PVA) sıklığıyla ilişkili olup olmadığının gösterilmesi amaçlanmıştır. Yöntemler: Ağustos 2012 ile Şubat 2013 arasında yapılan 282 adet 24 saatlik Holter retrospektif olarak değerlendirilmiştir. İlk olarak hastalar fQRS varlığı- na göre 2 gruba ayrılmış daha sonra da PVA sıklığına göre, Grup 1: seyrek PVA (<120 PVA/gün), Grup 2: orta sıklıkta PVA (120-720 PVA/gün) ve Grup 3: sık PVA (>720 PVA/gün) olacak şekilde 3 gruba ayrılmıştır. Çoklu lojistik regresyon analizi ile sık PVA belirteçleri incelenmiştir. Bulgular: Doksan sekiz hastada fQRS mevcuttu. İki grup arasında vücut kitle indeksi, cinsiyet, hipertansiyon ve şeker hastalığı açısından fark yoktu. fQRS olan hastalar daha yaşlı idi (54,9±15,6'ya karşı 47,0±16,3, p<0,001) ve ailesel koroner arter hastalığı öyküsü daha fazla idi (%25'e karşı %13, p=0,012). fQRS hastalarının aspirin kullanma oranları daha fazla idi (%28,6'ya karşı %10,4, p<0,001) ve sol atriyumları daha geniş idi (33.5±5.7 mm'e karşı 30,4±5,8 mm, p=0,001). fQRS varlığı PVA sıklığı ile anlamlı bir şekilde ilişkiliydi (Sık PVA için %27,7'ye karşı %7,6, p<0,001, orta sıklıkta PVA için %18,4'e karşı %11,4, p=0,012). Grup 1'in (n=202) %26,2'sinde, grup 2'nin (n=39) %46,2 sinde grup 3'ün (n=41) ise %65,9'unda fQRS mevcuttu. Çoklu lojistik regresyon analizinde sadece yaş (tehlike oranı: 4,24, %95 güvenlik aralığı 2,08-8,64, p=0,001) ve fQRS varlığı (tehlike oranı: 2,11, %95 güvenlik aralığı 1,00-4,45, p=0,05) sık PVA'nın bağımsız öngörücüsü olarak bulunmuştur. Sonuç: Bu çalışma göstermiştir ki, fQRS varlığı aşikar yapısal kalp hastalığı olmayanlarda sık PVA ile ilişkilidir.
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    Helikobakter pilori olgularının göz içi basıncı ve retina sinir lifi tabakası kalınlık ölçümlerinin incelenmesi
    (2014) Gencer, Baran; Güneş, Fahri; Tan, Yusuf Ziya; Akbal, Erdem; Tufan, Hasan Ali; Ekim, Yeliz; Şen, Hacer
    Amaç: Glokom olgularında Helikobakter pilori (HP) prevalansının yüksek olduğu geçmiş çalışmalarda gösterilmiştir. Prospektif çalışmamızda HP pozitif ve negatif olguların göz içi basınç (GİB) ve retina sinir lifi tabakası kalınlık (RSLTK) ölçümlerini karşılaştırmayı amaçladık. Yöntemler: Gastrit bulguları olan 91 hastada HP varlığı üre nefes testi veya gastrik biyopsi ile araştırıldı. Hastaların tam oftalmolojik muayeneleri takiben GİBı Goldmann aplanasyon tonometresi ve RSLTKı spektral optik koherens tomografi ile ölçüldü. Hastaların demografik ve klinik özellikleri kategorik değişkenler için ?² testi ve sürekli de- ğişkenler için Mann Whitney U testi ile karşılaştırıldı. Bulgular: Çalışma kriterlerine uyan 74 hastada (27 erkek, 47 kadın) HP pozitif ve 16 hastada (7 erkek, 9 kadın) ise HP negatif olarak saptandı. Ortanca (minimum-maksium) yaş değerleri HP pozitif grup için 46 (18-79) ve HP negatif grup için 51 (18-67) idi. HP pozitif 74 hastanın 147 gözü ve HP negatif 16 hastanın 31 gözü çalışmaya dahil edildi. GİB ortanca değerleri HP pozitif grupta 14 (7-21) mmHg ve HP negatif grupta 14 (8-18) mmHg olarak saptandı. Üst, temporal, alt ve nazal kadranlarda ölçülen RSLTKların ortanca değerleri HP pozitif grupta sırasıyla 122(98- 165), 68(50-101), 135(93-188), 79(51-120) mikron ve HP negatif grupta ise sırasıyla 120(94-161), 67(43-104), 129(94-166), 76(50-97) mikron olarak bulundu. İki grup arasında GİB ve RSLTK ölçümleri karşılaştırıldığında aralarında istatiksel anlamlı fark olmadığı görüldü (p>0,05). Sonuç: Bu çalışmada HP pozitif olguların GİB ve RSLTK ölçümlerinin HP negatif olgu grubuna göre anlamlı farklılık göstermediği bulundu. Glokom ile HP arasında ilişki olduğunu göstermek için geniş olgu serilerinde randomize vaka kontrollü histolojik ve serolojik çalışmaların yapılması gerekmektedir.
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    Hiperparatroidili bir Hastada Pubik ve Sakral Yetmezlik Kırığı
    (Çanakkale Onsekiz Mart Üniversitesi, 2014) Gökmen, Ferhat; Savaş, Yılmaz; Kömürcü, Erkam; Kızıldağ, Betül; Tan, Yusuf Ziya
    Yetmezlik kırıkları direnci azalmış kemiğe uygulanan normal veya fizyolojik bir stresin sonucu gelişen stres kırığının bir alt tipidir. Bu kırıklar kemiğin elastisitesinin veya mineral içeriğinin anormal olduğu birçok durumda ortaya çıkar. Yetmezlik kırığının en sık görülen sebebi postmenopozal osteoporozdur. Diğer önemli nedenler senil osteoporoz, osteomalazi, hiperparatroidi, radyasyon uygulanması, kortikosteroid tedavisi ve romatoid artrittir. Yetmezlik Kırığı ciddi kasık, kalça ağrısı ve güçsüzlüğü olan postmenopozal kadınlarda akla gelmelidir. Bu yazıda hiperparatroidisi olan bir hastada üst ve alt pubik ramusun yetmezlik kırığı ile birlikte sakral yetmezlik kırığı bulunan olgunun klinik ve radyolojik bulguları sunulmuştur.
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    Left Ventricular Twist Mechanics Are Impaired in Patients with Coronary Slow Flow
    (Wiley, 2015) Barutcu, Ahmet; Bekler, Adem; Temiz, Ahmet; Kirilmaz, Bahadir; Yener, Ali UEmit; Tan, Yusuf Ziya; Gazi, Emine
    PurposeCoronary slow flow (CSF) is a rare condition described as the delayed angiographic passage of a contrast agent in the absence of stenosis in epicardial coronary arteries. Left ventricular (LV) systolic and diastolic dysfunctions have been described in the presence of CSF. However, the effect of CSF on LV twist functions has not been assessed. We aimed to evaluate the effects of CSF on LV twist mechanics using speckle tracking echocardiography (STE). MethodsTwenty CSF patients (24-60years) were enrolled according to the exclusion criteria. Twenty subjects with similar demographic characteristics and normal coronary arteries were the controls. Participants were evaluated with conventional echocardiography and STE. ResultsThe general characteristics of the two groups were similar. LV twist, LV torsion, and apical rotation were impaired in the CSF group (P=0.015, P=0.012, and P<0.001, respectively). Time to peak twist (TPT) and time to peak untwisting (TPU) were prolonged in CSF patients (P<0.001 and P<0.001, respectively). In the CSF group, rotation-deformation delay was shortened (P<0.001) and global longitudinal strain (GLS) was lower (P<0.001). The thrombolysis in myocardial infarction (TIMI) frame count was negatively correlated with LV twist, LV torsion and apical rotation (P=0.002, r=-0.624; P=0.002, r=-0.624; and P=0.002, r=-0.632, respectively). ConclusionsWe demonstrated that LV twist mechanics are impaired in CSF patients. Worse LV twist parameters were associated with greater TIMI frame count.
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    Prognostic value of free/total PSA ratio in prediction of bone metastases in patient with prostate cancer
    (Elsevier Science Bv, 2018) Ozdemir, Semra; Tan, Yusuf Ziya; Ersay, Ahmet Resit; Ozturk, Fulya Koc; Ozdemir, Beril Su
    [Anstract Not Available]
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    Öğe
    Psöriatik artritli bir olguda bilateral üst ekstremite ödemi
    (2015) Gökmen, Ferhat; Akbal, Ayla; Savaş, Yılmaz; Zateri, Coşkun; Karaca, Adem; Tan, Yusuf Ziya
    Psöriatik artrit (PsA), seronegatif spondiloartropati grubunda yer alan,periferal artrit, entezit, spondilit ve psöriasis ile karakterize infamatuvarromatizmal bir hastalıktır. Lenfödem ekstremite distalinde daha fazlabir veya birden fazla bölgede görülebilen, tümörler, enfeksiyonlar,busitler, romatoid artrit, polimiyalji romatika gibi birçok infamatuvar venoninfamatuvar hastalığa sekonder olarak gelişebilen lenfatik akımdakiyavaşlama ile gelişen bir hastalıktır. Lenfödem PsAda nadir gelişen birkomplikasyondur. Sıklıkla asimetrik ve daha çok alt ekstremitede görülür.Bu yazıda PsA tanısı ile takip ettiğimiz ve her iki üst ekstremitede şişlikşikayeti ile başvuran ve yapılan incelemelerde bilateral üst ekstremite lenfödemi tanısı koyduğumuz olgu rapor edilmiştir.