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Öğe Effects of fine-needle aspiration biopsy (FNAB) nodule depth on pain score(Springer London Ltd, 2016) Toman, H.; Ozkul, F.; Erbag, G.; Erbas, M.; Simsek, T.; Adam, G.; Arik, M. K.Fine-needle aspiration biopsy (FNAB) of the thyroid is generally a well-tolerated procedure associated with weak levels of pain. However, pain may be very intense in some patients. The cause for the pain in these patients has not been identified. The hypothesis of this study is that there is a likely relationship between pain level and nodule depth during FNAB. Included in the study were 98 patients with euthyroid nodular goiter who underwent FNAB. When ultrasound guided thyroid fine-needle aspiration biopsy was performed findings such as the distance of the nodule to the skin, the size of the nodule, visual analogue scale (VAS) score values were recorded. The distance of nodule to skin and nodule size was measured, respectively, as 10.7 +/- 2.8 mm and 21.7 +/- 8.6 mm. Mean VAS score was 36 +/- 16. FNAB-related pain was correlated with the nodule depth (r = 0.43, p < 0.001). In the logistic regression analysis, we also found that high VAS score class was effected by only nodule depth (B = -1.619; OR 1.287; CI 1.057-1.565, p < 0.05). Our results show that pain increased significantly during FNAB in patients who had more deeply situated nodules. Local anesthetic methods may be recommended for these patients.Öğe Investigation of histopathological effects after intra-arterial sugammadex injection in an experimental animal model(Comenius Univ, 2016) Kiraz, H. A.; Toman, H.; Erbas, M.; Karabulut, Yuyucu Y.; Simsek, T.; Hanci, V; Uzun, M.PURPOSE: Intra-arterial injection of medications are related to mortality and morbidity. It was aimed to investigate the histopathological effects caused by two different intra-arterial doses of sugammadex, a new selective relaxant binding agent used to reverse the effects of steroidal systemic muscle relaxants used in surgeries carried out under general anesthesia. METHODS: A total of 15 rabbits were randomly divided into 3 groups. The control group was given 1 mL saline bolus into the central artery of the ear. The other two groups (Group Sgdx2 and group Sgdx16) were given 2 and 16 mg/kg sugammadex, respectively, intra-arterially. RESULTS: In control group, histopathological evaluation was in normal limits. The cross-sections belonging to Group Sgdx2 did not have any significant pathological change compared with control group (p > 0.05). Edema and single-cell necrosis were significantly higher in Group Sgdx16 when compared to control group (p < 0.05). In comparison to Group Sgdx2, single-cell necrosis was significantly higher in Group Sgdx16 (p < 0.05). CONCLUSION: Being broadly used in anesthesia, sugammadex should be administered with care because when given by intra-arterial route it may cause tissue damage and tissue loss and the patients' arteries should be carefully checked (Tab. 2, Fig. 3, Ref. 21). Text in PDF www.elis.sk.Öğe Investigation of the effects of oleuropein rich diet on rat enteric bacterial flora(Comenius Univ, 2016) Kiraz, A.; Simsek, T.; Tekin, S. Z.; Elmas, S.; Tekin, M.; Sahin, H.; Altinisik, H. B.OBJECTIVES AND BACKGROUND: Oleuropein is a phenolic compound of olive leaves. Enteric bacterial flora is very important for human health and diet is a directly affecting factor of enteric bacterial flora composition. In this study, it was hypothesized that oleuropein could reduce total aerobic bacterial count in rat caecal flora. METHODS: Twenty adult, male, Wistar albino rats were randomly divided into two groups. Group C (n=10) was fed with standard rat chow and water for 30 days. Group 0 (n=10) received olive leaf extract 20 mg/kg/day by intragastric gavage in addition to standard rat chow and water for 30 days. One gram of caecal content was collected from each rat and then consecutive 10-fold serial dilutions were prepared with a final concentration of 10(-8). Then 0.1 ml of each dilution were spread onto the surfaces of Plate Count Agar and Violet Red Bile Glucose Agar to enumerate the aerobic enteric bacteria. RESULTS: Total aerobic bacterial counts of Group 0 were significantly lower than of Group C in all agar plates inoculated with ceacal samples for every dilution (p<0.05). CONCLUSION: Adding oleuropein to enteral feeding solutions of critically ill patients may be adventageous in the presence of clinical conditions predisposing to bacterial translocation by reducing enteric bacterial counts (Tab. 1, Ref. 32). Text in PDF www.elis.sk.Öğe THE EFFECT OF OLEUROPEIN RICH DIET ON QTC INTERVAL IN ANESTHETIZED RABBITS(Lippincott Williams & Wilkins, 2016) Simsek, T.; Sahin, H.; Altinisik, H. B.; Altinisik, U.; Toman, H.; Kiraz, H. A.; Demiraran, Y.[Anstract Not Available]
