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    Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity
    (Springer, 2020) Ciftci, Halil, I; Can, Mustafa; Ellakwa, Doha E.; Suner, Salih C.; Ibrahim, Mohamed A.; Oral, Ayhan; Sekeroglu, Nazim
    Marine natural products have drawn a great deal of attention as a vital source of new drugs for the last five decades. However, marine organisms in the seas surrounding Turkey (the Black Sea, the Aegean Sea and the Mediterranean Sea) haven't been yet extensively explored. In the present study, three marine organisms (Dysidea avara, Microcosmus sabatieri and Echinaster sepositus) were sampled from the Dardanelles (Turkish Straits System, Western Turkey) by scientific divers, transferred to the laboratory and then were extracted with 70% ethanol. The extracts were tested for their cytotoxic effect against K562, KMS-12PE, A549, and A375 cancer cell lines. The sponge extract elicited the most promising cytotoxic activity, thus it was further evaluated against H929, MCF-7, HeLa, and HCT116 cancer cells. Most of the designated cells showed a considerable sensitivity for the sponge extract particularly H929, K562, KMS-12PE and HeLa cells with IC50 less than 10 mu g/mL. On the contrary, the other two extracts exhibited no cytotoxic activity on all cells at 100 mu g/mL concentration. The sponge extract was tested for its capacity to induce apoptosis in cancer cells and to inhibit a panel of tyrosine kinases showing remarkable results. The outcome of this study represents a platform for discovery of new chemotherapeutic agents of marine natural origin.
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    Geraniol and cinnamaldehyde as natural antibacterial additives for poly(lactic acid) and their plasticizing effects
    (Walter De Gruyter Gmbh, 2020) Akgun, Mert; Basaran, Ihsan; Suner, Salih C.; Oral, Ayhan
    The main goal of this study is to prepare antibacterial poly(lactic acid) (PLA) containing cinnamaldehyde and geraniol and to evaluate the antibacterial activity and assess the changes of physical properties of the PLA films. Cinnamaldehyde- and geraniol-incorporated (10%, 20%, 30%, and 50% v/w) PLA films were prepared via solution-casting. While preparing these films, plasticizers were not added to the matrix. Antibacterial activities of these films against Escherichia coli and Staphylococcus aureus were investigated by the disk diffusion method. Thermal degradation characteristics were analyzed via thermogravimetric analysis (TGA), glass transition, crystallization, and melting temperatures, and enthalpies of the films were determined from differential scanning calorimetry (DSC) scans. Tensile strength and elongationat-break values of neat PLA and antibacterial-compound-containing films were evaluated and compared after the mechanical tests. Moreover, the changes in the polymer morphology were observed by SEM analysis, and opacity of the films was determined by UV-vis spectroscopy. Our results showed that both compounds provided antibacterial effect to the PLA, with cinnamaldehyde being more effective than geraniol. Moreover, plasticization effects of the compounds were confirmed by DSC analysis.