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    Association of SARS-CoV-2 IgG Antibody Levels with Clinical/Laboratory Characteristics in COVID-19 Patients: Data from a Turkish Study
    (Clin Lab Publ, 2022) Karaali, Ridvan; Dinc, Harika O.; Ozdemir, Yusuf E.; Dalar, Zeynep G.; Kurt, Ahmet F.; Aktas, Ayse N.; Sirekbasan, Serhat
    Background: COVID-19 causes clinical manifestations ranging from asymptomatic infection to multi-organ failure. It is reported that those with severe disease have higher anti-SARS-CoV-2 antibody titers compared to asymptomatic or mild cases. We evaluated the correlation of antibody responses with laboratory and clinical indicators in COVID-19 patients. Methods: Seventy-nine male and 66 female patients (mean age: 39) with at least one positive SARS-CoV-2 RTPCR test and SARS-CoV-2 IgG antibody result after acute infection were included. Results: Seventy-six (52%), 45 (31%), and 24 (17%) patients had mild, moderate, and severe clinical findings, respectively. Patients with high body mass index and advanced age had significantly more severe disease (p < 0.001). A significant correlation was found between the increase in lymphopenia, C-reactive protein, ferritin, D-dimer, and lactate dehydrogenase and the severity of clinical findings (p = 0.0001). SARS-CoV-2 IgG antibody test was positive in 128 (88.3%) patients. A significant correlation was found between disease severity and antibody levels in the comparison of all groups (p < 0.001). Conclusions: Long-term monitoring of immune responses will be required to determine the appropriate time for the administration of new vaccines.
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    Öğe
    Exploring the Effects of Lucilia sericata Larvae on Biofilm-forming Bacteria in Wounds
    (2022) Eğribel, Merve; Sirekbasan, Serhat; Çakan, Hüseyin; Polat, Erdal
    Objective: Biofilm-induced chronic wound infections are among the most significant causes of treatment failures. Healing chronic wounds with biofilm is a major issue worldwide due to high costs and adverse effects on patients. In this study, we aimed to investigate the impacts of Lucilia sericata larvae on biofilm-forming bacteria in chronic wounds. Method: We recruited 30 patients applying to Istanbul University-Cerrahpasa, Traditional and Complementary Medicine Research and Application Center, Wound Healing Unit, between December 2019 and March 2021. We obtained swab cultures before and immediately after applying Larval Debridement Therapy (LDT). After identifying isolated bacteria, we examined all agents by susceptibility and biofilm formation. Results: While isolating only a single bacterial genus/species in 19 patients, we could detect more than one bacterial genus/species in 11 of them. Moreover, we observed biofilm formation in bacteria isolated from 21 patients, but it was not the case in bacteria grown in 9 patients. Following LDT, we discovered that the biofilm layer on wounds was removed in a short time (two to three sessions). Conclusion: Although many methods are adopted in healing chronic wounds with biofilm formation, they often remain ineffective. The therapy with L. sericata larvae, a simple and effective method, may promote rapid healing of biofilm- forming wounds.